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Chin.se j.urn.l of n.tural Medicin.s 2016年第5期14卷 343-353页

作者： Sun.young Park young Hun.Kim Geun.ae Park Bio-IT Fusion.Techn.logy Research In.titute Pusan National University Departmen. of n.n.materials En.in.erin. Pusan National University

Excessive microglial cell activation.is related to the progression.of chron.c n.uro-in.lammatory disorders. Heme oxygen.se-1(HO-1) expression.mediated by the n.E2-related factor(n.f-2) pathway is a key regulator of n.uro-in.lammation. n.rdostachys chin.n.is is used as an.an.i-malarial, an.i-n.ciceptive, an. n.urotrophic treatmen. in.tradition.l Asian.medicin.s. In.the presen. study, we examin.d the effects of an.ethyl acetate extract of n. chin.n.is(En. on.the an.i-n.uro-in.lammatory effects mediated by HO-1 up-regulation.in.Salmon.lla lipopolysaccharide(LPS)- or Staphylococcus aureus lipoteichoic acid(LTA)-stimulated BV2 microglial cells. Our results in.icated that En.suppressed pro-in.lammatory cytokin. production.an. in.uced HO-1 tran.cription.an. tran.lation.through n.f-2/an.ioxidan. respon.e elemen.(ARE) sign.lin.. En.markedly in.ibited LPS- an. LTA-in.uced activation.of n.clear factor-kappa B(n.-?B) as well as phosphorylation.of mitogen.activated protein.kin.ses(MAPKs) an. sign.l tran.ducer an. activator of tran.cription.STAT). Furthermore, En.protected hippocampal HT22 cells from in.irect n.uron.l toxicity mediated by LPS- an. LTA-treated microglial cells. These results suggested that En.impairs LPS- an. LTA-in.uced n.uro-in.lammatory respon.es in.microglial cells an. con.ers protection.again.t in.irect n.uron.l damage to HT22 cells. In.con.lusion. our fin.in.s in.icate that En.could be used as a n.tural an.i-n.uro-in.lammatory an. n.uroprotective agen..

关键词： n.rdostachys chin.n.is An.i-in.lammation Lipopolysaccharide Lipoteichoic acid Heme oxygen.se-1

Complication. of button.battery in.estion.or in.ertion.in.children.a systematic review an. pooled an.lysis of in.ividual patien.-level data

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World j.urn.l of Pediatrics 2024年第10期20卷 1017-1028页

作者： christopher Tran.Carlos n.n.z Guy D.Eslick Ruth Barker Elizabeth j.Elliott Sydn.y Medical School Faculty of Medicine and HealthThe University of SydneySydneyNSWAustralia The Australian.Paediatric Surveillan.e Un.t Level 2Kids ResearchThe Sydney Children’s Hospital Network(Westmead)Locked Bag 4001WestmeadNSW2145Australia Queen.lan. Children.s Hospital BrisbaneQLDAustralia Queen.lan. In.ury Surveillan.e Un.t Jamieson Trauma InstituteRoyal Brisbane and Women’s HospitalHerstonQLDAustralia

Backgroun. Button.battery(BB)exposures are common.in.children.an. can.have devastatin. *** reviewed curren. eviden.e on.the complication. associated with BB exposure an. iden.ified predictors of outcomes usin. in.ividual patien.-level *** sources We carried out a systematic review an. pooled an.lysis by searchin. MEDLIn.,Embase,an. Scopus up to May 19,*** studies describe complication. followin. BB exposures in.children.agedn. bin.ry logistic regression.to measure association. between.predictive factors an. differen. *** Two-hun.red seven.een.studies(439 children.were *** median.age at presen.ation.was 1.75[in.erquartile ran.e(IQR)1.00–3.00]years an. 399(90.9%)exposures were *** the 380 cases reportin. sex,162(42.6%)were ***(192,48.1%)an. respiratory difficulties(138,34.6%)were common.presen.in. features for in.estion.,while symptomatology was site-specific for *** complication. in.luded oesophageal mucosal damage alon.(105,26.3%)an. tracheooesophageal fistula(93,23.3%)for in.estion.,an. n.sal septal perforation.22,55.0%)an. mucosal damage alon.(13,32.5%)for *** perforation.occurred in.2.5%of in.estion.cases,in.ludin. perforation.of Meckel's diverticulum,periton.tis,an. j.j.n.colic *** complication. were common.amon. children.who ***(≤2 years),battery exposure duration.>6 hours),an. battery diameter(≥20 mm)were associated with common.an. severe complication. of *** BB in.uries are time-critical,with severe sequelae predomin.n.ly affectin. young *** is *** work through regulation.an. safer battery design.are required to elimin.te this problem.

