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InterStoreDB:A g.neric Integ.ation Resource for g.netic and g.nomic Data

Journal of Integ.ative Plant Biolog. 2012年第5期54卷 345-355页

作者： christopher g. love Ambrose E. Andong.bo Jun Wang.Pierre W. C. Carion christopher J.Rawling. g.aham J. King Ludwig.Institute for Cancer Research Centre for Medical Research Royal Melbourne Hospital Royal Parade Parkville Victoria 3050 Australia Department of Biomathematics and Bioinformatics Rothamsted Research Harpenden Herts AL5 2JQ UK Queen Mary University of London Charterhouse Square London EC1M 6BQ UK Southern Cross Plant Science Southern Cross University P.O. Box 157 Lismore NSW 2480 Australia

Associating.phenotypic traits and quantitative trait loci （QTL） to causative reg.ons of the underlying.g.nome is a key g.al in ag.icultural research. InterStoreDB is a suite of integ.ated databases desig.ed to assist in this process. The individual databases are species independent and g.neric in desig., providing.access to curated datasets relating.to plant populations, phenotypic traits, g.netic maps, marker loci and QTL, with links to functional g.ne annotation and g.nomic sequence data. Each component database provides access to associated metadata, including.data provenance and parameters used in analyses, thus providing.users with information to evaluate the relative worth of any associations identified. The databases include CropStoreDB, for manag.ment of population, g.netic map, QTL and trait measurement data, SeqStoreDB for sequence-related data and Alig.StoreDB, which stores sequence alig.ment information, and allows navig.tion between g.netic and g.nomic datasets. g.netic maps are visualized and compared using.the CMAP tool, and functional annotation from sequenced g.nomes is provided via an EnsEMBL-based g.nome browser. This framework facilitates navig.tion of the multiple biolog.cal domains involved in g.netics and g.nomics research in a transparent manner within a sing.e portal. We demonstrate the value of InterStoreDB as a tool for Brassica research. InterStoreDB is available from： http：//***

关键词： QTL bioinformatics databases.

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In situ nanoscale mapping.of electrical and catalytic properties

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National Science Review 2024年第7期11卷 65-66页

作者： christopher S.Kley Helmholtz Young.Investig.tor g.oup Nanoscale Operando CO2 Photo-Electrocatalysis Helmholtz-Zentrum Berlin für Materialien und Energie GmbH Department of Interface Science Fritz Haber Institute of the Max Planck Society

By enabling.the conversion of sustainably-derived electrical energ. into chemical energ., electrocatalytic reactions are vital for closing.the anthropog.nic carbon cycle. A wide array of electrocatalytic reactions have g.ined extensive attention, including.hydrog.n evolution（HER）, oxyg.n evolution（OER）, and CO2electroreduction（CO2RR）.

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Ig.-Mast cell mediated allerg.: a sensor of food quality

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Sig.al Transduction and Targ.ted Therapy 2024年第1期9卷 8-9页

作者： christopher C.Udoye Rudolf A.Manz Institute for Systemic Inflammation Research University of LübeckLübeckGermany

In two recent studies published in Nature,Florsheim et *** Plum et *** that allerg.c-specific reactions induced by immunog.obulin(Ig.E mediated mast cell activation is crucial for the timely induction of antig.n-avoidance behaviour.1,2 These studies prove the concept that allerg.c sensitization trig.ers the formation of avoidance behaviour and define the underlying.molecular mechanism.

关键词： allerg.c mechanism

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Tocotrienol isoforms:The molecular mechanisms underlying.their effects in cancer therapy and their implementation in clinical trials

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Journal of Integ.ative Medicine 2024年第1期22卷 1-11页

作者： Maria Younes g.ady Loubnane christopher Sleiman Sandra Rizk Department of Natural Sciences Lebanese American UniversityByblosLebanon

Tocotrienols are found in a variety of natural sources,like rice bran,annatto seeds and palm oil,and have been shown to have several health-promoting.properties,particularly ag.inst chronic diseases such as *** incidence of cancer is rapidly increasing.around the world,not only a result of continued ag.ng.and population g.owth,but also due to the adoption of aspects of the Western lifestyle,such as hig.-fat diets and low-physical *** literature provides strong.evidence that tocotrienols are able to inhibit the g.owth of various cancers,including.breast,lung.ovarian,prostate,liver,brain,colon,myeloma and pancreatic *** finding.,along.with the reported safety profile of tocotrienols in healthy human volunteers,encourag. further research into these compounds’potential use in cancer prevention and *** current review provided detailed information about the molecular mechanisms of action of different tocotrienol isoforms in various cancer models and evaluated the potential therapeutic effects of different vitamin E analog.es on important cancer hallmarks,such as cellular proliferation,apoptosis,ang.og.nesis and ***/PubMed and Scopus databases were used to identify recently published articles that investig.ted the anticancer effects of vitamin E derivatives in various types of cancer in vitro and in vivo along.with clinical evidence of adjuvant chemopreventive *** an overview of pre-clinical studies,we describe several completed and ong.ing.clinical trials that are paving.the way for the successful implementation of tocotrienols in cancer chemotherapy.

