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Standardized quantitative measurements of wrist cartilage in healthy humans using 3T magnetic resonance imaging

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World Journal of Orthopedics 2015年第8期6卷 641-648页

作者： Jean-Vincent Zink Philippe Souteyrand Sandrine Guis christophe Chagnaud Yann Le Fur Daniela Militianu Jean-Pierre Mattei Michael Rozenbaum Itzhak Rosner Maxime Guye Monique Bernard David Bendahan Department of Radiology Conception Hospital Aix-Marseille University Department of Rheumatology Ste marguerite Hospital Aix-Marseille University Faculté de Médecine de Marseille Aix-Marseille Université - CRMBM-CNRS 13005 Marseille France Department of Medical Imaging Rambam - Health Care Campus Haifa 35254 Israel Department of Rheum-atology Bnai Zion Medical Center Technion Haifa 31048 Israel Aix-Marseille Université - CEMEREM-CNRS AP-HM Pole Imagerie 13005 Marseille France

AIM: To quantify the wrist cartilage cross-sectional area in humans from a 3D magnetic resonance imaging(MRI) dataset and to assess the corresponding reproducibility. METHODS: The study was conducted in 14 healthy volunteers(6 females and 8 males) between 30 and 58 years old and devoid of articular pain. Subjectswere asked to lie down in the supine position with the right hand positioned above the pelvic region on top of a home-built rigid platform attached to the scanner bed. The wrist was wrapped with a flexible surface coil. MRI investigations were performed at 3T(Verio-Siemens) using volume interpolated breath hold examination(VIBE) and dual echo steady state(DESS) MRI sequences. Cartilage cross sectional area(CSA) was measured on a slice of interest selected from a 3D dataset of the entire carpus and metacarpalphalangeal areas on the basis of anatomical criteria using conventional image processing radiology software. Cartilage cross-sectional areas between opposite bones in the carpal region were manually selected and quantified using a thresholding ***: Cartilage CSA measurements performed on a selected predefined slice were 292.4 ± 39 mm2 using the VIBE sequence and slightly lower, 270.4 ± 50.6 mm2, with the DESS sequence. The inter(14.1%) and intra(2.4%) subject variability was similar for both MRI methods. The coefficients of variation computed for the repeated measurements were also comparable for the VIBE(2.4%) and the DESS(4.8%) sequences. The carpus length averaged over the group was 37.5 ± 2.8 mm with a 7.45% between-subjects coefficient of variation. Of note, wrist cartilage CSA measured with either the VIBE or the DESS sequences was linearly related to the carpal bone length. The variability between subjects was significantly reduced to 8.4% when the CSA was normalized with respect to the carpal bone ***: The ratio between wrist cartilage CSA and carpal bone length is a highly reproducible standardized measurement which norma

关键词： Cartilage Magnetic resonance imaging Wrist Quantification

Optimization of a Method for the Simultaneous Determination of Phloroglucinol and Trimethylphloroglucinol by High Performance Liquid Chromatography in Routine Use in a Pharmaceutical Industry in Abidjan

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Open Journal of Optimization 2023年第2期12卷 11-24页

作者： Jean-Kisito Kouamé Mariette Désirée Yéhé Claude Bérenger Ngalemo Ngantchouko Amani Germain Brou Carine Nina Ablé Aya Mélissa Diane Kouadio Bi Gogoua Désiré Vagny Vincent De Paul Ovi christophe N’cho Amin Gildas Komenan Gbassi National Public Health Laboratory (NPHL) Food Control Service Abidjan Ivory Coast Department of Analytical Sciences and Public Health Training and Research Unit (UFR) of Pharmaceutical and Biological Sciences Félix Houphou&#235t Boigny University Abidjan Ivory Coast Higher Institute of Health Sciences of the University of the Mountains (UdM) Bangangté Cameroon

