检索结果-南通市图书馆

The Triple Combination of Meropenem,Avibactam,and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers

在线全文

学校读者我要写书评

暂无评论

Engineering 2024年第7期38卷 124-132页

作者： Zhuoren Ling Alistair James Macdonald Farley Aditya Lankapalli Yanfang Zhang Shonnette Premchand-Branker Kate Cook Andrei Baran Charlotte Gray-Hammerton Claudia Orbegozo Rubio Edgars Suna Jordan Mathias Jürgen Brem Kirsty Sands Maria Nieto-Rosado Maria Mykolaivna Trush Nadira Naznin Rakhi Willames Martins Yuqing Zhou christopher Joseph Schofield Timothy Walsh Department of Biology&Ineos Oxford Institute for Antimicrobial Research University of OxfordOxford OX13REUK Chemistry Research Laboratory Department of Chemistry and the Ineos Oxford Institute for Antimicrobial ResearchUniversity of OxfordOxford OX13TAUK Latvian Institute of Organic Synthesis Riga LV-1006Latvia Department of Medical Microbiology Division of Infection and ImmunitySchool of MedicineCardiff UniversityCardiff CF144XNUK Enzymology and Applied Biocatalysis Research Center Faculty of Chemistry and Chemical EngineeringBabes-Bolyai UniversityCluj-Napoca 400028Romania

This work explores the potential of a triple combination of meropenem(MEM),a novel metallo-blactamase(MBL)inhibitor(indole-2-carboxylate 58(InC58)),and a serine-b-lactamase(SBL)inhibitor(avibactam(AVI))for broad-spectrum activity against carbapenemase-producing bacteria.A diverse panel comprising MBL-and SBL-producing strains was used for susceptibility testing of the triple combination using the agar dilution *** frequency of resistance(FoR)to MEM combined with InC58 was *** were sequenced and tested for cross resistance,fitness,and the stability of the resistance *** with the double combinations of MEM plus an SBL or MBL inhibitor,the triple combination extended the spectrum of activity to most of the isolates bearing SBLs(oxacillinase-48(OXA-48)and Klebsiella pneumoniae carbapenemase-2(KPC-2))and MBLs(New Delhi metallo-blactamases(NDMs)),although it was not effective against Verona integron-encoded metallo-blactamase(VIM)-carrying Pseudomonas aeruginosa(***)and OXA-23-carrying Acinetobacter baumannii(***).The FoR to MEM plus InC58 ranged from 2.22×10^(-7)to 1.13×10^(-6).The resistance correlated with mutations to ompC and comR,affecting porin C and copper permeability,*** mutants manifested a fitness cost,a decreased level of resistance during passage without antibiotic pressure,and cross resistance to another carbapenem(imipenem)and a b-lactamase inhibitor(taniborbactam).In conclusion,compared with the dual combinations,the triple combination of MEM with InC58 and AVI showed a much wider spectrum of activity against different carbapenemaseproducing bacteria,revealing a new strategy to combat b-lactamase-mediated antimicrobial resistance.

关键词： Carbapenemase Metallo/serine-b-lactamase inhibitor Avibactam Meropenem Antimicrobial resistance

Amplitude Variation with Offset Responses Modeling Study of Walkaway Vertical Seismic Profile Data at CO_2 Geological Storage Site,Ketzin,Germany

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2011年第5期85卷 1118-1126页

作者： Sayed Hesammoddin KAZEMEINI christopher JUHLIN Department of Earth Sciences Uppsala University

An important component of any CO_2 sequestration project is seismic monitoring for tracking changes in subsurface physical properties,such as velocity and *** reservoirs have different amplitude variation with offset(AVO) responses,which can define underground conditions. In the present paper we investigate walkaway vertical seismic profile(VSP) AVO response to CO_2 injection at the Ketzin site,the first European onshore CO_2 sequestration pilot study dealing with research on geological storage of CO_***,we performed rock physics analysis to evaluate the effect of injected CO_2 on seismic velocity using the Biot-Gassmann *** the basis of this model,the seismic response for different CO_2 injection saturation was studied using ray tracing *** then created synthetic walkaway VSP data,which we then *** contrast,synthetic seismic traces were created from borehole ***,we found that the amplitude of CO_2 injected sand layer with different gas saturations were increased with the offset when compared with the original brine target *** is the typical classⅢAVO anomaly for gas sand *** AVO responses matched the synthetic seismic traces very ***,walkaway VSP AVO response can monitor CO_2 distribution in the Ketzin area.