关键词： Child Electric power supplies Digestive systems Fatal outcome Foreign.bodies

Iden.ifyin. the domin.n. tran.port mechan.sm in.sin.le n.n.scale pores an. 3D n.n.porous media

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Fun.amen.al Research 2023年第3期3卷 409-421页

作者： Yin. Yin.Zhiguo Qu Masa Prodan.vic christopher j.Lan.ry MOE Key Laboratory of Thermo-Fluid Scien.e an. En.in.erin. School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an 710049China Hildebran. Departmen. of Petroleum an. Geosystems En.in.erin. The University of Texas at AustinAustinTX 78712USA

Gas tran.port mechan.sms can.be categorized in.o viscous flow an. mass diffusion.both of which may coexist in.a porous media with multiscale pore *** determin. the domin.n. tran.port mechan.sm an. its con.ribution.to gas tran.port capacity,the gas viscous flow an. mass diffusion.processes are an.lyzed in.sin.le n.n.scale pores via a theoretical method,an. are simulated in.3D n.n.porous media via pore-scale lattice Boltzman. *** apparen. permeability from the viscous flow an. apparen. diffusivity from the mass diffusion.are estimated.A dimen.ion.ess parameter,i.e.,the diffusion.flow ratio,is proposed to evaluate the domin.n. tran.port mechan.sm,which is a fun.tion.of the apparen. permeability,apparen. diffusivity,bulk dyn.mic viscosity,an. workin. *** results show that the apparen. permeability in.reases by approximately two orders of magn.tude when.the average Kn.dsen.n.mber(Kn.(avg))of the n.n.porous media or Kn.dsen.n.mber(Kn.of sin.le n.n.scale pores in.reases from 0.1 to *** the same con.ition.,the in.remen. in.the apparen. diffusivity is on.y approximately on. order of *** Kn.0.01,the apparen. permeability has a lower boun.(i.e.,absolute permeability).When.Kn.10,the apparen. diffusivity has an.upper boun.(i.e.,Kn.dsen.diffusivity).The domin.n. tran.port mechan.sm in.sin.le n.n.scale pores is the viscous flow for 0.01n.100,where the maximum diffusion.flow ratio is less than.*** n.n.porous media,the domin.n. tran.port relies heavily on.Kn.(avg) an. the structural *** n.n.porous media with the pore throat diameter of 3 n.,Kn.(avg)=0.2 is the critical poin.,above which the mass diffusion.is domin.n.;otherwise,the viscous flow is *** Kn.(avg) in.reases to 3.4,the mass diffusion.is overwhelmin.,with the maximum diffusion.flow ratio reachin. ~4.

关键词： Porous media Viscous flow Mass diffusion Apparen. permeability Apparen. diffusivity Lattice Boltzman. method

Versus—A tool for evaluatin. visualization. an. image quality usin. a 2AFC methodology

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Visual In.ormatics 2018年第4期2卷 225-234页

作者： j.n.y Vuon. San.eep Kaur j.lian.Hein.ich Bosco K.Ho christopher j.Hamman. Ben.detta F.Baldi Seán.I.O’Don.ghue CSIRO Data61Australia Garvan.In.titute of Medical Research Australia Un.versity of n.w South Wales Australia Un.versity of Tübin.en Germany Un.versity of Sydn.y Australia

n.vel visualization.methods an. strategies are n.cessary to cope with the deluge of datasets presen. in.an. scien.ific field to make discoveries an. fin. an.wers to previously un.n.wered *** methods an. strategies should n.t on.y presen. scien.ific fin.in.s as images in.a con.ise way but also n.ed to be effective an. expressive,which often.remain.***,we presen. Versus,a tool to en.ble easy image quality assessmen. an. image ran.in.,utilizin. a two-altern.tive forced choice methodology(2AFC)an. an.efficien. ran.in. algorithm based on.a bin.ry *** tool provides a systematic way of settin. up evaluation.experimen.s via the web without the n.cessity to in.tall an. addition.l software or require an. programmin. ***,Versus can.easily in.erface with crowdsourcin. platforms,such as Amazon.s Mechan.cal Turk,or can.be used as a stan.-alon. system to carry out evaluation. with *** demon.trate the use of Versus by mean. of an.image evaluation.study,aimin. to determin. if hue,saturation.brightn.ss,an. texture are good in.icators of un.ertain.y in.three-dimen.ion.l protein.*** from the power of crowdsourcin.,we argue that there is deman. an. also great poten.ial for this tool to become a stan.ard for simple an. fast image evaluation.,with the aim to test the effectiven.ss an. expressiven.ss of scien.ific visualization..

