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Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients:a nationwide Danish cohort study

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Journal of Geriatric Cardiology 2021年第11期18卷 897-907页

作者： Jesper Nielsen Kristian Hay Kragholm Sofie Brix Christensen Arne Johannessen Christian Torp-Pedersen Steen Buus Kristiansen Peter Karl Jacobsen Peter Steen Hansen Mogens Stig Djurhus christoffer Polcwiartek Peter Søgaard Anna Margrethe Thøgersen Uffe Jakob Ortved Gang Ole Dan Jørgensen Filip Lyng Lindgren Sam Riahi Department of Cardiology Aalborg University HospitalDenmark Department of Cardiology Gentofte HospitalCopenhagen University HospitalDenmark Department of Clinical Research and Cardiology Nordsjaellands HospitalHillerødDenmark Department of Cardiology Skejby University HospitalDenmark Department of Cardiology RigshospitaletCopenhagen University HospitalDenmark Mølholm Clinic VejleDenmark Department of Cardiology Odense University hospitalDenmark Department of Cardiology Roskilde University HospitalDenmark Department of Thoracic Surgery Odense University HospitalDenmark AF-Study group Aalborg University Hospital Denmark Clinical Institute Aalborg UniversityDenmark

OBJECTIVES To investigate complications within 30-days following first-time ablation for atrial fibrillation(AF),including a composite of cardiac tamponade,hematoma requiring intervention,stroke or death,in patients≥75 years of age,compared to pa-tients aged 65−74 *** addition,one-year all-cause mortality and AF relapse were ***&RESULTS All patients receiving their first catheter ablation for AF between 2012 and 2016 were identified us-ing Danish nationwide *** aged 65−74 years served as the reference group for patients≥75 *** of AF within one year was defined as cardioversion following a three-month blanking period,re-ablation or confirmed relapse within *** composite complication outcome did not differ between the two age groups,with 39/1554(2.8%)in patients 65−74 years of age,versus 5/199(2.5%)in older patients(adjusted HR=0.94),95%CI:0.37−2.39,P=0.896).Patients≥75 years or older had no increased hazard of death within 30 days after the procedure,with an incidence of 3/1554(0.2%)in younger pa-tients and 2/199(1.0%)in patients≥75 years of age(adjusted HR=4.71,95%CI:0.78−28.40,P=0.091).There was no difference in relapse of AF after one year between age groups(≥75 years adjusted HR=1.00,95%CI:0.78-1.26,P=0.969).CONCLUSION In patients≥75 years of age selected for catheter ablation for AF,the incidence of periprocedural complica-tions,as well as one-year freedom from AF showed no statistical difference,when compared to patients 65−74 years of age.

关键词： patients fibrillation atrial

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Antibiotics Resistance Profile of Bacillus cereus Strains Isolated from Soil and Pepper in Brazzaville

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Journal of Biosciences and Medicines 2022年第9期10卷 30-40页

作者： Isaac Samuel Onyankouang Nicole Prisca Makaya Dangui Nieko Cyr Jonas Morabandza Moїse Doria Kaya-Ongoto christoffer Pregna Mounkala Etienne Nguimbi Faculté des Sciences et Techniques Université Marien Ngouabi Brazzaville Congo Laboratoire National de Santé Publique Brazzaville Congo Laboratoire de Microbiologie Infectiologie et Immunologie Ecole Normale Supérieure Université Marien Ngouabi Brazzaville Congo

Introduction: Bacillus cereus and spores produced in various ecological niches are responsible for toxic infections in humans. This study is conducted to determine the antibiotics resistance profile of B. cereus strains isolated from soil and pepper consummated in Brazzaville. Methodology: An antimicrobial susceptibility test of 16 B. cereus strains from soil and peppers was performed using 11 antibiotics by the Kirby-Bauer’s diffusion on disc method. Results: Results revealed 100% (16/16) of resistance in penicillin G, amoxicillin, ceftazidime, rifampicin, and colistin, also 18.75% (3/16), 11.76% (2/16), and 18.75% (3/16) of resistance in doripenem, vancomycin and chloramphenicol respectively. In addition, we have observed 100% (16/16), 81.25% (13/16), 76.47% (13/16), 35.29% (5/16), 35.50% (6/16), and 12.5% (2/16) of sensitivity to line-zolid, tigecycline, ciprofloxacin, vancomycin, doripenem and chloram-phenicol respectively. However, all strains have been multidrug resistant (MDR) to betalactams, polypeptides, and ansamycins. Moreover, 7 strains (43.75%) have been variably multiresistant. One strain, Ri10 has been resistant to beta-lactams, polypeptides, ansamycins, cyclins and glycopeptides. No strain was ultraresistant (XDR) or largely insensitive (PDR) to different antibiotics. Conclusion: This study reveals that 51% of strains have been resistant to antibiotics, 32% are sensitive, and 17% have intermediate resistance. These results partly explain the high rate of gastroenteritis observed in Brazzaville due to food poisoning.

