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Conjugated hyperbilirubinemia presenting in first fourteen days in term neonates

World Journal of Hepatology 2017年第26期9卷 1108-1114页

作者： Fang Kuan Chiou christina Ong Kong Boo Phua Fares Chedid Ajmal Kader Gastro-enterology Service Paediatric Medicine KK Women’s and Children’s Hospital Neonatal Medicine Al Jalila Children’s Specialty Hospital Pediatric Gastroenterology Dubai Hospital

AIM To describe the etiology and characteristics of earlyonset conjugated hyperbilirubinemia(ECHB) presenting within 14 d of life in term *** Retrospective review was performed of term infants up to 28-d-old who presented with conjugated hyperbilirubinemia(CHB) at a tertiary center over a 5-year period from January 2010 to December 2014. CHB is defined as conjugated bilirubin(CB) fraction greater than 15% of total bilirubin and CB greater or equal to 25 μmol/L. ECHB is defined as CHB detected within 14 d of life. "Late-onset" CHB(LCHB) is detected at 15-28 d of life and served as the comparison *** Total of 117 patients were recruited: 65 had ECHB, 52had LCHB. Neonates with ECHB were more likely to be clinically unwell(80.0% vs 42.3%, P < 0.001) and associated with non-hepatic causes(73.8% vs 44.2%, P = 0.001) compared to LCHB. Multifactorial liver injury(75.0%) and sepsis(17.3%) were the most common causes of ECHB in clinically unwell infants, majority(87.5%) had resolution of CHB with no progression to chronic liver disease. Inborn errors of metabolism were rare(5.8%) but associated with high mortality(100%) in our series. In the subgroup of clinically well infants(n = 13) with ECHB, biliary atresia(BA) was the most common diagnosis(61.5%), all presented initially with normal stools and decline in total bilirubin but with persistent CHB. CONCLUSION Secondary hepatic injury is the most common reason for ECHB. BA presents with ECHB in well infants without classical symptoms of pale stools and deep jaundice.

关键词： Conjugated hyperbilirubinemia Biliary atresia Cholestasis Direct hyperbilirubinemia Neonatal jaundice

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Advanced diffusion magnetic resonance imaging in patients with Alzheimer’s and Parkinson’s diseases

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Neural Regeneration Research 2020年第9期15卷 1590-1600页

作者： Koji Kamagata christina Andica Taku Hatano Takashi Ogawa Haruka Takeshige-Amano Kotaro Ogaki Toshiaki Akashi Akifumi Hagiwara Shohei Fujita Shigeki Aoki Department of Radiology Juntendo University Graduate School of MedicineTokyoJapan Department of Neurology Juntendo University School of MedicineTokyoJapan

The prevalence of neurodegenerative diseases is increasing as human longevity increases. The objective biomarkers that enable the staging and early diagnosis of neurodegenerative diseases are eagerly anticipated. It has recently become possible to determine pathological changes in the brain without autopsy with the advancement of diffusion magnetic resonance imaging techniques. Diffusion magnetic resonance imaging is a robust tool used to evaluate brain microstructural complexity and integrity, axonal order, density, and myelination via the micron-scale displacement of water molecules diffusing in tissues. Diffusion tensor imaging, a type of diffusion magnetic resonance imaging technique is widely utilized in clinical and research settings;however, it has several limitations. To overcome these limitations, cutting-edge diffusion magnetic resonance imaging techniques, such as diffusional kurtosis imaging, neurite orientation dispersion and density imaging, and free water imaging, have been recently proposed and applied to evaluate the pathology of neurodegenerative diseases. This review focused on the main applications, findings, and future directions of advanced diffusion magnetic resonance imaging techniques in patients with Alzheimer's and Parkinson's diseases, the first and second most common neurodegenerative diseases, respectively.

