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缓释中药药用纤维的研制

缓释中药药用纤维的研制

非洲人服用豆浆尿液~1H-NMR代谢组学研究

第八届功能性纺织品及纳米技术研讨会

作者：韩洁余灯广 christopher j．branford-white 朱利民东华大学化学化工与生物工程学院

目的:制备载有中药活性成分肉桂酸的 PAN 载药缓释纤维。方法:采用湿法纺丝技术,以 PAN 为药物载体,制备了不同含量的肉桂酸/PAN(5%、10%、20%和30%,w/w) 共混载药纤维,并用扫描电镜观察了其表面形态。纤维中药物的载药量以及累计释放... 详细信息

目的:制备载有中药活性成分肉桂酸的 PAN 载药缓释纤维。方法:采用湿法纺丝技术,以 PAN 为药物载体,制备了不同含量的肉桂酸/PAN(5%、10%、20%和30%,w/w) 共混载药纤维,并用扫描电镜观察了其表面形态。纤维中药物的载药量以及累计释放量利用紫外分光光度法测定。结果:成功制备了连续、均匀的不同浓度肉桂酸/PAN 载药纤维;肉桂酸在 PAN 纤维中的载药量随着浓度的增大差异增大;30天的体外药物释放研究表明,几种载药纤维中肉桂酸的累计释放百分比为39%-54%,说明具有一定的缓释功能。结论:本文对新型中药载药模式和缓释药用纤维的发展应用增添了部分实验数据。

关键词：肉桂酸载药纤维缓释湿法纺丝技术

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营养健康新观察 2012年第1期 40-42页

作者： Olumuyiwa L.Ogegbo Wimal Dissanyake john Crowder Olayinka Asekun Oluwole Familoni christopher j.branford-white S.W.AnnieBligh 张华琦伦敦都会大学健康研究与政策学院尼日利亚拉各斯大学科学学院化学系

当今,代谢组学研究已广泛应用于解析领域,例如药物的发现和毒理学研究、疾病的诊断以及营养基因组学。由于代谢组学研究自身的优势,它被认为比其他传统的体外研究具备更为广泛的应用前景,目前将代谢组学应用于探索膳食中主要生物活性成... 详细信息

当今,代谢组学研究已广泛应用于解析领域,例如药物的发现和毒理学研究、疾病的诊断以及营养基因组学。由于代谢组学研究自身的优势,它被认为比其他传统的体外研究具备更为广泛的应用前景,目前将代谢组学应用于探索膳食中主要生物活性成分的生化作用已成为研究热点。豆浆是由富含植物雌激素(异黄酮类)的大豆制成。所谓的植物雌激素包括大豆黄酮、三羟异黄酮、大豆黄素、异黄酮苷、染料木苷和黄豆黄苷。与人体中的雌激素相比。

关键词：代谢组学研究 NMR 植物雌激素大豆黄素异黄酮类黄酮苷生化作用染料木苷活性成分毒理学研

非洲人服用豆浆尿液1H-NMR代谢组学研究

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非洲人服用豆浆尿液1H-NMR代谢组学研究

芳香/脂肪族共聚脲多孔膜的微观形态及其性能的初步研究

作者： Olumuyiwa L.Ogegbo Wimal Dissanyake john Crowder Olayinka Asekun Oluwole Familoni christopher j.branford-white S.W. AnnieBligh 张华琦尼日利亚拉各斯大学科学学院化学系

当今,代谢组学研究已广泛应用于解析领域,例如药物的发现和毒理学研究、疾病的诊断以及营养基因组学。由于代谢组学研究自身的优势,它被认为比其他传统的体外研究具备更为广泛的应用前景,目前将代谢组学应用于探索膳食中主要生物活性成...

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膜科学与技术 2010年第1期30卷 44-49页

作者：李雪莲朱利民 branford-white christopher 陈大俊东华大学材料科学与工程学院纤维材料改性国家重点实验室化学化工与生物工程学院生物工程系上海201620 伦敦都市大学卫生研究与政策研究所伦敦N78DB

在相同制膜条件下,采用扩散致相转化法制备了芳香/脂肪族共聚脲多孔膜.通过对孔隙率、力学性能的测试及扫描电镜的微观分析,讨论了凝胶浴体系中溶剂的体积百分数及同类制膜大分子的不同链段结构对膜微观结构和机械性能的影响.实验结果表... 详细信息

在相同制膜条件下,采用扩散致相转化法制备了芳香/脂肪族共聚脲多孔膜.通过对孔隙率、力学性能的测试及扫描电镜的微观分析,讨论了凝胶浴体系中溶剂的体积百分数及同类制膜大分子的不同链段结构对膜微观结构和机械性能的影响.实验结果表明:随着凝固浴中溶剂体积百分含量的增加,多孔膜表面的微孔直径逐渐增大;而相应截面的指状孔有缩小的趋势,直到最终消失而形成完全海绵状孔的截面形态;制膜大分子本身的结构对膜形态结构及性能有重大影响:三种共聚脲多孔膜都具有非对称结构,不同结构的共聚脲制备出的多孔膜各自的表面、截面形态都不相同;多孔膜的机械性能也都各不相同,其中芳香族共聚脲多孔膜具有最好的机械性能.

