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Structure-guided Capacitance Relationships in Oxidized Graphene Porous Materials Based Supercapacitors

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Energy & Environmental Materials 2023年第4期6卷 58-69页

作者： Srinivas Gadipelli Hanieh Akbari Juntao Li christopher A.howard Hong Zhang Paul R.Shearing Dan J.L.Brett College of Physics Sichuan UniversityChengdu 610064China Electrochemical Innovation Lab Department of Chemical EngineeringUniversity College LondonLondonWC1E 7JEUK Department of Physics and Astronomy University College LondonLondonWC1E 6BTUK

Supercapacitors formed from porous carbon and graphene-oxide(GO)materials are usually dominated by either electric double-layer capacitance,pseudo-capacitance,or *** to these combined features,reduced GO materials have been shown to offer superior capacitance over typical nanoporous carbon materials;however,there is a significant variation in reported values,ranging between 25 and 350 F g^(−1).This undermines the structure(e.g.,oxygen functionality and/or surface area)-performance relationships for optimization of cost and scalable *** work demonstrates important structure-controlled charge storage *** this,a series of exfoliated graphene(EG)derivatives are produced via thermal-shock exfoliation of GO precursors and following controlled graphitization of EG(GEG)generates materials with varied amounts of porosity,redox-active oxygen groups and graphitic *** results show significantly varied capacitance values between 30 and 250 F g^(−1)at 1.0 A g^(−1)in GEG structures;this suggests that for a given specific surface area the redox-active and hydrophilic oxygen content can boost the capacitance to 250–300%higher compared to typical mesoporous carbon *** with identical oxygen functionality show a surface area governed *** allows to establish direct structure-performance relationships between 1)redox-active oxygen functional concentration and capacitance and 2)surface area and capacitance.

关键词： electric double-layer capacitance graphene-oxide pseudocapacitance structure-performance relationships supercapacitors

Profiling proteomic responses to hexokinase-II depletion in terpene-producing Saccharomyces cerevisiae

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Engineering Microbiology 2023年第3期3卷 1-13页

作者： Zeyu Lu Qianyi Shen Lian Liu Gert Talbo Robert Speight Matt Trau Geoff Dumsday christopher B.howard Claudia E.Vickers Bingyin Peng ARC Centre of Excellence in Synthetic Biology Queensland University of TechnologyBrisbaneQLD4000Australia Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandBrisbaneQLD4072Australia Centre of Agriculture and the Bioeconomy School of Biology and Environmental ScienceFaculty of ScienceQueensland University of TechnologyBrisbaneQLD4000Australia CSIRO Synthetic Biology Future Science Platform Commonwealth Scientific and Industrial Research Organisation(CSIRO)Black MountainACT2601Australia School of Chemistry and Molecular Biosciences(SCMB) the University of QueenslandBrisbaneQLD4072Australia Metabolomics Australia(Queensland Node) Australian Institute for Bioengineering and Nanotechnology(AIBN)The University of QueenslandBrisbaneQLD4072Australia CSIRO Manufacturing ClaytonVIC3169Australia Eden Brew Pty Ltd GlenorieNSW2157Australia

Hexokinase II(Hxk2)is a master protein in glucose-mediated transcriptional repression signaling ***-grading Hxk2 through an auxin-inducible protein degradation previously doubled sesquiterpene(nerolidol)pro-duction at gram-per-liter levels in Saccharomyces *** transcriptomics/proteomics profiles in Hxk2-deficient background are important to understanding genetic and molecular mechanisms for improved nerolidol production and guiding further strain ***,proteomic responses to Hxk2 depletion are investi-gated in the yeast strains harboring a GAL promoters-controlled nerolidol synthetic pathway,at the exponential and ethanol growth phases and in GAL80-wildtype and gal80Δ*** metabolic pathways and amino acid metabolic pathways show diversified responses to Hxk2 depletion and growth on ethanol,including upregulation of alternative carbon catabolism and respiration as well as downregulation of amino acid ***-repression of GAL genes may contribute to improved nerolidol production in Hxk2-depleted ***-teen transcription factors associated with upregulated genes are *** Ash1-mediated repression on the RIM4 promoter shows the variation on the regulatory effects of different Ash1-binding sites and the syner-gistic effect of Ash1 and Hxk2-mediated *** validation of individual promoters shows that HXT1 promoter activities are glucose-dependent in hxk2Δbackground,but much weaker than those in HXK2-wildtype *** summary,inactivating HXK2 may relieve glucose repression on respiration and GAL promoters for improved bioproduction under aerobic conditions in *** proteomics profiles provide a better genetics overview for a better metabolic engineering design in Hxk2-deficient backgrounds.