In order to provide the population with safe, effective and good quality medicines, the pharmaceutical industries, before releasing batches of their products into the pharmaceutical circuit, put in place internal dosage methods to control the quality of these products. The present study consisted in optimizing a method for the simultaneous determination of Phloroglucinol (PHG) and Trimethylphloroglucinol (TPH) by high performance liquid chromatography (HPLC) routinely used in a pharmaceutical industry located in a township in Abidjan (Ivory Coast). The basic chromatographic conditions were those routinely used for the determination of these two molecules: mobile phase: acetonitrile/water (60/40), stationary phase (C18 BDS Hypersil 250 mm * 4.6 mm - 5 μm), detection wavelength (265 nm), flow rate, injection volume and run time configured at the equipment level were respectively 1 mL/min, 10 μL and 8 min. The method of preparation of the analytes (PHG and TPHG) was also applied by the pharmaceutical industry. The application of these different parameters at the equipment level made it possible to determine a chromatogram which highlights three chromatographic peaks with respective retention times (RT) of 0.773 min (unidentified compound), 2.275 min (PHG) and 7.269 min for an analysis time of 8 min with a better resolution of the peaks and baseline. The progressive optimization of different parameters such as the stationary phase (C18 YMC 150 mm * 4.6 mm - 3 μm), the proportion of the mobile phase: acetonitrile/water (80/20), the flow rate impelled by the pump (0.8 mL/min) and the modification of the analyte preparation mode (same amount of PHG and TPHG in a 50 mL volumetric flask) resulted in a final chromatogram that highlighted two chromatographic peaks at the respective RT of 2.391 min (PHG) and 3.735 min (TPHG) at a run time of 6 min. The chromatographic conditions that led to the final chromatogram can be used routinely by the pharmaceutical industry for the dete

关键词： PHG TPHG Pharmaceutical Industry Chromatographic Profile Chromatographic Peak

Potential therapeutic targets identified by integrated miRNA and mRNA expression profiling in Chagas disease:miRNA-associated pathology Development and Immune Response pathways

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Potential therapeutic targets identified by integrated miRNA...

第十届全国免疫学学术大会

作者： Ludmila Rodrigues Pinto Ferreira Frederico Moraes Ferreira Monique Andrade Baron Darlan da Silva Candido Laurie Laugier Sandrine Cabantous Amanda Farage Frade Ronaldo Honorato Barros Santos christophe Chevillard Jorge Kalil Edecio Cunha-Neto Laboratory of Immunology Heart Institute (InCor) University of Sao PauloSchool of Medicine Division of Clinical Immunology and Allergy University of Sao Paulo School of Medicine Universidade Santo Amaro (UNISA) INSERM U906 Aix-Marseille University AMU Faculte de Medecine Division of Transplantation Heart Institute (InCor) University of Sao PauloSchool of Medicine

Chronic Chagas Cardiomyopathy (CCC) is the severe manifestation of Chagasdisease, caused by infection with the protozoan parasite Trypanosoma *** is characterized by myocardial inflammation, arrhythmias, heart

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传染性法氏囊病的控制与疫苗接种

国外畜牧学（猪与禽） 2017年第7期37卷 3-6页

作者：陈丽园(译) 王桂军(译) 陈建康(审) 罗静如(制图) rick van oort christophe cazaban yannick gardin 不详 Ceva Sant动物保健公司(Ceva)

控制传染性法氏囊病[(Gumboro Disease,GD)或(Infectious Bursal Disease,IBD)]的主要方法之一是接种疫苗。自从20世纪60年代IBD初次暴发以来,接种疫苗就一直是成功控制该病临床症状的主要手段。

关键词：传染性法氏囊病病毒疫苗接种控制 Virus IBD疫苗免疫接种早期感染养殖场

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Clojure编程

早期资源发生上的差异对西江鲮Cirrhina moitorella和鲴Xenocyprininae种群共存的影响

作者： (Emerick Chas)埃默里克 (Carper Brian)布卡珀 (Grand christophe)格兰德

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早期资源发生上的差异对西江鲮Cirrhina moitorella和鲴Xenocypri...

