检索结果-南通市图书馆

The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases

Neural Regeneration Research 2024年第6期19卷 1206-1211页

作者： Matthias T.Wyss christine Heuer Marina Herwerth Institute of Pharmacology and Toxicology University of ZurichZürichSwitzerland Neuroscience Center Zurich(ZNZ) University of Zurich and ETH ZurichZürichSwitzerland Neurology Department University Hospital of ZurichZürichSwitzerland

Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of *** is also reflected by the widespread expression of two families of purinergic receptors(P1 and P2)with numerous *** the last few decades,there has been increasing evidence that purinergic signaling plays an important role in the regulation of immune ***,signals mediated by P2 receptors have been shown to contribute to immune system-mediated ***,interference with P2 receptors may be a promising strategy for the modulation of immune *** only a few clinical studies have been conducted in isolated entities with limited success,preclinical work suggests that the use of P2 receptor inhibitors may bear some promise in various autoimmune *** the association of P2 receptors with several disorders from this field,the use of P2 receptor antagonists in clinical therapy is still very *** this narrative review,we briefly review the involvement of the purinergic system in immunological responses and clinical studies on the effect of purinergic inhibition on autoimmune *** then open the aperture a bit and show some preclinical studies demonstrating a potential effect of purinergic blockade on autoimmune *** suramin,a non-specific purinergic inhibitor,as an example,we further show that off-target effects could be responsible for observed effects in immunological settings,which may have interesting ***,we believe that it is worthwhile to further investigate this hitherto underexplored area.

关键词： autoimmune diseases neurological disorders purinergic system P2 receptor inhibitors suramin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two adjacent NLR genes conferring quantitative resistance to clubroot disease in Arabidopsis are regulated by a stably inherited epiallelic variation

引用

Plant Communications 2024年第5期5卷 148-162页

作者： Antoine Gravot Benjamin Lie gard Leandro Quadrana Florian Veillet Yoann Aigu Tristan Bargain Juliette Benejam christine Lariagon Jocelyne Lemoine Vincent Colot Maria J.Manzanares-Dauleux Melanie Jubault IGEPP Institut Agro INRAEUniversitede Rennes35650 Le RheuFrance Institut de Biologie de l’Ecole Normale Superieure(IBENS) Ecole Normale SuperieureCentre National de la Recherche Scientifique(CNRS)Institut National de la Santeet de la Recherche Medicale(INSERM)75005 ParisFrance IGEPP INRAE Institut AgroUniversitede Rennes29260 PloudanielFrance Present address:Aix-Marseille University CEACNRSInstitute of Biosciences and BiotechnologiesBIAM Cadarache13108 Saint-Paul-lez-DuranceFrance.

Clubroot caused by the protist Plasmodiophora brassicae is a major disease affecting cultivated *** a combination of quantitative trait locus(QTL)fine mapping,CRISPR-Cas9 validation,and extensive analyses of DNA sequence and methylation patterns,we revealed that the two adjacent neigh-boring NLR(nucleotide-binding and leucine-rich repeat)genes AT5G47260 and AT5G47280 cooperate in controlling broad-spectrum quantitative partial resistance to the root pathogen *** in Arabidopsis and that they are epigenetically *** variation in DNA methylation is not associated with any nucleotide variation or any transposable element presence/absence variants and is stably ***-ations in DNA methylation at the Pb-At5.2 QTL are widespread across Arabidopsis accessions and corre-late negatively with variations in expression of the two *** study demonstrates that natural,stable,and transgenerationally inherited epigenetic variations can play an important role in shaping resistance to plant pathogens by modulating the expression of immune receptors.

关键词： methylation clubroot Plasmodiophora brassicae AT5G47260 AT5G47280 ADR1-L3 ddm1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ethnography and the Internet： Taking Account of Emerging Technological Landscapes

引用

Fudan Journal of the Humanities and Social Sciences 2017年第3期10卷 315-329页

作者： christine Hine Department of Sociology University of Surrey Guildford Surrey GU2 7XH UK

This article explores the strengths of ethnography as a methodology for exploring the complex social landscape of the contemporary Intemet. The article outlines the historical development of the Intemet, from Web 1.0 to a participatory Web 2.0 embedded within everyday life and ultimately to the prospect of an autonomous Internet of Things. The benefits of an ethnographic approach for understanding such developments in depth and examining taken-for-granted assumptions are outlined alongside an account of some of the challenges that digital technologies pose for an ethnographic methodology. Amongst these challenges are the difficulties inherent in mapping out a field site that effectively captures the complexity of online/offline connections and of developing a sufficient degree of immersion and co-presence for a.rich understanding to be attained. Finally, the challenges offered by the emergence of mobile Internet, algorithmic filtering of information and unpredictable flows of data are explored. It is suggested that the ethnographer of the Internet can usefully position their task as being to explore a socially constructed yet technologically mediated landscape, immersing themselves in it, interrogating how others experience it and mapping the ways in which it becomes meaningful to those who navigate its complexities.