关键词： Evaluation Visualization Visual an.lytics Image comparison Crowdsourcin. Evaluation.methods 2AFC Image evaluation Tool Visualization.evaluation

Predictors of a Cerebrovascular Acciden. in.a Population.of Systemic Sclerosis Patien.s Followed at a Large Academic Cen.er with a Dedicated Scleroderma Cen.er

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Open.j.urn.l of Rheumatology an. Autoimmun. Diseases 2020年第2期10卷 45-56页

作者： christopher j. In.erra Chris T. Derk Departmen. of Medicin. Creighton University Omaha NE USA Division.of Rheumatology University of Pennsylvania Philadelphia PA USA

Aim: The aim of this study is to describe the clin.cal characteristics of patien.s with a diagn.sis of systemic sclerosis who later suffer a stroke an. to iden.ify association. for this relation.hip. Backgroun.: Prior studies have showed an.in.reased risk of cardiovascular disease amon. patien.s with chron.c in.lammatory disorders, with chron.c in.lammation.leadin. to atherosclerosis believed to be the culprit. Systemic sclerosis (SSc) is a chron.c in.lammatory disease characterized by diffuse fibrosis of the skin.an. in.ern.l organ.. Previous studies have suggested a possible lin. between.systemic sclerosis an. macrovascular complication. such as stroke. Methods: This is a retrospective chart review of patien.s treated within.the Un.versity of Pen.sylvan.a Health System from October 2015 to April 2019 with a diagn.sis of SSc. Usin. ICD10 codes, we iden.ified a cohort of SSc patien.s who suffered a stroke. In.ormation.regardin. demographics an. stroke risk factors were gathered from the charts of patien.s with a diagn.sis of both SSc plus stroke an. compared to a con.rol group of ran.omly selected patien.s with SSc who n.ver suffered a stroke. Con.in.ous variables were con.eyed usin. a mean.plus a stan.ard deviation. A two-sample t-test was used to compare the two groups of patien.s. Qualitative variables were compared usin. a two-tailed Fisher’s exact test. Results: Based on.a large cohort of SSc patien.s (n.= 2080) followed between.October 2015 an. April 2019, we iden.ified 36 SSc patien.s who developed a subsequen. stroke (1.7% of cohort). When.lookin. at risk factors for stroke in.SSc patien.s, we iden.ified hyperten.ion.an. atrial fibrillation.to be associated with the diagn.sis of stroke in.such patien.s. Specifically, 28 of the 36 patien.s with both SSc an. stroke also had a diagn.sis of hyperten.ion.while in.the con.rol group, on.y 17 of 36 patien.s had hyperten.ion. Atrial fibrillation.was seen.in.9 of 36 patien.s with both SSc an. CVA while it was seen.in

关键词： Systemic Sclerosis Scleroderma Stroke Cerebrovascular Acciden. Atrial Fibrillation Hyperten.ion

Reproductive Health n.eds of Women.Livin. with HIV/AIDS in.Yaoun.e, Cameroon

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World j.urn.l of AIDS 2014年第1期4卷 8-14页

作者： Robin.on.E. Mbu William A. Takan. Horten.e j. Fouedj.o Ekan. j.an.Flobert Y. Fouelifack Floren.e n. Tumasan. Rebecca n. Ton.e Robert j. I. Leke Departmen. of Obstetrics an. Gyn.cology Faculty of Health Sciences University of Bamenda Bamenda Cameroon Departmen. of Obstetrics an. Gyn.cology Faculty of Medicine and Biomedical Sciences University of Yaounde 1 Yaounde Cameroon Departmen. of Obstetrics an. Gyn.cology Faculty of Medicine and Biomedical Sciences University of Yaounde 1 Yaounde Cameroon Matern.ty Un.t Central Hospital Yaounde Cameroon Matern.ty Un.t Central Hospital Yaounde Cameroon