关键词： Proteomics Glucose repression Metabolic engineering Crabtree effect Sesquiterpene Synthetic biology Genetic regulation

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： christopher J.O’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

An In Vivo Experimental Validation of a Computational Model of Human Foot

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Journal of Bionic Engineering 2009年第4期6卷 387-397页

作者： christopher J.Nester David howard Centre for Health Sport and Rehabilitation Sciences ResearchUniversity of Salford Salford M5 4WTUK

Reliable computational foot models offer an alternative means to enhance knowledge on the biomechanics of human foot. Model validation is one of the most critical aspects of the entire foot modeling and analysis *** paper presents an in vivo experiment combining motion capture system and plantar pressure measure platform to validate a three-dimensional finite element model of human *** Magnetic Resonance Imaging(MRI)slices for the foot modeling and the experimental data for validation were both collected from the same volunteer *** validated components included the comparison of static model predictions of plantar force,plantar pressure and foot surface deformation during six loading conditions,to equivalent measured *** the whole experiment,foot surface deformation,plantar force and plantar pressure were recorded simultaneously during six different loaded standing *** predictions of the current FE model were in good agreement with these experimental results.

关键词： human foot computational model plantar pressure

Comparative analysis of empirical and deep learning models for ionospheric sporadic E layer prediction

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Earth and Planetary Physics 2025年第1期9卷 10-19页

作者： BingKun Yu PengHao Tian XiangHui Xue christopher JScott HaiLun Ye JianFei Wu Wen Yi TingDi Chen XianKang Dou Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230088China CAS Key Laboratory of Geospace Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Department of Meteorology University of ReadingReading RG66BBUK

Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 *** they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite *** this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde *** deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular.

关键词： ionospheric sporadic E layer radio occultation ionosondes numerical model deep learning model artificial intelligence

Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations

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Protein & Cell 2010年第11期1卷 1023-1032页

作者： Prajwalini Mehere Qian Han Justin A.Lemkul christopher J.Vavricka howard Robinson David R.Bevan Jianyong Li Department of Biochemistry Virginia TechBlacksburgVA 24061USA CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Biology Department Brookhaven National LaboratoryUptonNY 11973USA

Tyrosine aminotransferase(TAT)catalyzes the transamination of tyrosine and other aromatic amino *** enzyme is thought to play a role in tyrosinemia type II,hepatitis and hepatic carcinoma *** objective of this study is to investigate its biochemical and structural characteristics and substrate specificity in order to provide insight regarding its involvement in these *** TAT(mTAT)was cloned from a mouse cDNA library,and its recombinant protein was produced using Escherichia coli cells and purified using various chromatographic *** recombinant mTAT is able to catalyze the transamination of tyrosine usingα-ketoglutaric acid as an amino group acceptor at neutral *** enzyme also can use glutamate and phenylalanine as amino group donors and p-hydroxyphenylpyruvate,phenylpyruvate and alpha-ketocaproic acid as amino group *** macromolecular crystallography we have determined the mTAT crystal structure at 2.9Å*** crystal structure revealed the interaction between the pyridoxal-5′-phosphate cofactor and the enzyme,as well as the formation of a disulphide *** detection of disulphide bond provides some rational explanation regarding previously observed TAT inactivation under oxidative conditions and reactivation of the inactive TAT in the presence of a reducing *** dynamics simulations using the crystal structures of Trypanosoma cruzi TAT and human TAT provided further insight regarding the substrate-enzyme interactions and substrate *** biochemical and structural properties of TAT and the binding of its cofactor and the substrate may help in elucidation of the mechanism of TAT inhibition and activation.

