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Diagnosis of autoimmune gastritis by high resolution magnification endoscopy

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World journal of Gastroenterology 2006年第28期12卷 4586-4587页

作者： George K Anagnostopoulos Krish Ragunath Anthony Shonde christopher j Hawkey Wolfson Digestive Diseases Centre University HospitalNottinghamUnited Kingdom

Endoscopic visualisation of gastric atrophy is usually not feasible with *** endoscopy. Magnifying endoscopy is helpful to analyze the subepithelial microvascular architecture as well as the mucosal surface microstructure without tissue biopsy. Using this technique we were able to describe the normal gastric microvasculature pattern and we also identified characteristic patterns in two cases of autoimmune atrophic gastritis.

关键词： Magnification endoscopy Autoimmune gastritis Collecting venules Subepithelial capillary network

Post electrical or lightning injury syndrome: a proposal for an American Psychiatric Association's Diagnostic and Statistical Manual formulation with implications for treatment

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Neural Regeneration Research 2017年第9期12卷 1405-1412页

作者： christopher j.Andrews Andrew D.Reisner Mary Ann Cooper Medicine The University of Queensland Lightning and Electrical Injuries Mt Ommaney Family Practice Forensic Diagnostic Center of District Nine Lightning Injury Research Program University of Illinois at Chicago African Centres for Lightning and Electromagnetics Network

In the past, victims of electrical and lightning injuries have been assessed in a manner lacking a system- atic formulation, and against ad hoc criteria, particularly in the area of neuropsychological disability. In this manner patients have, for example, only been partially treated, been poorly or incorrectly diagnosed, and have been denied the full benefit of compensation for their injuries. This paper contains a proposal for diagnostic criteria particularly for the neuropsychological aspects of the post injury syndrome. It pays attention to widely published consistent descriptions of the syndrome, and a new cluster analysis of post electrical injury patients. It formulates a proposal which could be incorporated into future editions of the American Psychiatric Association＇s Diagnostic and Statistical Manual （DSM）. The major neuropsycholog- ical consequences include neurocognitive dysfunction, and memory subgroup dysfunction, with ongoing consequences, and sometimes including progressive or delayed psychiatric, cognitive, and/or neurological symptoms. The proposed diagnostic criteria insist on a demonstrated context for the injury, both specifying the shock circumstance, and also physical consequences. It allows for a certain delay in onset of symptoms. It recognizes exclusory conditions. The outcome is a proposal for a DSM classification for the post electrical or lightning injury syndrome. This proposal is considered important for grounding patient treatment, and for further treatment trials. Options for treatment in electrical or lightning injury are summarised, and future trials are foreshadowed.

关键词： electrical injury lightning injury neuropsychology neuropsychiatry injury American Psychiatric Association's Diagnostic and Statistical Manual

Thulium：YAG VapoEnucleation of the prostate in large glands： a prospective comparison using 70- and 120-W 2-μm lasers

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Asian journal of Andrology 2012年第2期14卷 325-329页

作者： christopher Netsch Thorsten Bach Thomas RW Herrmann Andreas j Gross Department of Urology Asklepios Hospital BarmbekHamburg 22291Germany Department of Urology MHH Medical School of HannoverHannover 30625Germany

This study compared the efficacy of 70- and 120-w 2-μm thulium：YAG VapoEnucleation of the prostate （ThuVEP） for patients with benign prostatic obstruction （BPO）. A prospective analysis of 84 patients with symptomatic BPO and prostatic enlargement （t〉 60 ml） who underwent either 70-w （n=44） or 120-w ThuVEP （n=40） non-randomly was carried out. Patient demographics and perioperative and 12-month follow-up data were analysed. The mean prostate volume was 79.90---27.49 ml in patients who had received 70-w ThuVEP, which was less than in those who had received 120-w ThuVEP （88.53＋-25.10; P=0.033）. The mean enucleation （resected weight/laser time, 2.16±1.21 g min-1 vs. 1.23±0.60 g min-1; P=-0.013）, operation efficiency （resected weight/total operation time, 0.76±0.35 g min-1 vs. 0.42＋-0.27 g min-1; P=-0.000） and percentage of resected tissue （66.93%±22.79% vs. 45.41%±23.33%; P=-0.000） were higher with 120-w treatment compared to 70-w ThuVEP. One patient （1.2% of total patients）（in the 120-w group） required a blood transfusion postoperatively. Sixty-one patients （73%） were available for review at the 12-month follow-up time point. The quality of life （QoL）, International Prostate Symptom Score （IPSS）, maximum urinary flow rate （Qmax）, postvoiding residual urine （PVR） and prostate volume improved significantly after treatment （P≤ 0.035） and were not significantly different between those treated with the different devices （70- and 120-w）. The median prostate volume reduction was 81.70% and 82.19% with 70- and 120-w ThuVEP, respectively. The incidence of complications was low and did not differ between groups treated with the different devices. Two patients （2.4%）（one per group） had a bladder neck contracture at the follow-up. ThuVEP is a safe and efficacious procedure for the treatment of symptomatic BPO. The incidence of complications was low with both devices. The 120-w thulium：YAG device enhances the effectiveness of Th,VEP with reeard to the oercentaee of resected tissue