麻醉中肌肉松弛药与逆转剂应用指南—法国麻醉与重症监测治疗学会(SFAR 2020)

中国水产学会渔业资源与环境分会2013年学术交流会

作者：帅方敏李新辉 christophe.Baehr 李跃飞李捷杨计平 Sovan Lek 中国水产科学研究院珠江水产研究所法国气象研究中心法国图卢兹第三大学

＜正＞在现今各种捕捞压力以及各种生存环境都已经发生改变的情况下,了解鱼类群落里各种群的共存与维持机理对于渔业资源保护显得尤为重要。本研究选择西江肇庆江段具有相似生物学特性且个体大小相近的两个鲤科鱼类（鲮鱼Cirrhina moito... 详细信息

＜正＞在现今各种捕捞压力以及各种生存环境都已经发生改变的情况下,了解鱼类群落里各种群的共存与维持机理对于渔业资源保护显得尤为重要。本研究选择西江肇庆江段具有相似生物学特性且个体大小相近的两个鲤科鱼类（鲮鱼Cirrhina moitorella和鲴Xenocyprininae）作为研究对象,以2006-2012年野外调查数据为基础,以小波分析为主要研究方法,分析二者早期资源发生上的差异。

关键词：早期资源种群共存西江

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中华麻醉学杂志 2022年第7期42卷 771-793页

作者： Benoît Plaud christophe Baillard Jean-Louis Bourgain Gaëlle Bouroche Laetitia Desplanque Jean-Michel Devys Dominique Fletcher Thomas Fuchs-Buder Gilles Lebuffe Claude Meistelman Cyrus Motamed Julien Raft Frédérique Servin Didier Sirieix Karem Slim Lionel Velly Franck Verdonk Bertrand Debaene 巴黎大学巴黎公共援助医院麻醉和重症监护科圣路易医院巴黎75010法国巴黎大学巴黎公共援助医院麻醉和重症监护科科钦医院皇家港巴黎75014法国古斯塔夫-鲁西研究所麻醉科犹太城94800法国里昂贝拉尔中心麻醉科里昂69008法国巴黎公共援助医院麻醉和重症监护科克劳德·贝尔纳德医院巴黎75877法国罗斯柴尔德基金会医院麻醉和重症监护科巴黎75019法国凡尔赛-伊夫林地区圣康坦大学巴黎公共援助医院安布鲁瓦兹·帕雷医院麻醉科布洛涅-比扬古92100法国洛林大学南锡大学中心医院麻醉和重症监护科南锡地区54511法国里尔大学赫里兹医院麻醉和重症监护科里尔59037法国洛林癌症研究所麻醉科南锡地区54519法国 Marzet-Navarre集团综合医院麻醉科波城64000法国奥弗涅大学消化和肝胆外科埃斯坦医院克莱蒙费朗63100法国艾克斯-马赛大学蒂莫内医院麻醉和重症监护科马赛13385法国索邦大学圣安托万医院巴黎75012法国普瓦提埃大学麻醉和重症监护科普瓦提埃大学中心医院普瓦提埃86021法国

目的为更新1999年法国共识"麻醉中肌肉松弛药与逆转剂的应用"特召集16名专家成立共识委员会。编写开始时宣布庄重的利益声明与分歧监督原则,并在编写过程中予以执行,本指南编写全过程不依赖任何商业资助。所有作者均需遵循推荐分级的评... 详细信息

