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Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 506-511页

作者： Tom Florian Ulmer Anne Weiland Georg Lurje Christian Klink Anne Andert Hamid Alizai christoph Heidenhain Ulf neumann Department of General Visceral and Transplantation Surgery RWTH Aachen University Hospital Aachen Germany Department of Urology Helios Hospital Berlin-Buch Germany

BACKGROUND: Post-hepatectomy liver failure as a result of insufficient liver remnant is a feared complication in liver surgery. Efforts have been made to find new strategies to support liver regeneration. The aim of this study was to investigate the effects of terlipressin versus splenectomy on postoperative liver function and liver regeneration in rats undergoing 70%partial hepatectomy. METHODS: Seventy-two male Wistar rats were randomly assigned into three groups(n=24 in each group): 70% partial hepatectomy as control(PHC), 70% partial hepatectomy with splenectomy(PHS) or 70% partial hepatectomy with a micropump for terlipressin administration(PHT). Eight rats in each group were sacrificed on postoperative day(POD) 1,3 and 7. To assess liver regeneration, immunohistochemical analysis of liver tissue using bromodeoxyuridine(BrdU) and Ki-67 labeling was performed. Portal venous pressure, serum concentrations of creatinine, urea, albumin, bilirubin and prothrombin time as well as liver-, body-weight and their ratio were determined on POD 1, 3 and ***: The liver-, body-weight and their ratio were not statistically different among the groups. On POD 1, 3 and 7 portal venous pressure in the intervention groups(PHT:8.13 ±1.55, 10.38±1.30, 6.25±0.89 cm H2O and PHS: 7.50±0.93,8.88 ±2.42, 5.75±1.04 cm H2O) was lower compared to the control group(PHC: 8.63±2.06, 10.50±2.45, 6.50±2.67 cmH2O). Hepatocyte proliferation in the intervention groups was delayed, especially after splenectomy on POD 1(Brd U: PHS vs PHC, 20.85% ±13.05% vs 28.11%±10.10%; Ki-67, 20.14%±14.10% vs 23.96% ±11.69%). However, none of the differences were statistically ***: Neither the administration of terlipressin nor splenectomy improved liver regeneration after 70% partial hepatectomy in rats. Further studies assessing the regulation of portal venous pressure as well as extended hepatectomy animal models and liver function tests will help to further investigate mechanisms of live

关键词： liver regeneration liver failure terlipressin splenectomy hepatectomy

Grade of donor liver microvesicular steatosis does not affect the postoperative outcome after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 617-623页

作者： Anne Andert Tom Florian Ulmer Wenzel Schoning Daniela Kroy Marc Hein Patrick Hamid Alizai christoph Heidenhain Ulf neumann Maximilian Schmeding Department of General Visceral and Transplant SurgeryUniklinik RWTH Aachen AachenGermany Department of Internal Medicine Uniklinik RWTH Aachen AachenGermany Department of Anaesthesiology Uniklinik RWTH Aachen AachenGermany Department of General and Visceral Surgery Sana Hospital Düsseldorf-Gerresheim Germany

BACKGROUND:The potential effect of graft steatosis on the postoperative liver function is discussed controversially. The present study aimed to evaluate the effect of the donor liver microvesicular steatosis on the postoperative outcome after liver ***:Ninety-four patients undergoing liver transplantation at the University Hospital Aachen were included in this study. The patient cohort was divided into three groups according to the grade of microvesicular steatosis(MiS):MiS 60%(n=26).The outcomes after liver transplantation were evaluated, including the 30-day and 1-year patient and graft survival rates and the incidences of early allograft dysfunction(EAD) and primary nonfunction(PNF). RESULTS:The incidences of EAD and PNF did not differ significantly between the groups. We observed 5 cases of PNF,one occurred in the MiS 60% ***:Microvesicular steatosis of donor livers has no negative effect on the postoperative outcome after liver transplantation.

关键词： liver transplantation liver steatosis microvesicular steatosis early allograft dysfunction

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嵌入式系统在智能电器和能源管理中的应用

纸与光——Anke neumann的跨文化研究

作者： (德)christoph Grimm (德)Peter neumann (意)Stefan Mahlknecht

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照明设计 2014年第4期 86-90页

作者： Anke neumann Joachim Ritter christoph Beer

在传统的亚洲文化中，人们认为纸张是一种严肃的建筑材料，广泛地在人们的家中使用。在那里，人们发现纸张拥有诗意的效果。轻盈、柔和、弥漫甚至是稍纵即逝，正是所有的这些特质使纸张变得与众不同。当它与灯光结合的时候，几乎是半透... 详细信息

