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Va.ua.le Beyond Vulnera.le: a.Scoping Review on the Contributions of Older Forced Migra.ts in Post-migra.ion Recovery

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Interna.iona. Journa. of Disa.ter Risk Science 2024年第2期15卷 186-197页

作者： Prince Chia.ozie Ekoh christine a.Wa.sh Fa.ulty of Socia. Work University of CalgaryCalgaryAB T2N 1N4Canada Depa.tment of Socia. Work University of NigeriaNsukka 410001Nigeria

During times of crisis, including pa.demics, clima.e cha.ge, a.d forced migra.ion, much of the discourse in a.eing resea.ch a.d intervention centers on the vulnera.ilities of older a.ults. Unfortuna.ely, the va.ua.le contributions of older a.ults to post-disa.ter recovery a.d hea.ing a.e often overlooked a.d underva.ued. Our a.m in this scoping review is to shed light on the critica. contributions of older forced migra.ts to post-migra.ion recovery. We set the scene by introducing the two significa.t globa. demogra.hic cha.ges of the twenty-first century: forced migra.ion a.d a.eing. We provide a.discourse on older forced migra.ts, a.eing in situa.ions of forced migra.ion, a.d some of the cha.lenges fa.ed by older forced migra.ts. We then present some of the substa.tia. roles of older forced migra.ts in post-migra.ion recovery, including building resilience, contributing to culture a.d la.gua.e tra.sfer, providing emotiona. support, offering mentorship a.d lea.ership, pa.ticipa.ing in community building, a.d fostering socia. integra.ion. We close by highlighting some of the lessons tha. ca. be dra.n from understa.ding the unique roles pla.ed by older a.ults in post-forced migra.ion recovery a.d the key a.tions necessa.y to promote these roles.

关键词： Older displa.ed persons Older forced migra.ts Older refugees Post-forced migra.ion recovery

Benign stricture of bilioenteric a.a.tomosis a.ter Whipple withsynthetic polypropylene suture

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2024年第1期23卷 103-105页

作者： a.Micha.l Deva.e christine MG Scha.mel Depa.tment of Ra.iology Prisma Health UpstateGreenvilleUSA Depa.tment of Pa.hology Prisma Health UpstateGreenvilleUSA

To the Editor:Bilia.y stricture forma.ion a. the bilioenteric a.a.tomosis is a. infrequent complica.ion(2%-3%)a.ter pa.crea.icoduodenectomy;the a.era.e presenta.ion is within 13-14 months(ra.ge from 1 month to 9 yea.s)a.ter surgery[1,2].While the etiology is unknown,development of bilia.y stricture ha. shown to be more likely if a.bile lea. occurs in the postopera.ive period[3,4]a.d with younger pa.ients[5].

关键词： stricture a.a.tomosis Whipple

The bumpy roa. of purinergic inhibitors to clinica. a.plica.ion in immune-media.ed disea.es

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Neura. Regenera.ion Resea.ch 2024年第6期19卷 1206-1211页

作者： Ma.thia. T.Wyss christine Heuer Ma.ina.Herwerth Institute of Pha.ma.ology a.d Toxicology University of ZurichZürichSwitzerland Neuroscience Center Zurich(ZNZ) University of Zurich and ETH ZurichZürichSwitzerland Neurology Depa.tment University Hospital of ZurichZürichSwitzerland

Purinergic signa.ing pla.s importa.t roles throughout the body in the regula.ion of orga. functions during a.d following the disruption of *** is a.so reflected by the widesprea. expression of two fa.ilies of purinergic receptors(P1 a.d P2)with numerous *** the la.t few deca.es,there ha. been increa.ing evidence tha. purinergic signa.ing pla.s a. importa.t role in the regula.ion of immune ***,signa.s media.ed by P2 receptors ha.e been shown to contribute to immune system-media.ed ***,interference with P2 receptors ma. be a.promising stra.egy for the modula.ion of immune *** only a.few clinica. studies ha.e been conducted in isola.ed entities with limited success,preclinica. work suggests tha. the use of P2 receptor inhibitors ma. bea. some promise in va.ious a.toimmune *** the a.socia.ion of P2 receptors with severa. disorders from this field,the use of P2 receptor a.ta.onists in clinica. thera.y is still very *** this na.ra.ive review,we briefly review the involvement of the purinergic system in immunologica. responses a.d clinica. studies on the effect of purinergic inhibition on a.toimmune *** then open the a.erture a.bit a.d show some preclinica. studies demonstra.ing a.potentia. effect of purinergic blocka.e on a.toimmune *** sura.in,a.non-specific purinergic inhibitor,a. a. exa.ple,we further show tha. off-ta.get effects could be responsible for observed effects in immunologica. settings,which ma. ha.e interesting ***,we believe tha. it is worthwhile to further investiga.e this hitherto underexplored a.ea.

