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Communities and service providers address access to perinatal care in postconflict northern Uganda:socialising evidence for participatory action

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Family Medicine and Community Health 2021年第2期9卷 1-10页

作者： Loubna Belaid Pamela Atim Eunice Atim Emmanuel Ochola Martin Ogwang Pontius Bayo Janet Oola Isaac Wonyima Okello Ivan Sarmiento Laura Rojas-Rozo Kate Zinszer christina Zarowsky neil Andersson CIET/PRAM Family Medicine McGill UniversityMontrealQuébecCanada Public Health Gulu UniversityGuluUganda Maternal and child health Nwoya Health DistrictNwoyaUganda St Mary's Lacor Hospital GuluUganda Family Medicine McGill UniversityMontrealQuébecCanada Preventive and social medicine University of MontrealMontrealQuébecCanada Universidad Autónoma de Guerrero Centro de Investigación de Enfermedades TropicalesAcapulcoMexico

Objectives Describe participatory codesign of interventions to improve access to perinatal care services in northern *** design Mixed-methods participatory research to codesign increased access to perinatal *** cognitive mapping,focus groups and a household survey identified and documented the extent of obstructions to *** dialogue focused stakeholder discussions of this evidence to address the obstacles to *** significant change stories explored the participant experience of this *** Three parishes in nwoya district in the Gulu region,northern *** Purposively sampled groups of women,men,female youth,male youth,community health workers,traditional midwives and service *** of seven stakeholder categories included 5-8 participants in each of three *** Stakeholders identified several obstructions to accessing perinatal care:lack of savings in preparation for childbirth in facility costs,lack of male support and poor service provider *** suggested joining saving groups,practising saving money and income generation to address the short-term financial *** recommended increasing spousal awareness of perinatal care and they proposed improving service provider *** described their own improved care-seeking behaviour and patient-provider relationships as short-term gains of the *** Participatory service improvement is feasible and acceptable in postconflict settings like northern *** communities in identifying perinatal service delivery issues and reflecting on local evidence about these issues generate workable community-led solutions and increases trust between community members and service providers.

关键词： service services action

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神经肌肉电刺激对脑卒中患者上肢功能影响的随机研究

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中华物理医学与康复杂志 2009年第10期31卷 663-666页

作者：林子玲燕铁斌郑正涛 christina WY Hui-chan 中山大学附属第五医院康复医学科珠海519000 中山大学附属第二医院康复医学科美国伊利诺斯大学医学院

目的探讨神经肌肉电刺激（nMES）对脑卒中偏瘫患者上肢功能的影响。方法将37例初发脑卒中患者分层后随机分为nMES组（n=19）和对照组（n=18）。2组常规治疗相同，nMES组同时给予nMES治疗，电极分别放在患侧肩外展肌群和伸腕肌群处；刺... 详细信息

目的探讨神经肌肉电刺激（nMES）对脑卒中偏瘫患者上肢功能的影响。方法将37例初发脑卒中患者分层后随机分为nMES组（n=19）和对照组（n=18）。2组常规治疗相同，nMES组同时给予nMES治疗，电极分别放在患侧肩外展肌群和伸腕肌群处；刺激频率为30Hz，脉宽为300μs，通电／断电比为5s／5S，波升／波降比为1s／1S，强度为0～90mA，随患者感觉而定。治疗每天1次，每次30min，每周5次，共3周。入选患者分别于治疗前、治疗2周和3周后进行评定：采用Fugl-Meyer运动功能评定量表（FMA）中上肢部分评定上肢运动功能，采用改良Barthel指数（MBI）评定日常生活活动能力；23例（nMES组11例，对照组12例）在治疗前及治疗3周后接受体感诱发电位（SEP）评测。结果治疗3周后，nMES组与对照组FMA评分、MBI评分以及SEP参数比较，差异均有统计学意义（P〈0．05）。结论nMES可以改善脑卒中患者偏瘫上肢运动功能，提高日常生活活动能力。

关键词：脑卒中神经肌肉电刺激上肢随机对照研究

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转移过程对CVD生长的石墨烯质量的影响

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科学通报 2014年第33期59卷 3322-3328页

作者：梁学磊李伟 CHEnG GuangJun CALIZO Irene HACKER christina A HIGHT WALKER Angela R RICHTER Curt A 彭练矛北京大学电子学系纳米器件物理与化学教育部重点实验室 nanoelectronics Group Semiconductor and Dimensional Metrology DivisionNational Institute of Standards and TechnologyGaithersburg MD 20899 USA

