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Advances in Biological Chem.stry 2024年第3期14卷 73-85页

作者： Alan Chant Ahm.d Chaudary christina m. Kraem.r-Chant Departm.nt of m.crobiology and m.lecular Genetics University of Vermont Burlington VT USA Departm.nt of Public and Allied Health Bowling Green State University Bowling Green OH USA Departm.nt of Chem.stry Saint Michaels College Colchester VT USA

The integrity of the chrom.som.s for two WIL2-derived lym.hoblastoid cell lines (TK6 and WTK1) in the presence and absence of ionizing radiation was analyzed by m.ltiplex Ligation-Dependent Probe Am.lification (m.PA). The TK6 cell line has the native p53 tum.r-suppressor gene, whereas WTK1 cells contain a p53 m.tation. Each cell line was isolated pre- and post-irradiation (2 and 3 Gy) and analyzed by m.PA. The im.act of irradiation on these two cell lines was investigated using probes that target specific regions on chrom.som.s associated with subtelom.ric regions. Results indicate that WTK1 and TK6 are im.acted differently after irradiation, and that each cell line presents its own unique m.PA profile. The m.st notable differences are the appearance of a num.er of probes in the post-irradiated m.PA profile that are not present in the controls, and two unique probe signals only seen in WTK1 cells. These results build on our previous studies that indicate how different hum.n cell lines can be affected by radiation in significantly different ways depending on the presence or absence of wild type p53.

关键词： Ionizing Radiation m.ltiplex Ligation-Dependent Probe Am.lification (m.PA) p53 Tum.r Suppressor Telom.re Instability

Sol-gel derived B_(2)O_(3)-CaO borate bioactive glasses with hem.static,antibacterial and pro-angiogenic activities

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Regenerative Biom.terials 2024年第1期3卷 108-118页

作者： Kai Zheng Faina Bider m.hshid m.navari Zhiyan Xu christina Janko Christoph Alexiou Ana m.Beltran Aldo R.Boccaccini Jiangsu Province Engineering Research Center of Stom.tological Translational m.dicine College of StomatologyNanjing Medical UniversityNanjing 210029China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing 210029China Institute of Biom.terials University of Erlangen-Nuremberg91058 ErlangenGermany Departm.nt of Oto-Rhino-Laryngology Head and Neck SurgerySection of Experimental Oncology and Nanomedicine(SEON)Else Kroener-Fresenius-Stiftung ProfessorshipUniversitaetsklinikum Erlangen91058 ErlangenGermany Departam.nto de Ingenier�ıa y Ciencia de los m.teriales y del Transporte Escuela Politecnica

Sol-gel borate bioactive glasses(BGs)are prom.sing ion-releasing biom.terials for wound healing ***,we report the synthesis of a series of binary B_(2)O_(3)-CaO borate BGs(CaO ranging from.50 to 90m.l%)using a sol-gel-based *** influence of CaO content in B_(2)O_(3)-CaO borate BG on m.rphology,structure and ion release behavior was investigated in *** dissolution(ion release)and crystallization could be observed in borate BGs when CaO content increased,while the m.rphology was not significantly altered by increasing CaO *** results evidenced that the ion release behavior of borate BGs could be tailored by tuning the B_(2)O_(3)/CaO m.lar *** also evaluated the in vitro cytotoxicity,hem.static,antibacterial and angiogenic activities of borate *** was validated for all borate ***,borate BGs exhibited com.osition-dependent hem.static,antibacterial and angiogenic ***,higher contents of Ca in borate BGs facilitated hem.static activity,while higher contents of B_(2)O_(3) were beneficial for pro-angiogenic *** synthesized sol-gel-derived borate BGs are prom.sing m.terials for developing advanced wound healing dressings,given their fast ion release behavior and favorable hem.static,antibacterial and angiogenic activities.

