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enabling low-cost decentralized power reserves adopting carbon dioxide for green methane exchange in stabilized clathrate adsorbent

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Journal of energy Chemistry 2024年第10期97卷 438-443页

作者： Lucas Hanssens Maarten Houlleberghs C.Vinod Chandran Geert Watson Sambhu Radhakrishnan Pascal Van Der Voort Joeri F.M.Denayer christine e.A.Kirschhock Johan A.Martens eric Breynaert Centre for Surface Chemistry and Catalysis-Characterization and Application Team (COK-KAT) NMR/X-Ray Platform for Convergence Research (NMRCoRe) Centre for Ordered Materials Organometallics and Catalysis (COMOC) Department of Chemistry Ghent University Department of Chemical engineering Vrije Universiteit Brussel

*** circular methane energy systems In recent decades,methane-based energy systems have rapidly gained traction across the globe because of the increasing availability of low-cost methane production ***,fossil methane... 详细信息

关键词： Long duration energy storage Green methane Carbon neutrality Confined clathrate hydrates CH4 /CO2 exchange Direct gas exchange eNeRGY-STORAGe CONFINeD NANOSPACe TO-MeTHANe GAS MeCHANISMS ADSORPTION HYDROGeN

Comparison of fungal vs bacterial infections in the medical intensive liver unit:Cause or corollary for high mortality?

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World Journal of Hepatology 2024年第3期16卷 379-392页

作者： Sarah Khan Hanna Hong Stephanie Bass Yifan Wang Xiao-Feng Wang Omar T Sims christine e Koval Aanchal Kapoor Christina C Lindenmeyer Department of Internal Medicine Cleveland ClinicClevelandOH 44195United States Cleveland Clinic Lerner College of Medicine Cleveland ClinicClevelandOH 44195United States Department of Pharmacy Cleveland ClinicClevelandOH 44195United States Department of Quantitative Health Sciences/Biostatistics Section Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology Hepatology and NutritionCleveland ClinicClevelandOH 44195United States Department of Infectious Disease Cleveland ClinicClevelandOH 44195United States Department of Critical Care Medicine Cleveland ClinicClevelandOH 44195United States

BACKGROUND Due to development of an immune-dysregulated phenotype,advanced liver disease in all forms predisposes patients to sepsis acquisition,including by opportunistic pathogens such as *** data exists on fungal infection within a medical intensive liver unit(MILU),particularly in relation to acute on chronic liver *** To investigate the impact of fungal infections among critically ill patients with advanced liver disease,and compare outcomes to those of patients with bacterial *** From our prospective registry of MILU patients from 2018-2022,we included 27 patients with culture-positive fungal infections and 183 with bacterial *** compared outcomes between patients admitted to the MILU with fungal infections to bacterial *** was extracted through chart *** All fungal infections were due to Candida species,and were most frequently blood *** among patients with fungal infections was significantly worse relative to the bacterial cohort(93%vs 52%,Pe majority of the fungal cohort developed grade 2 or 3 acute on chronic liver failure(ACLF)(90%vs 64%,P=0.02).Patients in the fungal cohort had increased use of vasopressors(96%vs 70%,P=0.04),mechanical ventilation(96%vs 65%,Pe to acute kidney injury(78%vs 52%,P=0.014).On MILU admission,the fungal cohort had significantly higher Acute Physiology and Chronic Health evaluation(108 vs 91,P=0.003),Acute Physiology Score(86 vs 65,P=0.003),and Model for end-Stage Liver Disease-Sodium scores(86 vs 65,P=0.041).There was no significant difference in the rate of central line use preceding culture(52%vs 40%,P=0.2).Patients with fungal infection had higher rate of transplant hold placement,and lower rates of transplant;however,differences did not achieve statistical *** Mortality was worse among patients with fungal infections,likely attributable to severe ACLF *** studies examinin

关键词： Fungal Infection Sepsis Acute on chronic liver failure Intensive care

The MYC2-PUB22-JAZ4 module plays a crucial role in jasmonate signaling in tomato

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Molecular Plant 2024年第4期17卷 598-613页

