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A New Nano-Platform for Drug Release via Nanotubular Aluminum Oxide

Journal of Biomaterials and Nanobiotechnology 2011年第3期2卷 226-233页

作者： Kunbae Noh Karla S. Brammer Chulmin Choi Seung Hyun Kim christine J. Frandsen Sungho Jin 不详

Nanotubular materials have many favorable properties for drug delivery. We present here a pioneering study of controlled release of a model drug, amoxicillin, from the internal nanopore structure of self-ordered, periodically spaced-apart aluminum oxide with an innovative, nanotubular geometry. This aluminum oxide nanotube geometry has not yet been revealed for biological applications, thus we have selected this oxide nanotube structure and demonstrated its ability as a drug carrier. Controlled, sustained release was achieved for over 5 weeks. The release kinetics from the nanotube layer was thoroughly characterized and it was determined that the amount of drug released was proportional to the square root of time. This type of controlled release and longevity from the nanotube layer has potential for therapeutic surface coatings on medical implants. Furthermore, this type of geometry has many features that are advantageous and biologically relevant for enhancing tissue biointegration.

关键词： AAO nanotube antibiotics drug release implant surface

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Distribution and Diversity of Rhizobial Populations Associated with <i>Acacia senegal</i>(L.) Willd. Provenances in Senegalese Arid and Semiarid Regions

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Open Journal of Forestry 2014年第2期4卷 136-143页

作者： Niokhor Bakhoum christine Le Roux Diégane Diouf Aboubakry Kane Fatou Ndoye Dioumacor Fall Robin Duponnois Kandioura Noba Samba Ndao Sylla Antoine Galiana Baillarguet Research Center UMR 113 IRD/CIRAD UMR82/AGRO-M/UM2 USC INRA 1242 Laboratory of Tropical and Mediterranean Symbioses (LSTM) Montpellier France Bel-Air Research Center IRD/ISRA/UCAD Common Microbiology Laboratory (LCM) Dakar Senegal Bel-Air Research Center IRD/ISRA/UCAD Common Microbiology Laboratory (LCM) Dakar Senegal National Centre of Forest Research (CNRF)/Senegalese Institute of Agricultural Research (ISRA) Dakar Senegal Plant Biology Department Cheikh Anta Diop University of Dakar (UCAD) Dakar Senegal Bel-Air Research Center IRD/ISRA/UCAD Common Microbiology Laboratory (LCM) Dakar Senegal

Abstract: Distribution and diversity of rhizobial strains associated with Acacia senegal (L.) Willd. in relation to seed provenances in soils from arid (Dahra) and semiarid (Goudiry) zones of Senegal were investigated. PCR-RFLP performed on 16S-23S rDNA intergenic spacer (IGS) of nodule crude extracts revealed a high genetic diversity of rhizobial strains, which was higher in the semiarid region than in the arid region. The distribution of rhizobial populations was influenced by soil physical and chemical characteristics, and by A. senegal provenances as shown by the analysis of correspondence. In contrast, the phenotypic diversity of rhizobial strains was not correlated with the soil origin. The phylogenetic tree (performed by the maximum likelihood algorithm) of IGS 16S-23S sequences showed that most of the rhizobial strains nodulating A. senegal were closely related to Mesorhizobium plurifarium. Our results showed that rhizobial taxa associated with A. senegal were mainly distributed according to soil physical and chemical characteristics, and A. senegal provenances. A large subset of A. senegal root-nodulating bacteria had high diversity that correlated with the most favourable environmental conditions. Understanding the diversity and distribution of rhizobial strains may be exploited in the formulation of A. senegal inoculants for different seed provenances for resilience to soil stresses in various environmental conditions.

关键词： Acacia senegal Mesorhizobium Diversity Symbiosis Ecology Phylogeny

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根—茎间系统信号驱动茉莉酸依赖的根结线虫抗性

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科学新闻 2020年第2期 96-96页

作者：周艳虹喻景权王郭婷胡超轶周杰 Ya Liu Jiaxing Cai Caizhe Pan Yu Wang Xiaodan Wu Kai Shi Xiaojian Xia christine H.Foyer 浙江大学浙江大学农业与生物技术学院英国伯明翰大学

文章简介植物在进化中形成了一系列适应季节和环境变化的内在机制,然而对于植物如何通过不同器官互作来应对生物与非生物胁迫则知之甚少。本研究发现,番茄根系在受到根结线虫(Meloidogyne incognita)侵染时会产生依赖于类谷氨酸受体(GLR... 详细信息

文章简介植物在进化中形成了一系列适应季节和环境变化的内在机制,然而对于植物如何通过不同器官互作来应对生物与非生物胁迫则知之甚少。本研究发现,番茄根系在受到根结线虫(Meloidogyne incognita)侵染时会产生依赖于类谷氨酸受体(GLR3.5)的电信号和依赖于植物NADPH氧化酶(RBOH1)的质外

关键词：根结线虫电信号信号驱动

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