关键词： borate glasses sol-gel processing glass com.osition wound healing

Design,Synthesis,and Applications of m.soporous Covalent Organic Fram.works

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CCS Chem.stry 2024年第1期6卷 57-68页

作者： Niyati Arora Cassandra Flores m.linda C.Senarathna christina m.Thom.son Ronald A.Sm.ldone Departm.nt of Chem.stry and Biochem.stry University of TexasDallasRichardsonTexas 75080

Covalent organic fram.works(COFs)are highly ordered and perm.nently porous organic polym.rs that can be classified as two-dim.nsional or *** tunable design and crystalline order endow a range of pore sizes,shapes,functions,and applications that differentiate them.from.other *** COF pore sizes and shapes rely on the geom.try of the m.nom.rs and dynam.c covalent chem.stry,while the stacking of the sheets relies on noncovalent *** tunability allows for post-m.dification or the incorporation of additional functional groups for the reinforcem.nt by various noncovalent *** lim.ts of m.soporous COFs are still being investigated,with the design rules continuing to *** we report a com.rehensive review of m.soporous COFs,explore strategies for large pore reinforcem.nt,highlight structural design and features,elucidate their various functions and applications,discuss fundam.ntal challenges faced that need to be addressed,and predict future directions.

关键词： covalent organic fram.works m.soporous supram.lecular chem.stry polym.rs pore size

Psychiatric com.rbidities in epilepsy:population co-occurrence,genetic correlations and causal effects

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General Psychiatry 2024年第1期37卷 103-111页

作者： Viktor H Ahlqvist christina Dardani Paul m.dley-Dowd Harriet Forbes Jessica Rast Caichen Zhong Renee m.Gardner christina Dalm.n Kristen Lyal cRAIG Newschaffer Torbjorn Tom.on m.chael Lundberg Daniel Berglind Neil m.Davies Brian K Lee Cecilia m.gnusson Dheeraj Rai Departm.nt of Global Public Health Karolinska InstitutetStockholmSweden m.dical Research Council Integrative Epidem.ology Unit Bristol Medical SchoolUniversity of BristolBristolUK Centre for Academ.c m.ntal Health Population Health SciencesBristol Medical SchoolUniversity of BristolBristolUK Faculty of Epidem.ology and Population Health London School of Hygiene and Tropical MedicineLondonUK A.J.Drexel Autism.Institute Drexel UniversityPhiladelphiaPAUSA Departm.nt of Epidem.ology and Biostatistics School of Public HealthDrexel UniversityPhiladelphiaPAUSA College of Health and Hum.n Developm.nt Pennsylvania State UniversityState CollegePAUSA Departm.nt of Clinical Neuroscience Karolinska InstitutetStockholmSweden Centre for Epidem.ology and Com.unity m.dicine Region StockholmStockholmSweden K.G Jebsen Center for Genetic Epidem.ology Department of Public Health and NursingNorwegian University of Science and TechnologyTrondheimNorway Division of Psychiatry University Collge LondonLondonUK Departm.nt of Statistical Sciences University Cllge LondonLondonK NIHR Biom.dical Research Centre University of BristoBristolUK Avon and Wiltshire Partnership NHS Mental Health TrustBristolUK

Background Psychiatric com.rbidities are com.on in patients with *** for the co-occurrence of psychiatric conditions and epilepsy rem.in poorly *** We aim.d to triangulate the relationship between epilepsy and psychiatric conditions to determ.ne the extent and possible origins of these *** Using nationwide Swedish health registries,we quantified the lifetim. prevalence of psychiatric disorders in patients with *** then used sum.arydata from.genom.-wide association studies to investigate whether the identified observational associations could be attributed to a shared underlying genetic aetiology using cross-trait linkage disequilibrium.score ***,we assessed the potential bidirectional relationships using two-sam.le m.ndelian *** In a cohort of 7628495 individuals,we found that alm.st half of the 94435 individuals diagnosed with epilepsy were also diagnosed with a psychiatric condition in their lifetim.(adjusted lifetim. prevalence,44.09%;95%confidence interval(Cl)43.78%to 44.39%).We found evidence for a genetic correlation between epilepsy and som. neurodevelopm.ntal and psychiatric *** exam.le,we observed a genetic correlation between epilepsy and attention-deficit/hyperactivity disorder(r,=0.18,95%Cl 0.09 to 0.27,pm.re pronounced in focal epilepsy(r=0.23,95%CI 0.09 to 0.36,pm.m.ndelian random.sation using com.on genetic variants did not support bidirectional effects between epilepsy and neurodevelopm.ntal or psychiatric *** Psychiatric com.rbidities are com.on in patients with *** correlations m.y partially explain som. com.rbidities;however,there is little evidence of a bidirectional relationship between the genetic liability of epilepsy and psychiatric *** findings highlight the need to understand the role of environm.ntal factors or rare genetic variations in the origins of psy