作者： Shaofang Wu Chaoyi Hu Changan Zhu Yanfen Fan Jie Zhou Xiaojia Xia Kai Shi Yanhong Zhou christine H.Foyer Jingquan Yu Department of Horticulture Zijingang CampusZhejiang UniversityHangzhou 310058China Hainan Institute Zhejiang UniversityYazhou Bay Science and Technology CitySanya 572025China College of Horticulture Northwest Agriculture&Forestry UniversityXianyang 712100China School of Biosciences College of Life and Environmental SciencesUniversity of BirminghamEdgbaston B152TTUK Key Laboratory of Horticultural Plants Growth and Development Agricultural Ministry of ChinaZhejiang UniversityHangzhou 310058China

Jasmonates(JAs),a class of lipid-derived stress hormones,play a crucial role across an array of plant physiological processes and stress *** JA signaling is thought to rely predominantly on the degradation of specific JAZ proteins by SCF^(COI1),it remains unclear whether other pathways are involved in the regulation of JAZ protein ***,we report that PUB22,a plant U-box type e3 ubiquitin ligase,plays a critical role in the regulation of plant resistance against Helicoverpa armigera and other JA responses in *** COI1 physically interacts with JAZ1/2/5/7,PUB22 physically interacts with JAZ1/3/4/***22 ubiquitinates JAZ4 to promote its degradation via the 26S proteasome ***,we observed that pub22 mutants showreduced resistance to ***,whereas jaz4 single mutants and jaz1 jaz3 jaz4 jaz6 quadruple mutants have enhanced *** hypersensitivity of pub22 mutants to herbivores could be partially rescued by JAZ4 ***,we found that expression of PUB22 can be transcriptionally activated by MYC2,thus forming a positive feedback circuit in JA *** noticed that the PUB22-JAZ4 module also regulates other JA responses,including defense against ***,inhibition of root elongation,and anthocyanin *** together,these results indicate that PUB22 plays a crucial role in plant growth and defense responses,together with COI1-regulated JA signaling,by targeting specific JAZs.

关键词： PUB22 JAZ COI1 MYC2 JA signaling Solanum lycopersicum

Growth Inhibition Occurs Independently of Cell Mortality in Tomato (Solanum lycopersicum) exposed to High Cadmium Concentrations

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Journal of Integrative Plant Biology 2008年第3期50卷 300-310页

作者： christine Delpre Stanley Lutts Unitde Biologie vgtale Universitcatholique de Louvain5(Bte 13) Place Croix du Sud1348 Louvain-la-NeuveBelgium Unitde Biologie vgtale Universit catholique de Louvain5(Bte 13) Place Croix du Sud1348 Louvain-la-NeuveBelgium

In order to analyze the adaptation potential of tomato shoots to a sudden increase in Cd concentration, tomato plants （Solanum lycopersicum L. var. Ailsa Craig） were exposed under controlled environmental conditions to a high dose of this heavy metal （250 μm CdCl2） in nutrient solution for 7 and 14d. Both root and shoot growth was completely inhibited but all plants remained alive until the end of the treatment. Cell viability remained unaffected but the activity of the mitochondrial alternative pathway was stimulated by Cd stress at the expense of the cytochrome pathway. Cadmium concentration was higher in roots than in shoots and a decrease in the rate of net Cd translocation was noticed during the second week of stress. Cadmium decreased both leaf conductance （gl） and chlorophyll concentration. However, the effect on net CO2 assimilation remained limited and soluble sugars accumulated in leaves. Photochemical efficiency of PSII （FvlFm） was not affected despite a decrease in the number of reaction centers and an inhibition of electron transfer to acceptors of PSII. It is concluded that tomato shoot may sustain short term exposure to high doses of cadmium despite growth inhibition. This property implies several physiological strategies linked to both avoidance and tolerance mechanisms.

