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Sol-gel derived B_(2)O_(3)-CaO borate bioactive glasses with hemostatic,antibacterial and pro-angiogenic activities

Regenerative Biomaterials 2024年第1期3卷 108-118页

作者： Kai Zheng Faina Bider mahshid monavari Zhiyan Xu christina Janko Christoph Alexiou Ana m.Beltran Aldo R.Boccaccini Jiangsu Province Engineering Research Center of Stomatological Translational medicine College of StomatologyNanjing Medical UniversityNanjing 210029China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing 210029China Institute of Biomaterials University of Erlangen-Nuremberg91058 ErlangenGermany Department of Oto-Rhino-Laryngology Head and Neck SurgerySection of Experimental Oncology and Nanomedicine(SEON)Else Kroener-Fresenius-Stiftung ProfessorshipUniversitaetsklinikum Erlangen91058 ErlangenGermany Departamento de Ingenier�ıa y Ciencia de los materiales y del Transporte Escuela Politecnica

Sol-gel borate bioactive glasses(BGs)are promising ion-releasing biomaterials for wound healing ***,we report the synthesis of a series of binary B_(2)O_(3)-CaO borate BGs(CaO ranging from 50 to 90mol%)using a sol-gel-based *** influence of CaO content in B_(2)O_(3)-CaO borate BG on morphology,structure and ion release behavior was investigated in *** dissolution(ion release)and crystallization could be observed in borate BGs when CaO content increased,while the morphology was not significantly altered by increasing CaO *** results evidenced that the ion release behavior of borate BGs could be tailored by tuning the B_(2)O_(3)/CaO molar *** also evaluated the in vitro cytotoxicity,hemostatic,antibacterial and angiogenic activities of borate *** was validated for all borate ***,borate BGs exhibited composition-dependent hemostatic,antibacterial and angiogenic ***,higher contents of Ca in borate BGs facilitated hemostatic activity,while higher contents of B_(2)O_(3) were beneficial for pro-angiogenic *** synthesized sol-gel-derived borate BGs are promising materials for developing advanced wound healing dressings,given their fast ion release behavior and favorable hemostatic,antibacterial and angiogenic activities.

关键词： borate glasses sol-gel processing glass composition wound healing

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magneto-polaron induced intersubband optical transition in a wide band gap Ⅱ–Ⅵ semiconductor quantum dot

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Journal of Semiconductors 2015年第3期36卷 1-6页

作者： P.christina Lily Jasmine A.John Peter Department of Physics N.M.S.Sermathai Vasan College for Women Department of Physics Government Arts College

Effects of LO-phonon contribution on the electronic and the optical properties are investigated in a ***.2 Se/ZnSe quantum dot in the presence of magnetic field strength. The magneto-polaron induced hydro- genic binding energy as a function of dot radius in the wide band gap quantum dot is calculated. The oscilla- tor strength and the spontaneous lifetime are studied taking into account the spatial confinement, magnetic field strength and the phonon contribution. Numerical calculations are carried out using variational formulism within the single band effective mass approximation. The optical properties are computed with the compact density matrix method. The magneto-polaron induced optical gain as a function of photon energy is observed. The results show that the optical telecommunication wavelength in the fiber optic communications can be achieved using CdSe/ZnSe semiconductors and it can be tuned with the proper applications of external perturbations.

关键词： electronic states optical absorption intersubband transition quantum dot

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Lubiprostone vs Senna in postoperative orthopedic surgery patients with opioid-induced constipation:A double-blind,active-comparator trial

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World Journal of Gastroenterology 2014年第43期20卷 16323-16333页

作者： christina m marciniak Santiago Toledo Jungwhalia Lee michael Jesselson Jillian Bateman Benjamin Grover Joy Tierny Department of Physical medicine and Rehabilitation School of MedicineNorthwestern UniversityChicagoIL 60611United States Department of Preventive medicine Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611United States University of Chicago medical Center ChicagoIL 60637United States The Rehabilitation Institute of Chicago ChicagoIL 60611United States Chicago College of Osteopathic medicine ChicagoIL 60515United States

AIm: To investigate the efficacy of lubiprostone compared to Senna on bowel symptoms and constipation in post-operative orthopedic patients treated with opioids.