关键词： Alzheimer's disease biomarkers diffusional kurtosis imaging disease progression early diagnosis free-water imaging neurites neurite orientation dispersion and density imaging Parkinson's disease

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Rural-urban differences in distributions and determinants of facility delivery among women in Bangladesh

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Global Health Journal 2023年第4期7卷 222-229页

作者： Jannatun Nayeem christina Stennett Atia Sharmeen Md Mahbub Hossain Gulam Muhammed Al Kibria Comilla Medical College Comilla 3500Bangladesh University of Maryland School of Medicine BaltimoreMD 21201United States Morgan State University BaltimoreMD 21093United States Texas A&M School of Public Health College StationTexasTX 77843United States Johns Hopkins Bloomberg School of Public Health BaltimoreMD 21205United States

Introduction:The utilization of facility delivery is crucial to achieve sustainable development goals by reducing maternal and neonatal *** study aimed to compare the distributions and determinants of childbirth in health facilities in urban and rural regions of ***:Cross-sectional data from the 2017-2018 Bangladesh Demographic and Health Survey were *** logistic regression was ***:A total of 4751 women were included in the *** 50%of childbirths took place in health facilities,63.4%and 44.6%in urban and rural regions,***,the odds of the association between facility delivery and the studied factors were *** women had significantly lower odds of facility delivery in both rural(adjusted odds ratio[AOR]=0.3,95%confidence interval[CI]:0.2 to 0.5)and urban(AOR=0.2,95%CI:0.1 to 0.5)*** both regions,women with higher education levels,highly educated husbands,antenatal care(ANC),and higher wealth indexes had significantly higher odds of facility ***:Several common associated factors were ***,differences were observed regarding distributions of these *** differences in facility delivery utilization could result from lower ANC utilization,socioeconomic status,and transportation facilities in rural regions than urban regions;therefore,improving these conditions could increase facility delivery in these regions.

关键词： Bangladesh Facilitydelivery Determinants Distributions Urban Rural Childbirth

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Characterization of microbial communities associated with African desert dust and their implications for human and ecosystem health

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Chinese Journal Of Geochemistry 2006年第B8期25卷 218-219页

作者： christina A. Kellogg Florida Integrated Science Center U.S. Geological Survey St. Petersburg USA

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Prevalence of selective immunoglobulin A deficiency in Greek children and adolescents with type 1 diabetes

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World Journal of Pediatrics 2016年第4期12卷 470-476页

作者： Styliani Giza Eleni Kotanidou Efimia Papadopoulou-Alataki Maria christina Antoniou Ioanna Maggana Ioannis Kyrgios Assimina Galli-Tsinopoulou 4th Department of Pediatrics Faculty of MedicineAristotle University of ThessalonikiPapageorgiou General HospitalThessalonikiGreece

Background:The association of selective immunoglobulin A(IgA)deficiency with type 1 diabetes(T1D)remains *** study was to evaluate serum IgA concentrations in Greek children and adolescents with ***:In two hundred individuals with T1D,serum IgA concentrations were quantitatively determined using ***:Immunoglobulin A deficiency was detected in 6(3.0%)of 200 patients who were subjected to immunological *** infections were not recorded,but human papilloma virus infection was clinically suspected and confirmed by laboratory examination in a 5-year-old *** regard to coincidence of selective IgA deficiency with autoimmune diseases,celiac disease was detected in a girl and juvenile idiopathic arthritis in a *** IgA concentrations differed significantly when patients were grouped according to age at the beginning of the study(P<0.001),age at diagnosis of T1D(P=0.015)and coincidence of celiac disease(CD)(P=0.038).However,when the age of the patients was adjusted,difference in serum IgA concentrations was not statistically significant despite CD was present or ***,serum IgA concentrations were positively correlated with serum IgG(P<0.001)and IgE(P=0.001)concentrations and negatively correlated with serum antigliadin antibody IgG(P=0.035)*** was no association or correlation of serum IgA concentrations with glycemic ***:The prevalence of selective IgA deficiency in Greek children and adolescents with T1D is high(3.0%).The correlation of serum IgA concentrations with serum IgG,IgE and anti-gliadin antibody IgG concentrations needs further investigation.

关键词： adolescents children immunoglobulin A deficiency type 1 diabetes

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Spectral Modifications of Graphene Using Molecular Dynamics Simulations

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Journal of Modern Physics 2014年第4期5卷 149-156页

作者： David Liesegang christina Oligschleger Department of Applied Science Bonn-Rhine-Sieg University of Applied Sciences Rheinbach Germany

We investigated graphene structures grafted with fullerenes. The size of the graphene sheets ranges from 6400 to 640,000 atoms. The fullerenes (C60 and C240) are placed on top of the graphene sheets, using different impact velocities we could distinguish three types of impact. Furthermore, we investigated the changes of the vibrational properties. The modified graphene planes show additional features in the vibronic density of states.

