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Risk of Cardiovascular Events in Patients with Primary Biliary Cholangitis-Systematic Review

Journal of Clinical and Translational Hepatology 2018年第2期6卷 119-126页

作者： Duminda Suraweera christina fanous Melissa Jimenez Myron J.Tong Sammy Saab Department of Medicine Olive-View Medical CenterSylmarCAUSA Department of Surgery at the University of California at Los Angeles Los AngelesCAUSA Huntington Research Institute PasadenaCAUSA Department of Medicine at the University of California at Los Angeles Los AngelesCAUSA

Background and Aims:Hypercholesterolemia is a common finding in patients with primary biliary cholangitis(PBC)and is a well-defined risk factor for cardiovascular ***,studies have been mixed on whether PBC patients do,in fact,have higher cardiovascular *** aim of this study is to review the current literature and provide an evidence-based assessment of cardiovascular risk in PBC ***:We performed a systematic literature search on PubMed re-garding patients with PBC and cardiovascular events from the database inception to July 1,2017.A total of 33 articles ful-filling our inclusion criteria were ***:The majority of the studies evaluated yielded no statistically significant dif-ference in cardiovascular disease in the PBC population com-pared to the general ***,some reports found a statistically significantly increase in coronary artery *** studies have looked at the specific lipid profile of pa-tients with PBC with *** these lipid ab-normalities differ by stage of disease,there is evidence to suggest that the specific lipid profile in PBC may have lower atherogenicity than in patients with hypercholesterolemia without *** looking at patients with PBC with other risk factors for cardiovascular disease,such as hypertension and metabolic syndrome,have consistently found a higher risk for cardiovascular disease in these *** treat-ment is effective in reducing lipid levels and possibly improv-ing endothelial inflammation in patients with PBC with ***:There is not enough evidence to suggest an increased risk of cardiovascular dis-ease in patients with PBC with hypercholesterolemia,except for those individuals with concomitant features of metabolic *** patients with PBC with no additional cardiovas-cular risk factors,individual risk/benefit discussion on lipid-lowering treatment should be considered.

关键词： Primary biliary cholangitis(PBC) Cardiovascular risk Hypercholesterolemia

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