在传统的亚洲文化中，人们认为纸张是一种严肃的建筑材料，广泛地在人们的家中使用。在那里，人们发现纸张拥有诗意的效果。轻盈、柔和、弥漫甚至是稍纵即逝，正是所有的这些特质使纸张变得与众不同。当它与灯光结合的时候，几乎是半透明的。

关键词： neumann 跨文化建筑材料纸张半透明

Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: A case report and review of literature

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World Journal of Gastroenterology 2006年第14期12卷 2293-2296页

作者： Antonino Spinelli Guido Schumacher Andreas Pascher Enrique Lopez-Hanninen Hussain Al-Abadi christoph Benckert Igor M Sauer Johann Pratschke Ulf P neumann Sven Jonas Jan M Langrehr Peter Neuhaus Department of General Visceral and Transplantation Surgery Charitè-Universitatsmedizin BerlinCampus Virchow KlinikumAugustenburger Platz 113353 BerlinGermany Department of Radiology Charitè-Universitatsmedizin Berlin Campus Virchow KlinikumAugustenburger Platz 113353 BerlinGermany

Xanthogranulomatous cholecystitis （XGC） is a destructive inflammatory disease of the gallbladder, rarely involving adjacent organs and mimicking an advanced gallbladder carcinoma. The diagnosis is usually possible only after pathological examination. A 46 year-old woman was referred to our center for suspected gallbladder cancer involving the liver hilum, right liver lobe, right colonic flexure, and duodenum. Brushing cytology obtained by endoscopic retrograde cholangiography （ERC） showed high-grade dysplasia. The patient underwent an en-bloc resection of the mass, consisting of right Iobectomy, right hemicolectomy, and a partial duodenal resection. Pathological examination unexpectedly revealed an XGC. Only six cases of extended surgical resections for XGC with direct involvement of adjacent organs have been reported so far. In these cases, given the possible coexistence of XGC with carcinoma, malignancy cannot be excluded, even after cytology and intraoperative frozen section investigation. In conclusion, due to the poor prognosis of gallbladder carcinoma on one side and possible complications deriving from highly aggressive inflammatory invasion of surrounding organs on the other side, it seems these cases should be treated as malignant tumors until proven otherwise. Clinicians should include XGC among the possible differential diagnoses of masses in liver hilum.

关键词： Xanthogranulomatous cholecystitis Gallbladder cancer Gallbladder carcinoma

Spin-polarized electron beam generation in the colliding-pulse injection scheme

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Matter and Radiation at Extremes 2023年第6期8卷 49-62页

作者： Zheng Gong Michael J.Quin Simon Bohlen christoph HKeitel Kristjan Põder Matteo Tamburini Max-Planck-Institut für Kernphysik Saupfercheckweg 169117 HeidelbergGermany Deutsches Elektronen-Synchrotron DESY Notkestr.8522607 HamburgGermany

Employing colliding-pulse injection has been shown to enable the generation of high-quality electron beams from laser-plasma ***,by using test particle simulations,Hamiltonian analysis,and multidimensional particle-in-cell simulations,we lay the theoretical framework for spin-polarized electron beam generation in the colliding-pulse injection ***,we show that this scheme enables the production of quasi-monoenergetic electron beams in excess of 80%polarization and tens of pC charge with commercial 10-TW-class laser systems.

关键词： polarized scheme enable

Pathologic Q Waves and Prolonged QTc Time in Preoperative ECG Are Predictive for Perioperative Cardiovascular Events

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World Journal of Cardiovascular Diseases 2014年第10期4卷 498-509页

作者： Thomas Wolters Michael Weber Thomas neumann Hans-Georg Strauß Andreas Luchner Manfred Seeberger Christian Mueller christoph Liebetrau Svetlana Apostolovic Radmilo Jankovic Dragic Bankovic Marina Jovic Vesselin Mitrovic Holger Nef Helge Mollmann Karl Werdan Christian W. Hamm Axel Schlitt Department of Medicine III University Clinic Halle (Saale) Halle Germany Department of Medicine Clinic Grabs Grabs Switzerland Department of Cardiology Kerckhoff Heart and Thorax Center Bad Nauheim Germany Department of Medicine II Clinic Gro&szlig -Umstadt Gro&szlig -Umstadt Germany Department of Medicine II University of Regensburg Regensburg Germany Department of Cardiology University of Basel Basel Switzerland University Cardiology Clinic Ni&scaron Serbia Department of Mathematical Sciences University of Kragujevac Kragujevac Serbia Department of Medicine I University Clinic of Gie&szlig en and Marburg Gie&szlig en Germany Department of Medicine I Paracelsus-Harz-Clinic Bad Suderode Quedlinburg Germany

