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Diagnosis and Objective Pain Assessment of Traditional Chinese Medicine May Be Useful to Demonstrate Specific Effects of Acupuncture in Low Back Pain: A Prospective, Randomized, Controlled and Single Blinded Pre-study

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Journal of Acupuncture and Tuina Science 2013年第3期11卷 155-159页

作者： Susana Seca Paula Capelo Thomas Efferth christoph alexander doenitz Sven Schroeder Ana Anjos Jorge Machado Henry Johannes Greten Institute of Biomedical Sciences Abel Salazar (ICBAS) University of PortoPortoPortugal Heidelberg School of Chinese Medicine Heidelberg Germany University Hospital Center of Coimbra CoimbraPortugal Department of Pharmaceutical Biology Institute of Pharmacy and BiochemistryJohannes Gutenberg UniversityMainzGermany Institute of Biomedical Sciences Abel Salazar (ICBAS) University of Porto Porto Portugal HanseMerkur Center for Traditional Chinese Medicine University Medical Center Hamburg-Eppendorf Hamburg Germany Porto Biomechanics Laboratory (LABIOMEP) University of Porto Portugal German Society of Traditional Chinese Medicine Heidelberg Germany

Objective: To prove specific effects of acupuncture on chronic pain. It was speculated that the potential specific effectiveness of acupuncture could be better shown in more properly designed studies. Therefore, diagnoses of both Western medicine and traditional Chinese medicine (TCM) were used as inclusion criteria to allocate acupoints more precisely to the complaints of the patients. Secondly, objectively measurable parameters of pain relief in addition to usual Visual Analogue Scale (VAS) were chosen to quantify the effects of acupuncture. Methods: The study was prospective, randomized, controlled and single-blinded. Eighteen patients with chronic back pain and TCM diagnosis of a Taiyang/Yangming syndrome received one single session of acupuncture chosen according to TCM diagnosis or acupuncture on points outside the meridian system (controls). We evaluated pain via VAS and increased mobility via inclinometry of the back. Results: Although the sample size was small, there was a statistically significant improvement in pain and mobility in the intervention group (n=13), but not in the control group (n=5). The calculated sample size adequate power was lower for inclinometry than for VAS, indicating that VAS is less probable to discriminate acupuncture effects. Conclusion: Objectively measurable physical parameters such as the angle of flexion before and after acupuncture (inclinometry) may be more suitable to measure pain relief than subjective assessment by VAS in acupuncture studies. TCM diagnosis may be a helpful inclusion criterion in studies on acupuncture, so as to potentially allocate interventions better to the complaints of patients.

关键词：腰骶部疼痛繁体中文药针灸治疗假冒的针灸使随机化的控制试用 R246.2

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Optical probing of ultrafast laser-induced solid-to-overdense-plasma transitions

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Light(Science & Applications) 2024年第5期13卷 973-984页

作者： Yasmina Azamoum Georg alexander Becker Sebastian Keppler Guillaume Duchateau Stefan Skupin Mickael Grech Fabrice Catoire Sebastian Hell Issa Tamer Marco Hornung Marco Hellwing alexander Kessler Franck Schorcht Malte christoph Kaluza GSI Helmholtzzentrum für Schwerionenforschung Planckstr.164291 DarmstadtGermany. Helmholtz Institute Jena Fröbelstieg 307743 JenaGermany. Institute of Optics and Quantum Electronics Friedrich-SchillerUniversität JenaMax-Wien-Platz 107743 JenaGermany. CEA-CESTA 15 Avenue des SablièresCS6000133116 Le BarpCedexFrance Institut Lumière Matière UMR 5306-CNRSUniversitéde Lyon 169622 VilleurbanneFrance. LULI CNRSCEASorbonne UniversitéInstitut Polytechnique de ParisPalaiseauFrance. Universitéde Bordeaux-CNRS-CEA CELIAUMR 5107 TalenceFrance