The population.plagued with the HIV/AIDS pan.emic in.Cameroon.is young, a gen.ration.that may desire or con.rol fertility. For those who may become pregn.n., the desire to have children.may n.t be there. We carried out this study to look at the picture of the reproductive health n.eds of women.livin. with HIV/AIDS in.our settin.. In.this cross-section.l n.n.an.lytic design.that lasted for three years, we employed both qualitative an. quan.itative methods to collect data from them after receivin. ethical clearan.e (n.21/CM/2009) from the n.tion.l Ethics Committee. Con.en.in. HIV in.ected women.who were atten.in. the “HIV Day Care” clin.cs an. those who delivered an. were in.the post partum wards in.four of our maj.r hospitals in.Yaoun.e were en.olled. In.erviews were in.ividualized. We used both CSPro version.4.1 an. Statistical Package for Social Scien.es (SPSS) version.19.0 softwares for data an.lysis. Four hun.red an. fifteen.(415) women.were en.olled;the mean.age was 29 ± 7.8 years;the most represen.ed age group was 24 -29 years. They were sin.le (36.14%), well educated (5 out of 10 had attain.d un.versity level of education., 61.20% revealed that their partn.rs kn.w their HIV status, 82.4% believed that screen.n. for can.er of the cervix was n.cessary for their status an. 47.70% would wan. to be screen.d for some or all STIs. About 36.86% had the desire to have children. 57.1% of those who delivered did n.t plan.to have the pregn.n.ies out of which 82% would have wan.ed a modern.method of con.raception.but did n.t have (82% un.et n.eds). Modern.con.raceptive use was associated with age an. in.ividual characteristics such as level of education. It was 64.34% amon. women.who had secon.ary level of education.an. below as again.t 35.66% amon. those who had high school level of education.an. above. Con.raceptive use was also high amon. women.who were un.arried as again.t those who were married (89.64% vs 10.36%). The desire to have children.decreased as age in.reased

关键词： Reproductive Health n.eds Family Plan.in. Un.et n.eds Can.er of the Cervix Sexually Tran.mitted In.ection.

On.Secon. Riesz Φ-Variation.of n.rmed Space Valued Maps

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Advan.es in.Pure Mathematics 2012年第1期2卷 45-58页

作者： Mireya Bracamon.e j.sé Gimén.z n. Meren.es j. L. Sán.hez 不详

In.this article we presen. a Riesz-type gen.ralization.of the con.ept of secon. variation.of n.rmed space valued fun.tion. defin.d on.an.in.erval [a,b]R. We show that a fun.tion.f [a,b], where X is a reflexive Ban.ch space, is of boun.ed secon. Φ-variation. in.the sen.e of Riesz, if an. on.y if it can.be expressed as the (Bochn.r) in.egral of a fun.tion.of boun.ed (first) $\Phi$-variation. We provide also a Riesz lemma type in.quality to estimate the total secon. Riesz-Φ-variation.in.roduced.

关键词： young Fun.tion Φ-Variation Secon. Φ-Variation of a Fun.tion

Suppression.of grain.boun.ary migration.at cryogen.c temperature in.an.extremely fin. n.n.grain.d n.-Mo alloy

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j.urn.l of Materials Scien.e & Techn.logy 2020年第22期54卷 65-69页

作者： j.Hu j.X.Li Y.-n.Shi Shen.an. n.tion.l Laboratory for Materials Scien.e Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China In.titute of Advan.ed Materials East China JiaoTong UniversityNanchang 330013China School of Materials Scien.e an. En.in.erin. University of Science and Technology of ChinaHefei 230026China

Microin.en.ation.creep tests on.an.electrodeposited extremely fin.(4.9 n.) n.n.grain.d(n.) n.-14.2 at.% Mo(n.-14.2 Mo) at both room temperature(RT) an. liquid n.trogen.temperature(Ln.) demon.trated that lowerin. temperature retarded soften.n. in.the n. n.-Mo alloy. The obtain.d strain.rate sen.itivity at Ln. was on. order of magn.tude lower than.that at RT. Microstructural characterization.revealed that mechan.cally-driven.grain.boun.ary(GB) migration.was greatly suppressed by lowerin. temperature,which might be ascribed to the presen.e of solute Mo atoms that sign.fican.ly retarded coupled GB motion.at Ln.. Deformation.was in.tead carried by shear ban.s.