关键词： Constipation Opioids Lubiprostone Senna Orthopedics Rehabilitation

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Split liver transplantation: Current developments

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World Journal of Gastroenterology 2018年第47期24卷 5312-5321页

作者： christina Hackl Katharina m Schmidt Caner Süsal Bernd Dohler martin Zidek Hans J Schlitt Department of Surgery University Hospital RegensburgRegensburg 93053Germany Collaborative Transplant Study (CTS) Institute of ImmunologyHeidelberg UniversityHeidelberg 69120Germany

In 1988, Rudolf Pichlmayr pioneered split liver transplantation(SLT), enabling the transplantation of one donor liver into two recipients-one pediatric and one adult patient. In the same year, Henri Bismuth and colleagues performed the first full right/full left split procedure with two adult recipients. Both splitting techniques were rapidly adopted within the transplant community. However, a SLT is technically demanding, may cause increased perioperative complications, and may potentially transform an excellent deceased donor organ into two marginal quality grafts. Thus, crucial evaluation of donor organs suitable for splitting and careful screening of potential SLT recipients is warranted. Furthermore, the logistic background of the splitting procedure as well as the organ allocation policy must be adapted to further increase the number and the safety of SLT. Under defined circumstances, in selected patients and at experienced transplant centers, SLT outcomes can be similar to those obtained in full organ LT. Thus, SLT is an important tool to reduce the donor organ shortage and waitlist mortality, especially for pediatric patients and small adults. The present review gives an overview of technical aspects, current developments, and clinical outcomes of SLT.

关键词： Liver transplantation organ shortage in situ split extended right lobe left lateral lobe living donor

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Updates on treatment of irritable bowel syndrome

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World Journal of Gastroenterology 2008年第17期14卷 2639-2649页

作者： Christopher W Hammerle christina m Surawicz Department of medicine University of Colorado Health Sciences Center Harborview medical Center University of Washington

Irritable bowel syndrome （IBS） is a highly prevalent gastrointestinal disorder characterized by abdominal pain and discomfort in association with altered bowel habits. It is estimated tD affect 10%-15% of the Western population, and has a large impact on quality of life and （in）direct healthcare costs. IBS is a multifactorial disorder involving dysregulation within the brain-gut axis, and it is frequently associated with gastrointestinal motor and sensory dysfunction, enteric and central nervous system irregularities, neuroimmune dysregulation, and postinfectious inflammation. As with other functional medical disorders, the treatment for IBS can be challenging. Conventional therapy for those with moderate to severe symptoms is largely unsatisfactory, and the development of new and effective drugs is made difficult by the complex pathogenesis, variety of symptoms, and lack of objective clinical findings that are the hallmark of this disorder. Fortunately, research advances over the past several decades have provided insight into potential mechanisms responsible for the pathogenesis of IBS, and have led to the development of several promising pharmaceutical agents. In recent years there has been much publicity over several of these new IBS medications （alosetron and tegaserod） because of their reported association with ischemic colitis and cardiovascular disease. While these agents remain available for use under restricted prescribing programs, this highlights the need for continued development of safe and effective medication for IBS. This article provides a physiologicallybased overview of recently developed and frequently employed pharmaceutical agents used to treat IBS, and discusses some non-pharmaceutical options that may be beneficial in this disorder.