Understanding the solid target dynamics resulting from the interaction with an ultrashort laser pulse is a challenging fundamental multi-physics problem involving atomic and solid-state physics,plasma physics,and laser *** of the initial interplay of the underlying processes is essential to many applications ranging from lowpower laser regimes like laser-induced ablation to high-power laser regimes like laser-driven ion *** the properties of the so-called pre-plasma formed as the laser pulse’s rising edge ionizes the target is complicated from the theoretical and experimental point of view,and many aspects of this laser-induced transition from solid to overdense plasma over picosecond timescales are still open *** the one hand,laser-driven ion acceleration requires precise control of the pre-plasma because the efficiency of the acceleration process crucially depends on the target properties at the arrival of the relativistic intensity peak of the *** the other hand,efficient laser ablation requires,for example,preventing the so-called“plasma shielding”.By capturing the dynamics of the initial stage of the interaction,we report on a detailed visualization of the pre-plasma formation and ***-thin diamond-like carbon foils are shown to transition from solid to plasma during the laser rising edge with intensities<10^(16)W/cm^(2).Single-shot near-infrared probe transmission measurements evidence sub-picosecond dynamics of an expanding plasma with densities above 10^(23)cm^(−3)(about 100 times the critical plasma density).The complementarity of a solid-state interaction model and kinetic plasma description provides deep insight into the interplay of initial ionization,collisions,and expansion.

关键词： laser acceleration solid

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Vertical power flow forecast with LSTMs using regular training updatestrategies

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能源与人工智能(英文) 2022年第2期8卷 92-99页

作者： Katharina Brauns christoph Scholz alexander Schultz AndréBaier Dominik Jost Fraunhofer IEE Königstor 5934119 KasselGermany

The strong growth of renewable energy sources as well as the increasing amount of volatile energy consumptionis leading to major challenges in the electrical grid. In order to ensure safety and reliability in the electricitygrid, a high quality of power flow forecasts for the next few hours are needed. In this paper we investigateforecasts of the vertical power flow at transformer between the medium and high voltage grid. Forecastingthe vertical power flow is challenging due to constantly changing characteristics of the power flow at thetransformer. We present a novel approach to deal with these challenges. For the multi step time series forecastsa Long-Short Term Memory (LSTM) is used. In our presented approach an update process where the model isretrained regularly is investigated and compared to baseline models. The model is retrained as soon as asufficient amount of new measurements are available. We show that this retraining mostly captures changesin the characteristic of the transformer that the model has not yet seen in the past and therefore cannot bepredicted by the model without an update process. To give more weight to recent data, we examined differentstrategies in terms of the number of epochs and the learning rate. We show that our new approach significantlyoutperforms the investigated baseline models. On average, we achieved an improvement of about 8% with theregular update process compared to the approach without update process.

关键词： Vertical power flow Forecasting LSTM

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Three-dimensional visualization of planta clathrin-coated vesicles at ultrastructural resolution

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Molecular Plant 2022年第10期15卷 1533-1542页

作者： alexander Johnson Walter A.Kaufmann christoph Sommer Tommaso Costanzo Dana A.Dahhan Sebastian Y.Bednarek Jiri Friml Institute of Science and Technology Austria(ISTA) 3400KlosterneuburgAustria UW-Madison Department of Biochemistry433 Babcock Dr.MadisonWI 53706USA

Biological systems are the sum of their dynamic three-dimensional(3D)***,it is critical to study biological structures in 3D and at high resolution to gain insights into their physiological *** microscopy of metal replicas of unroofed cells and isolated organelles has been a key technique to visualize intracellular structures at nanometer ***,many of these methods require specialized equipment and personnel to complete ***,we present novel accessible methods to analyze biological structures in unroofed cells and biochemically isolated organelles in 3D and at nanometer resolution,focusing on Arabidopsis clathrin-coated vesicles(CCVs).While CCVs are essential trafficking organelles,their detailed structural information is lacking due to their poor preservation when observed via classical electron microscopy protocols ***,we establish a method to visualize CCVs in unroofed cells using scanning transmission electron microscopy tomography,providing sufficient resolution to define the clathrin coat ***,the samples are prepared directly on electron microscopy grids,removing the requirement to use extremely corrosive acids,thereby enabling the use of this method in any electron microscopy ***,we demonstrate that this standardized sample preparation allows the direct comparison of isolated CCV samples with those visualized in ***,to facilitate the high-throughput and robust screening of metal replicated samples,we provide a deep learning analysis method to screen the“pseudo 3D”morphologies of CCVs imaged with 2D ***,our work establishes accessible ways to examine the 3D structure of biological samples and provide novel insights into the structure of plant CCVs.