关键词： Antibiotics Resistance Bacillus cereus Soil Pepper

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Single Molecule Applications of Quantum Dots

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Journal of Modern Physics 2013年第11期4卷 27-42页

作者： Thomas E. Rasmussen Liselotte Jauffred Jonathan Brewer Stefan Vogel Esben R. Torbensen B. christoffer Lagerholm Lene Oddershede Eva C. Arnspang 1Departments of Physics Chemistry Pharmacy Biochemistry and Molecular Biology University of Southern Denmark Odense Denmark 2National Institutes of Health Bethesda USA 3Department of Molecular Biology and Genetics and Interdisciplinary Nanoscience Center Aarhus University Aarhus Denmark 1Departments of Physics Chemistry Pharmacy Biochemistry and Molecular Biology University of Southern Denmark Odense Denmark 2Weatherall Institute of Molecular Medicine University of Oxford Oxford UK Departments of Physics Chemistry Pharmacy Biochemistry and Molecular Biology University of Southern Denmark Odense Denmark Niels Bohr Institute University of Copenhagen Copenhagen Denmark

Fluorescent nanocrystals composed of semiconductor materials were first introduced for biological applications in the late 1990s. The focus of this review is to give a brief survey of biological applications of quantum dots (QDs) at the single QD sensitivity level. These are described as follows: 1) QD blinking and bleaching statistics, 2) the use of QDs in high speed single particle tracking with a special focus on how to design the biofunctional coatings of QDs which enable specific targeting to single proteins or lipids of interest, 3) a hybrid lipid-DNA analogue binding QDs which allows for tracking single lipids in lipid bilayers, 4) two-photon fluorescence correlation spectroscopy of QDs and 5) optical trapping and excitation of single QDs. In all of these applications, the focus is on the single particle sensitivity level of QDs. The high applicability of QDs in live cell imaging experiments held together with the prospects in localization microscopy and single molecule manipulation experiments gave QDs a promising future in single molecule research.

关键词： Quantum Dots Single Particle Tracking Fluorescence Correlation Spectroscopy Optical Tweezers

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肌肉减少症:早期预防还是过度诊断?

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英国医学杂志中文版 2022年第5期25卷 250-255页

作者： christoffer Bjerre Haase John Brandt Brodersen Jacob Bülow 汪奕名(译) 宋奇繁(译) Centre of General Practice Department of Public HealthUniversity of CopenhagenDenmark Primary Health Care Research Unit Region ZealandDenmark Institute of Sports Medicine Bispebjerg HospitalCopenhagenDenmark 重庆医药高等专科学校

临床定义:肌肉减少症是指由衰老引起的骨骼肌体量流失和功能下降,与发病率和死亡率的升高相关。随着人口老龄化进程加深,人们对该疾病的现状和治疗方案的研究热度也有所增加。诊断演进:肌肉减少症于1989年首次被描述为随着年龄增长,人... 详细信息