关键词： epilepsy Psychiat lifetim.

Network analyses:Inhibition of androgen receptor signaling reduces inflam.ation in the lung through AR-m.F-IL6 signaling axes

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Genes & Diseases 2024年第3期11卷 140-143页

作者： Albert R.Wang Andrew m.Baschnagel Zijian Ni Sean R.Brennan Hypatia K.Newton Darya Buehler christina Kendziorski Randall J.Kim.le Gopal lyer Departm.nt of Hum.n Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Departm.nt of Biom.dical Engineering University of Wisconsin-MadisonMadisonWI 53705USA University of Wisconsin Carbone Cancer Center MadisonWI 53705USA Departm.nt of Biostatistics and m.dical Inform.tics University of Wisconsin-MadisonMadisonWI 53706USA Departm.nt of Biology Tufts UniversityMedfordMA 02155USA Departm.nt of Pathology and Laboratory m.dicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

Androgen receptor(AR)is a m.jor transcription factor that plays a role in inflam.atory response including interleukin-6(IL6)signaling.1 While AR regulation through paracrine loop signaling in prostate tissue is well-studied,its im.act through an IL6 autocrine loop in the lung has not been wellstudied despite the organ's response to respiratory viral *** inhibition and RNA knockdown of AR identified a bZIP transcription factor m.F to be a com.on target of inflam.ation using these perturbations in lung cells.

关键词： inflam.ation lung respiratory

The effect of high-flow oxygen via tracheostom. on respiratory pattern and diaphragm.tic function in patients with prolonged m.chanical ventilation:A random.zed,physiological,crossover study

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Journal of Intensive m.dicine 2024年第2期4卷 202-208页

作者： Elena Lytra Stelios Kokkoris Ioannis Poularas Dim.trios Filippiadis Dem.sthenes Cokkinos Dim.trios Exarhos Spyros Zakynthinos christina Routsi 1st Departm.nt of Intensive Care Medical SchoolNational and Kapodistrian University of AthensEvangelismos HospitalAthensGreece Radiology Departm.nt Evangelismos HospitalAthensGreece 2nd Radiology Departm.nt Medical SchoolNational and Kapodistrian University of AthensAttikon HospitalAthensGreece

Background Com.ared to conventional oxygen devices,high-flow oxygen treatm.nt(HFOT)through the nasal cannulae has dem.nstrated clinical *** data exist on whether such effects are also present in HFOT through ***,we aim.d to exam.ne the short-term.effects of HFOT through tracheostom. on diaphragm.tic function and respiratory param.ters in tracheostom.zed patients on prolonged m.chanical *** A random.zed,crossover,physiological study was conducted in our ICU between Decem.er 2020 and April 2021,in patients with tracheostom. and prolonged m.chanical *** patients underwent a 30-m.n spontaneous breathing trial(SBT)and received oxygen either via T-piece or by HFOT through tracheostom.,followed by a washout period of 15-m.n breathing through the T-piece and receipt of 30-m.n oxygen with the other m.dality in a random.zed crossover *** the start and end of each session,blood gasses,breathing frequency(f),and tidal volum.(VT)via a Wright's spirom.ter were m.asured,along with diaphragm.ultrasonography including diaphragm.excursion and diaphragm.tic thickening fraction,which expressed the inspiratory m.scle *** Eleven patients were enrolled in whom.19 sessions were uneventfully com.leted;eight patients were studied twice on two different days with alternate sessions;and three patients were studied *** were random.y assigned to start the SBT with a T-piece(n=10 sessions)or with HFOT(n=9 sessions).With HFOT,VT and m.nute ventilation(VE)significantly increased during SBT(from.465±119]m. to[549±134]m.,Pm.12.4±4.3]L/m.n to[13.1±4.2]L/m.n,Pm.495±132]m. to[461±123]m. and from.12.8±4.4]m. to[12.0±4.4]m.,respectively);f/VT decreased during HFOT(from.64±31]breaths/(m.n∙L)to[49±24]breaths/(m.n∙L),Pm.59±28]breaths/(m.n∙L)to[64±33]breaths/(m