关键词： Arabidopsis thaliana clathrin-coated vesicles STEM tomography electron microscopy clathrin-mediated endocytosis

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Reduced formation of peroxide and radical species stabilises iron-based hybrid catalysts in polymer electrolyte membrane fuel cells

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Journal of Energy Chemistry 2022年第2期31卷 433-438页

作者： Dongyoon Shin Sabita Bhandari Marc FTesch Shannon ABonke Frédéric Jaouen Sonia Chabbra christoph Pratsch alexander Schnegg Anna K.Mechler Max Planck Institute for Chemical Energy Conversion Stiftstr.34–3645470 Mülheim an der RuhrGermany ICGM Univ.MontpellierCNRSENSCMMontpellierFrance Fritz Haber Institute of the Max Planck Society Department of Inorganic ChemistryFaradayweg 4-614195 BerlinGermany

The incorporation of Pt into an iron-nitrogen-carbon(Fe NC)catalyst for the oxygen reduction reaction(ORR)was recently shown to enhance catalyst stability without Pt directly contributing to the ORR ***,the mechanistic origin of this stabilisation remained *** is established herein with rotating ring disc experiments that the side product,H_(2)O_(2),which is known to damage FeNC catalysts,is suppressed by the presence of *** formation of reactive oxygen species is additionally inhibited,independent of intrinsic H_(2)O_(2) formation,as determined by electron paramagnetic *** electron microscopy identifies an oxidised Fe-rich layer covering the Pt particles,thus explaining the inactivity of the latter towards the *** insights develop understanding of Fe NC degradation mechanisms during ORR catalysis,and crucially establish the required properties of a precious metal free protective catalyst to improve Fe NC stability in acidic media.

关键词： Electrochemistry Fuel cells Oxygen reduction reaction Non-precious metal catalyst Hybrid catalyst Stability

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Over-the-scope-grasper: A new tool for pancreatic necrosectomy and beyond-first multicenter experience

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World Journal of Gastrointestinal Surgery 2022年第8期14卷 799-808页

作者： Markus Brand Jeannine Bachmann christoph Schlag Ulrich Huegle Imdadur Rahman Edris Wedi Benjamin Walter Oliver Moschler Lukas Sturm alexander Meining Department of Internal Medicine II University of WürzburgWürzburg 97080Germany Department of Surgery Klinikum rechts der IsarUniversity of MünchenMünchen 81675Germany Department of Gastroenterology and Hepatology University of ZürichZürich 8091Switzerland Department of Gastroenterology and Hepatology Klinikum Koln-HolweideKoln 50968Germany Department of Gastroenterology University Hospital SouthamptonSouthampton SO166YDUnited Kingdom Department of Gastroenterology Gastrointestinal Oncology and Interventionell EndoscopySana Klinikum OffenbachOffenbach 63069Germany Department of Internal Medicine I University of UlmUlm 89070Germany Department of Gastroenterology Marienhospital OsnabrückOsnabrück 49074Germany Department of Internal Medicine II University of FreiburgFreiburg 79106Germany