关键词： cadmium chlorophyll fluorescence growth heavy metal toxicity Lycopersicon esculentum tomato

effects of mountain pine beetle-killed forests on source water contributions to streamflow in headwater streams of the Colorado Rocky Mountains

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Frontiers of earth Science 2017年第3期11卷 496-504页

作者： christine e. WeHNeR John D. STeDNICK Watershed Science Program College of Natural Resources Colorado State University Fort Collins CO 80523-1472 USA

Natural or human-influenced disturbances are important to the health and diversity of forests, which in turn, are important to the water quantity and quality exported from a catchment. However, human-induced disturbances （prescribed fire and harvesting） have been decreasing, and natural disturbances （fires and insects） have been increasing in frequency and severity. One such natural disturbance is the mountain pine beetle （MPB）, （Denclroctonus ponderosae） an endemic species. A recent epidemic resulted in the mortality of millions of hectares of lodgepole pine （Pinus contorta） forests in Colorado, USA. Beetle-induced tree mortality brings about changes to the hydrologic cycle, including decreased transpiration and interception with the loss of canopy cover. This study examined the effect of the mountain pine beetle kill on source water contributions to streamflow in snowmelt- dominated headwater catchments using stable isotopes （2H and ~80） as tracers. Study catchments with varying level of beetle-killed forest area （6% to 97%） were sampled for groundwater, surface water, and precipitation. Streams were sampled to assess whether beetle-killed forests have altered source water contributions to streamflow. Ground- water contributions increased with increasing beetle-killed forest area （p = 0.008）. Both rain and snow contributions were negatively correlated with beetle-killed forest area （p = 0.035 and p = 0.011, respectively）. As the beetle-killed forest area increases, so does fractional groundwater contribution to streamflow.

关键词： mountain pine beetle isotope tracers stream-flow generation headwaters

Decreased plasma urotensin Ⅱ levels inversely correlate with extent and severity of coronary artery disease

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Journal of Geriatric Cardiology 2007年第2期4卷 105-110页

作者： V. Borlongan christine e. Stahl Department of Neurology Medical College of Georgia Augusta GA 30912 USA Department of Internal Medicine Dwight D. Eisenhower Army Medical Center Fort Gordon GA 30909 USA

Objective To determine the plasma urolensin Ⅱ(UII) levels in various types of coronary heart disease and to clarify how the plasma UII levels correlate with the clinical presentation, extent and severity of coronary artery atherosclerosis (CAD). Methods: One hundred and three aged patients undergoing elective diagnostic coronary angiography for proven or clinical suspected coronary heart disease were enrolled in this study. The extent and severity of coronary artery disease were evaluated by vessel score and Gensini score, respectively. Plasma UII levels were measured by radioimmunoassay. Results: The plasma UII levels in the patients with modest to severe coronary stenosis (3.03±0.34 pg/ml, 1.83±0.67 pg/ml) were significantly lower than that in subjects with normal coronary artery (4.80±1.11 pg/ml, Pe plasma UII levels in patients with coronary heart disease were also significantly lower than that in patients with insignificant coronary stenosis (P ed to patients with stable angina pectoris, plasma UII levels in patients with acute coronary syndrome were significantly decreased (1.89±0.51 pg/ml vs 2.42±0.77 pg/ml, P evels were found to be negatively correlated with the severity of coronary artery stenosis (r = -0.488, Pell as the vessel score (r = -0.408, Pe patients with CAD. Conclusion: Significant inverse correlations exist between the plasma UII levels, and the extent and severity of coronary artery stenosis. These findings suggest that plasma UII contribute to the development and progression of coronary artery stenosis, and may be a novel marker to predict clinical types, as well as the extent and severity of coronary artery disease in the patients.

关键词： Urotensin Ⅱ Coronary artery atherosclerosis Coronary heart disease

Influence of psychosocial factors on treatment of elderly Chinese patients with hypertension

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Journal of Geriatric Cardiology 2007年第4期4卷 202-207页

作者： Cesar V. Borlongan christine e. Stahl Department of Neurology Medical College of Georgia Augusta Department of Internal Medicine Dwight D.Eisenhower Army Medical Center Fort Gordon