Aims: The value of ECG in the perioperative risk stratification under modern treatment options is uncertain. The main objective of the present analysis was to determine the usefulness of a pre-operative ECG derivation for evaluating the risk of perioperative morbidity and mortality. Methods: We performed a secondary analysis of the prospective, international, multicenter, observational “No-Risk” Study (N-terminal B-type natriuretic peptide [NT-proBNP] for the assessment of the perioperative cardiac risk after major noncardiac surgery) to determine the prognostic value of 12-lead ECG. Inclusion criteria were age >55 years and at least one of the following cardiovascular risk factors: arterial hypertension, diabetes mellitus, dyslipidemia, active smoking, and family history positive for coronary heart disease. The combined primary endpoint included total mortality, acute myocardial infarction (NSTEMI and STEMI), cardiopulmonary resuscitation, heart failure, and asystole or ventricular fibrillation during hospitalization. ECGs from 616 patients enrolled from 2006 to 2009 prior to noncardiac surgery in the No-Risk Study were analyzed. Results: The mean age was 67.6 (±8.1) years;300 (48.7%) patients were male. Fourteen (2.3%) patients suffered from the combined primary endpoint while in the hospital. In Kaplan-Meier analyses, a pathologic Q wave and QTc > 500 ms were significantly related to the incidence of the primary endpoint (p p = 0.042, respectively), whereas other ECG parameters such as LBBB, RBBB, PQ interval, QRS interval, and others were not related to worse in-hospital outcome. Conclusion: The 12-lead ECG is still an important diagnostic tool for perioperative risk assessment of cardiovascular events in noncardiac surgery in patients at risk.

关键词： ECG Perioperative Risk Cardiovascular Risk

肿瘤18F-FDG PET/MRI全身显像专家共识(德国)

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中华核医学与分子影像杂志 2020年第9期40卷 549-555页

作者：王洋洋杨光杰(译) 王振光(审校) Lale Umutlu Thomas Beyer Johannes Stefan Grueneisen christoph Rischpler Harald H Quick Veit-Haibach Patrick Matthias Eiber Sandra Purz Gerald Antoch Sergios Gatidis Konstantin Nikolaou Jürgen FSchaefer IvoRausch Herrmann Ken K.Herrmann B.J.Krause S.O.Schoenberg L.Umutlu F.Anton G.Antoch M.Hacker M.Luster S.neumann D.Vorwerk 青岛大学附属医院核医学科PET/CT中心 266100 Department of Diagnostic and Interventional Radiology and Neuroradiology University-Hospital EssenGermany QIMP Group Centre for Medical Imaging and Biomedical EngineeringMedical University of ViennaAustria Department of Nuclear Medicine University-Hospital EssenGermany High-Field-and Hybrid-MR-Imaging University-Hospital EssenGermany Joint Department of Medical Imaging University of TorontoCanada Department of Nuclear Medicine Klinikum rechts der IsarTechnical University of MunichGermany Department of Nuclear Medicine University of LeipzigGermany Department of Diagnostic and Interventional Radiology University DüsseldorfMedical FacultyDüsseldorfGermany Department of Diagnostic and Interventional Radiology University-Hospital TübingenGermany Department of Nuclear Medicine University Medical Center RostockGermany Department of Clinical Radiology and Nuclear Medicine University Medical Center MannheimGermany Deutsche Röntgengesellschaft BerlinGermany Division of Nuclear Medicine Department of Biomedical Imaging and Image-guided TherapyMedical University ViennaAustria Department of Nuclear Medicine University Hospital MarburgGermany Department of Radiology Klinikum IngolstadtGermany

PET/MRI一体机在2006年被首次提出可应用于临床;2010年,首台临床型PET/MRI一体机诞生。在20世纪早期,PET/CT和SPECT/CT一体机的广泛应用体现了融合显像的优势,为PET/MRI一体机的产生奠定了基础。目前,全球大约有150台全身PET/MRI一体机... 详细信息

PET/MRI一体机在2006年被首次提出可应用于临床;2010年,首台临床型PET/MRI一体机诞生。在20世纪早期,PET/CT和SPECT/CT一体机的广泛应用体现了融合显像的优势,为PET/MRI一体机的产生奠定了基础。目前,全球大约有150台全身PET/MRI一体机投入了临床应用,其中肿瘤显像是PET/MRI的主要应用领域之一。迄今为止,尽管PET/MRI临床应用在增加,但标准化的PET/MRI扫描方案还很少。因此,有必要制定患者检查和多中心研究都可遵循的标准化且一致性好的显像方案。该文总结了18F-脱氧葡萄糖(FDG)PET/MRI全身显像的患者就诊、检查准备、工作流程、显像方案以及报告书写等主要方面的专家共识,由长期使用PET、MRI和较早使用PET/MRI的相关资深专家制定。

关键词： PET/MRI 肿瘤全身显像专家共识