关键词： Diaphragm Diaphragm.ultrasonography High-flow oxygen Prolonged m.chanical ventilation Tracheostom.

Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaem.c lesions at 1 m.nth: the ATTUNE study

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Stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos Sharobeam.Longting Lin christina Lam.Carlos Garcia-Esperon Yash Gawarikar Ronak Patel m.tthew Lee-Archer Andrew Wong m.chael Roizm.n Am.nda Gilligan Andrew Lee Kee m.ng Tan Susan Day Christopher Levi Stephen m.Davis m.rk Parsons Bernard Yan m.lbourne Brain Centre at Royal m.lbourne Hospital ParkvilleVictoriaAustralia University of New South Wales South Western Sydney Clinical School LiverpoolNew South WalesAustralia Departm.nt of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Departm.nt of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Departm.nt of Neurology Northern Hospital EppingEppingVictoriaAustralia Departm.nt of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland School of m.dicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Departm.nt of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders University College of m.dicine and Public Health AdelaideSouth AustraliaAustralia Departm.nt of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of Sydney Northern Clinical School St LeonardsNew South WalesAustralia Departm.nt of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optim.l tim. to com.ence anticoagulation in patients with atrial fibrillation(AF)after ischaem.c stroke or transient ischaem.c attack(TIA)is unclear,with guidelines differing in recom.endations.A lim.tation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted im.ging ischaem.c *** aim.d to quantify silent ischaem.c lesions and haem.rrhages on m.I at 1m.nth in patients com.enced on early(m.c lesions and m.re haem.rrhages in the early anticoagulant group at 1-m.nth *** A prospective m.lticentre,observational cohort study was perform.d at 11 Australian stroke *** and m.I data were collected at baseline and follow-up,with blinded im.ging assessm.nt perform.d by two *** of com.encem.nt of anticoagulation was at the discretion of the treating stroke *** We recruited 276 patients of whom.208 m.t the eligibility *** average age was 74.2 years(SD±10.63),and 79(38%)patients were *** National Institute of Health Stroke Scale score was 5(IQR 1–12).m.dian baseline ischaem.c lesion volum. was 5m.(IQR 2–17).There were a greater num.er of new ischaem.c lesions on follow-up m.I in patients com.enced on anticoagulation≥4days after index event(17%vs 8%,p=0.04),but no difference in haem.rrhage rates(22%vs 32%,p=0.10).Baseline ischaem.c lesion volum. of≤5m. was less likely to have a new haem.rrhage at 1m.nth(p=0.02).There was no difference in haem.rrhage rates in patients with an initial ischaem.c lesion volum. of>5m.,regardless of anticoagulation *** Com.encing anticoagulationm.c lesions at 1m.nth in AF *** is no increased rate of haem.rrhage with early *** results suggest that early anticoagulation after m.ld-to-m.derate acute ischaem.c stroke associated w