关键词： CO_2 injection rock physics amplitude variation with offset walkaway vertical seismic profile seismic modeling

Jet flows from bubbles during subcooled pool boiling on micro wires

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2005年第4期48卷 385-402页

作者： D. M. christopher Laboratory of Phase Change and Interfacial Transport Phenomena Department of Thermal Engineering Tsinghua University Beijing 100084 China

An experimental investigation was conducted on subcooled nucleate boiling on ultra-small wires having diameters of 25―100 μm. High-speed photography and laser PIV (Particle Image Velocimetry) technology were used to visually observe the bubble dynamics. For highly subcooled boiling at moderate heat fluxes, the bubbles generally remained attached to the micro heating wires and bubble-top jet flows were clearly observed. Smaller bubbles usually had stronger bubble-top jet flows, while larger bubbles seemed to produce multi-jet flows. The structures of the bubble-top jet flows, as well as multi-jet flows, were proposed from the experimental observation. A model was developed to describe jet flow phenomena from bubbles on micro wires. Numerical simulations for bubbles having diameter of 0.03 and 0.06 mm showed that both the bubble-top and multi-jet flows were induced by a strong Marangoni effect due to high temperature gradients near the wire. The predicted velocity magnitudes and flow structures agreed very well with experimental measurements. The bubble size relative to the wire is an important factor affecting the jet flow structure. For a 0.03 mm bubble on a 0.1 mm wire, only a bubble-top jet flow forms, while a complex multi-jet flow pattern forms around the bubble with a weak bubble-top jet and two side jet flows for a 0.06 mm bubble.

关键词： subcooled boiling, bubble, multi-jet, jet flow, PIV, Marangoni, CFD.

Clinical variability and molecular heterogeneity inprostate cancer

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2016年第4期18卷 543-548页

作者： Jonathan Shoag christopher E Barbieri Department of Urology NewYork-Presbyterian Hospital Weill Cornell Medical College New York USA Sandra and Edward Meyer Cancer Center Weill Cornell Medica College New York USA.

Prostate cancer is a clinically heterogeneous disease, with some men having indolent disease that can safely be observed, while others have aggressive, lethal disease. Over the past decade, researchers have begun to unravel some of the genomic heterogeneity that contributes to these varying clinical phenotypes. Distinct molecular sub-classes of prostate cancer have been identified, and the uniqueness of these sub-classes has been leveraged to predict clinical outcomes, design novel biomarkers for prostate cancer diagnosis, and develop novel therapeutics. Recent work has also elucidated the temporal and spatial heterogeneity of prostate cancer, helping us understand disease pathogenesis, response to therapy, and progression. New genomic techniques have provided us with a window into the remarkable clinical and genomic heterogeneity of prostate cancer, and this new perspective will increasingly impact patient care.

关键词： cell biology ERG genomics molecular heterogeneity prostate cancer sequencing serine peptidase inhibitor, Kazaltype 1 SPOP tumor profiling

Recapturing meaning: Toward a new material-based design theory for architecture

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Architectural Research 2022年第4期11卷 609-617页

作者： christopher Bardt Faculty of Architecture Rhode Island School of DesignRhode IslandUSA

Architects and students of architecture today are less physically engaged with modeling and drawing representations of proposed things and increasingly rely on digital means and methods that are transforming their embodied interactions with actual materials. The result is that meaning, which makes architecture so central to our cultures, is being diminished. It is being replaced by a misplaced belief that "better" buildings and architecture result from increased use of digital tools. To recapture meaning will require a new design theory for architecture that builds on material engagement theory and the critical role of resistance and sensuous reasoning in the design process, which material has historically provided.

关键词： Architecture Design Material engagement Material-based design Meaning Digital tools

Development of a web-platform for mining applications

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2018年第1期28卷 95-99页

作者： christopher Newman Zach Agioutantis Nathaniel Schaefer Department of Mining Engineering University of Kentucky

‘‘Web ground control"(web GC) provides users with instantaneous access to mine design applications anywhere, at any time, through a web *** a web-based multiple-tier architecture, users are able to easily access ground control designs, perform on-demand calculations in the field, as well as facilitate project collaborations across multiple users, devices, and operating ***, the web GC platform contains five ground control related design applications previously developed and distributed by the US National Institute of Occupational Safety and Health(NIOSH), that is, analysis of roof bolt stability(ARBS), analysis of longwall pillar stability(ALPS), analysis of retreat mining stability(ARMPS), analysis of retreat mining stability–highwall mining(ARMPS-HWM), and analysis of horizontal stress in mining(AHSM).With respect to design decisions made by the web GC development team, the web GC platform will be able to further integrate future mine design applications providing the mining industry with one of a kind umbrella suite of ground control related software available at ones *** following paper provides a detailed overview on the current state of the web GC platform with discussions ranging from back-end database development and design to the front-end user-platform *** on current progress in platform development as well as beta testing results, the web GC platform is scheduled for release in the fall of 2018.

