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Pleiotropic effects of apolipoprotein A-Ⅱ on high-density lipoprotein functionality, adipose tissue metabolic activity and plasma glucose homeostasis

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The Journal of Biomedical Research 2020年第1期34卷 14-26页

作者： Evangelia Zvintzou Eva Xepapadaki christina kalogeropoulou Serafoula Filou Kyriakos EKypreos Department of Pharmacology University of Patras Medical SchoolRio AchaiasTK 26500Greece

Apolipoprotein A-Ⅱ(APOA-Ⅱ) is the second most abundant apolipoprotein of high-density lipoprotein(HDL)synthesized mainly by the liver and to a much lesser extent by the intestine. Transgenic mice overexpressing human APOA-Ⅱ present abnormal lipoprotein composition and are prone to atherosclerosis, though in humans the role for APOA-Ⅱ in coronary heart disease remains controversial. Here, we investigated the effects of overexpressed APOA-Ⅱ on HDL structure and function, adipose tissue metabolic activity, glucose tolerance and insulin sensitivity. C57BL/6 mice were infected with an adenovirus expressing human APOA-Ⅱ or a control adenovirus Ad GFP, and five days post-infection blood and tissue samples were isolated. APOA-Ⅱ expression resulted in distinct changes in HDL apoproteome that correlated with increased antioxidant and anti-inflammatory activities. No effects on cholesterol efflux from RAW 264.7 macrophages were observed. Molecular analyses in white adipose tissue(WAT) indicated a stimulation of oxidative phosphorylation coupled with respiration for ATP production in mice overexpressing APOA-Ⅱ. Finally, overexpressed APOA-Ⅱ improved glucose tolerance of mice but had no effect on the response to exogenously administered insulin. In summary, expression of APOA-Ⅱ in C57BL/6 mice results in pleiotropic effects with respect to HDL functionality, adipose tissue metabolism and glucose utilization, many of which are beneficial to health.

关键词： apolipoprotein A-Ⅱ high-density lipoprotein adipose tissue glucose tolerance insulin sensitivity

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Apolipoprotein E in diet-induced obesity:a paradigm shift from conventional perception

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The Journal of Biomedical Research 2018年第3期32卷 183-190页

作者： Kyriakos E.Kypreos Eleni A.Karavia Caterina Constantinou Aikaterini Hatziri christina kalogeropoulou Eva Xepapadaki Evangelia Zvintzou Department of Pharmacology University of Patras Medical School

Apolipoprotein E（APOE） is a major protein component of peripheral and brain lipoprotein transport *** in peripheral circulation does not cross the blood brain barrier or blood cerebrospinal fluid barrier. As a result,peripheral APOE expression does not affect brain APOE levels and vice versa. Numerous epidemiological studies suggest a key role of peripherally expressed APOE in the development and progression of coronary heart disease while brain APOE has been associated with dementia and Alzheimer＇s disease. More recent studies, mainly in experimental mice, suggested a link between Apoe and morbid obesity. According to the latest findings, expression of human apolipoprotein E3（APOE3） isoform in the brain of mice is associated with a potent inhibition of visceral white adipose tissue（WAT） mitochondrial oxidative phosphorylation leading to significantly reduced substrate oxidation,increased fat accumulation and obesity. In contrast, hepatically expressed APOE3 is associated with a notable shift of substrate oxidation towards non-shivering thermogenesis in visceral WAT mitochondria, leading to resistance to obesity. These novel findings constitute a major paradigm shift from the widely accepted perception that APOE promotes obesity via receptor-mediated postprandial lipid delivery to WAT. Here, we provide a critical review of the latest facts on the role of APOE in morbid obesity.

关键词： apolipoprotein E morbid obesity white adipose tissue energy metabolism

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Liver Imaging Reporting and Data System criteria for the diagnosis of hepatocellular carcinoma in clinical practice: A pictorial minireview

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World Journal of Gastroenterology 2022年第32期28卷 4540-4556页

作者： christina Liava Emmanouil Sinakos Elissavet Papadopoulou Lamprini Giannakopoulou Stamatia Potsi Anestis Moumtzouoglou Anthi Chatziioannou Loukas Stergioulas Lydia kalogeropoulou Ioannis Dedes Evangelos Akriviadis Danai Chourmouzi 4^(th)Department of Internal Medicine Hippokratio HospitalAristotle University of ThessalonikiThessaloniki 54642Greece Department of Radiology Interbalkan Medical CenterThessaloniki 57001Greece

Hepatocellular carcinoma(HCC)is the sixth most common *** main risk factors associated with HCC development include hepatitis B virus,hepatitis C virus,alcohol consumption,aflatoxin B1,and nonalcoholic fatty liver ***,hepatocarcinogenesis is a complex multistep *** factors lead to hepatocyte malignant transformation and HCC *** and surveillance of HCC can be made with the use of liver ultrasound(US)every 6 ***,the sensitivity of this imaging method to detect HCC in a cirrhotic liver is limited,due to the abnormal liver *** tomography(CT)and magnetic resonance imaging(MRI)are considered to be most useful tools for at-risk patients or patients with inadequate *** biopsy is still used for diagnosis and prognosis of HCC in specific nodules that cannot be definitely characterized as HCC by *** the American College of Radiology designed the Liver Imaging Reporting and Data System(LI-RADS),which is a comprehensive system for standardized interpretation of CT and MRI liver examinations that was first proposed in *** 2018,it was integrated into the American Association for the Study of Liver Diseases guidance statement for ***-RADS is designed to ensure high sensitivity,precise categorization,and high positive predictive value for the diagnosis of HCC and is applied to“highrisk populations”according to specific *** importantly LI-RADS criteria achieved international collaboration and consensus among liver experts around the world on the best practices for caring for patients with or at risk for HCC.

关键词： Hepatocellular carcinoma Hepatocarcinogenesis Computed tomography Magnetic resonance imaging Liver Imaging Reporting and Data System

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