关键词： Internet Ethnography Social media Participant observation Methodology Community Internet of Things Field site Landscape Algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Egg CD9 protein tides correlated with sperm oscillations tune the gamete fusion ability in mammal

引用

Journal of Molecular Cell Biology 2018年第6期10卷 494-502页

作者： Benjamin Ravaux Sophie Favier Eric Perez and christine Gourier Laboratoire de Physique Statistique Ecole Normale Superieure/PSL Research UniversityUPMC Univ Paris 06Universite Paris DiderotCNRS75005 ParisFrance

Mammalian fertilization involves membrane events-adhesion,fusion,sperm engulfment,membrane block to polyspermy-whose causes remain largely ***,specific oscillations of the sperm in contact with the egg were shown to be necessary for *** a microfluidic chip to impose the venue for the encounter of two gametes allowed real-time observation of the membrane remodelling occurring at the sperm/egg *** spatiotemporal mapping of egg CD9 revealed that this protein concentrates at the egg/sperm interface as a result of sperm oscillations,until a CDg-rich platform is nucleated on which fusion immediately takes *** 2-5 min after fusion,most of the CD9 leaves the egg for the external aqueous *** an egg membrane wave engulfs the sperm head in^25 *** results show that sperm oscillations initiate the CD9 recruitment that causes gamete fusion after which CD9 and associated proteins leave the membrane in a process likely to contribute to block *** highlight that the gamete fusion story in mammals is an unexpected interplay between mechanical constraints and proteins.

关键词： mammalian fertilization membrane dynamics real-time imaging CDg sperm oscillations gamete fusion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clay minerals in the late Quaternary sediment of Tulare Lake,California: Implications for climate change, weathering, and erosion processes

引用

International Journal of Sediment Research 2019年第5期34卷 432-443页

作者： Junhua Guo christine Pyles William Krugh Rob Negrini Department of Geological Sciences California State UniversityBakersfield

The clay mineralogy of Tulare Lake sediment was examined to investigate hydroclimatic and environmental changes in the southern Sierra Nevada Mountains(SNM) since the most recent glacial *** of clay mineral assemblages elucidates significant changes in weathering, erosion, and hydroclimatic condition in the catchment. During the last glacial period(24.4–15.1 cal ka BP), low illite content implies less physical erosion of the granitic batholith rocks and a cold and arid environment in the southern SNM. Abrupt increases of illite content at 21.8–20.8 and 17.6 cal ka BP resulted from the glacier advances to the ablation zone and illite-rich glacier flour was transported down to the lake. The gradual increase of smectite induced by progressive depletion of illite-rich glacier flour from 17.6 cal ka BP toward the end of this period indicates climate was beginning to get warm and wet. From 11.9 to5.3 cal ka BP, two warm and wet periods(10.7–9.4 and 8.2–5.2 cal ka BP) were characterized by high smectite/illite content ratios and low illite crystallinity values, suggesting intensive rainfall precipitation and more physical erosion in the highland and lowland catchment as well as more smectite formation in the terrace soils. Since the last glacial period, physical erosion, in comparison to the chemical weathering,was the dominant process responding to the hydroclimatic change in the Tulare Lake *** to weak chemical weathering was signified by the mostly low illite chemical weathering index of the core sediments. Such results suggest that vegetation cover in the southern SNM was low and limited.