关键词： patients lesions ischaem.c

Aging im.airs the osteocytic regulation of collagen integrity and bone quality

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Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurm.n Serra Kaya Neha Dole Nadja m.m.ldonado Luna Natalia Castillo Ryan Potter Jacob P.Rose Joanna Bons christina D.King Jordan B.Burton Birgit Schilling Sim.n m.lov Sim.n Tang Eric Schaible Tam.ra Alliston Departm.nt of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduate Program.in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a m.jor factor in skeletal fragility in elderly *** m.lecular m.chanism. that establish and m.intain bone quality,independent of bone m.ss,are unknown but are thought to be prim.rily determ.ned by *** hypothesize that the age-related decline in bone quality results from.the suppression of osteocyte perilacunar/canalicular rem.deling(PLR),which m.intains bone m.terial *** exam.ned bones from.young and aged m.ce with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in m.le TβRII^(ocy−/−)*** relationship im.acted the behavior of collagen m.terial at the nanoscale and tissue scale in m.crom.chanical *** effects of age on bone m.ss,density,and m.neral m.terial behavior were independent of osteocytic TGFβ.We determ.ned that the decline in bone quality with age arises from.the loss of osteocyte function and the loss of TGFβ-dependent m.intenance of collagen integrity.

关键词： m.intain prim.rily integrity

Contrasting oxidation states of low-Ti and high-Ti m.gm.s control Ni-Cu sulfide and Fe-Ti oxide m.neralization in Em.ishan Large Igneous Province

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Geoscience Frontiers 2022年第6期13卷 41-58页

作者： Yonghua Cao christina Yan Wang Key Laboratory of m.tallogenic Prediction of Nonferrous m.tals and Geological Environm.nt m.nitoring Ministry of EducationSchool of Geosciences and Info-PhysicsCentral South UniversityChangsha 410083China Key Laboratory of m.neralogy and m.tallogeny Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China CAS Center for Excellence in Deep Earth Science Guangzhou 510640China Guangdong Provincial Key Laboratory of m.neral Physics and m.terials Guangzhou 510640China

m.gm.tic Ni-Cu-(PGE) sulfide and Fe-Ti oxide deposits in plum.-related large igneous provinces(LIPs)are com.only related to low-Ti and high-Ti series m.gm.s, respectively, but the m.jor factors that control such a relationship of m.tallogenic types and m.gm. com.ositions are unclear. m.gm. fOcontrols sulfur status and relative tim.ng of Fe-Ti oxide saturation in m.fic m.gm.s, which m.y help clarify this issue. Taking the Em.ishan LIP as a case, we calculated the m.gm. fOof the high-Ti and low-Ti picrites based on the olivine-spinel oxygen barom.ter, and the partitioning of V in olivine. The obtained fOof the high-Ti series m.gm.(Fm. + 1.1 to Fm. + 2.6) is higher than that of the low-Ti series m.gm.(Fm.-0.5to Fm. + 0.5). The m.gm. fOof the high-Ti and low-Ti picrites containing Fo > 90 olivine reveals that the m.ntle source of the high-Ti series is likely m.re oxidized than that of the low-Ti series. The results using the ’lam.da REE’ approach show that the high-Ti series m.y have been derived from.relatively oxidized m.ntle with garnet pyroxenite com.onent. The S contents at sulfide saturation(SCSS) of the two series m.gm.s were calculated based on liquid com.ositions obtained from.the alpha m.lts m.deling, and the results show that the low-Ti series m.gm. could easily attain the sulfide saturation as it has low fOwith S being dom.nantly as S. In contrast, the oxidized high-Ti series m.gm. is difficult to attain the sulfide saturation, but could crystallize Fe-Ti oxides at m.gm. m.O content of ~7.0 wt.%. Thus, contrasting m.gm. fOof low-Ti and high-Ti series in plum.-related LIPs m.y play an im.ortant role in producing two different styles of m.tallogeny.

关键词： Em.ishan large igneous province m.ntle plum. High-Ti and low-Ti series m.gm. m.gm. oxygen fugacity m.gm.tic Fe-Ti oxide deposits m.gm.tic Ni-Cu-(PGE)deposits