关键词： Irritable bowel syndrome Treatment Pharmacotherapy Challenges Opportunities

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Feasibility,efficacy,and safety of animal-assisted activities with visiting dogs in inpatient pediatric oncology

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World Journal of Pediatrics 2024年第9期20卷 915-924页

作者： Katja Steff maximilian Grasemann Kira Ostermann Sarah christina Goretzki Peter-michael Rath Dirk Reinhardt michael m.Schündeln Pediatric Hematology and Oncology Department of Pediatrics ⅢUniversity of Duisburg-EssenHufelandstr.5545122EssenGermany Department of Psychology Medical School HamburgHamburgGermany Pediatric Infectiology Department of Pediatrics ⅠUniversity of Duisburg-EssenEssenGermany Institute of medical microbiology University of Duisburg-EssenEssenGermany

Background Childhood cancer entails a heavy burden for patients and their *** advances in overall survival rates have increasingly brought long-term quality of life into ***-assisted activities(AAAs)have long been hypothesized to alleviate the burden on pediatric patients and their peers in the hospital ***,their use in inpatient pediatric oncology has been a sensitive issue mainly due to the fear of infections,resulting in a lack of *** study presents data on the feasibility,safety,and efficacy of AAAs from a single German *** Between 2018 and 2022,60 patients(median age=10.3 years)diagnosed with malignancy and undergoing treatment were visited by an intervention dog(total visits=100).Patients were screened for infections as per hospital policy,with additional microbiological testing performed based on *** dog was screened for human pathogens and *** data and hospitalizations were analyzed from two months prior to the first visit until two months after the last *** of being in the hospital,both with and without planned animal-assisted interventions and pre-and post-intervention state stress,were measured using a validated visual analogue scale(0-10).Results Patients benefited from AAAs,showing increased acceptance of being in the hospital(median:7.25 vs.4.50,Pmedian state stress ratings one hour after the visit compared to one hour before the visit(1.00 vs.4.25,Pmber of infections or unplanned hospitalizations,and no zoonoses were *** microbial screening tests of the dog were *** AAAs with visiting dogs in inpatient pediatric oncology are feasible and *** they hold promise for enhancing patients’well-being,further prospective studies are needed.

关键词： Animal-assisted activities Animal-assisted interventions Animal-assisted therapy Feasibility Infection control Inpatient pediatric oncology Safety Stress response Therapy dog Visiting dog

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THE *** CENTER AS A LIVING LABORATORY:CONNECTING CAmPUS SUSTAINABILITY GOALS WITH THE EDUCATIONAL mISSION AT HAmPSHIRE COLLEGE,AmHERST,mA

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Journal of Green Building 2018年第4期13卷 125-145页

作者： christina m.Cianfrani Sarah Hews Jason Tor Jason J.Jewhurst Claire Shillington matthew Raymond Associate Professor of Hydrology School of Natural ScienceHampshire CollegeAmherstMA Associate Professor of mathematics School of Natural ScienceHampshire CollegeAmherstMA Professor of microbiology School of Natural ScienceHampshire CollegeAmherstMA AIA Principal Bruner/Cott ArchitectsCambridge MA School of Natural Science Hampshire CollegeAmherstMA

*** The *** Center In 2016 the *** Center became Hampshire College’s first new building in 40 years(Figure 1).Located at the heart of the Hampshire College campus,the *** Center is a multi-purpose facility intended to embody a high threshold of for-ward-thinking sustainable design:generating its own energy;capturing and treating its own water;and processing and recycling its *** design also embodies a broader definition of“green”building,prioritizing non-toxic materials,local and ethical prod-ucts,and principals of biophilia and natural ***e new building,which includes classrooms,offices,and a community caféand gallery,serves as a primary entry point to the campus and was designed to engage prospective students as well as provide community *** the spring of 2018,the Kern Center became the 17th building to be certified and meet the Living Building Challenge(LBC)(International Living Future Institute,2018a)after a year of post-occupancy performance *** 17,000 square feet,it is the largest Living Building on a higher education campus and considering the relatively small size of the college(~1300 students)it showcases Hampshire College’s substantial commitment to sustainable design and *** Living Building Challenge A program of the International Living Future Institute,the Living Building Challenge is a building certification system and sustainable design framework for creating built environments that have a positive impact on people and the environ-ment(International Living Future Institute,2018a).The Challenge is organized into seven performance areas covering different aspects of holistic sustainable design:place,water,energy,health+happiness,materials,equity,and *** order to achieve“Living”status,projects must fulfill all imperatives in each of these *** College Hampshire College is an innovative private college in Amherst,***e academic program is highly dynamic