关键词： Clay mineralogy Sierra Nevada Mountains Glaciers Weathering Tulare Lake

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Redefining pandemic preparedness:Multidisciplinary insights from the CERP modelling workshop in infectious diseases,workshop report

引用

Infectious Disease Modelling 2024年第2期9卷 501-518页

作者： Marta C.Nunes Edward Thommes Holger Fröhlich Antoine Flahault Julien Arino Marc Baguelin Matthew Biggerstaff Gaston Bizel-Bizellot Rebecca Borchering Giacomo Cacciapaglia Simon Cauchemez Alex Barbier--Chebbah Carsten Claussen christine Choirat Monica Cojocaru Catherine Commaille-Chapus Chitin Hon Jude Kong Nicolas Lambert Katharina B.Lauer Thorsten Lehr Cédric Mahe Vincent Marechal Adel Mebarki Seyed Moghadas Rene Niehus Lulla Opatowski Francesco Parino Gery Pruvost Andreas Schuppert Rodolphe Thiébaut Andrea Thomas-Bachli Cecile Viboud Jianhong Wu Pascal Crépey PascalCrepey Center of Excellence in Respiratory Pathogens(CERP) Hospices Civils de Lyon(HCL)and Centre International de Recherche en Infectiologie(CIRI)Équipe SantéPubliqueÉpidémiologie etÉcologieÉvolutive des Maladies Infectieuses(PHE3ID)Inserm U1111CNRS UMR5308ENS de LyonUniversitéClaude Bernard Lyon 1LyonFrance South African Medical Research Council Vaccines&Infectious Diseases Analytics Research UnitFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa New Products and Innovation(NPI) Sanofi Vaccines(Global)TorontoOntarioCanada Department of Mathematics and Statistics University of GuelphGuelphOntarioCanada Fraunhofer Institute for Algorithms and Scientific Computing(SCAI) Department of BioinformaticsSchloss BirlinghovenSankt AugustinGermany University of Bonn Bonn-Aachen International Center for IT(b-it)BonnGermany Institute of Global Health Faculty of MedicineUniversity of GenevaGenevaSwitzerland and Swiss School of Public HealthZürichSwitzerland Department of Mathematics University of ManitobaWinnipegManitobaCanada MRC Centre for Global Infectious Disease Analysis School of Public HealthImperial College LondonLondonUK Centre for Mathematical Modelling of Infectious Diseases Department of Infectious Disease EpidemiologyLondon School of Hygiene&Tropical MedicineLondonUK National Center for Immunization and Respiratory Diseases(NCIRD) US Centers for Disease Control and Prevention(CDC)AtlantaGAUSA Departement of Computational Biology Departement of Global HealthInstitut PasteurParisFrance Institut de Physique des Deux Infinis de Lyon(IP2I) UMR5822IN2P3/CNRSUniversitéClaude Bernard Lyon 1VilleurbanneFrance Mathematical Modelling of Infectious Diseases Unit Institut PasteurUniversitéParis CitéUMR2000 CNRSParisFrance Decision and Bayesian Computation Institut PasteurUniversitéParis CitéCNRS UMR 3571France Fraunhofer-Institute for Translational Medicine and Pharmacology HamburgGermany Institute of Global Health Faculty of MedicineUniversity of

In July 2023,the Center of Excellence in Respiratory Pathogens organized a two-day workshop on infectious diseases modelling and the lessons learnt from the Covid-19 *** report summarizes the rich discussions that occurred during the *** workshop participants discussed multisource data integration and highlighted the benefits of combining traditional surveillance with more novel data sources like mobility data,social media,and wastewater *** advancements were noted in the development of predictive models,with examples from various countries showcasing the use of machine learning and artificial intelligence in detecting and monitoring disease *** role of open collaboration between various stakeholders in modelling was stressed,advocating for the continuation of such partnerships beyond the pandemic.A major gap identified was the absence of a common international framework for data sharing,which is crucial for global pandemic ***,the workshop underscored the need for robust,adaptable modelling frameworks and the integration of different data sources and collaboration across sectors,as key elements in enhancing future pandemic response and preparedness.

关键词： Modelling Covid-19 Infectious diseases Pandemic preparedness Workshop

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The impact of having an oxygen-rich microporous surface in carbon electrodes for high-power aqueous supercapacitors

引用

Journal of Energy Chemistry 2021年第2期30卷 36-48,I0002页

作者： Servann Herou Maria Crespo Ribadeneyr Philipp Schlee Hui Luo Liviu Cristian Tanase christine Roβberg Magdalena Titirici Chemical Engineering Department Imperial College LondonImperial College RdKensingtonLondon SW72AZUK National Institute of Materials Physics Atomiştilor 405A077125 Măgurele–IlfovRomania Fraunhofer-Zentrum für Chemisch-Biotechnologische Prozesse CBP Am Haupttor06237 LeunaGermany

The growth of electrical transportation is crucially important to mitigate rising climate change concerns regarding materials *** are high-power devices,particularly suitable for public transportation since they can easily store breaking energy due to their high-rate charging ***,they can function with two carbon electrodes,which is an advantage due to the abundance of carbon in biomass and other waste materials(i.e.,plastic waste).Newly developed supercapacitive nanocarbons display extremely narrow micropores(100 kW kg^(-1)),using fourty times less activating agent than traditionnal chemically activated *** also demonstrate that the affinity between the carbon and the electrolyte is of paramount importance to maintain rapid ionic diffusion in narrow ***,this facile synthesis method shows that low-cost and bio-based free-standing electrode materials with reliable supercapacitive performances can be used in electrochemistry.