关键词： Ground control Stability Web application Cloud computing

A review of rural transformation studies:Definition,measurement,and indicators

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2023年第12期22卷 3568-3581页

作者： Dong WANG Chunlai CHEN christopher FINDLAY Crawford School of Public Policy Australian National UniversityCanberra 2600Australia

The paper reviews studies of rural transformation in three dimensions-definition,measurement,and indicators-and summarises the findings of rural transformation *** scope of rural transformation includes four elements-productivity,rurality,inclusiveness,and *** concepts of the dimensions of rural transformation and their associated indicators are insufficient for policy decision-making,as they lack objectivity,feasibility,accountability,comprehensiveness,and *** research to develop new measures to assess rural transformation in developing countries is ***,there is potential to explore the topic in some directions:urbanisation strategy,public intervention(i.e.,institution,policy,and investment),gender inclusiveness,market creation,and international trade.

关键词： rural transformation agricultural transformation structural change

Using big data and machine learning to rank traffic signals in Tennessee

在线全文

学校读者我要写书评

暂无评论

Journal of Traffic and Transportation Engineering(English Edition) 2023年第5期10卷 918-933页

作者： christopher Winfrey Piro Meleby Lei Miao Department of Engineering Technology Middle Tennessee State UniversityMurfreesboroTN 37132USA

This paper discusses low-cost approaches capable of ranking traffic intersections for the purpose of signal *** extracted intersections that are comprised of multiple roads,defined by alphanumeric traffic message channel segment codes per international classification *** of these road segments includes a variety of metrics,including congestion,planning time index,and bottleneck ranking information provided by the Regional Integrated Transportation Information *** first approach was to use a ranking formula to calculate intersection rankings using a score between 0 and 10 by considering data for different times of the day and different days of the week,weighting weekdays more heavily than weekends and morning and evening commute times more heavily than other times of *** second method was to utilize unsupervised machine learning algorithms,primarily k-means clustering,to accomplish the intersection ranking *** first approach this by checking the performance of basic k-means clustering on our data *** then explore the ranking problem further by utilizing data provided by traffic professionals in the state of *** exploration involves using MATLAB to minimize the mean-squared error of intersection rankings to determine the optimum weights in the ranking formula based on a city’s professional *** then attempted an optimization of our weights via a brute-force search approach to minimize the distance from ranking formula results to the clustering *** the ranking information was aggregated into an online SQL database hosted by Amazon web services that utilized the PHP scripting language.

关键词： Unsupervised machine learning Clustering k-means Traffic signals

Selective and taxon-dependent effects of semi-feral cattle grazing on tree regeneration in an old-growth Mediterranean mountain forest

在线全文

学校读者我要写书评

暂无评论

Forest Ecosystems 2020年第1期7卷 128-140页

作者： Xavier Fortuny christopher Carcaillet Sandrine Chauchard Ecole Pratique des Hautes Etudes(EPHE) PSL University75014 ParisFrance Laboratoire d’ cologie des Hydrosystèmes Naturels et Anthropisés(UMR5023 CNRS UniversitéLyon 1ENTPE)69622 VilleurbanneFrance Universitéde Lorraine AgroParisTechINRAEUMR Silva54000 NancyFrance

Background:In Mediterranean mountain socio-ecosystems,both grazing by livestock and the dry season may influence tree ***,the relative contributions of these drivers are poorly known,even though present and future canopy composition might result from past and present variations in climate and herbivore *** study aims to test how semi-feral cattle presence and season affect tree ***:The study was conducted using permanent plots inside and outside a cattle exclosure in an old-growth Mediterranean *** and seedlings were counted five times per year(winter,early spring,middle spring,summer,fall)and monitored over 7 ***:Semi-feral cattle exclusion increased Acer,Fagus,Ilex,Pinus,Prunus and Quercus sapling densities and increased Acer,Fraxinus,Ilex,Quercus and Sorbus seedling ***,the dry season did not exert any noticeable effects on the sapling or seedling densities of any of the studied ***:Semi-feral cattle presence may limit tree regeneration through taxon-dependent effects,which suggests that the current decrease in grazing livestock across the Mediterranean basin will modify recruitment processes and,likely,future forest ***:Semi-feral cattle presence acts as a selective driver of tree community composition.

关键词： Cattle Climate Experiment Herbivory Forest pastoralism