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Higher risk of type 2 diabetes in young women with polycystic ovary syndrome: A 10-year retrospective cohort study

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World Journal of Diabetes 2022年第3期13卷 240-250页

作者： wan-Ting Liao Jing-Yang Huang ming-Tsung Lee Yu-Cih Yang Chun-Chi wu Institute of Medicine Chung-Shan Medical UniversityTaichung 402Taiwan Chinese Medicine Department Show Chwan Memorial HospitalChanghua 500Taiwan Research Center for Health Data Science Chung Shan Medical University HospitalTaichung 402Taiwan National Center for Geriatrics and Welfare Research National Health Research InstitutesYunlin 632Taiwan Clinical Trial Research Center China Medical University HospitalTaichung 404Taiwan

BACKGROUND Polycystic ovary syndrome(PCOS)is a common disorder in women of reproductive *** the last few decades,research studies have revealed that PCOS is strongly associated with metabolic disorders,including metabolic syndrome,obesity,insulin resistance and *** observation has shown that women with PCOS are expected to have an increased risk of developing type 2 diabetes(T2DM)in the *** To assess the hazard ratio(HR)of T2DM between women with/without *** This population-based,retrospective cohort study evaluated data retrieved from the National Health Insurance Research *** subjects were women with PCOS(n=2545)identified on the basis of diagnosis,testing,or treatment codes,and women without PCOS as controls(n=2545).The HR of T2DM between women with or without PCOS was the main outcome measure *** Our study found that, during a 10-year follow-up period, the overall incidence of T2DM was 6.25per 1000 person-years in the PCOS group compared with 1.49 in the control group. Afteradjustment for potential confounding variables, the overall incidence of T2DM was higher in thePCOS group vs the control group (HR = 5.13, 95%CI: 3.51-7.48, P < 0.0001). The risk of developingT2DM subsequent to PCOS decreased with increasing diagnosis age: the adjusted HR was 10.4 inthe 18–24-year age group, 5.28 in the 25-29-year age group, and 4.06 in the 29-34-year age ***, no such significant association was noted in women older than 35 *** findings highlight the importance of prompting a more aggressive treatment to preventdiabetes in women diagnosed with PCOS at a young age, and, in contrast, the lessened importanceof this type of intervention in women diagnosed with PCOS at a late reproductive age.

关键词： Polycystic ovary syndrome Diabetes Incidence Hazard ratio Population-based cohort study

Male sterility in crops: Application of human intelligence to natural variation

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The Crop Journal 2021年第6期9卷 1219-1222页

作者： Xiangyuan wan Suowei wu Yunbi Xu Zhongzhi International Institute of Agricultural Biosciences Shunde Graduate SchoolResearch Center of Biology and AgricultureUniversity of Science and Technology BeijingBeijing 100096China Beijing Engineering Laboratory of Main Crop Bio-Tech Breeding Beijing International Science and Technology Cooperation Base of Bio-Tech BreedingBeijing Solidwill Sci-Tech Co.Ltd.Beijing 100192China National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China International Maize and Wheat Improvement Center(CIMMYT) El Batan56130 TexcocoMexico

*** Global food security faces a severe challenge,as world population is predicted to grow by 25%and reach 10 billion by the mid-21 st century[1].With limited agricultural land and fresh water,greater and more sustainable crop production needs to be achieved by use of modern agricultural technologies[2,3].Among these are developing and exploiting more efficient heterosis utilization strategy with male sterile lines for hybrid breeding and seed production.

关键词： crops breeding sterile

Red clump stars from the LAMOST dataⅠ: identification and distance

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Research in Astronomy and Astrophysics 2015年第8期15卷 1166-1181页

作者： Jun-Chen wan Chao Liu Li-Cai Deng Wen-Yuan Cui Yong Zhang Yong-Hui Hou ming Yang Yue wu Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of Sciences Physics Department Hebei Normal University Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences

We present a sample of about 120 000 red clump candidates selected from the LAMOST DR2 catalog based on the empirical distribution model in the effective temperature vs. surface gravity plane. Although, in general, red clump stars are considered as standard candles, they do not exactly stay in a narrow range of absolute magnitude, but may have a range of more than one magnitude depending on their initial mass. Consequently, conventional oversimplified distance estimations with the assumption of a fixed luminosity may lead to systematic bias related to the initial mass or age, which can potentially affect the study of the evolution of the Galaxy with red clump stars. We therefore employ an isochrone-based method to estimate the absolute magnitude of red clump stars from their observed surface gravities, effective temperatures and metallicities. We verify that the estimation removes the systematics well and provides initial mass/age estimates that are independent of distance with accuracy better than 10%.

