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Hypothesis and Thought Experiment: Comparing Cognitive Competition of Neandertals and Early Humans, to Our Coming Contest with AIs

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journal of Social Computing 2024年第2期5卷 122-131页

作者： Margaret Boone Rappaport christopher j.Corbally The Human Sentience Project LLC TucsonAZ 85704USA the Department of Astronomy Steward ObservatoryUniversity of ArizonaTucsonAZ 85719USA

The history of how Homo sapiens out-survived the Neanderthals is recalled here with the goal of conceiving an edge in our coming competition with a faster, stronger artificial intelligence (AI) who has far greater capacity for information storage. The social and cognitive differences between the two hominid species, Homo sapiens and Homo neanderthalensis, are described. Based on findings from genomics, neuroscience, archaeology, and paleobiology, it appears possible that the capacities of Homo sapiens could outreach those of AIs in some ways. Especially important are human visuospatial, cultural, and, oddly enough, theological capacities, and the interaction of these capacities in group problem-solving. While communication between AIs is fast and can be widespread, the authors ask whether this is the right kind of communication for solving problems of survival. An important question is explored throughout: Is it ethical to withhold from AIs human-like capacities that may become possible to install? Finally, a worrisome question is broached: Is it the best course to create AIs in our own image to safeguard our existence in unknown future interactions with extraterrestrial species, both organic and inorganic?

关键词： cognitive evolution neuroscience genomics visuospatial capacity family structure navigation ethics extraterrestrials

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Genetics of Gallstone Disease and Their Clinical Significance: A Narrative Review

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journal of Clinical and Translational Hepatology 2024年第3期12卷 316-326页

作者： christopher j.Costa Minh Thu T.Nguyen Haleh Vaziri George Y.Wu Department of Medicine University of Connecticut Health CenterFarmingtonCTUSA Division of Gastroenterology and Hepatology University of Connecticut Health CenterFarmingtonCTUSA

Gallstone(GS)disease is common and arises from a combination of genetic and environmental *** genetic abnormalities specifically leading to cholesterol GSs are rare,there are clinically significant gene variants associated with cholesterol *** contrast,most bilirubin GSs can be attributed to genetic *** pathogenesis of cholesterol and bilirubin GSs differs *** GSs are notably influenced by genetic variants within the ABC protein superfamily,including ABCG8,ABCG5,ABCB4,and ABCB11,as well as genes from the apolipoprotein family such as ApoB100 and ApoE(especially the E3/E3 and E3/E4 variants),and members of the MUC ***,bilirubin GSs are associated with genetic variants in highly expressed hepatic genes,notably UGT1A1,ABCC2(MRP2),ABCC3(MRP3),CFTR,and MUC,alongside genetic defects linked to hemolytic anemias and conditions impacting *** genetic cases constitute a small portion of GS disease,recognizing genetic predisposition is essential for proper diagnosis,treatment,and genetic counseling.

关键词： Gallstones Cholelithiasis ATP-binding cassette transporters ABCG8 protein Human UDP-glucuronosyltransferase A1

Management of gestational diabetes mellitus via nutritional interventions:The relevance of gastric emptying

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World journal of Diabetes 2024年第7期15卷 1394-1397页

作者： Wei-Kun Huang Ryan j jalleh christopher K Rayner Tong-Zhi Wu Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health The University of AdelaideAdelaide 5000Australia Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health The University of Adelaide and Department of Gastroenterology and HepatologyRoyal Adelaide HospitalAdelaide 5000Australia

Gestational diabetes mellitus(GDM)represents one of the most common medical complications of pregnancy and is important to the well-being of both mothers and offspring in the short and long *** intervention remains the mainstay for the management of *** efficacy of nutritional approaches(*** restriction and small frequent meals)to improving the maternal-neonatal outcomes of GDM was attested to by Chinese population data,discussed in two articles in recent issues of this ***,a specific focus on the relevance of postprandial glycaemic control was *** rather than fasting hyperglycaemia often represents the predominant manifestation of disordered glucose homeostasis in Chinese women with *** is now increasing appreciation that the rate of gastric emptying,which controls the delivery of nutrients for digestion and absorption in the small intestine,is a key determinant of postprandial glycaemia in both health,type 1 and 2 *** remains to be established whether gastric emptying is abnormally rapid in GDM,particularly among Chinese women,thus contributing to a predisposition to postprandial hyperglycaemia,and if so,how this influences the therapeutic response to nutritional *** is essential that we understand the role of gastric emptying in the regulation of postprandial glycaemia during pregnancy and the potential for its modulation by nutritional strategies in order to improve postprandial glycaemic control in GDM.

