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Inter-hospital transfers and door-to-balloon times for STEMI: a single centre cohort study

Journal of Geriatric Cardiology 2020年第6期17卷 321-329页

作者： RenéForsyth Zhong-Hua SUN christopher reid Rachael Moorin Department of Medical Radiation Sciences Curtin UniversityPerthAustralia School of Public Health NHMRC Centre of Research Excellence in Cardiovascular Outcomes ImprovementPerthAustralia Centre of Research Excellence in Therapeutics Monash UniversityMelbourneAustralia School of Public Health Curtin UniversityPerthAustralia School of Population and Global Health the University of Western AustraliaCrawleyAustralia

Background Key performance indices such as door-to-balloon times have long been recognized as quality metrics in reducing time to care for patients with acute coronary syndromes(ACS). In the situation where patients do not present to a facility capable of 24/7 percutaneous coronary interventions(PCI) delays in time to therapy can exceed the recommendation of 90 min or less. This study aimed to evaluate the impact of transfers on performance indices for patients diagnosed with ST-segment elevation myocardial infarction(STEMI). Methods Over a seven month collection period, all patients presenting with symptoms suggestive of ACS and admitted for PCI were studied. Patients were divided into dichotomous groups of direct presentations or transfers from a secondary non-PCI capable hospital with key times recorded, including symptom-onset, first hospital and PCI-capable hospital arrival and balloon inflation times to evaluate time of treatment for STEMI patients. Results Of the 87 patients diagnosed with STEMI, transferred patients experienced statistically significant delays in symptom-onset to the PCI-capable hospital(PCI-H) arrival(215 vs. 95 min, P < 0.001), symptom-onset to balloon inflation(225 vs. 160 min, P = 0.009) and first hospital arrival to balloon inflation times(106 vs. 56 min, P < 0.001). Only 28%(n = 9) of transferred patients underwent balloon inflation within 90 min from first hospital arrival, while 60%(n = 19) did within 120 min, although all received balloon inflation within 90 min from arrival at the PCI-H. After controlling for confounding factors of socio-economic status, presentation date/time and diagnostic category, transferred patients experienced an average 162% longer delays from symptom-onset to PCI-H door arrival, and 98% longer delays in symptom-onset to balloon inflation;compared to patients who present directly to the PCI-H. No statistically significant differences were noted between transferred and direct patients when measured from PCI-

关键词： Acute coronary syndrome Door-to-balloon times Inter-hospital transfers ST-segment elevation myocardial infarction

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Compositionally Driven Viscometric Behaviors of Poly (Alkyl Methacrylates) in Lubricating Oils

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Advances in Chemical Engineering and Science 2022年第2期12卷 65-86页

作者： reid A. Patterson christopher P. Kabb David M. Nickerson Eugene Pashkovski Research and Development The Lubrizol Corporation Wickliffe USA

Viscosity index (VI) and shear stability index (SSI) are standard methods used in the lubricant industry to determine temperature-viscosity dependency and resistance to product degradation, respectively. A variety of oil-soluble polymers, including poly(alkyl methacrylates) (PAMAs) are routinely used to control these properties in fully-formulated liquid lubricants. In this report, we use reversible addition-fragmentation chain transfer (RAFT) polymerization to precisely target identical degrees of polymerization in a family of PAMAs with varying lauryl, hexyl, butyl, ethyl, and methyl groups. Then, expanding on previous methodology reported in the literature, we establish structure property relationships for these PAMAs, specifically looking at how intrinsic viscosity [η] and Martin interaction parameters KM relate to VI and SSI characteristics. While the intrinsic viscosity [η] is associated with the volume of macromolecules at infinite dilution, the parameter KM reflects the hydrodynamic interactions of polymer chains at actual polymer concentrations in lubricating oils. In this paper, we show that the dependence of VI on the non-dimensional concentration c/c* (or c[η]) can be presented in a form of master curve with shift factors proportional to KM that decreases with increasing size of alkyl groups. This finding implies that even in the dilute regime, the coil-expansion theory used to explain the effect of macromolecules on VI should be complemented with the idea of hydrodynamic interactions between polymer molecules that can be controlled by the choice of alkyl chains in the family of PAMAs.

关键词： Viscosity Index Shear Stability Index Polymethacrylates Lubricating Oils

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抗抑郁药停药综合征

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中国实用乡村医生杂志 2008年第2期15卷 40-43页

作者： christopher H. Warner William Bobo Carolynn Warner Sara reid James Rachal 丛潜佟晓宁赵文嫣孙乃会 Winn Armycommunity Hospital 中国医科大学学生处七年制办公室

抗抑郁药药物疗法的中止有时可以导致抗抑郁药停药综合征，早期的报道将其称为“停药反应”，症状包括类似流感的症状、失眠、恶心、感觉失调以及觉醒过度。所有抗抑郁药均曾有过停药综合征的病例报道，或在药品说明书中有警告，提示突... 详细信息

抗抑郁药药物疗法的中止有时可以导致抗抑郁药停药综合征，早期的报道将其称为“停药反应”，症状包括类似流感的症状、失眠、恶心、感觉失调以及觉醒过度。所有抗抑郁药均曾有过停药综合征的病例报道，或在药品说明书中有警告，提示突然停药或药物逐渐减量时，可能会出现上述一系列反应。抗抑郁药包括选择性5-羟色胺重吸收抑制剂（SSRIs）、三环类抗抑郁药、

关键词：停药综合征抗抑郁药

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