临床定义:肌肉减少症是指由衰老引起的骨骼肌体量流失和功能下降,与发病率和死亡率的升高相关。随着人口老龄化进程加深,人们对该疾病的现状和治疗方案的研究热度也有所增加。诊断演进:肌肉减少症于1989年首次被描述为随着年龄增长,人们会出现消瘦、体重减少的现象。直到1997年,肌肉减少症才被当做一种疾病得以提出。2010—2014年,6个共识性定义将该疾病的诊断重点转移到了肌肉功能的评估上。2016年,肌肉减少症被分配指定代码M62.84,列入国际疾病分类名录(ICD-10-CM)。诊断依据:研究肌肉减少症的专家小组认为,将该疾病编入ICD-10诊断代码或许可以提高人们对该疾病的识别和认知,进而吸引资助者和赞助商提供更多的研究资源,为该疾病的治疗方案研发提供支持。有效尝试:早发现、早治疗可以降低肌肉减少症的发病率和死亡率,提高患者的生活质量。流行状况:肌肉减少症在60~70岁人群中的患病率估计为5%~13%,80岁以上人群的患病率为11%~50%。到2050年,肌肉减少症的全球患病人数可能会多达20亿。过度诊断的依据:最近关于肌肉减少症筛查和诊断的研究还没有涉及对该疾病过度诊断风险评估的内容。就目前来看,对该疾病的过度诊断是很难避免的,因为目前对该疾病的治疗效果与对患者进行健康相关行为指导的效果没有差异。过度诊断的危害:目前尚无关于肌肉减少症过度诊断危害的调查研究,但有间接证据表明,给人们贴上疾病的标签,提示他们发病和死亡风险提升,会给人们带来心理负担。证据的局限性:对肌肉减少症的诊断尚未显示出改善疾病预后的作用。目前还没有证据表明,治疗肌肉减少症的效果会优于体育锻炼和饮食调节等常规医学建议。此外,基于性别和区域差异的诊断临界值确定是随意且未经验证的。诊断结果无法将病理性肌肉损失与年龄增长导致的正常肌肉萎缩加以区分。

关键词：肌肉减少症国际疾病分类过度诊断专家小组肌肉功能间接证据健康相关行为死亡风险

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The sustainability of valuable metals—recycling of residues from stainless steel production

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Baosteel Technical Research 2010年第S1期4卷 136-页

作者： Kristina BESKOW Andreas RUH christoffer LUNDSTRM Uan Hagfors Teknologi AB Djursholmsvgen 30 SE-18352 TbySweden Befesa Steel Services GmbH Albert-Hahn-Str.9 47269 DuisburgGermany

The European stainless steel producers generate 20 -30 kg dust per ton of produced stainless *** dust formed during various stages of the production process contains valuable metals such as Cr,Ni and *** general this dust is considered as a hazardous *** not taken care of the dust will be an environmental risk causing potential problems such as leaching of heavy metals into groundwater and pollution of land and *** applying techniques for recycling the dust the problem is minimized and valuable metals are recovered and re-used as raw material in the steel making process,leading to a significant reduction of the consumption of natural resources to decelerate the climate change and ensure a sustainable *** of the business segments of Befesa Zinc S.L.U.,a subsidiary company of Abengoa,is the recycling of dusts and other residues containing nickel,chromium and molybdenum from the stainless steel *** technologies applied are submerged arc reduction smelting(Befesa Valera S.A.S.,Gravelines,France) and plasma reduction smelting(Befesa ScanDust AB,Landskrona,Sweden).Stainless steel plant dusts,mill scale and other residues are delivered in closed containers and big bags by ship,rail or truck and *** a preparation of the residues and charging into the pyrometallurgical furnace,the metal compounds contained in the charge are reduced to metals in the presence of the carbon *** Befesa ScanDust,the regularly tapped liquid metal is cast in the form of granules via the Granshot^(?) granulation *** granulated product has many advantages such as excellent preheating properties and fast melting when added to a metallurgical *** granules size and shape also makes it very suitable to handle with most raw material handling *** granulating the so-called alloyed pig iron(API) a high metallic yield is achieved ensuring maximum recovery of metal and less new dust generation compared to a crushed *** granules

关键词： recycling stainless steel dust Befesa Granshot metal granulation sustainable development

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超极化磁共振波谱的原理和应用

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磁共振成像 2015年第12期6卷 881-887页

作者：齐海云张晓璐徐雅芳文建国许予明程敬亮 Albert P.Chen Lotte Bonde Bertelsen Steffen Ringgaard christoffer Laustsen Hans Stodkilde-Jorgensen MR研究中心临床医学系奥胡斯大学郑州大学第一附属医院郑州450052 GE Healthcare

通过动态核极化(dynamic nuclear polarization,DNP)的方法使原子核自旋极化达到热平衡之上来增强分子磁共振10,000倍以上的信号,这一过程称为超极化(hyperpolarization,HP)。溶解性DNP允许超极化分子以液体形式转移至生物体内,可实时... 详细信息

通过动态核极化(dynamic nuclear polarization,DNP)的方法使原子核自旋极化达到热平衡之上来增强分子磁共振10,000倍以上的信号,这一过程称为超极化(hyperpolarization,HP)。溶解性DNP允许超极化分子以液体形式转移至生物体内,可实时观测体内的生物灌注、代谢产物的运输和代谢反应。该技术的发明克服了传统磁共振信号低,不能实时监测体内代谢过程的缺点。本文旨在介绍动态核极化的定义和技术、常用的超极化生物探针、超极化磁共振波谱图像的结果分析以及初步的动物实验和临床试验结果。

