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Heart‘omicsin’AGEing (HOMAGE):design,research objectives and characteristics of the common database

The Journal of Biomedical Research 2014年第5期28卷 349-359页

作者： Lotte Jacobs Lutgarde Thijs Yu Jin Faiez Zannad Alexandre Mebazaa Philippe Rouet Florence Pinet christophe bauters Burkert Pieske Andreas Tomaschitz Mamas Mamas Javier Diez Kenneth McDonald John G F Cleland Hans-Peter Brunner-La Rocca Stephane Heymans Roberto Latini Serge Masson Peter Sever Christian Delles Stuart Pocock Timothy Collier Tatiana Kuznetsova Jan A Staessen Studies Coordinating Centre Research Unit Hypertension and Cardiovascular EpidemiologyKU Leuven Department of Cardiovascular Sciences University of Leuven Centre d'Investigation Clinique Pierre Drouin and U 961 Hypertension and Heart Failure UnitInstitut Lourrain du Coeur etdes VaisseauxInsermNancyFrance Department of Anesthesiology and Critical Care Medicine InsermUMR-S942Hopital LariboisiereUniversite Paris Diderot Equipe obesite et insuffisance cardiaque Universite UPSInserm I2MCUMR 1048ToulouseFrance Inserm U744CHRULilleFrance Department of Cardiology Medical University Graz Cardiovascular Institute University of ManchesterManchesterUK Division of Cardiovascular Sciences Foundation for Applied Medical ResearchUniversity of Navarra Heart Failure Unit St Vincent's University Hospital University College Dublin Department of Cardiology University of HullUK Department of Cardiology Maastricht University Medical CentreNetherlands Center for Heart Failure Research Department of CardiologyMaastricht UniversityNetherlands Department of Cardiovascular Research IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri" International Center for Circulatory Health Imperial College Institute of Cardiovascular and Medical Sciences BHF Glasgow Cardiovascular Research CenterUniversity of Glasgow London School of Hygiene and Tropical Medicine

Heart failure is common in older people and its prevalence is *** Heart ＇omics＇ in AGEing（HOMAGE） project aims to provide a biomarker approach that will improve the early diagnosis of heart failure.A large clinical database,based on（1） prospective population studies or（2） cross-sectional,prospective studies or randomized controlled trials（RCTs） of patients at risk for or with overt cardiovascular disease will be constructed to determine most promising ＇omics＇-based biomarkers to identify the risk of developing heart failure and/or *** studies,patient cohorts and RCTs are eligible for inclusion in the common database,if they received ethical approval to obtain and share data and have baseline information on cardiovascular risk ***,the HOMAGE database includes 43,065 subjects,from 20 studies in eight European countries,including healthy subjects from three population studies in France,Belgium and Italy（n = 7,124）,patients with heart failure（n = 4,312） from four cohorts in the UK,Spain and Switzerland and patients at high risk for cardiovascular disease（n = 31,629） in 13 *** is anticipated that more partners will join the consortium and enlarge the pooled *** large merged database will be a useful resource with which to identify candidate biomarkers that play a role in the mechanism underlying the onset and progression of heart failure.

关键词： left ventricle heart failure heart failure with reduced ejection fraction heart failure with preserved ejection fraction population science morbidity mortality

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