Objective The aim of the study is to investigate the effects of psychosocial factors on the treatment of elderly patients with hypertension. Methods Atotalof 260 elderly Chinese patients with hypertension were treated with benazepril alone or benazepril combined with amlodipine for 8 weeks. The target blood pressure (BP) (both eved in 180 patients, who were then assigned to the well-controlled BP group;the rest were placed in the modestly controlled BP group. The psychosocial factors present in both groups were assessed by the Hamilton depression scale, Hamilton anxiety scale, life event scale and social support evaluation list before and after anti-hypertensive treatment. Results There were no significant differences in gender, mean age, hist ory of hypertension, education and smoking habit, or in SBP and DBP between the groups before treatment. Significant differences were also not found in all psychosocial factors before and after treatment in the patients. However, significant differences were found between the groups with respect to post-treatment SBP and marital status. The patients with modestly controlled BP had significantly higher scores, as well as incidents, on the depressive, anxiety, and stressful life event scales than those with well-controlled BP. The patients with well-controlled BP had significantly higher scores in tangible support, subjective support, and social support compared to the patients with modestly controlled BP. Logistic regression analysis showed the independent contribution of psychosocial factors in reaching the goal of lowering BP at treatment endpoint in these hypertensive patients. Conclusions The results suggest that psychosocial factors stand as a main barrier to achieving the BP-lowering target in the management of elderly Chinese patients with hypertension.(J Geriatr Cardiol 2007;4:202-207.)

关键词： hypertension psychosocial factor elderly treatment outcome

early pregnancy in the horse revisited–does exception prove the rule?

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Journal of Animal Science and Biotechnology 2016年第2期7卷 117-124页

作者： christine Aurich Sven Budik Artificial Insemination and embryo Transfer Vetmeduni ViennaVeterinarplatz 11210 ViennaAustria

early equine pregnancy shares many features with that of more intensively assessed domestic animals species, but there are also characteristic differences. Some of those are poorly understood. Descent of the equine conceptus into the uterine lumen occurs at day 5 to 6 after ovulation but is only possible when the embryo secretes prostaglandin e2. Although maintenance of equine pregnancy probably involves secretion of a conceptus derived anti-luteolytic factor, this agent has not been identified. Rapid growth, conceptus mobility and presence of an acellular capsule at the time of maternal recognition of pregnancy, i.e. between days 12 and 14, are prerequisites to avoid pregnancy loss. Progesterone together with 5α-pregnanes is secreted by the corpus luteum and induces the production of endometrial histotroph which is responsible for conceptus nutrition until placention. A stable contact between the outer trophoblast layer of the allantochorion and the luminal epithelium of the endometrium is not established before days 40 to 42 of pregnancy.

关键词： Conceptus Horse Maternal recognition Pregnancy

Precision medicine in hearing loss

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Journal of Genetics and Genomics 2018年第2期45卷 99-109页

作者： Jason R.Rudman christine Mei Sara e.Bressler Susan H.Blanton Xue-Zhong Liu Department of Otoloryngology University of Miami Miller School of Medicine Miami FL 33136 USA Dr. John T. Macdonald Foundation Department of Human Cenetics University of Miami Miller School of Medicine Miami FL 33136 USA John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine Miami FL 33136 USA

Precision medicine（PM） proposes customized medical care based on a patient＇s unique genome, biomarkers, environment and behaviors. Hearing loss（HL） is the most common sensorineural disorder worldwide and is frequently caused by a single genetic mutation. With recent advances in PM tools such as genetic sequencing and data analysis, the field of HL is ideally positioned to adopt the strategies of ***, we review current and future applications of PM in HL as they relate to the four core qualities of PM（P4）： predictive, personalized, patient-centered, and participatory. We then introduce a strategy for effective incorporation of HL PM into the design of future research studies, electronic medical records,and clinical practice to improve diagnostics, prognostics, and, ultimately, individualized patient treatment. Finally, specific anticipated ethical and economic concerns in this growing era of genomics-based HL treatment are discussed. By integrating PM principles into translational HL research and clinical practice, hearing specialists are uniquely positioned to effectively treat the heterogeneous causes and manifestations of HL on an individualized basis.

关键词： Precision medicine Personalized medicine Hearing loss Genetics