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Toward the identi?cation and role of structural variations during dog domestication

National Science Review 2019年第1期6卷 123-124页

作者： christophe hitte University of Rennes

To date, we know little about the genetic diversity and development mechanisms that, through the process of domestication, have made the modern dog emerge. Following the processes of domestication and a phase of intense artificial selection,dogs became our auxiliaries for hunting, guarding and finally our best friends. The range of phenotypic diversity in dogs today greatly exceeds that of its ancestors, the wolves, making dogs the most morphologically diverse species of terrestrial mammals[1]. To advance these domestication research questions, studies are now focusing on differences in the content, organization and structure of the genome, called structural variations (SV),as a major source of genetic and phenotypic diversity. In addi-

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Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health

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National Science Review 2019年第4期6卷 810-824页

作者： Elaine A.Ostrander Guo-Dong Wang Greger Larson Bridgett M.von Holdt Brian W.Davis Vidhya Jagannathan christophe hitte Robert K.Wayne Ya-Ping Zhang National Human Genome Research Institute National Institutes of Health State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Palaeogenomics and Bio-Archaeology Research Network School of Archaeology University of Oxford Department of Ecology and Evolutionary Biology Princeton University College of Veterinary Medicine and Biomedical Sciences Texas A&M University Institute of Genetics Vetsuisse Faculty University of Bern IGDR CNRS University of Rennes Department of Ecology and Evolutionary Biology University of CaliforniaLos Angeles the Dog10K Consortium

Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10 K Consortium(http://***10 ***) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 *** effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.

关键词： genomics genome-wide association studies(GWAS) breed selection variation evolution

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