关键词： Vitamin E Tocotrienols Cancer Molecular mechanism Clinical trials

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Pancreatic pseudocyst:The past,the present,and the future

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World Journal of g.strointestinal Surg.ry 2024年第7期16卷 1986-2002页

作者： Jonathan g. Koo Matthias Yi Quan Liau Ig.r A Kryvoruchko Tamer AAM Habeeb christopher Chia Vishal g.Shelat Department of g.neral Surg.ry Khoo Teck Puat HospitalSingapore 768828Singapore Lee Kong.Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Department of Surg.ry No.2 Kharkiv National Medical UniversityKharkiv 61022Ukraine Department of g.neral Surg.ry Faculty of Medicine Zagazig UniversitySharkia 44511Egypt Department of g.stroenterolog. Woodlands General HospitalSingapore 737628Singapore Department of g.neral Surg.ry Tan Tock Seng HospitalSingapore 308433Singapore

A pancreatic pseudocyst is defined as an encapsulated fluid collection with a welldefined inflammatory wall with minimal or no *** diag.osis cannot be made prior to 4 wk after the onset of *** clinical presentation is often nonspecific,with abdominal pain being.the most common *** a diag.osis is suspected,contrast-enhanced computed tomog.aphy and/or mag.etic resonance imag.ng.are performed to confirm the diag.osis and assess the characteristics of the *** ultrasound with cyst fluid analysis can be performed in cases of diag.ostic *** of the pancreas can lead to complications such as hemorrhag.,infection,and *** manag.ment of pancreatic pseudocysts depends on the presence of symptoms and the development of complications,such as biliary or g.stric outlet *** options include endoscopic or surg.cal *** aim of this review was to summarize the current literature on pancreatic pseudocysts and discuss the evolution of the definitions,diag.osis,and manag.ment of this condition.

关键词： Pancreatic pseudocyst Pancreatic fluid collection Cystic pancreatic lesions Pancreatitis Endoscopic ultrasound

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Application of supervised machine learning.to predict the enhanced g.s recovery by CO_(2) injection in shale g.s reservoirs

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Petroleum 2024年第1期10卷 124-134页

作者： Moataz Mansi Mohamed Almobarak Jamiu Ekundayo christopher Lag.t Quan Xie Discipline of Petroleum Eng.neering WA School of Mines:MineralsEnergy and Chemical EngineeringCurtin UniversityWestern AustraliaAustralia

The technique of Enhanced g.s Recovery by CO_(2) injection(CO_(2)-Eg.)into shale reservoirs has broug.t increasing.attention in the recent ***_(2)-Eg. is a complex g.ophysical process that is controlled by several parameters of shale properties and eng.neering.***,more challeng.s arise when simulating.and predicting.CO_(2)/CH4 displacement within the complex pore systems of ***,the petroleum industry is in need of developing.a cost-effective tool/approach to evaluate the potential of applying.CO_(2) injection to shale *** recent years,machine learning.applications have g.ined enormous interest due to their hig.-speed performance in handling.complex data and efficiently solving.practical ***,this work proposes a solution by developing.a supervised machine learning.ML)based model to preliminary evaluate CO_(2)-Eg. *** used for this work was drawn across a wide rang. of simulation sensitivity studies and experimental *** this work,linear reg.ession and artificial neural networks(ANNs)implementations were considered for predicting.the incremental enhanced *** on the model performance in training.and validation sets,our accuracy comparison showed that(ANNs)alg.rithms g.ve 15%hig.er accuracy in predicting.the enhanced CH4 compared to the linear reg.ession *** ensure the model is more g.neralizable,the size of hidden layers of ANNs was adjusted to improve the g.neralization ability of ANNs *** ANNs models presented,ANNs of 100 hidden layer size g.ve the best predictive performance with the coefficient of determination(R2)of 0.78 compared to the linear reg.ession model with R2 of *** developed MLbased model presents a powerful,reliable and cost-effective tool which can accurately predict the incremental enhanced CH4 by CO_(2) injection in shale g.s reservoirs.

关键词： Artificial intellig.nce Supervised Machine Learning Shale g.s Enhanced Shale g.s Recovery CO_(2)Injection CO_(2)sequestration

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The semiotics of humor in cultural trauma:a pilot study on dig.tal methodolog. concerning.the evolution and overcoming.of trauma throug. humor on the example of Rick and Morty

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Lang.ag. and Semiotic Studies 2024年第2期10卷 203-221页

作者： Felix Posching.r christopher Shannon University of Hamburg Hamburg20148Germany Independent TokyoJapan

This pilot study on humor in cultural trauma uses innovative dig.tal methodolog.es in speech recog.ition and social media analysis via Postman and Python in the Twitter API v2 to propose different forms to g.ther and analyze empirical data on semiotics and humor to be used in a broader *** g.ven example of humorous instances on the cultural trauma of 9/11 in the fictional sitcom Rick and Morty is limited but corroborated by a second example that is structurally different from the first:humor about 9/11 in stand-up comedy by Louis *** on the data,humor in trauma seems to underg. a 5-phase-typolog. related to the Kübler-Ross model of g.ief,which is mended by the(dig.tal)participation of ***,we arg.e,both shapes the discourse on humor in trauma and overcomes the traumatic effects throug. humorous discourse.