关键词：超极化动态核极化生物探针生物反应器磁共振波谱磁共振成像

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patients with inflammatory bowel disease:Mechanisms and possible clinical impact

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World Journal of Gastroenterology 2021年第17期27卷 2039-2053页

作者： Trond Espen Detlie Jonas christoffer Lindstrøm Marte Eide Jahnsen Elisabeth Finnes Heinz Zoller Bjørn Moum Jørgen Jahnsen Department of Gastroenterology Akershus University HospitalLørenskog 1478Norway Institute of Clinical Medicine University of OsloOslo 0316Norway Health Services Research Unit Akershus University HospitalLørenskog 1478Norway Division of Medicine Department of GastroenterologyOslo University Hospital UllevålOslo 0424Norway Department of Medicine II Gastroenterology and HepatologyMedical University of InnsbruckInnsbruck A-6020Austria

BACKGROUND High-dose intravenous iron is an effective treatment option for iron deficiency(ID)or ID anaemia(IDA)in inflammatory bowel disease(IBD).However,treatment with ferric carboxymaltose(FCM)has been associated with the development of *** To investigate mechanisms behind the development of hypophosphatemia after intravenous iron treatment,and disclose symptoms and clinical manifestations related to hypophosphatemia *** A prospective observational study of adult IBD patients with ID or IDA was conducted between February 1,2017 and July 1,2018 at two separate university hospitals in the southeast region of *** received one dose of 1000 mg of either FCM or ferric derisomaltose(FDI)and were followed for an observation period of at least 7 *** and urine samples were collected for relevant analyses at baseline,week 2 and at week *** symptoms were assessed at the same timepoints using a respiratory function test,a visual analogue scale,and a health-related quality of life *** A total of 106 patients was available for analysis in this *** FCM treatment group consisted of 52 patients and hypophosphatemia was present in 72.5%of the patients at week 2,and in 21.6%at week *** comparison,the FDI treatment group consisted of 54 patients and 11.3%of the patients had hypophosphatemia at week 2,and 3.7%at week *** difference in incidence was highly significant at both week 2 and 6(P<0.001 and P<0.013,respectively).We observed a significantly higher mean concentration of intact fibroblast growth factor 23(P<0.001),a significant rise in mean urine fractional excretion of phosphate(P=0.004),a significant decrease of 1,25-dihydroxyvitamin D(P<0.001)and of ionised calcium levels(P<0.012)in the FCM-treated patients compared with patients who received *** clinical symptoms could with certainty be related to hypophosphatemia,since neither the respiratory function test,SF-36(36-item short form health s

关键词： Iron deficiency Hypophosphatemia Inflammatory bowel disease Ferric carboxymaltose Ferric derisomaltose

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新版高血压指南存在过度诊断和过度治疗风险疾病的界限应由包括患者在内的多学科小组来定义

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英国医学杂志中文版 2020年第4期23卷 181-183页

作者： christoffer Bjerre Haase Janos Valery Gyuricza John Brodersen 趁映璇(译) Section of General Practice and Research Unit for General Practice Department of Public HealthUniversity of CopenhagenDenmark Department of Preventive Medicine University of Sao PauloSao PauloBrazil Primary Health Care Research Unit Zealand RegionDenmark 河南大学附属郑州颐和医院CCU

英国国家健康与临床优化研究所(NICE)发布了一份最新成人高血压诊断和管理指南草案。其中主要的变化是,建议对10年以上心血管疾病风险为10%的1期高血压患者使用药物治疗—这低于之前20%的治疗阈值,同时考虑对风险低于10%的年轻患者进行... 详细信息

英国国家健康与临床优化研究所(NICE)发布了一份最新成人高血压诊断和管理指南草案。其中主要的变化是,建议对10年以上心血管疾病风险为10%的1期高血压患者使用药物治疗—这低于之前20%的治疗阈值,同时考虑对风险低于10%的年轻患者进行治疗。NICE提出这些建议背后的证据有限,其认为“有证据表明治疗1期高血压患者可带来一定获益”,但“治疗1期高血压患者,尤其是治疗其中心血管风险较低的人群,存在诸多不确定风险。”