关键词： Molecular Dynamics Graphene Nano-Systems

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Curriculum Reform of“Woven Fabric Structure Design and Application”in Higher Vocational College Based on Industry-College Partnerships

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Sociology Study 2023年第2期13卷 75-82页

作者： Yan Chen christina Andin Shandong Vocational College of Light Industry ZiboShandongChina Universiti Malaysia Sabah SabahMalaysia

The curriculum“Woven Fabric Structure Design and Application”is the core curriculum of textile majors in higher vocational colleges,which plays a very important role in the cultivation of students’vocational ability and professional *** curriculum reform of“Woven Fabric Structure Design and Application”through the deep cooperation of industry-college partnerships,the comprehensive analysis of the major training objectives and graduation requirements,the redesign of the curriculum teaching content,the improvement of the teaching method and the examination method,has achieved good results.

关键词： woven fabric structure design and application curriculum reform higher vocational education industry-college partnerships

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Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases

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World Journal of Gastroenterology 2006年第41期12卷 6627-6633页

作者： Claudia Rubie Vilma Oliveira Frick Mathias Wagner christina Weber Bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling Department of General- Visceral-Vascular-and Paediatric SurgeryUniversity of the SaarlandHomburg/Saar 66421Germany Institute of Pathology University of the SaarlandHomburg/Saar 66421Germany Institute of Medical Biometrics Epidemiologyand Medical InformaticsUniversity of the SaarlandHomburg/ Saar 66421Germany

AIM： To evaluate and compare the expression profiles of CXCL12 （SDF-1）, CCL19 （MIP-3β）, CCL20 （MIP-3a） and CCL21 （6Ckine, Exodus2） and their receptors on RNA and protein levels in hepatocellular carcinoma （HCC） versus colorectal liver metastases （CRLM） and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS： Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent nontumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS： Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up-regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION： Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up-regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies.

关键词： Chemokines Chemokine receptors Gene expression Hepatocellular carcinoma Colorectal liver metastases

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Transgenerational Inheritance and Resetting of Stress, Induced Loss of Epigenetic Gene Silencing in Arabidopsis

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Molecular Plant 2010年第3期3卷 594-602页

作者： christina Lang-Mladek Olga Popova Kathrin Kiok Marc Berlinger Branislava Rakic Werner Aufsatz Claudia Jonak Marie-Theres Hauser Christian Luschnig Department of Applied Genetics and Cell Biology University of Applied Life Sciences and Natural Resources (BOKU) Muthgasse 18 1190 Vienna Austria Gregor Mendel Institute of Molecular Plant Biology Austrian Academy of Sciences Dr. Bohr-Gasse 3 1030 Vienna Austria

Plants, as sessile organisms, need to sense and adapt to heterogeneous environments and have developed sophisticated responses by changing their cellular physiology, gene regulation, and genome stability. Recent work dem- onstrated heritable stress effects on the control of genome stability in plants--a phenomenon that was suggested to be of epigenetic nature. Here, we show that temperature and UV-B stress cause immediate and heritable changes in the epi- genetic control of a silent reporter gene in Arabidopsis. This stress-mediated release of gene silencing correlated with pronounced alterations in histone occupancy and in histone H3 acetylation but did not involve adjustments in DNA meth- ylation. We observed transmission of stress effects on reporter gene silencing to non-stressed progeny, but this effect was restricted to areas consisting of a small number of cells and limited to a few non-stressed progeny generations. Further- more, stress-induced release of gene silencing was antagonized and reset during seed aging. The transient nature of this phenomenon highlights the ability of plants to restrict stress-induced relaxation of epigenetic control mechanisms, which likely contributes to safeguarding genome integrity.

关键词： Abiotic stress epigenome stability histone acetylation gene silencing.

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The City Mouse and the Garden Mouse

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小学生时代（大嘴英语） 2019年第3期 24-26页

作者： christina Rossetti Helen Cann(图) 不详

The city mouse lives in a house;The garden mouse lives in a bower, He's friendly with the frogs, And sees the pretty plants in flowers.

关键词： city mouse garden mouse plants in flowers

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