关键词： Porous carbon materials Lignin Supercapacitors Oxygen groups

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biochar as a Soil Ameliorant: How Biochar Properties Benefit Soil Fertility—A Review

引用

Journal of Geoscience and Environment Protection 2021年第10期9卷 28-46页

作者： christine Beusch Institute of Ecology Chair of Soil Science Technische Universit&#228t Berlin Berlin Germany

In recent years, biochar has received great attention among researchers worldwide. This carbon-rich material, mainly produced from residues from agriculture and forestry, holds a wide range of properties, e.g. large specific surface area, high cation exchange capacity, and substantial nutrient contents, that can have beneficial effects when added to soils. This review is giving a brief introduction to biochar properties and how feedstock, pyrolysis temperature, and time influence these properties. As the majority of studies concentrate on the soil amending effects of biochar, this review also provides an overview of how biochar affects the chemical, physical, hydrological, and biological properties of soils. For example, biochar addition to soils can raise the pH, increase the organic carbon content, enhance nutrient retention, foster porosity, augment the water-holding capacity, and increase microbial biomass. Consequently, biochar can contribute to soil fertility, increase yields, help closing nutrient cycles, and thus help secure food safety in a region. However, the knowledge about the long-term effects is still limited and should be broadened by a more systematic testing of biochar effects in the future to help bring the benefits of biochar into practice.

关键词： Biochar Soil Amendment Feedstock Pyrolysis Temperature Soil Fertility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

iPhone和Android，谁将成为赢家？

引用

新营销 2011年第4期13卷 18-19页

作者： Brian Cruikshank Leslie rich christine Ong 任毅恒（翻译）王亚丁（翻译）不详益普索美国Ipsos OTX MediaCT

iPhone已成为智能手机崛起的同义词，但伴随着市场份额的飙升，Android近来频频见诸报端。Android的迅猛发展对iPhone意味着什么？iPhone具有更加强大的品牌资产吗？还是随着其他产品的涌入，再加上iPhone4负面传闻的影响，其光彩会随... 详细信息

iPhone已成为智能手机崛起的同义词，但伴随着市场份额的飙升，Android近来频频见诸报端。Android的迅猛发展对iPhone意味着什么？iPhone具有更加强大的品牌资产吗？还是随着其他产品的涌入，再加上iPhone4负面传闻的影响，其光彩会随之黯淡吗？

关键词：赢家智能手机市场份额品牌资产同义词负面

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tourism and heritage in the enhancement of Tianjin

引用

Built Heritage 2020年第2期4卷 1-20页

作者： Bruno Chauffert-Yvart Françoise Ged Yue Lu christine Mengin Émilie Rousseau 不详 International Research Center for Architectural Heritage Conservation Shanghai Jiao Tong UniversityShanghaiChina Equipe Interdisciplinaire de Recherches sur le Tourisme UniversitéParis 1 Panthéon-Sorbonne21 rue Broca75005 ParisFrance Full list of author information is available at the end of the article

This article examines what is being promoted about Tianjin’s rich heritage through its tourism and heritage *** industrial city traditionally known for its crafts and gastronomy,Tianjin has gradually begun to promote its Chinese heritage and,since the 2000s,its city centre,which is noteworthy for its former foreign concessions and 19th-and 20th-century architectural *** long neglect,the city centre has become a major component in the promotion of the *** on the analysis of tourism materials and studies conducted since the mid-2000s,this article first discusses the development of tourism in Tianjin and the chronology and interweaving of the services involved in heritage ***,it focuses on the reception of the city’s tourism offerings and on urban development operations in two sectors,Wudadao(or‘Five avenues’),located in the former British Concession,and the‘I-Style Town’in the former Italian Concession.

关键词： Tianjin Foreign concessions Tourism Built heritage Heritage policies Wudadao I-style town

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：