利用化学气象沉淀法(CVD)在金属衬底上生长的石墨烯制备电子器件需要先把石墨烯转移到绝缘基底上,转移过程对器件制备的成功率和性能的均匀性有重要影响.转移过程中导致的石墨烯破损和金属生长基底残余颗粒污染受到普遍重视,然而由金属... 详细信息

利用化学气象沉淀法(CVD)在金属衬底上生长的石墨烯制备电子器件需要先把石墨烯转移到绝缘基底上,转移过程对器件制备的成功率和性能的均匀性有重要影响.转移过程中导致的石墨烯破损和金属生长基底残余颗粒污染受到普遍重视,然而由金属基底腐蚀液导致的石墨烯表面污染还没有引起足够的重视.本文利用拉曼光谱和X射线光电子能谱(XPS)证明了转移过程中金属基底腐蚀液会在石墨烯表面引入污染,利用我们发展的"改良的RCA(radio corporation of America)清洗(modified RCA clean)"转移工艺能够有效地去除这种污染.这对提高后续制备的电子器件的性能有重要意义.

关键词：石墨烯转移污染拉曼光谱 XPS

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Investigational growth factors utilized in animal models of spinal fusion: Systematic review

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World Journal of Orthopedics 2019年第4期10卷 176-191页

作者： Ethan Cottrill A Karim Ahmed noah Lessing Zachary Pennington Wataru Ishida Alexander Perdomo-Pantoja Sheng-fu Lo Elizabeth Howell christina Holmes C Rory Goodwin nicholas Theodore Daniel M Sciubba Timothy F Witham Department of neurosurgery The Johns Hopkins Hospital Department of neurosurgery Duke University Medical Center

BACKGROUnD Over 400000 Americans annually undergo spinal fusion surgeries, yet up to 40%of these procedures result in pseudoarthrosis even with iliac crest autograft, the current "gold standard" treatment. Tissue engineering has the potential to solve this problem via the creation of bone grafts involving bone-promoting growth factors(e.g., bone morphogenetic protein 2). A broad assessment of experimental growth factors is important to inform future work and clinical potential in this area. To date, however, no study has systematically reviewed the investigational growth factors utilized in preclinical animal models of spinal *** To review all published studies assessing investigational growth factors for spinal fusion in animal models and identify promising agents for *** We conducted a systematic review of the literature using PubMed, Embase,Cochrane Library, and Web of Science databases with searches run on May 29 th,2018. The search query was designed to include all non-human, preclinical animal models of spinal fusion reported in the literature without a timespan limit. Extracted data for each model included surgical approach, level of fusion,animal species and breed, animal age and sex, and any other relevant characteristics. The dosages/sizes of all implant materials, spinal fusion rates,and follow-up time points were recorded. The data were analyzed and the results reported in tables and text. PRISMA guidelines were followed for this systematic *** Twenty-six articles were included in this study, comprising 14 experimental growth factors: AB204(n = 1); angiopoietin 1(n = 1); calcitonin(n = 3);erythropoietin(n = 1); basic fibroblast growth factor(n = 1); growth differentiation factor 5(n = 4), combined insulin-like growth factor 1 +transforming growth factor beta(n = 4); insulin(n = 1); nELL-1(n = 5); noggin(n= 1); P-15(n = 1); peptide B2 A(n = 2); and secreted phosphoprotein 24(n = 1).The fusion rates of the current gold sta

关键词： Spinal fusion Growth factor Pseudoarthrosis Systematic review

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Ambient air quality and the risk for Chronic Obstructive Pulmonary Disease among Metro Manila Development Authority traffic enforcers in Metro Manila:An exploratory study

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Chronic Diseases and Translational Medicine 2021年第2期7卷 117-124页

作者： Xerxes Seposo Audrey Lynn A.Arcilla Jose Guillermo n.De Guzman III Enrico Miguel S.Dizon Andrea nova R.Figuracion christina Micaela M.Morales Pauleena Katriona A.Tugonon Geminn Louis C.Apostol School of Medicine and Public Health Ateneo de Manila UniversityDon Eugenio Lopez Sr.Medical Complex Ortigas Avenue 1604Pasig CityPhilippines School of Tropical Medicine and Global Health Nagasaki University1-12-4 Sakamot 1-12-4 SakamotooNagasaki852-8523Japan