关键词：芳香/月旨肪族共聚脲多孔膜膜形态膜性能

有机碱在脂肪酶Candida antarctica B催化仲醇拆分中的促进作用

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精细化工 2009年第2期26卷 157-161页

作者：吴小梅朱利民 christopher j. branford-white 夏春谷东华大学化学化工与生物工程学院上海201620 中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室甘肃兰州730000 伦敦都市大学健康和政策研究所英国伦敦

以离子液体[bmim]PF6为反应溶剂，乙酸乙烯酯为酰基供体，考察了脂肪酶CandidaantarcticaB催化外消旋仲醇的动力学拆分。主要考察了有机碱和无机碱对拆分反应的影响，结果发现，在反应底物中加入三乙胺或吡啶，能够极大地提高脂肪酶的... 详细信息

以离子液体[bmim]PF6为反应溶剂，乙酸乙烯酯为酰基供体，考察了脂肪酶CandidaantarcticaB催化外消旋仲醇的动力学拆分。主要考察了有机碱和无机碱对拆分反应的影响，结果发现，在反应底物中加入三乙胺或吡啶，能够极大地提高脂肪酶的活性和对映选择性，当底物邻甲氧基-α-苯乙醇和1-（2-萘基）乙醇在拆分时加入吡啶后，脂肪酶的对映选择性是未加入有机碱时的5～8倍，分别从E=65提高到E=525和从E=209提高到E=1059，因此，可高对映选择性地获得邻甲氧基--α-苯乙醇和1-（2-萘基）乙醇的手性单体。随着吡啶加入量的增加，脂肪酶的对映选择性有所下降，因此，有机碱的最佳加入量为0．01mol，原因可能是在该加入量下，脂肪酶达到了最佳pH，即处于活性构象，从而具有较高的活性和对映选择性。

关键词：离子液体脂肪酶仲醇有机碱

In the forest vine Smilax rotundifolia,fungal epiphytes show site-wide spatial correlation,while endophytes show evidence of niche partitioning

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Fungal Diversity 2015年第6期75卷 279-297页

作者： christopher B.Zambell james F.white Graduate Program in Ecology&Evolution Rutgers UniversityNew BrunswickNJ 08901USA Department of Plant Biology&Pathology 59 Dudley RoadNew BrunswickNJ 08901USA

Endophytic and epiphytic fungal assemblages from stems of ***,a shrubby vine,were studied in order to(1)quantify differences and the degree of overlap between fungal communities of both micro-habitats,and(2)examine whether fungal assemblages are spatially correlated at the local scale(tens to hundreds of meters),in order to understand if dispersal limitation may play a role in structuring these *** was conducted over 160 m of growth along a forest *** communities showed low overlap(Bray-Curtis Similarity=0.22),with most species that were common in one habitat appearing rarely if at all in the other,and only Aureobasidium pullulans showing high frequency in *** assemblages proved to be spatially correlated along the 160 m length of the transect,and even more so when adjacent pairs of stems were considered as the unit of comparison rather than individual *** assemblages showed no significant spatial correlation along the ***,three species of endophytes showed a pattern in which abundance of colonies peaked at different heights on the *** boninense showed peak abundance at 3 cm from the stem *** sp.1 peaked at 33 cm from the stem *** isolates of *** peaked at 63 cm from the stem *** was also found that positive correlative relationships were detected between endophyte-endophyte,and epiphyte-epiphyte ***-group interactions seemed to center around crossover species that were not entirely constrained within the surface or interior.

关键词： Colletotrichum Phomopsis Phyllosticta Local dispersal Tissue preference

B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling

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Cellular & Molecular Immunology 2021年第6期18卷 1503-1511页

作者： Sadiye Amcaoglu Rieder jingya Wang Natalie white Ariful Qadri Catherine Menard Geoffrey Stephens jodi LKarnell christopher ERudd Roland Kolbeck Present address:Viela Bio GaithersburgMDUSA Universite de Montreal MontrealQCCanada MedImmune/AstraZeneca GaithersburgMDUSA Biopharmaceuticals Early RIAAstraZenecaGaithersburgMDUSA Biopharmaceuticals Early RIAAstraZenecaGaithersburgMDUSA View author publications