关键词： stars: general—stars: horizontal-branch—stars: statistics—stars: distances—Galaxy: stellar content

Selective oxidation using in-situ generated hydrogen peroxide over titanosilicates

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Chinese Journal of Structural Chemistry 2024年第6期43卷 12-14页

作者： Zhipeng wan Hao Xu Peng wu State Key Laboratory of Petroleum Molecular&Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal UniversityShanghai200062China Institute of Eco-Chongming Shanghai202162China

Titanosilicates are a class of heteroatom-containing zeolitic materials with tetrahedrally coordinated Ti^(4+)ions incorporated into crystalline zeolite frameworks,with TS-1,Ti-MWW and Ti-MOR as representative and attractive selective oxidation *** liquid-phase oxidations of a variety of substrates such as olefins and ketones with the green oxidant of H_(2)O_(2)over titanosilicates under mild conditions have attracted considerable research interests in the clean production of fine and bulk chemicals,among which propylene epoxidation and cyclohexanone ammoximation have been industrialized[1].

关键词： silicate zeolite propylene

Small intestinal bacteria overgrowth decreases small intestinalmotility in the NASH rats

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World Journal of Gastroenterology 2008年第2期14卷 313-317页

作者： wan-Chun wu Wei Zhao Sheng Li Department of Gastroenterology Yijishan Hospital Wuhu 241000 Anhui ProvinceChina

AIM: To explore the relationship between small intestinalmotility and small intestinal bacteria overgrowth(SIBO) in Nonalcoholic steatohepatitis (NASH), andto investigate the effect of SIBO on the pathogenesisof NASH in rats. The effect of cidomycin in alleviatingseverity of NASH is also studied. METHODS: Forty eight rats were randomly dividedinto NASH group (n = 16), cidomycin group (n = 16)and control group (n = 16). Then each group weresubdivided into small intestinal motility group (n = 8),bacteria group (n = 8) respectively. A semi-solid coloredmarker was used for monitoring small intestinal *** proximal small intestine was harvested under sterilecondition and processed for quantitation for aerobes(E. coli) and anaerobes (Lactobacilli). Liver pathologicscore was calculated to qualify the severity of *** ALT, AST levels were detected to evaluate theseverity of hepatitis. RESULTS: Small intestinal transit was inhibited inNASH group (P < 0.01). Rats treated with cidomycinhad higher small intestine transit rate than rats in NASHgroup (P < 0.01). High fat diet resulted in quantitativealterations in the aerobes (E. coli ) but not in theanoerobics (Lactobacill). There was an increase in thenumber of E. coli in the proximal small intestinal florain NASH group than in control group (1.70 ± 0.12 log10(CFU/g) vs 1.28 ± 0.07 log10 (CFU/g), P < 0.01). TNF-αconcentration was significantly higher in NASH groupthan in control group (1.13 ± 0.15 mmol/L vs 0.57 ±0.09 mmol/L, P < 0.01). TNF-α concentration was lowerin cidomycin group than in NASH group (0.63 ± 0.09mmol/L vs 1.13 ± 0.15 mmol/L, P < 0.01). Treatmentwith cidomycin showed its effect by significantly loweringserum ALT, AST and TNF-α levels of NASH rats. CONCLUSION: SIBO may decrease small intestinalmovement in NASH rats. SIBO may be an importantpathogenesis of Nash. And treatment with cidomycin by mouth can alleviate the severity of NASH.

关键词： Nonalcoholic steatohepatitis Small intestinal motility Small intestinal bacteria overgrowth treatment

Agricultural Investment Project Decisions Based on an Interactive Preference Disaggregation Model Considering Inconsistency

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3125-3146页

作者： Xingli wu Huchang Liao Shuxian Sun Zhengjun wan Business School Sichuan UniversityChengdu610064China National Institute of Measurement and Testing Technology Chengdu610021China

Agricultural investment project selection is a complex multi-criteria decision-making problem,as agricultural projects are easily influenced by various risk factors,and the evaluation information provided by decisionmakers usually involves uncertainty and *** literature primarily employed direct preference elicitation methods to address such issues,necessitating a great cognitive effort on the part of decision-makers during evaluation,specifically,determining the weights of *** this study,we propose an indirect preference elicitation method,known as a preference disaggregation method,to learn decision-maker preference models fromdecision *** enhance evaluation ease,decision-makers merely need to compare pairs of alternatives with which they are familiar,also known as reference *** linguistic preference relations are employed to account for the presence of incomplete and uncertain information in such pairwise *** address the inconsistency among a group of decision-makers,we develop a pair of 0-1mixed integer programming models that consider both the semantics of linguistic terms and the belief degrees of ***,we conduct a case study and comparative *** reveal the effectiveness of the proposed model in solving agricultural investment project selection problems with uncertain and inconsistent decision information.