BACKGROUND Endoscopic treatment of pancreatic necrosis can be challenging and timeconsuming because sticky necrotic debris is sometimes difficult to remove. The over-the-scope-grasper, a new tool that has recently become available for this purpose, might also be useful for other indications. However, clinical data on the efficacy and safety of this new device are *** To evaluate the technical success and safety of the device in a multicenter *** The over-the-scope-grasper was used in nine selected endoscopic centers between November 2020and October 2021 for appropriate indications. Overall, 56 procedures were included in the *** retrospectively evaluated procedural parameters of all endoscopic interventions using a predefined questionnaire, with special respect to technical success, indications, duration of intervention, type of sedation, and complications. In the case of pancreatic necrosectomy, the access route, stent type, number of necrosis pieces removed, and clinical handling were also *** A total of 56 procedures were performed, with an overall technical success rate of 98%. Most of the procedures were endoscopic pancreatic necrosectomies(33 transgastric, 4 transduodenal). In 70%of the procedures, access to the necrotic cavity was established with a lumen apposing metal *** technical success of pancreatic necrosectomy was 97%, with a mean of 8 pieces(range, 2-25pieces) of necrosis removed in a mean procedure time of 59 min(range, 15-120 min). In addition,the device has been used to remove blood clots(n = 6), to clear insufficiency cavities before endoluminal vacuum therapy(n = 5), and to remove foreign bodies from the upper gastrointestinal tract(n = 8). In these cases, the technical success rate was 100%. No moderate or severe/fatal complications were reported in any of the 56 *** These first multicenter data demonstrate that the over-the-scope-grasper is a promising device for endoscopic pancreat

关键词： Over-the-scope-grasper Endoscopic pancreatic necrosectomy Grasper Direct endoscopic necrosectomy Pancreatic necrosis Endoscopic tool

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Numerical Modelling of the Powder Metallurgical Manufacturing Chain of High Strength Sintered Gears

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Chinese Journal of Mechanical Engineering 2021年第6期34卷 3-20页

作者： Ali Rajaei Yuanbin Deng Oliver Schenk Soheil Rooein alexander Bezold christoph Broeckmann Institute for Materials Applications in Mechanical Engineering(IWM)of RWTH Aachen University Augustinerbach 452062 AachenGermany

This paper presents a digital model for the powder metallurgical(PM)production chain of high-performance sintered gears based on an integrated computational materials engineering(ICME)*** and finite element methods(DEM and FEM)were combined to describe the macroscopic material response to the thermomechanical loads and process conditions during the entire production *** microstructural evolution during the sintering process was predicted on the meso-scale using a Monte-Carlo *** effective elastic properties were determined by a homogenization method based on modelling a representative volume element(RVE).The results were subsequently used for the FE modelling of the heat treatment *** the development of multi-scale models,it was possible obtain characteristics of the microstructural *** predicted hardness and residual stress distributions allowed the calculation of the tooth root load bearing capacity of the heat-treated sintered gears.

关键词： ICME Process chain Powder metallurgy Multiscale modelling and simulation Digital model Sintered gear

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Osteotomy of the Margo Medialis Scapulae to Approach Subscapular and Subrhomboid Tumors. A Technical Note

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Open Journal of Orthopedics 2022年第8期12卷 351-356页

作者： G. Ulrich Exner Jan Leuzinger christoph Sternberg alexander Metzdorf Pascal A. Schai Orthopaedie Zentrum Zuerich Zuerich Switzerland Etzelclinic Pfaeffikon Switzerland Clinica Luganese Moncucco Lugano Switzerland Luzerner Kantonsspital Wolhusen Wolhusen Switzerland

Purpose: The approach to resect subscapular and subrhomboid tumors needs elevation of the scapula. This is usually performed by detaching the muscles from the margo medialis of the scapula. We wish to communicate our technique of a longitudinal osteotomy of the margo medialis for improved refixation of the muscles. Patients and Methods: 5 patients with subscapular and one patient with a subrhomboid benign tumor were operated on using this technique. Results: All patients achieved stable healing and full functional recovery;only in one patient there was slightly reduced elevation of the arm. Conclusion: Elevation of the muscles inserting into the medial scapular margo with a small rim of bone facilitates refixation and allows for excellent restitution of function.