关键词： tyrosine aminotransferase crystal structure substrate specificity tyrosine tyrosinemia

Peri-articular elbow fracture fixations with magnesium implants and a review of current literature: A case series

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World Journal of Orthopedics 2024年第3期15卷 215-229页

作者： christopher Fang Antony Xavier Rex Premchand Derek howard Park Dong Hao Toon Department of Orthopaedic Surgery Khoo Teck Puat HospitalNational Healthcare GroupSingapore 768828Singapore

BACKGROUND In recent years,the use of Magnesium alloy implants have gained renewed popularity,especially after the first commercially available ConformitéEuropéenne approved Magnesium implant became available(MAGNEZIX®CS,Syntellix)in *** To document our clinical and radiographical outcomes using magnesium implants in treating peri-articular elbow *** Our paper was based on a retrospective case series ***-operatively,a standardized surgical technique was utilized for insertion of the magnesium ***–operatively,clinic visits were standardized and physical exam findings,functional scores,and radiographs were obtained at each *** complications were *** Five patients with 6 fractures were recruited(2 coronoid,3 radial head and 1 capitellum).The mean patient age and length of follow up was 54.6 years and 11 months *** fractures healed,and none exhibited loss of reduction or complications requiring revision *** patient developed synovitis of the elbow joint or suffered electrolytic reactions when titanium implants were used *** Although there is still a paucity of literature available on the subject and further studies are required,magnesium implants appear to be a feasible tool for fixation of peri-articular elbow fractures with promising results in our *** In recent years,the use of Magnesium alloy implants in orthopaedic surgeries have gained renewed *** from being bioabsorbable,negating the need for implant removal,magnesium also has good osteoconductive properties[1-4].Biomechanically,it exhibits greater biomechanical strength than any pre-existing polymers,and reduces the stress-shielding effect associated with titanium and steel implants as it has a Young’s modulus closer to bone[4].Currently,the main utility of magnesium implants in the orthopaedic community is within the foot and ankle community where satisfactory results have been reported

关键词： Magnesium screw Fracture Peri-articular Elbow

Protecting miners from coal bursts during development above historic mine workings in Harlan County,KY

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International Journal of Mining Science and Technology 2021年第1期31卷 111-116页

作者： christopher Mark Mine Safety and Health Administration PittsburghPA 15236USA

In order to reach a large,untapped reserve of high-quality coal,D8 Cloverlick Mine proposed to mine a corridor nearly 600 m deep beneath the Benham Spur of Black Mountain,Kentucky’s highest peak.D8 Cloverlick Mine was extracting the Owl seam,but the corridor’s route lay approximately 20 m above century-old mine workings in the C–(Darby)*** to the concern,three serious coal bursts had recently occurred in nearby Owl seam *** of the old workings seemed to indicate that the underlying C–seam had been fully ***,two of the coal bursts had occurred above areas where the C–Seam was also shown as mined *** Safety and Health Administration(MSHA)Technical Support therefore investigated the records of past mining to better understand the old mine *** conditions observed in current Owl seam workings were also compared with the maps of the old C–seam *** study concluded that the presence of hazardous underlying remnants could not be ruled *** mitigate the burst risk,D8 Cloverlick Mine adopted a strategy of stress probe drilling.A self-propelled coal drill was used to auger 11.5-m-long,small diameter holes in advance of *** each hole was drilled,the cuttings were measured to detect the presence of highly stressed *** the crossing was successfully completed without incident.

关键词： Coal bursts Underground mining Room-and-pillar Destressing

An updated empirical model for ground control in *** coal mines

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International Journal of Mining Science and Technology 2021年第2期31卷 163-174页

作者： christopher Mark Mine Safety and Health Administration PittsburghPA 15217USA

Multiple seam interactions are a major source of ground instability in several *** methods are well suited for this problem,because while the mechanics multiple seam interactions are very complex and poorly understood,many mining case histories are available for *** study makes use of an updated database that includes 356 multiseam case histories,including 67 unsuccessful *** paper describes in detail the process used to design the study,collect the data,conduct the statistical analysis,and develop the quantitative *** model can be used for mine planning in multiple seam situations,and has been made available as a module within the Analysis of Coal Pillar Stability(ACPS)computer program.

关键词： Underground Coal Multiseam Ground control Pillar design Empirical