关键词： sustainability higher education Living Building Challenge regenerative design Net Zero innovative curriculum development

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Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups

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World Journal of Gastroenterology 2015年第9期21卷 2759-2769页

作者： christina m Hester Venkatakrishna R Jala morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu Department of Family medicine Research Division University of Kansas Medical CenterKansas CityKS 66160United States University of Kansas Cancer Center University of Kansas medical Center Kansas CityKS 66160United States James Graham Brown Cancer Center and Department of microbiology and Immunology University of LouisvilleLouisvilleKY 40202United States Department of Pharmacology Dalhousie UniversityHalifaxNS B3H 4R2Canada Department of molecular and Integrative Physiology University of Kansas Medical CenterKansas CityKS 66160United States

AIm:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White ***:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA ***,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the *** used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all ***:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic *** also found that participant microbial profiles differed by racial/ethnic *** Americans had significantly more Firmicutes than Whites,with enriched *** Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of *** also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in ***:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions.

关键词： Colorectal cancer Short chain fatty acids Racial/e

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Probing shock geometry via the charge to mass ratio dependence of heavy ion spectra from multiple spacecraft observations of the 2013 November 4 event

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Research in Astronomy and Astrophysics 2016年第12期16卷 101-106页

作者： Lulu Zhao Gang Li Glenn m. mason christina Cohen Richard mewaldt mihir Desai Rob Ebert maher Al-Dayeh Department of Physics and Space Sciences Florida Institute of Technology FL 32901 USA Department of Space Science and CSPAR University of Alabama in Hun-tsville Huntsville Alabama 35801 USA Applied Physics Laboratory Johns Hopkins University Laurel MD 20723 USA California Institute of Technology Pasadena CA 91125 USA Southwest Research Institute San Antonio TX 78228 USA University of Texas at San Antonio San Antonio TX 78249 USA

In large Solar Energetic Particle （SEP） events, ions can be accelerated at coronal mass ejection （CmE）-driven shocks to very high energies. The spectra of heavy ions in many large SEP events show features such as roll-overs or spectral breaks. In some events when the spectra are plotted in terms of energy/nucleon, they can be shifted relative to each other to make the spectral breaks align. The amount of shift is charge to mass ratio （Q/A） dependent and varies from event to event. This can be understood if the spectra of heavy ions are organized by the diffusion coefficients （Cohen et al. 2005）. In the work of Li et al. （2009）, the Q/A dependence of the scaling is related to shock geometry when the CmE-driven shock is close to the Sun. For events where multiple in-situ spacecraft observations exist, one may expect that different spacecraft are connected to different portions of the CmE-driven shock that have different shock geometries, therefore yielding different Q/A dependence. In this work, we examine one SEP event which occurred on 2013 November 4. We study the Q/A dependence of the energy scaling for heavy ion spectra using helium, oxygen and iron ions. Observations from STEREO-A, STEREO-B and ACE are examined. We find that the scalings are different for different spacecraft. We suggest that this is because ACE, STEREO- A and STEREO-B are connected to different parts of the shock that have different shock geometries. Our analysis indicates that studying the Q/A scaling of in-situ particle spectra can serve as a powerful tool to remotely examine the shock geometry for large SEP events.

关键词： Sun: particle emission -- acceleration of particles

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microglial complex I activity: a crucial factor for smoldering inflammation in the central nervouss system

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3165-3166页

作者： Jana K.Sonner christina mayer manuel A.Friese Institute of Neuroimmunology and multiple Sclerosis University Medical Center Hamburg-EppendorfHamburgGermany

In their article published in Nature,Peruzotti-Jametta et *** metabolic reprogramming of microglia as a defining characteristic of their persistent and harmful activation during inflammatory neurodegeneration,which is observable in conditions like multiple sclerosis(mS).Subsequently,the authors demonstrate how mitigating mitochondrial dysregulation in microglia alleviates disease progression in an animal model of mS,thereby unveiling a potential novel target for the treatment of mS(Fig.1).

关键词： inflammation thereby

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