关键词： Subscapular/Subrhomboid Tumors Surgical Access Osteotomy of Margo Medialis Scapulae

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Stroke-like onset of brain stem degeneration presents with unique MRI sign and heterozygous NMNAT2 variant:a case report

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Translational Neurodegeneration 2016年第1期5卷 181-185页

作者： alexander Schulz Franziska Wagner Martin Ungelenk Ingo Kurth christoph Redecker Hans Berger Department of Neurology Jena University HospitalFriedrich Schiller University JenaJena 07747Germany Department of Genetics and Program in Cellular Neuroscience Neurodegeneration and RepairYale University School of MedicineNew HavenCT 06510USA Institute of Human Genetics Jena University HospitalFriedrich-Schiller-University JenaJena 07743Germany Institute of Human Genetics Uniklinik RWTH AachenAachen 52074Germany

Background:Acute-onset neurodegenerative diseases in older patients are rare clinical cases,especially when the degeneration only affects specific regions of the nervous *** neurological disorders have been described in which the degeneration of brain parenchyma originates from and/or primarily affects the brain *** diagnosis in these patients,however,is often complicated due to a poor understanding of these diseases and their underlying *** presentation:In this manuscript we report on a 73-year-old female who had experienced a sudden onset of complex neurological symptoms that progressively worsened over a period of 2 *** evaluation had suggested a MRI-negative stroke as underlying *** combination of patient’s medical history,clinical examination and exceptional pattern of brain stem degeneration presenting as“kissing swan sign”in MR imaging was strongly suggestive of acute onset of alexander’s *** leukoencephalopathy is caused by GFAP(glial fibrilary acidic protein)gene mutations and may present with brain stem atrophy and stroke-like onset of symptoms in elderly ***,a pathognomonic GFAP gene mutation could not be identified by Sanger ***:After an extended differential diagnosis and exclusion of other diseases,a definite diagnosis of the patient’s condition presently remains ***,whole-exome sequencing performed from patient’s blood revealed 12 potentially disease-causative heterozygous variants,amongst which several have been associated with neurological disorders in vitro and in vivo–in particular the axon degeneration-related NMNAT2 gene.

关键词： Brain stem atrophy Dementia alexander’s disease Whole-exome sequencing Kissing swan sign NMNAT2 Axon degeneration

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Glycolytic Shunts Replenish the Calvin-Benson-Bassham Cycle as Anaplerotic Reactions in Cyanobacteria

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Molecular Plant 2020年第3期13卷 471-482页

作者： alexander Makowka Lars Nichelmann Dennis Schulze Katharina Spengler christoph Wittmann Karl Forchhammer Kirstin Gutekunst Department of Biology Botanical InstituteUniversity Kiel24118 KielGermany Institute for Systems Biotechnology Saarland University66123 SaarbruckenGermany Organismic Interactions Department Interfaculty Institute for Microbiology and Infection MedicineUniversity

The recent discovery of the Entner-Doudoroff(ED)pathway as a third glycolytic route beside Embden-Meyerhof-Parnas(EMP)and oxidative pentose phosphate(OPP)pathway in oxygenic photoautotrophs requires a revision of their central carbohydrate *** this study,unexpectedly,we observed that deletion of the ED pathway alone,and even more pronounced in combination with other glycolytic routes,diminished photoautotrophic growth in continuous light in the cyanobacterium Synechocystis *** ***,we found that the ED pathway is required for optimal glycogen catabolism in parallel to an operating Calvin-Benson-Bassham(CBB)*** is counter-intuitive that glycolytic routes,which are a reverse to the CBB cycle and do not provide any additional biosynthetic intermediates,are important under photoautotrophic ***,observations on the ability to reactivate an arrested CBB cycle revealed that they form glycolytic shunts that tap the cellular carbohydrate reservoir to replenish the *** together,our results suggest that the classical view of the CBB cycle as an autocatalytic,completely autonomous cycle that exclusively relies on its own enzymes and C02 fixation to regenerate ribulose-1,5-bisphosphate for Rubisco is an *** propose that in common with other known autocatalytic cycles,the CBB cycle likewise relies on anaplerotic reactions to compensate for the depletion of intermediates,particularly in transition states and under fluctuating light conditions that are common in nature.

关键词： central carbohydrate metabolism Calvin-Benson-Bassham cycle Entner-Doudoroff pathway oxidative pentose phosphate pathway Embden-Meyerhof-Parnas pathway cyanobacteria

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