Background::Air pollution and poor ambient air quality are significantly related to multiple health *** associated disease is chronic obstructive pulmonary disease(COPD),a preventable disease with several contributing factors and one of the leading causes of morbidity/mortality locally and globally.A potentially high-risk population are traffic enforcers who are constantly exposed to air *** the Philippines,the MMDA has the widest coverage in traffic *** study determined the risk of COPD among Metro Manila Development Authority(MMDA)traffic enforcers in relation to ambient air quality level,as well as identified other factors that increase the risk of developing ***::Fifty-two MMDA traffic enforcers deployed in PM 2.5 air quality sensor areas in Metro Manila from 2016 to 2018 were recruited through stratified *** International Primary Airways Guidelines(IPAG)questionnaire was utilized to measure risk of *** health and working history were obtained through *** of environment and natural resources provided PM 2.5 ambient air quality data which aided in the construction of the Exposure-Month *** logistic regression was used to examine the association of PM 2.5 together with the relevant factors and the risk of ***::We found statistically significant associations between PM 2.5 and COPD among high risk category[odds risk(OR):1.24,95%confidence interval(CI):1.07-1.44].Age(Moderate,OR:1.16,95%CI:0.98-1.38 and High,OR:10.06,95%CI:4.02-25.17)and chest pain(Moderate,OR:68.65,95%CI:1.71-2.75×103)were potential risk factors,whereas body mass index(BMI)(OR:0.05,95%CI:0.01-0.53)exhibited protective ***::Exposure to PM 2.5 was associated with an increased risk of COPD among high-risk category MMDA traffic *** and chest pain were potential risk factors to risk of COPD,whereas BMI exhibited a potential protective *** of this study can be used for cli

关键词： Chronic obstructive pulmonary disease Traffic enforcers Air pollution Occupational risk Philippines

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Discovery of novel thieno[3,2-b]pyrrole 5-carboxamides as potent inhibitors of Chikungunya virus

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中国药理学与毒理学杂志 2015年第S1期29卷 107-107页

作者： K C CHInG Y W KAM Lisa FP nG christina L.L CHAI nUS Graduate School for Integrative Sciences and Engineering Singapore 117456 Department of Pharmacy Faculty of Science national University of Singapore Singapore117543 Singapore Immunology network Singapore 138648 Department of Biochemistry Yong Loo Lin School of Medicine national University of Singapore Centre for Translational Medicine Singapore 117599 Institute of Chemical and Engineering Sciences Singapore 138665

Chikungunya fever(CHIKF)is an arboviral disease that typically consists of an acute illness with fever,skin rash,and incapacitating *** causative agent of CHIKF is Chikungunya virus(CHIKV),an alphavirus that is transmitted by the Aedes *** the re-emergence of CHIKV as an epidemic threat,there is no approved effective anti-viral treatment currently available for *** our preliminary studies,selected small molecule inhibitors of arboviruses related to CHIKV were investigated and this led us to identify compounds with thieno[3,2-b]pyrrole scaffold as *** on the discovery of our best hit compounds,5-carboxylic acid thieno[3,2-b]pyrrole 1 and 5-carboxamide thieno[3,2-b]pyrrole 2,the main aim of this study is to optimize their anti-viral activities by synthesizing analogs of thieno[3,2-b]pyrroles 1 and 2 and examine their activities against *** these two parallel optimization studies,we synthesized two series of thieno[3,2-b]pyrroles,namely the 5-carboxylic acids and 5-carboxamides that possessed a variety of substituents at n4,C2,C6 or C5positions of the thieno[3,2-b]pyrrole *** compounds were then examined for their cytotoxicity effects and anti-viral activities using a luminescence-labelled CHIKV infectious *** most potent compound in our studies was found in the 5-carboxamide *** synthesis,biological activity and structure-activity relationship(SAR)will be presented and discussed in detail.

