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中国生物工程学会第六次全国会员代表大会暨第九届学术年会

作者： Tanguy Y.Seiwert Zhixiang Zuo Michaela K.Keck Arun Khattri Chandra S.Pedamallu Thomas Stricker christopher Brown Trevor J.Pugh Petar Stojanov Juok Cho Michael S.Lawrence Gad Getz Johannes Br?gelmann Rebecca DeBoer Ralph R.Weichselbaum alexander Langerman Louis Portugal Elizabeth Blair Kerstin Stenson Mark W.Lingen Ezra E.W.Cohen Everett E.Vokes Kevin P.White Peter S.Hammerman Section of Hematology/Oncology Department of MedicineThe University of Chicago The University of Chicago Comprehensive Cancer Center Institute for Genomics and Systems Biology University of Chicago Broad Institute of Harvard and MIT Department of Medical Oncology Dana Farber Cancer Institute Department of Pathology Microbiologyand ImmunologyVanderbilt University Department of Genetics University of Pennsylvania Department of Radiation Oncology The University of Chicago Department of Otolaryngology/Head and Neck Surgery The University of Chicago Department of Pathology University of Chicago

Purpose:The genetic differences between human papilloma virus(HPV)–positive and –negative head and neck squamous cell carcinomas(HNSCC) remain largely *** identify differential biology and novel therapeutic targets for both entities,we determined mutations and copy-number aberrations in a large cohort of locoregionally advanced *** Design:We performed massively parallel sequencing of 617 cancer-associated genes in 120 matched tumor/normal samples(42.5% HPV-positive).Mutations and copy-number aberrations were determined and results validated with a secondary ***:The overall mutational burden in HPV-negative and HPV-positive HNSCC was similar with an average of 15.2 versus14.4 somatic exonic mutations in the targeted cancer-associated ***-negative tumors showed a mutational spectrum concordant with published lung squamous cell carcinoma analyses with enrichment for mutations in TP53,CDKN2 A,MLL2,CUL3,NSD1,PIK3 CA,and NOTCH ***-positive tumors showed unique mutations in DDX3 X,FGFR2/3 and aberrations in PIK3 CA,KRAS,MLL2/3,and NOTCH1 were enriched in HPVpositive *** targetable genomic alterations were identified in FGFR1,DDR2,EGFR,FGFR2/3,EPHA2,and PIK3 ***,CCND1,and FGFR1 amplifications occurred in HPV-negative tumors,whereas 17.6% of HPV-positive tumors harbored mutations in fibroblast growth factor receptor genes(FGFR2/3),including six recurrent FGFR3 S249 C ***-positive tumors showed a 5.8% incidence of KRAS mutations,and DNArepair gene aberrations,including 7.8% BRCA1/2 mutations,were ***:The mutational makeup of HPV-positive and HPV-negative HNSCC differs significantly,including targetable *** harbors multiple therapeutically important genetic aberrations,including frequent aberrations in the FGFR and PI3K pathway genes.

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2015年美国心脏协会／美国卒中协会对2013年急性缺血性卒中患者早期处理指南关于血管内治疗的局部更新

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国际脑血管病杂志 2015年第11期23卷 801-814页

作者：蔡必扬李华代齐良徐格林南京军区南京总医院神经内科 210002

目的本指南旨在对急性缺血性卒中血管内治疗的现有推荐意见提供局部更新。如相关内容与上一版指南重叠，则以本指南的推荐意见为准。方法此次局部更新对2013年以来发表的8项有关血管内治疗的临床随机试验结果和其他相关资料进行了分析... 详细信息

目的本指南旨在对急性缺血性卒中血管内治疗的现有推荐意见提供局部更新。如相关内容与上一版指南重叠，则以本指南的推荐意见为准。方法此次局部更新对2013年以来发表的8项有关血管内治疗的临床随机试验结果和其他相关资料进行了分析。本文并未对上一版指南发布后的所有文献进行全面回顾，而仅仅纳入了支持对现有推荐意见进行修改的关键性新证据。指南撰写委员会成员由美国心脏协会（American Heart Association，AHA）／美国卒中协会（American Stroke Association，ASA）卒中委员会下属的科学声明监督委员会以及AHA／ASA文稿监督委员会任命。整个指南制定过程严格遵守AHA的利益冲突政策。采用美国心脏协会，美国卒中协会的疗效确定性水平和证据分级方案对推荐意见进行分级。由6名同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南草案进行发表前审阅。结果本循证指南介绍了急性缺血性卒中血管内治疗的患者选择、操作规程以及促进血管内治疗的医疗体系。结论某些血管内介入操作被证明能够为经过选择的急性缺血性卒中患者提供临床益处，应组建相应的医疗体系以促进血管内治疗的开展。