关键词： Multiple criteria analysis preference disaggregation inconsistency probability linguistic preference relation investment project selection

Stiffness Distribution and Aeroelastic Performance Optimization of High-Aspect-Ratio Wings

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Transactions of Nanjing University of Aeronautics and Astronautics 2016年第3期33卷 243-251页

作者： wan Zhiqiang Du Ziliang wu Qiang Yang Chao School of Aeronautic Science and Engineering Beihang University Beijing 100191 P. R. China Shanghai Aircraft Design and Research Institute Shanghai 201210 P. R. China

The relationship between stiffness distribution and aeroelastic performance for a beam-frame model and a3-D model is investigated based on aeroelastic optimization of global stiffness design for high-aspect-ratio *** sensitivity information of wing spanwise stiffness distribution with respect to the twist angle at wing tip,the vertical displacement at wing tip,and the flutter speed are obtained using a sensitivity method for both *** the relationship between stiffness distribution and aeroelastic performance is summarized to guide the design *** using the genetic/sensitivity-based hybrid algorithm,an optimal solution satisfying the strength,aeroelastic and manufacturing constraints is *** is found that the summarized guidance is well consistent with the optimal solution,thus providing a valuable design advice with *** study also shows that the aeroelastic-optimization-based global stiffness design procedure can obtain the optimal solution under multiple constraints with high efficiency and precision,thereby having a strong application value in engineering.

关键词： aeroelastic high-aspect-ratio wing stiffness design structural optimization sensitivity analysis

Carbon, nitrogen and phosphorus stoichiometry in Japanese anchovy (Engraulis japonicus) from the Huanghai Sea, China

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Acta Oceanologica Sinica 2012年第4期31卷 154-160页

作者： HUANG Liang wu Ying wan Ruijing ZHANG Jing College of Resources and Environment Science East China Normal UniversityShanghai 200062China College of Chemistry and Chemical Engineering Jiujiang UniversityJiujiang 332005China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200062China Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao 266071China

Generally, nutrient cycle is closely related to the element distribution in biomass and the popula- tion dynamics in ecosystems. Carbon, nitrogen and phosphorus in Japanese anchovy （Engraulis japonicus） of different body lengths from the Huanghai Sea （Yellow Sea） were determined to better understand their variability and reasons during its life history. The mean content was 45.12%, 10.12% and 2.02% for C, N and P, respectively. Significant differences in C, N and P elemental composition were found among different sizes, which could be explained by varying proportions of storage compounds in whole body fish, and varying degrees of ossification. Considering abun- dant resources in Japanese anchovy, it was an important P-pool in the cycle of P. Moreover, the excreted N/P ratio was significantly different in fishes of different sizes, especially at high gross growth efficiency. In the past two decades, overexploitation tended to cause smaller body length in the community structure of anchovy, which presumably changed the nutrient cycle in food webs of the Huanghai Sea. Exptrapolation of the results indicates that Japanese anchovy may be important for conveying nutrient in the Huanghai Sea.

关键词： Japanese anchovy (Engraulis japonicus) nutrient elements the Huanghai Sea

Microbialite of anoxic condition from Permian-Triassic transition in Guizhou,China

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Science China Earth Sciences 2007年第7期50卷 1040-1051页

作者： wu YaSheng JIANG HongXia YANG wan FAN JiaSong Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China Department of Geology Wichita State University1845 FairmountWichitaKS 67260USA

Spherical microfossils are present in the Hindeodus parvus zone of the Lower Triassic in Ziyun,Guizhou Province. They generally range from 0.15 to 0.30 mm across,with micritic wall and filled by micro-sparry calcites,and are evenly scattered in micritic matrix. Their abundance makes the rock as-signed to microbialites. The accompanied organisms include ostracods and algal mat,but no gastro-pods or bivalves. Presence of small (wang et al. (2005),and (6) stromatolites. All these microbialites are not reefs in the proper sense,and the argument that Permian reef ecosystems extended into the Mesozoic is incorrect.

关键词： Microbialites reefs Permian-Triassic boundary mass extinction end-Permian