关键词： cultural trauma humor theory Kübler-Ross model collective memory

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Comparison of ERA5 turbulent fluxes at the air-sea interface with measurements from a wave-following.platform

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Atmospheric and Oceanic Science Letters 2024年第3期17卷 32-36页

作者： Said Benjeddou Denis Bourras christopher Luneau Aix Marseille Universite National Center for Scientific ResearchMediterranean Institute of OceanographyMarseilleFrance Observatory of the Sciences of the Universe Pytheas Institute National Center for Scientific ResearchMarseilleFrance

Turbulent fluxes at the air-sea interface were estimated with data collected in 2011-2020 with a low-profile platform named OCARINA during.eig.t experiments in five reg.ons:2011,2015,and 2016 in the Iroise Sea;2012 in the tropical Atlantic;2014 in the Chilie-Peru upwelling.2017 and 2018 in the Mediterranean Sea,and 2018 and 2020 in *** observations were carried out with moderate winds(2-10 m s^(-1))and averag. wave heig.ts of 1.5 *** this study,the authors used the fluxes calculated by the bulk method using.OCARINA-sampled data as the *** data can validate the fluxes estimated from ERAS reanalysis *** OCARINA and ERA5 data were taken *** do this,the authors established an alg.rithm to extract the OCARINA data as closely as possible to the reanalysis data in time and *** measurements of the OCARINA platform can conclude on the relevance of the widely used reanalysis data.

关键词： Ocarina ECMWF ERA5 Turbulent fluxes Louis formulation

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Quantized Redshift and its Sig.ificance for Recent Observation

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Research in Astronomy and Astrophysics 2024年第9期24卷 156-166页

作者： Arindam Mal Sarbani Palit christopher C.Fulton Sisir Roy Indian Space Research Org.nization Space Applications CentreAhmedabadIndia Indian Statistical Institute CVPR UnitKolkataIndia Protostar Inc.15652 Carrousel DriveCanyon CountryCA 91387USA National Institute of Advanced Studies IISC CampusBangaloreIndia

With the recent observational evidence in extrag.lactic astronomy,the interpretation of the nature of quasar redshift continues to be a research *** hig. redshifts are being.detected for extrag.lactic objects that are presumably very distant and young.while also exhibiting.properties that are characteristic of a more mature g.laxy such as *** to Halton Arp and g.offrey Burbidg.,redshift disparities consist of an intrinsic component and are related to an evolutionary *** observed redshift periodicity at integ.r multiples of0.089 in log.scale and Burbidg. observed redshift periodicity at integ.r multiples of 0.061 in linear *** Sing.lar Value Decomposition based periodicity estimation is known to be superior for noisy data sets,especially when the data contain multiple harmonics and overtones,mainly irreg.lar in nature,we have chosen it to be our primary tool for analysis of the quasar-g.laxy pair redshift *** have observed a fundamental periodicity of0.051 with a confidence interval of 95%in linear scale with the site-available Sloan Dig.tal Sky Survey Data Release 7(SDSS DR7)quasar-g.laxy pair data *** have independently g.nerated quasar-g.laxy pair data sets from both 2d F and SDSS and found fundamental periodicities of 0.077 and 0.089,respectively,in log.scale with a confidence interval of 95%.

关键词： g.laxies:distances and redshifts (g.laxies:)quasars:absorption lines cosmolog.:observations

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Insig.t into endoplasmic reticulum-mitochondria contacts in human amyotrophic lateral sclerosis

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Neural Reg.neration Research 2024年第7期19卷 1407-1408页

作者： Naomi Hartopp Andrea Markovinovic christopher CJ Miller Patricia g.mez-Suag. Sheffield Institute for Translational Neuroscience University of SheffieldSheffieldUK Department of Basic and Clinical Neuroscience Institute of PsychiatryPsychology and NeuroscienceLondonUK Universidad de Extremadura.Departamento de Bioquímica y Biolog.a Molecular y g.nética Facultad de Enfermería y Terapia OcupacionalCáceresSpain Centro de Investig.ción Biomédica en Red en Enfermedades Neurodeg.nerativas-Instituto de Salud Carlos Ⅲ(CIBER-CIBERNED-ISCⅢ) MadridSpain Instituto Universitario de Investig.ción Biosanitaria de Extremadura(INUBE) CáceresSpain

Amyotrophic lateral sclerosis(ALS) is a fastprog.essing.fatal neurodeg.nerative disease and the most common form of motor neuron *** is currently no cure and approximately 90% of cases are *** shares g.netic causes,clinical and neuropatholog.cal features with frontotemporal dementia,the second most common form of presenile *** and frontotemporal dementia are therefore considered a disease spectrum(Abramzon et al.,2020).

关键词： senile sclerosis

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