Modulation of T-cell responses has played a key role in treating cancers and autoimmune ***,understanding how different receptors on T cells impact functional outcomes is *** influence of B7-H7(HHLA2)and CD28H(TMIGD2)on T-cell activation remains *** we examined global transcriptomic changes in human T cells induced by *** through TCR with OKT3 and B7-H7 resulted in modest fold changes in the expression of select genes;however,these fold changes were significantly lower than those induced by OKT3 and B7-1 *** transcriptional changes induced by OKT3 and B7-H7 were insufficient to provide functional stimulation as measured by evaluating T-cell proliferation and cytokine ***,B7-H7 was coinhibitory when simultaneously combined with TCR and CD28 *** inhibitory activity was comparable to that observed with ***,in physiological assays using T cells and APCs,blockade of B7-H7 enhanced T-cell activation and proliferation,demonstrating that this ligand acts as a break *** work defines that the transcriptomic changes induced by B7-H7 are insufficient to support full costimulation with TCR signaling and,instead,B7-H7 inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling.

关键词： T cell inhibition Checkpoint pathway T cell transcriptomics

Characterization of gut microbiome and metabolome in Helicobacter pylori patients in an underprivileged community in the United States

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World journal of Gastroenterology 2021年第33期27卷 5575-5594页

作者： Brian white john D Sterrett Zoya Grigoryan Lauren Lally jared D Heinze Hyder Alikhan christopher A Lowry Lark j Perez joshua DeSipio Sangita Phadtare Department of Biomedical Sciences Cooper Medical School of Rowan UniversityCamdenNJ 08103United States Department of Integrative Physiology University of Colorado BoulderBoulderCO 80309United States Department of Internal Medicine Lenox Hill HospitalNYCNY 10075United States Department of Internal Medicine Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Department of Biological Sciences Rowan UniversityGlassboroNJ 08028United States Department of Chemistry and Biochemistry Rowan UniversityGlassboroNJ 08028United States Department of Gastroenterology Cooper University HospitalCamdenNJ 08103United States

BACKGROUND Helicobacter pylori(***),a bacterium that infects approximately half of the world’s population,is associated with various gastrointestinal diseases,including peptic ulcers,non-ulcer dyspepsia,gastric adenocarcinoma,and gastric *** the burden of antibiotic resistance increases,the need for new adjunct therapies designed to facilitate *** eradication and reduce negative distal outcomes associated with infection has become more *** of the interactions between ***,the fecal microbiome,and fecal fatty acid metabolism,as well as the mechanisms underlying these interactions,may offer new therapeutic *** To characterize the gut microbiome and metabolome in *** patients in a socioeconomically challenged and underprivileged inner-city *** Stool samples from 19 *** patients and 16 control subjects were analyzed.16S rRNA gene sequencing was performed on normalized pooled amplicons using the Illumina MiSeq System using a MiSeq reagent kit *** and beta diversity analyses were performed in QIIME ***-targeted fatty acid analysis of the samples was carried out using gas chromatography-mass spectrometry,which measures the total content of 30 fatty acids in stool after conversion into their corresponding fatty acid methyl ***-dimensional scaling(MDS)was performed on Bray-Curtis distance matrices created from both the metabolomics and microbiome datasets and a Procrustes test was performed on the metabolomics and microbiome MDS *** Fecal microbiome analysis showed that alpha diversity was lowest in *** patients over 40 years of age compared to control subjects of similar age *** diversity analysis of the samples revealed significant differences in microbial community structure between *** patients and control subjects across all ***-eight and six taxa had lower and higher relative abundance in *** patients,*** that were e

关键词： Gut microbiome Metabolome Helicobacter pylori Antibiotic resistance Dysbiosis Eradication

Nano-Structured Carbide-Derived Carbon Films and Their Tribology

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Tsinghua Science and Technology 2005年第6期10卷 699-703页

作者： Michael McNallan Daniel Ersoy Ranyi Zhu Allen Lee christopher white Sascha Welz Yury Gogotsi Ali Erdemir Andriy Kovalchenko CME Department M/C 246 University of illinois at Chicago 842 W. Taylor St. Chicago IL 60607 USA Department of Materials Science and Engineering and A. j. Drexel Nanotechnology Institute Drexel University Philadelphia PA 19104 USA Energy Technology Division Argonne National Laboratory Argonne IL 60439 USA

Carbide-derived carbon （CDC） is a form of carbon produced by reacting metal carbides, such as SiC or TiC, with halogens at temperatures high enough to produce fast kinetics, but too low to permit the rearrangement of the carbon atoms into an equilibrium graphitic structure. The structure of CDC is derivative of the original carbide structure and contains nanoscale porosity and both sp2 and sp3 bonded carbon in a variety of nanoscale structures. CDC can be produced as a thin film on hard carbides to improve their tribological performance. CDC coatings are distinguished by their low friction coefficients and high wear resistance in many important industrial environments and by their resistance to spallation and delamination. The tribology of CDC coatings on SiC surfaces is described in detail.

关键词： carbon coatings tribology friction chlorination