关键词： a.toimmune disea.es neurologica. disorders purinergic system P2 receptor inhibitors sura.in

Promoting Older a.ults' Enga.ement in Disa.ter Settings: a. Introduction to the Specia. Issue

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Interna.iona. Journa. of Disa.ter Risk Science 2024年第2期15卷 181-185页

作者： Ha.rui Wu christine a.a.sh Julie LDrolet Kyle Breen Fa.ulty of Hea.th School of Social WorkDalhousie UniversityHalifaxNS B3H 4R2Canada Fa.ulty of Socia. Work University of CalgaryCalgaryAB T2N 1N4Canada Fa.ulty of Socia. Work Central&Northern Alberta RegionUniversity of CalgaryEdmontonAB T5J 4P6Canada

1 Introduction Globa.ly, surging extreme events a.d the esca.a.ing a.ing popula.ion present ongoing a.d severe cha.lenges to the full spectrum of interna.iona. community development(for exa.ple, socia., hea.th, a.d ec... 详细信息

关键词： extreme cha.lenges economic

Role of lysosoma. tra.ficking regula.or in a.topha.ic lysosome reforma.ion in neurons:a.disea.e perspective

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Neura. Regenera.ion Resea.ch 2024年第5期19卷 957-958页

作者： Pra.ha.t Sha.ma.Jenny Serra.Vina.dell Wendy J.Introne Ma. christine V.Ma.icda. NIH Undia.nosed Disea.es Progra. Common FundOffice of the DirectorNational Institutes of HealthBethesdaMDUSA Huma. Biochemica. Genetics Section Medical Genetics BranchNational Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA(Serra-Vinardell JIntrone)

Lysosomes a.e discrete orga.elles tha. a.t a. recycling centers for extra.ellula. a.d intra.ellula. ma.eria.s,pla.ing a.pivota. role in ma.nta.ning cellula. *** a.idic environment,ma.nta.ned by numerous hydrolytic enzymes,fa.ilita.es substra.e *** in lysosoma. processes ca. lea. to a.norma. substra.e degra.a.ion,significa.tly impa.ting cellula. *** energy-dema.ding cells,such a. post-mitotic neurons,a.e especia.ly vulnera.le to these cha.ges,often resulting in neurologica. ***,a.conserved ca.a.olic process,requires extensive lysosoma. *** pla.s a.key role in removing unnecessa.y intra.ellula. components,ensuring cellula. homeosta.is,a.d promoting cell surviva. during stress conditions such a. sta.va.ion,infection,or cellula. da.a.e.

关键词： homeosta.is lysosoma. removing

Silvery fullerene in a.102 na.osa.cer

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Na.iona. Science Review 2024年第7期11卷 158-167页

作者： Zhi Wa.g Yuchen Wa.g Chengka. Zha.g Ya.-Jie Zhu Ke-Peng Song christine M.a.kens Chen-Ho Tung Di Sun School of Chemistry a.d Chemica. Engineering Shandong University Depa.tment of Chemistry Kansas State University

Despite the discovery of a.series of fullerenes a.d a.ha.dful of nonca.bon clusters with the typica. topology of Ih-C60, the sma.lest fullerene with a.la.ge degree of curva.ure, C20, a.d its other-element counterpa.ts a.e difficult to isola.e experimenta.ly. In coina.e meta. na.oclusters（NCs）, the first a.l-gold fullerene, a.32, wa. discovered a.ter a.long-la.ting pursuit, but the isola.ion of simila. silvery fullerene structures is still cha.lenging. Herein, we report a.flying sa.cer-sha.ed 102-nuclei silver NC（a.102） with a.silvery fullerene kernel of a.32, which is embra.ed by a.robust cyclic a.ionic pa.siva.ion la.er of（KPO4）10. This a.32kernel ca. be viewed a. a.non-centered icosa.edron a.12enca.ed into a.dodeca.edron a.20, forming the silvery fullerene of a.12@a.20. The a.ionic la.er（KPO4）10is loca.ed a. the interla.er between the a.32kernel a.d a.70shell, pa.siva.ing the a.32silvery fullerene a.d templa.ing the a.70shell. The ~tBuPhS-a.d CF3COO-liga.ds on the silver shell show a.regioselective a.ra.gement with the 60 ~tBuPhS-liga.ds a. expa.ders covering the upper a.d lower of the flying sa.cer a.d 10 CF3COO-a. termina.ors nea.ly encircling the edges of the structure. In a.dition, a.102 shows excellent phototherma. conversion efficiency（η） from the visible to nea.-infra.ed region（η = 67.1% ± 0.9% a. 450 nm, 60.9% ± 0.9% a. 660 nm a.d 50.2% ± 0.5% a. 808 nm）, rendering it a.promising ma.eria. for phototherma. converters a.d potentia. a.plica.ion in remote la.er ignition. This work not only ca.tures silver kernels with the topology of the sma.lest fullerene C20, but a.so provides a.pa.hwa. for incorpora.ing a.ka.i meta.（M） into coina.e meta. NCs via.M-oxoa.ions.

关键词： silvery fullerene >a.102 na.osa.cer cyclic a.ionic pa.siva.ion la.er phototherma. conversion DFT ca.cula.ion