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Oncofertility in adolescent and young adult hereditary cancer: Considerations for genetics professionals

World Journal of Medical Genetics 2015年第4期5卷 52-59页

作者： Gwendolyn P Quinn Beth N Peshkin Ivana Sehovic Meghan Bowman christina tamargo Susan T Vadaparampil Health Out-comes and Behavior Program Moffitt Cancer CenterDepartment of Oncologic SciencesMorsani College of MedicineUniversity of South Florida Cancer Prevention and Control Program Georgetown Lombardi Comprehensive Cancer Center Health Outcomes and Behavior Program Moffitt Cancer Center

Adolescents and young adults(AYA)with a cancer diagnosis or those at risk for cancer due to hereditary cancer syndromes may benefit from genetic counseling and testing not only to manage personal risk but also to address reproductive concerns,especially *** opportunity for genetic counselors to provide important risk information is relevant to both the newly diagnosed as well as to unaffected carriers and ***,genetic counselors may need additional training in reproductive options related to AYA cancer to provide this valuable *** commentary uses hereditary breast and ovarian cancer syndrome as a model to highlight important considerations when discussing preimplanatation genetic diagnosis and prenatal diagnosis,particularly in the context of expanded testing for hereditary cancer risk including multigene panels or whole exome or whole genome *** hereditary cancers are also addressed;however,less is known about the psychosocial and fertility concerns in these AYA ***,we provide an overview of the concept of"oncofertility"-the linkage between cancer care and reproductive medicine that aims to expand the reproductive opportunities of cancer patients-and offer support for the expansion of guidelines to include genetic counselors in AYA cancer patients’treatment planning related to reproductive health and fertility.

关键词： Fertility Oncology Genetic counselors Decision-making Oncofertility Adolescent young adults Training Health professionals

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