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Ancient *** Myths and Evidence

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Journal of Ancient Civilizations 2000年第1期15卷 97-104页

作者： Lucy GOODISON christine morris Carol Hershenson

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Ancient *** Myths and Evidence

引用

Journal of Ancient Civilizations 2000年 97-104页

作者： Lucy GOODISON,christine morris,Carol Hershenson

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Global analysis of sensitivity of bioretention cell design elements to hydrologic performance

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Water Science and Engineering 2011年第3期4卷 246-257页

作者： Yan-wei SUN Xiao-mei WEI christine A. POMEROY College of Water Resources and Architectural Engineering Northwest A ＆ F University Yangling 712100 P. R. China Department of Civil and Environmental Engineering University of Utah Salt Lake City UT 84112 USA

Analysis of sensitivity of bioretention cell design elements to their hydrologic performances is meaningful in offering theoretical guidelines for proper design. Hydrologic performance of bioretention cells was facilitated with consideration of four metrics： the overflow ratio, groundwater recharge ratio, ponding time, and runoff coefficients. The storm water management model （SWMM） and the bioretention infiltration model RECARGA were applied to generating runoff and outflow time series for calculation of hydrologic performance metrics. Using a parking lot to build a bioretention cell, as an example, the morris method was used to conduct global sensitivity analysis for two groups of bioretention samples, one without underdrain and the other with underdrain. Results show that the surface area is the most sensitive element to most of the hydrologic metrics, while the gravel depth is the least sensitive element whether bioretention cells are installed with underdrain or not. The saturated infiltration rate of planting soil and the saturated infiltration rate of native soil are the other two most sensitive elements for bioretention cells without underdrain, while the saturated infiltration rate of native soil and underdrain size are the two most sensitive design elements for bioretention cells with underdrain.

关键词： bioretention hydrologic performance global sensitivity analysis morris method

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Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model

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World Journal of Gastroenterology 2005年第44期11卷 6910-6919页

作者： Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer Department of Internal Medicine Ⅰ Section of Experimental Radiology Department of Medical Biometry

AIM： To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model. METHODS： To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine （5-FC）, we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase （YCD） and the yeast uracil phosphoribosyltransferase （YUPRT） gene. RESULTS： In vitro stably transduced morris rat hepatoma cells （MH） expressing the bifunctional SuperCD suicide gene （MH SuperCD） showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH cells stably expressing YCD solely （MH YCD） or the cytosine deaminase gene of bacterial origin （MH BCD）, respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions （P〈0.01） under both high dose as well as low dose systemic 5-FC application, whereas MH tumors without transgene expression （MH naive） showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness （SuperCD〉〉 YCD〉〉BCD〉〉〉negative control） was defined as a result of a direct in vivo comparison of all three suicide genes. CONCLUSION： Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model, thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine.

关键词： YCD/YUPRT fusion Cytosine deaminase GDEPT Suicide gene therapy Hepatoma therapy

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