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General Optimal Polynomial Approximants,Stabilization,and Projections of Unity

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Analysis in Theory and Applications 2023年第4期39卷 309-329页

作者： christopher Felder Department of Mathematics and Statistics Washington University In St.LouisSt.LouisMo 63136USA

In various Hilbert spaces of analytic functions on the unit disk,we charac-terize when a function has optimal polynomial approximants given by truncations of a single power series or,equivalently,when the approximants *** also intro-duce a generalized notion of optimal approximant and use this to explicitly compute orthogonal projections of 1 onto certain shift invariant subspaces.

关键词： Optimal polynomial approximants inner functions

Exploiting a chink in the armor:engineering broadly neutralizing monoclonal antibodies for SARS-like viruses

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Signal Transduction and Targeted Therapy 2021年第7期6卷 1944-1945页

作者： Mirko Cortese christopher J.Neufeldt Department of Infectious Diseases Molecular VirologyHeidelberg UniversityHeidelbergGermany

In a recent article published in Science,Rappazzo and co-authors1 engineered a human monoclonal antibody to bind and neutralize a broad range of SARS-like *** authors used a directed evolution approach with yeast surface display on antibodies isolated from a SARS-CoV-1 survivor,to engineer a broad-spectrum neutralizing antibody with improved neutralization breath,potency,and resistance to viral spike glycoprotein(S protein)mutations(Fig.1).

关键词： neutral SARS antibodies

Chromatoprobe as a sample-sparing technique for residual solvent analysis of drug discovery candidates by gas chromatography

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Journal of Pharmaceutical Analysis 2017年第4期7卷 265-269页

作者： christopher J.Poronsky Jingfang Qian Cutrone Bristol-Myers Squibb Research and DevelopmentWallingfordCT 06492USA

In drug discovery research, residual solvent measurement is an integral part of purity analysis for synthesis of a drug candidate before it is used for toxicity testing. This is usually carried out using gas chromatography(GC)with direct injection sample introduction. This method requires testing compounds to be soluble at high concentrations( > 50 mg/mL, usually in DMSO) to achieve acceptable sensitivity, a hurdle which is not always achievable for some samples such as cyclic peptides and oligonucleotides. To overcome the limitation associated with the direct injection approach, a new method using the Chromatoprobe thermal extraction device was developed for quantifying residual solvents of drug discovery compounds. This method not only consumes significantly less material(less than 1 mg), but also shows higher sensitivity than the direct injection *** addition, because no diluent is required with the Chromatoprobe thermal extraction, all residual solvents can be detected and measured without further method optimization. In our study, we compared data from GC residual solvent analysis using the Chromatoprobe solid sample introduction to those of the direct injection method for seven in-house samples. Our results showed a good agreement between the data from these two sample introduction methods. Thus, the Chromatoprobe sample introduction method provided a samplesparing alternative to the direct injection method for the measurement of residual solvents in drug *** method can be particularly useful for residual solvent analysis in samples that are available only in limited amounts, poorly soluble, and/or unstable in the diluents used for the direct injection method.

关键词： Chromatoprobe Thermal extraction Gas chromatography Residual solvent Drug discovery

An ICT model for increased adoption of farm input information in developing countries:A case in Sikasso,Mali

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Information Processing in Agriculture 2019年第1期6卷 26-46页

作者： Macire Kante Robert Oboko christopher Chepken University of Nairobi P.O.Box 30197-00100 GPONairobiKenya Centre National de la Recherche Scientifique et Technologique BamakoMali

Information and Communication Technologies(ICT)play a key role in the dissemination of information on farm inputs for their increased ***-scale cereal farmers have been exposed to ICT-based farm input information in developing ***,an underuse of these ICTs services has led to an insignificant adoption of farm input *** underuse was due to certain *** purpose of this study was to propose an ICT model for increased adoption of farm input information by establishing these factors and their relationships.A convenient sample of 300 small-scale cereal farmers was selected in Sikasso,Mali to gather *** partial least squares structural equation modelling technique was used to assess the model that was being *** used the technique to establish the measurement model validity and to assess the structural model(hypotheses).The result suggested that the model was highly predictive of the Use of ICT-based farm input information(80.7%).In addition,use of these ICT-based farm input information was also highly predictive(68.4%)of the Increased Adoption of farm input information by small-scale cereal farmers in developing countries.

关键词： Cereal farmers Productivity ICT-based farm input information Developing countries Mali

A general-purpose machine learning framework for predicting properties of inorganic materials

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npj Computational Materials 2016年第1期2卷 70-76页

作者： Logan Ward Ankit Agrawal Alok Choudhary christopher Wolverton Department of Materials Science and Engineering Northwestern UniversityEvanstonILUSA Department of Electrical Engineering and Computer Science Northwestern UniversityEvanstonILUSA

A very active area of materials research is to devise methods that use machine learning to automatically extract predictive models from existing materials *** prior examples have demonstrated successful models for some applications,many more applications exist where machine learning can make a strong *** enable faster development of machine-learning-based models for such applications,we have created a framework capable of being applied to a broad range of materials *** method works by using a chemically diverse list of attributes,which we demonstrate are suitable for describing a wide variety of properties,and a novel method for partitioning the data set into groups of similar materials to boost the predictive *** this manuscript,we demonstrate how this new method can be used to predict diverse properties of crystalline and amorphous materials,such as band gap energy and glass-forming ability.