关键词：心血管风险过度治疗年轻患者管理指南心血管疾病风险过度诊断高血压诊断药物治疗

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西57号街公寓

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城市环境设计 2019年第2期118卷 228-239页

作者： David Brown Aleksander Tokarz Alessandro Ronfini Alessio Valmori Alvaro Mendive Benjamin Schulte Birk Daugaard Celine Jeanne christoffer Gotfredsen Daniel Sundlin Dominyka Mineikyte Eivor Davidsen Felicia Guldberg Florian Oberschneider Soren Grunert Gabrielle Nadeau Gül Ertekin Ho Kyung Lee Hongyi Jin Julian Liang Julianne Gola Laura Youf Lucian Racovitan Marcella Martinez Maria Nikolova Maya Shopova Mitesh Dixit Nicklas A.Rasch Ola Hariri Riccardo Mariano Steffan Heath Stanley Lung Tara Hagan Thilani Rajarathna Tyler Polich Valentina Mele Valerie Lechene Xu Li Yi Li Aaron Hales Alessandro Ronfini Brian Foster christoffer Gotfredsen Francesca Portesine Ho Kyung Lee Hongyi Jin Ivy Hume Jenny Chang Lauren Turner Mina Rafiee Rakel Karlsdottir Tara Hagan Thomas Fagan Tiago Barros Valentina Mele Iwan Baan 朱翰林

西57号街公寓结合了欧洲庭院建筑和传统曼哈顿高层的特点,并兼具两者的优点:通透的院落建筑的紧凑与高效性以及摩天楼拥有的广阔视野。通过让建筑三个角保持较低姿态而仅将东北角提升至450英尺(约137.2米),使得庭院面向哈德逊河的视野开... 详细信息

西57号街公寓结合了欧洲庭院建筑和传统曼哈顿高层的特点,并兼具两者的优点:通透的院落建筑的紧凑与高效性以及摩天楼拥有的广阔视野。通过让建筑三个角保持较低姿态而仅将东北角提升至450英尺(约137.2米),使得庭院面向哈德逊河的视野开阔,让较低的夕阳也能照进街区深处,并优雅地为一旁的Helena Tower保留河景。建筑的形式随着观察者的位置而不断变换。从西侧的高速公路上看,它

关键词： Section 局部剖面图

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乐高之家

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城市环境设计 2019年第2期118卷 62-73页

作者： Snorre Nash Andreas Klok Pedersen Agne Tamasauskaite Annette Birthe Jensen Ariel Joy Norback Wallner Ask Hvas Birgitte Villadsen Chris Falla christoffer Gotfredsen Daruisz Duong Vu Hong David Zahle Esben christoffersen Franck Fdida Ioana Fartadi Scurtu Jakob Andreassen Jakob Ohm Laursen Jakob Sand Jakub Matheus Wlodarczyk Jesper Bo Jensen Jesper Boye Andersen Julia Boromissza Kasper Reimer Hansen Katarzyna Krystyna Siedlecka Katarzyna Stachura Kekoa Charlot Leszek Czaja Lone Fenger Albrechtsen Louise B?geskov Hou Mads Enggaard Stidsen Magnus Algreen Suhr Manon Otto Marta Christensen Mathias Bank Stigsen Michael Kepke Ole Dau Mortensen Ryohei Koike Sergiu Calacean S?ren Askehave Stefan Plugaru Stefan Wolf Thomas Jakobsen Randb?ll Tobias Hjortdal Tommy Bj?rnstrup Iwan Baan Kim Christensen 陈思瑾

"乐高之屋展现了乐高积木的无限可能性。通过系统的创造力,让所有年龄段的孩子都能够使用这些工具来创造他们自己的世界,并通过游戏的方式生活其中。最棒的是,建筑和乐高游戏都是这样的:使人们能够想象比现状更令人兴奋和更具表现力的... 详细信息

"乐高之屋展现了乐高积木的无限可能性。通过系统的创造力,让所有年龄段的孩子都能够使用这些工具来创造他们自己的世界,并通过游戏的方式生活其中。最棒的是,建筑和乐高游戏都是这样的:使人们能够想象比现状更令人兴奋和更具表现力的新世界,并为他们提供使之成为现实的技能。这就是孩子们每天用乐高积木来做的事情,这也是我们今天用真实的砖石在乐高之屋里完成的事情,使比伦德向真

关键词：乐高积木展览空间

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