关键词： Chikungunya virus thieno[3,2-b]pyrrole 5-carboxami

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Compatibility of early natural enemy introductions in commercial pepper and tomato greenhouses with repeated pesticide applications

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Insect Science 2020年第5期27卷 1111-1124页

作者： Beatriz Dader Ignacio Colomer Angeles Adan Pilar Medina Elisa Vinuela Unidad de Proteccion de Cultivos Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de Biosistemas(ETSIAAB)Universidad Polit^cnica de Madrid(UPM)MadridSpain Departamento de Ingenieria Rural Escuela Superior de IngenieriaUniversidad de AlmeriaAlmeriaSpain

Successful integrated pest management in protected crops implies an evalu-ation of the compatibility of pesticides and natural enemies(nE),as control strategies that only rely on one tactic can fail when pest populations exceed nE activity or pests become resistant to *** in Almeria(Spain),growers release nE prior to transplanting or early in the crop cycle to favor their settlement before pest arrival because this improves biocontrol efficacy,although it extends pesticide exposure *** pur-pose of this research was to evaluate the compatibility of two applications of pesticides with key nE in 2-year trials inside tomato and sweet pepper commercial greenhouses:nesidiocoris tenuis(Reuter)(Hemiptera:Miridae),Orius laevigatus(Say)(Hemiptera:Anthocoridae)and Amblyseius swirskii(Athias-Henriot)(Acari:Phytoseidac).In tomato,flubendiamide and chlorantraniliprole(IOBC category 1)were compatible with ***,but chlorpyrifos.:methyl and spinosad(IOBC categories 2-3),which efectively reduced Tiuta absoluta(Meyrick)(Lepidoptera:Gelechidae)density,compromised its predatory *** sweet pepper,chlorantraniliprole(IOBC category 1)was the only pesticide compatible with *** while chlorantraniliprole,emamectin benzoate,spirote-tramat and pymetrozine were harmless(IOBC category 1)to Amblyseius swirskii,and sulfoxaflor slightly harmful(IOBC category 2)to this phytoseiid predator.

关键词： Amblyseius swirskii chemical control Frankliniella occidentalis nesidiocoris tenuis Orius laevigatus Tuta absoluta

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Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors

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Bone Research 2024年第3期12卷 611-620页

作者： Brenda Krishnacoumar Martin Stenzel Hilal Garibagaoglu Yasunori Omata Rachel L.Sworn Thea Hofmann natacha Ipseiz Magdalena A.Czubala Ulrike Steffen Antonio Maccataio Cornelia Stoll christina Böhm Martin Herrmann Stefan Uderhardt Robert H.Jenkins Philip R.Taylor Anika Grüneboom Mario M.Zaiss Georg Schett Gerhard Krönke Carina Scholtysek Department of Internal Medicine 3-Rheumatology and Immunology Friedrich-Alexander University Erlangen-Nürnberg(FAU)and Universitätsklinikum Erlangen91054 ErlangenGermany Deutsches Zentrum für Immuntherapie(DZI) Friedrich-Alexander University Erlangen-Nürnberg(FAU)and Universitätsklinikum Erlangen91054 ErlangenGermany Department of Biopsectroscopy Leibniz Institut für Analytische Wissenschaften-ISAS-e.V.Bunsen-Kirchhoff-Str.11Dortmund 44227Germany Medical Faculty University HospitalUniversity Duisburg-EssenEssen 45147Germany Systems Immunity Research Institute Heath ParkCardiff UniversityCardiff CF144XNUK Optical Imaging Competence Centre(FAU OICE) Exploratory Research UnitFriedrich-Alexander University Erlangen-Nürnberg(FAU)ErlangenGermany Division of Infection&Immunity Heath ParkCardiff UniversityCardiff CF144XNUK Deutsches Rheuma-Forschungszentrum Berlin BerlinGermany Department of Rheumatology and Clinical Immunology Charité-Universitätsmedizin BerlinBerlinGermany

Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing ***,the exact molecular factors and mechanisms controlling osteoclast fusion remain incompletely *** we identify RAnKL-mediated activation of caspase-8 as early key event during osteoclast fusion.

关键词： incomplete exact activation

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普通金雀花种群在高温下的本土和入侵幼苗抗旱性

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Journal of Plant Ecology 2023年第3期16卷 80-95页

作者： Mathias christina Céline Gire Mark R.Bakker Alan Leckie Jianming Xue Peter W.Clinton Zaira negrin-Perez JoséRamon Arevalo Sierra Jean-Christophe Domec Maya Gonzalez InRAE Bordeaux Sciences AgroUMR 1391 ISPAF-33882 Villenave-d'OrnonFrance CIRAD PERSYST DepartmentUPR 115 AIDA97490 Sainte-ClotildeLa ReunionFrance AIDA PERSYST DepartmentUniv MontpellierCIRADMontpellierFrance new Zealand Forest Research Institute trading as Scion 8440 ChristchurchNew Zealand Department of Botany Ecology and Plant PhysiologyUniversity of La Laguna38206 La LagunaSpain