关键词： benign prostatic obstruction laser prostate Revolix Tm:YAG ThuVEP VapoEnucleation

High–Speed electron beam curing of thick electrode for high energy density Li-ion batteries

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Green Energy & Environment 2019年第4期4卷 375-381页

作者： Zhijia Du christopher j.janke jianlin Li David L.Wood III Energy and Transportation Science Division Oak Ridge National LaboratoryOak RidgeTN 37831USA Chemical Sciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA

Electron beam curing is demonstrated as a promising method for high speed,low cost and environmentally friendly battery electrode *** work reports transfer of this process to pilot scale equipment and evaluation of electrochemical performance in prototype 1.5 Ah pouch *** LiNi0.5Mn0.3Co0.2O2(NMC532)composite electrodes with an areal loading of 25 mg cm^-2(~4 mAh cm^-2)are successfully cured at a line speed of 500 feet per minute at 275 *** to the NMC532 cathode processed via a conventional coating method,the electron beam cured electrodes show higher capacity fade in the first 100 cycles,but similar fade rate *** improvement strategies are proposed and *** work demonstrates that electron beam curing is a promising method for manufacturing thick battery electrodes at high speeds and low capital/operation cost.

关键词： Electron beam curing Li-ion batteries Thick electrode

Wing, tail, and vocal contributions to the complex acoustic signals of courting Calliope hummingbirds

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Current Zoology 2011年第2期57卷 187-196页

作者： christopher james CLARK Peabody Museum of Natural History Yale University PO Box 208106 New Haven CT 06511 USA Museum of Vertebrate Zoology University of California- Berkeley Berkeley CA USA

Multi-component signals contain multiple signal parts expressed in the same physical modality. One way to identify individual components is if they are produced by different physical mechanisms. Here, I studied the mechanisms generating acoustic signals in the courtship displays of the Calliope hummingbird Stellula calliope. Display dives consisted of three synchronized sound elements, a high-frequency tone （hfl）, a low frequency tone （lft）, and atonal sound pulses （asp）, which were then followed by a frequency-modulated fall. Manipulating any of the rectrices （tail-feathers） of wild males impaired production of the lft and asp but not the hfl or fall, which are apparently vocal. I tested the sound production capabilities of the rectrices in a wind tunnel. Single rectrices could generate the lft but not the asp, whereas multiple rectrices tested together produced sounds sitlfilar to the asp when they fluttered and collided with their neighbors percussively, representing a previously unknown mechanism of sound production. During the shuttle display, a trill is generated by the wings during pulses in which the wingbeat frequency is elevated to 95 Hz, 40% higher than the typical hovering wingbeat frequency. The Calliope hummingbird courtship displays include sounds produced by three independent mechanisms, and thus include a minimum of three acoustic signal components. These acoustic mechanisms have different constraints and thus potentially contain different messages. Producing multiple acoustic signals via multiple mechanisms may be a way to escape the constraints present in any single mechanism .

关键词： Calliope Hummingbird Courtship Multicomponent Signal Sonation Wind Tunnel

What job can a bug give?A controversy over the arsenic-guzzling bacterium cultured by NASA

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Protein & Cell 2011年第4期2卷 261-263页

作者： Mingwei Sun christopher j.Vavricka Baoli Zhu CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CASPMI)Beijing 100101China College of Life Sciences University of Science and Technology of ChinaHefei 230027China

The mysteries of life’s evolution on our planet drive us to explore the limits of *** forms on Earth as we know are composed of six essential elements:carbon,hydrogen,oxygen,nitrogen,sulfur and ***,a recently published research work funded by the National Aeronautics and Space Administration(NASA),USA,has almost shaken the fundamental knowledge about what is life made of on *** research team led by NASA astrobiologist Felisa Wolfe-Simon described a microbe isolated from California’s Mono Lake that could sustain its growth by using toxic chemical arsenic(As)instead of phosphorus(P).This surprising discovery was published online by Science Express on December 2 last year(Wolfe-Simon et al.,2010,online).If the authors of the paper were right,we would have to expand our definition of life on this *** arsenic-bug they grew was dubbed GFAj-1,which interestingly stands for“Give Felisa A job.”