关键词： Gastric emptying Postprandial glycaemia Diet Nutritional interventions Gestational diabetes mellitus

Deterministic epidemic models overestimate the basic reproduction number of observed outbreaks

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Infectious Disease Modelling 2024年第3期9卷 680-688页

作者： Wajid Ali christopher E.Overton Robert R.Wilkinson Kieran j.Sharkey Department of Mathematical Sciences University of LiverpoolPeach StreetLiverpoolL697ZXEnglandUnited Kingdom Department of Applied Mathematics Liverpool John Moores UniversityByrom StreetLiverpoolL35UXEnglandUnited Kingdom

The basic reproduction number,R_(0),is a well-known quantifier of epidemic ***,a class of existing methods for estimating R_(0)from incidence data early in the epidemic can lead to an over-estimation of this *** particular,when fitting deterministic models to estimate the rate of spread,we do not account for the stochastic nature of epidemics and that,given the same system,some outbreaks may lead to epidemics and some may ***,an observed epidemic that we wish to control is a major *** amounts to implicit selection for major outbreaks which leads to the over-estimation *** formally characterised the split between major and minor outbreaks by using Otsu's method which provides us with a working *** show that by conditioning a‘deterministic’model on major outbreaks,we can more reliably estimate the basic reproduction number from an observed epidemic trajectory.

关键词： Estimating R_(0) Simple birth-death process Major outbreak Conditioned epidemic Stochastic fade-out

Comparative utility of vestibular function tests in patients with peripheral and central vestibular dysfunction

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journal of Otology 2024年第1期19卷 5-9页

作者： Cameron B.Fattahi christopher Zaro janice j.Chung Richard F.Lewis Divya A.Chari Department of Otolaryngology-Head and Neck Surgery UMASS Memorial Medical CenterUniversity of Massachusetts Chan Medical SchoolWorcesterMAUSA jenks Vestibular Physiology Laboratory Massachusetts Eye and EarBostonMAUSA Department of Otolaryngology-Head and Neck Surgery Massachusetts Eye and EarHarvard Medical SchoolBostonMAUSA Department of Neurology Harvard Medical SchoolBostonMAUSA

Background: Bithermal caloric irrigation, video head impulse test(vHIT), and rotational testing are commonly used to assess peripheral vestibular function, but the relative clinical utility of each test in differentiating patients with peripheral vestibulopathy is ***: To determine whether(1) the combination of two or more vestibular tests enhances diagnostic utility over a single test;(2) abnormal test results on vestibular tests correlate with one ***: Retrospective analysis of data collected from multidisciplinary vestibular clinics at two academic medical centers from 2016 to ***: 150 patients(54.10 ± 15.09 years, 88 females) were included. No individual test was significantly better at predicting the presence of peripheral vestibular damage(p > 0.05). vHIT test results improved significantly when combined with either the caloric test(p = 0.007) or rotary chair test(p = 0.039). Caloric and rotational testing had high sensitivity(74.65% and 76.06%, respectively) and specificity(83.54% and 78.48%, respectively). vHIT demonstrated excellent specificity(89.87%) but poor sensitivity(47.89%). Caloric, vHIT, and rotary chair tests results did not correlate with one another(p > 0.05).Conclusions: Vestibular function tests have comparable diagnostic utility, yet each offers unique advantages. Caloric and rotational testing may be best suited for screening peripheral damage and vHIT may function ideally as a confirmatory test.

关键词： vestibular patients specificity

Surgeon preferences in the treatment of thumb carpometacarpal osteoarthritis

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World journal of Orthopedics 2024年第5期15卷 435-443页

作者： Edward j Wu Bradley W Fossum Wyatt Vander Voort christopher O Bayne Robert M Szabo Department of Orthopedic Surgery University of Minnesota Medical SchoolMinneapolisMN 55455United States Department of Orthopaedic Surgery UC Davis School of MedicineSacramentoCA 95817United States