入侵物种的气候生长需求在其本土和非本土环境之间保持一致的假设是评估入侵风险的关键生态学问题。本研究通过生长箱实验,比较水分和温度对普通金雀花幼苗(Ulex europaeus L.)本土种群和入侵种群生长和死亡率的影响。从本土(法国大陆... 详细信息

入侵物种的气候生长需求在其本土和非本土环境之间保持一致的假设是评估入侵风险的关键生态学问题。本研究通过生长箱实验,比较水分和温度对普通金雀花幼苗(Ulex europaeus L.)本土种群和入侵种群生长和死亡率的影响。从本土(法国大陆和西班牙)和非本土(新西兰、加那利群岛和留尼旺岛)的5个地区的20个种群中采集了种子样本。幼苗在两种温度处理(环境温度和高温)和两种水处理(灌溉和干旱)中生长超过36天。温度升高被定义为在不同国家的生态位边缘观察到的最高温度。虽然温度升高增加了幼苗的生长,但干旱处理增加了死亡率并限制了幼苗的生长。在高温和干旱条件下,本土种群的死亡率(53%)高于入侵种群(16%)。在这些受限的气候条件下,入侵幼苗的地上和地下发育也好于本土幼苗。虽然表型可塑性在本土种群和入侵种群之间没有差异,但种群之间总干物质生物量的差异可能与起源气候(尤其是降水)的差异有关。评估入侵物种种群之间表型变化的重要性对于确定其气候分布范围的边缘以及对突出应集中管理以限制其传播的区域都至关重要。

关键词：入侵外来植物干旱气候生态位定植

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Influence of anastomoses on intestine ischemia and cefuroxime concentrations:Evaluated in the ileum and colon in a porcine model

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World Journal of Gastrointestinal Pathophysiology 2021年第1期12卷 1-13页

作者： Pelle Hanberg Mats Bue Maja Thomassen Uffe Schou Løve Josephine Olsen Kipp christina Harlev Elisabeth Petersen Kjeld Søballe Maiken Stilling Department of Orthopaedic Surgery Horsens Regional HospitalHorsens 8700Denmark Aarhus Microdialysis Research Group Orthopaedic Research UnitAarhus University HospitalAarhus N 8200Denmark Department of Clinical Medicine Aarhus UniversityAarhus N 8200Denmark Department of Orthopaedic Surgery Aarhus University HospitalAarhus N 8200Denmark Department of Surgery Viborg Regional HospitalViborg 8800Denmark

BACKGROUnD Anastomotic leakage is a serious complication following gastrointestinal surgery and is associated with increased morbidity and *** incidence of anastomotic leakage is determined by anatomy and is reported to be between 4%-33%for colon anastomosis and 1%-3%for small intestine *** etiology of anastomotic leakage of the intestine has been divided into three main factors:healing disturbances,communication between intra-and extra-luminal compartments,and *** three factors interact,and one factor will inevitably lead to the other two factors resulting in tissue ischemia,tissue necrosis,and anastomotic *** To evaluate ischemic metabolites and cefuroxime concentrations in both anastomosis and non-anastomosis ileum and colon in a porcine *** Eight healthy female pigs(Danish Landrace breed,weight 58-62 kg)were included in this *** catheters were placed for sampling of ischemic metabolites(glucose,lactate,glycerol,and pyruvate)and cefuroxime concentrations in both anastomosis and non-anastomosis ileum and *** 1.5 g was administered as an intravenous infusion over 15 ***,dialysates and blood samples were collected over 8 h and the ischemic metabolites and cefuroxime concentrations were quantified in all *** concentrations of glucose,lactate,glycerol and pyruvate were determined using the CMA 600 Microdialysis Analyzer with Reagent Set A(M Dialysis AB,Sweden),and the concentrations of cefuroxime and meropenem were quantified using a validated ultra-high-performance liquid chromatography *** Only the colon anastomosis induced mean ischemic lactate/pyruvate ratios above 25(ischemic cut-off)throughout the entire sampling interval,and simultaneously decreased glucose *** mean time for which cefuroxime concentrations were maintained above the clinical breakpoint minimal inhibitory concentration for Escherichia coli(8μg/mL)ranged between 116-128 min

关键词： Anastomosis Cefuroxime Colon Ileum Ischemic metabolites Microdialysis

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