关键词： AHA科学声明血管内介入治疗动脉内输注神经影像学支架卒中治疗学

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世界开放:韧性、新生与安全

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国际经济评论 2023年第2期 9-29,4页

作者：张宇燕顾学明克里斯托弗·皮萨里德斯林毅夫易小准朱民柯睿智河合正弘亚历山大·罗曼诺夫中国社会科学院世界经济与政治研究所国家全球战略智库上海虹桥国际经济论坛研究中心英国伦敦经济学院北京大学国家发展研究院北京大学新结构经济学研究院北京大学南南合作与发展学院不详中国国际经济交流中心联合国贸易和发展会议全球化与战略发展司日本东京大学日本东京大学东北亚经济研究所俄罗斯科学院世界经济与国际关系研究所俄罗斯科学院亚太研究中心

2022年11月5日,第五届虹桥国际经济论坛《世界开放报告2022》发布暨国际研讨会举办,与会专家分享了各自在全球开放理论、政策和实践方面的体会与观点。近年来,先有少数国家力主本国优先和脱钩断链,后有新冠疫情和地缘政治危机叠加冲击,... 详细信息

2022年11月5日,第五届虹桥国际经济论坛《世界开放报告2022》发布暨国际研讨会举办,与会专家分享了各自在全球开放理论、政策和实践方面的体会与观点。近年来,先有少数国家力主本国优先和脱钩断链,后有新冠疫情和地缘政治危机叠加冲击,人类又一次站在历史的十字路口:开放还是封闭?西方式经济全球化的相对衰落为新的全球化类型和战略打开了空间。中国的开放永远在路上,只有继续开放,才能在逆境中突围。在迷雾笼罩之下,在料峭春寒之中,推动世界开放的新生力量已经萌发,并在茁壮成长。数字经济和绿色发展将成为重组全球要素资源、重塑全球经济结构、改变全球竞争格局的关键力量。

关键词：逆全球化国家安全地缘政治经济制裁数字经济绿色发展

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不同方法获得的脂肪来源干细胞再生能力比较：超声辅助吸脂与传统脂肪抽吸对比

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中国美容整形外科杂志 2015年第8期26卷 J0011-J0011页

作者： David Atashroo Dominik Duscher Zeshaan N. Maan Elizabeth R. Zielins Kevin Paik alexander Whittam Michelle Lin Adrian McArdle christopher Duldulao t Graham G. Walmsley Michael S.Hu Ruth Tevlin Derrick C. Wan Geoffrey C. Gurtner Michael T. Longaker 朱利娜高景恒张晨袁继龙不详《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科辽宁省人民医院整形外科

背景与目的超声辅助吸脂（ultrasound assisted liposuction，UAL）因其获取脂肪容易，且可让创伤和失血最小化，受到整形外科医师的青睐。但是，很少有研究报道这种方法获取的脂肪来源干细胞（adipose derived stromal cells，ADSCs）... 详细信息

背景与目的超声辅助吸脂（ultrasound assisted liposuction，UAL）因其获取脂肪容易，且可让创伤和失血最小化，受到整形外科医师的青睐。但是，很少有研究报道这种方法获取的脂肪来源干细胞（adipose derived stromal cells，ADSCs）的质量。ADSCs在基于细胞的治疗方法中的作用也在急剧增长。因此，本研究比较了传统脂肪抽吸（suctionassistedliposuction，SAL）方法获得的ADSCs与UAL方法获得的ADSCs之间再生能力的差异。方法分别采用SAL和UAL方法，从健康人中获取脂肪并培养ADSCs；采用荧光辅助细胞分选（fluorescent assisted cell sorting，FACS）方法，分析ADSCs的产量。利用MTT比色法分析ADSCs的增殖能力，并在培养基中进行成脂和成骨分化诱导。将基因表达谱与qPCR进行对比。利用细胞染色比较成脂和成骨分化标记物。建立小鼠创伤愈合模型，在水凝胶支架上，分别播种采用SAL方法获取的ADSCs（SAL组）和采用UAL方法获取的ADSCs（UAL组），水凝胶组只加入水凝胶作为对照，同时比较3组的组织再生能力。结果UAL与SAL方法获得的ADSCs相比，在细胞数量和增殖能力方面的差异无统计学意义。油红O染色显示两者成脂分化能力没有差异，分化7d时，PPAR-γ受体和LPL的表达差异无统计学意义也证实了这一点（P〉0．05）。同样，碱性磷酸酶和茜素红染色也显示了两者相似的成骨分化能力，而且成骨标志物Runx-2、骨桥蛋白和骨钙蛋白的表达差异也无统计学意义（P〉0．05）。SAL组和UAL组的愈合速度明显大于水凝胶组（P〈0．05），SAL和UAL两组之间差异无统计学意义（P〉0．05）。结论与传统SAL方法相比，UAL方法可获得相等增殖能力的ADSCs，并用于以细胞疗法为基础的治疗。

关键词：细胞再生能力脂肪抽吸吸脂超声 ADSCs 脂肪来源干细胞成骨分化整形外科医师

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

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Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

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JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Agnese Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han Muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di Milano and Dipartimento di Fisica dell Universitàdi Milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and University of Milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector

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