BACKGROUND Primary thumb carpometacarpal(CMC)osteoarthritis is one of the most common conditions encountered by hand *** the vast number of operations that have been proposed,none have demonstrated results significantly superior to trapeziectomy *** The purpose of our study was to determine why surgeons opt for their technique in treating CMC *** A cross-sectional survey of active members of the American Society for Surgery of the Hand was conducted to evaluate the reasons behind their preferred technique in the treatment of isolated thumb CMC *** were contacted by email once and provided with a link to a de-identified survey consisting of 5 treatment questions and 5 demographic *** Of 950 responses were received.40.5%of surgeons preferred trapeziectomy+ligament reconstruction tendon interposition(LRTI),followed by trapeziectomy+suspensionplasty(28.2%),suture button suspension(5.9%),trapeziectomy alone(4.6%),prosthetic arthroplasty(3.2%),arthrodesis(1.1%),and other(6.6%).Proponents of trapeziectomy+LRTI cited familiarity(73.2%),exposure during fellowship(48.8%)and less proximal migration(60%)to be the main reasons affecting their *** who preferred trapeziectomy+suspensionplasty most reported simplicity(74.9%),fewer complications(45.3%),less proximal migration(43.8%),and avoidance of autogenous tissue harvest(42.7%).Advocates of suture button suspension cited avoidance of autogenous tissue harvest(80.4%),shorter immobilization(76.8%),and quicker recovery(73.2%)with their *** of trapeziectomy alone cited simplicity(97.7%),fewer complications(86.4%),and avoidance of autogenous tissue harvest(59.1%).In their comments,45%of surgeons choosing trapeziectomy alone cited evidence as an additional *** of prosthetic arthroplasty cited improved pinch strength(83.3%)and improved range of motion(63.3%),while those preferring arthrodesis cited better pinch strength(90%)and freque

关键词： Thumb carpometacarpal Osteoarthritis Trapeziectomy Ligament reconstruction tendon interposition Suspensionplasty Preferences Trends

Graphene-calcium carbonate coating to improve the degradation resistance and mechanical integrity of a biodegradable implant

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journal of Magnesium and Alloys 2024年第1期12卷 394-404页

作者： Lokesh Choudhary Parama Chakraborty Banerjee R.K.Singh Raman Derrek E.Lobo christopher D.Easton Mainak Majumder Frank Witte jörg F.Löffler Department of Mechanical and Aerospace Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Department of Chemical and Biological Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Nanoscale Science and Engineering Laboratory(NSEL) Bldg 37Monash UniversityClayton CampusMelbourneVIC 3800Australia CSIRO Materials Science and Engineering Bayview AvenueClaytonVIC 3168Australia julius Wolff Institute and Berlin Brandenburg Center for Regenerative Therapies Charité–Universitätsmedizin BerlinAugustenburger Platz 113353 BerlinGermany Laboratory of Metal Physics and Technology Department of MaterialsETH Zurich8093 ZurichSwitzerland

Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body *** necessitates the synthesis of a suitable coating that may improve the corrosion resistance of these implants without compromising their mechanical *** this study,an AZ91 magnesium alloy,as a representative for a biodegradable Mg implant material,was modified with a thin reduced graphene oxide(RGO)-calcium carbonate(CaCO_(3))composite *** analytical and in-vitro electrochemical characterization reveals that this coating significantly improves the corrosion resistance and mechanical integrity,and thus has the potential to greatly extend the related application field.

关键词： Graphene coating Biodegradable implant Hydroxyapatite Corrosion Magnesium alloy

A new perspective on intervertebral disc calcification—from bench to bedside

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Bone Research 2024年第1期12卷 50-61页

作者： Emanuel j.Novais Rajkishen Narayanan jose A.Canseco Koen van de Wetering christopher K.Kepler Alan S.Hilibrand Alexander R.Vaccaro Makarand V.Risbud Department of Orthopaedic Surgery Sidney Kimmel Medical CollegeThomas Jefferson UniversityPhiladelphiaPAUSA Unidade Local de Saúde do Litoral Alentejano Orthopedic DepartmentSantiago do CacémPortugal Rothman Orthopedic Institute at Thomas jefferson University PhiladelphiaPAUSA

Disc degeneration primarily contributes to chronic low back and neck ***,there is an urgent need to understand the spectrum of disc degeneration phenotypes such as fibrosis,ectopic calcification,herniation,or mixed *** these phenotypes,disc calcification is the least *** calcification,by definition,is the pathological mineralization of soft tissues,widely studied in the context of conditions that afflict vasculature,skin,and ***,disc calcification is associated with poor surgical outcomes and back pain refractory to conservative *** is frequently seen as a consequence of disc aging and progressive degeneration but exhibits unique molecular and morphological characteristics:hypertrophic chondrocyte-like cell differentiation;TNAP,ENPP1,and ANK upregulation;cell death;altered Pi and PPi homeostasis;and local *** studies in mouse models have provided a better understanding of the mechanisms underlying this *** is essential to recognize that the presentation and nature of mineralization differ between AF,NP,and EP ***,the combination of anatomic location,genetics,and environmental stressors,such as aging or trauma,govern the predisposition to ***,the systemic regulation of calcium and Pi metabolism is less important than the local activity of PPi modulated by the ANK-ENPP1 axis,along with disc cell death and differentiation *** there is limited understanding of this phenotype,understanding the molecular pathways governing local intervertebral disc calcification may lead to developing disease-modifying drugs and better clinical management of degeneration-related pathologies.

关键词： degeneration metabolism intervertebral