目的为更新1999年法国共识"麻醉中肌肉松弛药与逆转剂的应用"特召集16名专家成立共识委员会。编写开始时宣布庄重的利益声明与分歧监督原则,并在编写过程中予以执行,本指南编写全过程不依赖任何商业资助。所有作者均需遵循推荐分级的评价、制定与评估系统的原则(Grading of Recommendations,Assessment,Development and Evaluation,GRADE?),以评估这些推荐意见的证据质量,规避基于低质量证据做出强推荐的可能性。故有少数推荐意见仍未分等级。方法专家组的讨论主要集中在以下8个问题:(1)在无面罩通气困难标准的情况下,是否有必要在注射肌肉松弛药前检查面罩通气的可行性?面罩通气是否有必要使用肌肉松弛药?(2)为便于气管插管是否有必要使用肌肉松弛药?(3)是否有必要使用肌肉松弛药以便于声门上气道装置的置入及管理相关并发症?(4)是否有必要应用神经肌肉阻滞监测来进行气道管理?(5)是否有必要应用肌肉松弛药以利于手术的进行?如有必要,是哪种手术?(6)术中是否有必要监测神经肌肉阻滞程度?(7)防治肌肉松弛药残留阻滞作用的策略是什么?(8)在特殊人群中(如电休克治疗、肥胖、儿童、神经肌肉疾病、肝/肾功能衰竭、老年患者)使用肌肉松弛药和逆转剂的适应证及注意事项是什么?所有问题都采用研究对象、干预、对照和预后(Population,Intervention,Comparison and Outcome,PICO)模型中的临床问题予以阐明,并生成证据档案,最后采用GRADE?系统评估文献分析的结果并进行推荐。结果SFAR指南专家组提出了31项关于麻醉中应用肌肉松弛药与逆转剂的推荐意见。在这些推荐意见中,有11项是属于强推荐(GRADE 1±),有20项是属于弱推荐(GRADE 2±),有5项应用GRADE?系统无法给出推荐意见,其中2个问题生成了专家意见。经过2轮讨论和1次修订后,所有指南和方案都获得了专家组的一致同意。结论关于麻醉中应用肌肉松弛药与逆转剂的多项强推荐意见,专家间意见基本一致。SFAR推荐在整个麻醉过程中使用神经肌肉功能监测仪来监测神经肌肉阻滞程度。

关键词：肌肉松弛药逆转剂神经肌肉监测专家指南更新

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现代隧道窑

砖瓦 2017年第6期 68-71页

作者：克里斯多夫.奥勃特斯蒂尔集团德雷克萨工程有限责任公司美国科罗拉多80235

在砖瓦的行业里我们把隧道窑定义为一个可连续烧结砖瓦产品的焙烧设备，而热/冷空气则与制品移动方向相反的方向运行。隧道窑的两个主要的优势在于：①利用循环气体在冷却和烧结的产品之间传递热量，从而减少燃料消耗；②通过动态的过... 详细信息

在砖瓦的行业里我们把隧道窑定义为一个可连续烧结砖瓦产品的焙烧设备，而热/冷空气则与制品移动方向相反的方向运行。隧道窑的两个主要的优势在于：①利用循环气体在冷却和烧结的产品之间传递热量，从而减少燃料消耗；②通过动态的过程增加产能。主要的缺点在于这样的窑炉不易被停止和重启。鉴于1kg的空气和1kg的黏土及页岩具有相同的比热（分别是0.24和0.22kcal/kg/C）,我们可以得出这样的结论：一个完美的隧道窑，约1kg单向运行的空气可以冷却1kg反向运行的产品。

关键词：隧道窑砖瓦产品连续烧结冷空气焙烧设备移动方向循环气体燃料消耗

10 PW peak power femtosecond laser pulses at ELI-NP

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High Power Laser Science and Engineering 2022年第3期10卷 25-29页

作者： christophe Radier Olivier Chalus Mathilde Charbonneau Shanjuhan Thambirajah Guillaume Deschamps Stephane David Julien Barbe Eric Etter Guillaume Matras Sandrine Ricaud Vincent Leroux Caroline Richard François Lureau Andrei Baleanu Romeo Banici Andrei Gradinariu Constantin Caldararu Cristian Capiteanu Andrei Naziru Bogdan Diaconescu Vicentiu Iancu Razvan Dabu Daniel Ursescu Ioan Dancus Calin Alexandru Ur Kazuo ATanaka Nicolae Victor Zamfir Thales LAS France 78990ÉlancourtFrance Thales Systems Romania 060071 BucurestiRomania Extreme Light Infrastructure-Nuclear Physics IFIN-HH077125 MagureleRomania Physics Doctoral School Bucharest University077125 MagureleRomania Laser Engineering Osaka UniversityOsaka 565-0871Japan

We report on the generation and delivery of 10.2 PW peak power laser pulses,using the High Power Laser System at the Extreme Laser Infrastructure–Nuclear Physics *** this work we demonstrate for the first time,to the best of our knowledge,the compression and propagation of full energy,full aperture,laser pulses that reach a power level of more than 10 PW.

关键词： high-power laser ultra-short laser pulses