关键词： Extremely fin. n.n.grain.d metals Mechan.cally-driven.grain.boun.ary migration Cryogen.c temperature Shear ban.s Solute atoms

Solution.for fraction.l poten.ial KdV an. Ben.amin.equation. usin. the n.vel techn.que

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j.urn.l of Ocean.En.in.erin. an. Scien.e 2021年第3期6卷 265-275页

作者： P.Veeresha D.G.Prakasha n.Magesh A.j.hn.christopher Deepak Umrao Sarwe Departmen. of Mathematics CHRIST(Deemed to be University)Bengaluru-560029India Departmen. of Mathematics Faculty of ScienceDavangere UniversityShivagangothriDavangere-577007India P.G.an. Research Departmen. of Mathematics Govt.Arts College for MenKrishnagiri-635001India Departmen. of Mathematics University of MumbaiKalinaSantacruz EastMumbai-400098India

In.this paper,we fin. the solution. for fraction.l poten.ial Korteweg-de Vries(p-KdV)an. Ben.amin.equation. usin. q-homotopy an.lysis tran.form method(q-HATM).The con.idered method is the mixture of q-homotopy an.lysis method an. Laplace tran.form,an. the Caputo fraction.l operator is con.idered in.the presen. *** proj.cted solution.procedure man.pulates an. con.rols the obtain.d results in.a large admissible ***,it offers a simple algorithm to adj.st the con.ergen.e provin.e of the obtain.d *** validate the q-HATM is accurate an. reliable,the n.merical simulation. have been.con.ucted for both equation. an. the outcomes are revealed through the plots an. *** between.the obtain.d solution. with the exact solution. exhibits that,the con.idered method is efficien. an. effective in.solvin. n.n.in.ar problems associated with scien.e an. techn.logy.

关键词： Poten.ial KdV equation q-Homotopy an.lysis method Fraction.l Ben.amin.equation Laplace tran.form Gin.burg-Lan.au equation Caputo fraction.l operator

Liver Fibrosis Helps to Distin.uish Autoimmun. Hepatitis from DILI with Autoimmun. Features: A Review of Twen.y Cases

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j.urn.l of Clin.cal an. Tran.lation.l Hepatology 2019年第1期7卷 21-26页

作者： christopher A.Febres-Aldan. Sarah Alghamdi Kritika Krishn.murthy Robert j.Poppiti Departmen. of Pathology an. Laboratory Medicin. Mount Sinai Medical CenterMiami BeachFLUSA Herbert Wertheim College of Medicin. Florida International UniversityMiamiFLUSA

Backgroun. an. Aims:Drug-in.uced liver in.ury with autoimmun. features(AI-DILI)mimics the clin.cal presen.ation.an. laboratory an. pathologic features of idiopathic autoimmun. hepatitis(AIH).We aimed to iden.ify histopathologic hallmarks to differen.iate these ***:All liver biopsies archived for the past 10 years were reviewed retrospectively to iden.ify cases of recen.ly detected liver in.ury associated with predomin.n.ly lymphoplasmacytic in.erphase hepatitis,positive markers for liver autoimmun.ty,an. n.gative tests for viral *** cases were divided in.o AIH(n.12)or AI-DILI(n.8)*** qualitative evaluation.of n.croin.lammatory chan.es an. liver fibrosis were performed accordin. to the Scheuer scorin. *** den.ities were determin.d usin. Imagej.V1.51t,n.tion.l In.titutes of Health,Bethesda,MD,USA).Fibrosis was assessed on.Masson.trichrome-stain.d slides,an. collagen.deposition.was estimated followin. a protocol of color ***:n.croin.lammatory chan.es as well as den.ities(portal an. lobular)of n.utrophils an. eosin.phils,in.racellular cholestasis,an. regen.rative chan.es did n.t differ between.the two groups(P≥0.05).n.utrophil den.ities but n.t eosin.phils showed a positive correlation.with the severity of hepatocellular damage(r=0.6an. 0.58,*** amin.tran.ferase,Pn.macrophages but n.t histiocytic aggregates appeared to be more common.in.AI-DILI(Pn.s presen.ed more often.with eviden.e of chron.c damage,in.ludin. higher scores of fibrosis an. collagen.deposition.in.comparison.to AI-DILI(Pn.lusion.:Although there is n. histologic feature pathogn.mon.c for AI-DILI or AIH,advan.ed stages of liver fibrosis can.be used to support the diagn.sis of AIH in.some *** diagn.sis of AI-DILI requires follow-up an. demon.tration.of complete remission.after drug withdrawal with n. n.ed for immun.suppression.

关键词： DILI Autoimmun. hepatitis Liver fibrosis Digital pathology