关键词： method properties inorganic

Bioavailability of Arsenic and Antimony in Terrestrial Ecosystems:A Review

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Pedosphere 2019年第6期29卷 681-720页

作者： Saeed BAGHERIFAM Trevor CBROWN christopher MFELLOWS Ravi NAIDU Chemistry-School of Science and Technology University of New EnglandArmidale NSW 2351(Australia Global Centre for Environmental Remediation Faculty of Science and Inform ation TechnologyUniversity o f NewcastleUniversity DriveCallaghan N S W 2308(Australia

Arsenic (As) and antimony (Sb) are metalloids that belong to group 15 of the periodic table and exhibit toxic properties in the environment. They mostly occur naturally at low concentrations in soil, although these can be significantly elevated in both aquatic and terrestrial food chains as a result of dispersion from anthropogenic sources, e.g ., mining activities. The bioavailability, i.e., the proportion of the contaminant in soil and dust that is available for uptake by plants and other living organisms, presents the greatest risk to terrestrial ecosystems. Various in vivo and in vitro methods have been used to measure As and Sb bioaccessibility in soil and dust. In vivo measurement of bioavailability can be time consuming, expensive, and unethical;thus, in vitro methods are commonly preferred. However, there is considerable uncertainty around the efficacy of in vitro tools used to measure the bioavailable fractions of As and Sb. The results of these methods are dependent on many variables, e.g., soil characteristics, contaminant sources, and chemical composition of in vitro methods. Therefore, substantial variations are observed between in vitro and in vivo results obtained from different test animals and endpoints. In this paper, we review the literature on As and Sb bioavailability in terrestrial ecosystems and current in vivo and in vitro techniques used for assessing bioavailability and bioaccessibility of metalloids. This would reveal research gaps and allow scientists and environmental policy makers to gain a deeper understanding of the potential risks associated with these metalloids in the environment.

关键词： Bioaccessibility Bioavailable fraction Contamination Environmental risk assessment Metalloids Phytoavailability Relative bioavailability Soil characteristics Toxicant

Spatially adaptive long-term semi-Lagrangian method for accurate velocity advection

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Computational Visual Media 2018年第3期4卷 223-230页

作者： Takahiro Sato christopher Batty Takeo Igarashi Ryoichi Ando The University of Tokyo Tokyo Japan University of Waterloo Waterloo Canada. National Institute of Informatics Japan.

We introduce a new advection scheme for fluid *** main contribution is the use of long-term temporal changes in pressure to extend the commonly used semi-Lagrangian scheme further back along the time *** algorithm starts by tracing sample points along a trajectory following the velocity field backwards in time for many *** this backtracing process,the pressure gradient along the path is integrated to correct the velocity of the current time *** show that our method effectively suppresses numerical diffusion,retains small-scale vorticity,and provides better long-term kinetic energy preservation.

关键词： fluid simulation advection method ofcharacteristics spatially adaptive inte-gration interpolation error correction

Tuning periodicity of polymer-decorated carbon nanotubes

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Science China Chemistry 2012年第5期55卷 802-807页

作者： LAIRD Eric D. LI christopher Y. A. J. Drexel Nanotechnology Institute and Department of Materials Science and Engineering Drexel University Philadelphia Pennsylvania 19104 USA

Carbon nanotube (CNT) is one of the most extensively investigated nanomaterials. Patterning soft matter such as liquid crystals and polymers on CNTs could potentially enable various applications for CNTs. We have demonstrated that controlled polymer crystallization using CNTs as the 1D nucleation sites can lead to periodically functionalized CNTs. Here we show that selected crystalline block copolymers can be periodically decorated along CNTs. This facile technique opens a gateway to periodic patterning on 1-D nanomaterials.

关键词： polymer crystallization carbon nanotube block copolymers

Memory, Rite, and Tradition： A Comparative Confucian-Christian Literary Analysis

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Frontiers of Philosophy in China 2014年第2期9卷 301-317页

作者： christopher David Hancock Wolfson College Oxford University Oxford OX2 6UD UK

I The Confucian Classics and Christian Scriptures speak often about the role ＂the past＂ plays in shaping individual and communal character, life, perception, morality and purpose. In both Christianity and classical Confucianism, memory, rite and tradition are each accorded a central place in preserving and interpreting the past as a dynamic force in the present. The first part of this paper studies points of thematic similarity in Christian and Confucian interpretation of memory, rite and tradition. In the second part of the paper, however, critical points of divergence are addressed; for behind the formal similarities lie deeper intellectual, relational and moral differences in understanding the nature and function of ＂the past＂ in determining both the present and the future. Comparative literary analysis provides a rich resource for contemporary application of the Confucian Classics and Christian Scriptures to discussion of cultural memory and global harmony. The comparative reading of ＇texts＇ also provides an important point of access for understanding the role literature itself plays in determining the form, content and power of memory, ritual and tradition in both Confucianism and Christianity.

关键词： Confucianism Bible Augustine memory anamnesis ritual