关键词： bug planet Express

Organization of future training in bariatric gastroenterology

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World journal of Gastroenterology 2017年第35期23卷 6371-6378页

作者： Timothy R Koch Timothy R Shope christopher j Gostout Center for Advanced Laparoscopic General and Bariatric Surgery Med Star Washington Hospital Center and Georgetown University School of Medicine Division of Gastroenterology and Hepatology Mayo Clinic

A world-wide rise in the prevalence of obesity continues. This rise increases the occurrence of, risks of, and costs of treating obesity-related medical conditions. Diet and activity programs are largely inadequate for the long-term treatment of medically-complicated obesity. Physicians who deliver gastrointestinal care after completing traditional training programs, including gastroenterologists and general surgeons, are not uniformly trained in or familiar with available bariatric care. It is certain that gastrointestinal physicians will incorporate new endoscopic methods into their practice for the treatment of individuals with medically-complicated obesity, although the longterm impact of these endoscopic techniques remains under investigation. It is presently unclear whether gastrointestinal physicians will be able to provide or coordinate important allied services in bariatric surgery, endocrinology, nutrition, psychological evaluation and support, and social work. Obtaining longitudinal results examining the effectiveness of this ad hoc approach will likely be difficult, based on prior experience with other endoscopic measures, such as the adenoma detection rates from screening colonoscopy. As a longterm approach, development of a specific curriculum incorporating one year of subspecialty training in bariatrics to the present training of gastrointestinal fellows needs to be reconsidered. This approach should be facilitated by gastrointestinal trainees' prior residency training in subspecialties that provide care for individuals with medical complications of obesity, including endocrinology, cardiology, nephrology, and neurology. Such training could incorporate additional rotations with collaborating providers in bariatric surgery, nutrition, and psychiatry. Since such training would be provided in accredited programs, longitudinal studies could be developed to examine the potential impact on accepted measures of care, such as complication rates, outcomes, and

关键词： Obesity Bariatrics Bariatric surgery Intragastric balloon Endoscopic sleeve gastroplasty Nutrition Endoscopy Training

Synthesis and Bioassay of 4-Substituted 2-Oxoglutaric Acids

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Chinese Chemical Letters 2006年第2期17卷 156-158页

作者： Qiu Yun CHEN Qing Shan LIU christopher j. SCHOFIELD Department of Chemistry Huangshan University Tunxi 245021 Department of Chemistry University of Oxford South Park Road Oxford OX1 3TA UK

Three 2-oxoglutaric acid analogues were synthesized. Their interaction with factor- inhibiting hypoxia-inducible factor （FIH） was studied using LC-MS method. The results show that hydrophobic substitutes of 2-oxoglu... 详细信息

关键词： 2-Oxoglutatic acid analogues inhibitor.

Live-cell fluorescence imaging of ciliary dynamics

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Biophysics Reports 2021年第2期7卷 101-110页

作者： Quanlong Lü Chuanmao Zhang christopher j.Westlake Laboratory of Cellular and Developmental Signaling Center for Cancer Research National Cancer Institute National Institutes of Health Ministry of Education Key Laboratory of Cell Proliferation and Differentiation College of Life Sciences Peking University

The cilium was one of the first organelles observed through a microscope. Motile cilia appear as oscillating cell appendages and have long been recognized to function in cell motility. In contrast, the far more widespread non-motile cilia, termed primary cilia, were thought to be vestigial and largely ignored following their initial description over a century ago. Only in the last two decades has the critical function of primary cilia been elucidated. Primary cilia play essential roles in signal transduction,chemical sensation, mechanosensation and light detection. Various microscopy approaches have been important for characterizing the structure, dynamics and function of the cilia. In this review, we discuss the application of live-cell imaging technologies and their contribution to our current understanding of ciliary processes.

关键词： Cilia Ciliogenesis Ciliary dynamics Live-cell fluorescence imaging