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Neural plasticity in Parkinson's disease:a neuroimaging perspective

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Neural Regeneration Research 2024年第6期19卷 1203-1205页

作者： christina Andica Koji Kamagata Department of Radiology Juntendo University Graduate School of MedicineTokyoJapan Faculty of Health Data Science Juntendo UniversityChibaJapan

Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least *** disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum.

关键词： rigidity tremor primarily

Machine learning based state-of-charge prediction of electrochemical green hydrogen production:Zink-Zwischenschritt-Elektrolyseur(ZZE)

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Energy and AI 2024年第2期16卷 269-276页

作者： Daniel Vila Elisabeth Hornberger christina Toigo STOFF2 GmbH–Gebäude H/Flughafen Tegel 1 13405 BerlinGermany University of Applied Sciences Upper Austria Stelzhamerstraße 23A-4600 WelsAustria Centre for Economic Research on Inclusivity and Sustainability at the University of Galway University RoadGalwayIreland

The intermittency of renewable energy is a key limiting factor for the successful decarbonization of both energy producing and consuming sectors. Green hydrogen has the potential to act as the central energy vector connecting hard-to-abate sectors to renewable power. However, combining energy storage and conversion for a holistic electrolyzer system remains challenging. Here, we show the innovative Zink-Zwischenschritt Elektrolyseur (ZZE), or Zinc Intermediate step Electrolyzer in English, that temporarily decouples the water splitting reaction and uses zinc to store electrical energy in chemical form. To perform optimal operation of a ZZE system, machine learning models were applied to predict the state of charge of a lab scale ZZE system. Using various models, we were able to determine the effectiveness of the prediction and contrast it to state of charge predictions of other energy storage systems. We show that a bi-directional long short-term memory neural network approach has the lowest error within the testing environment. This work serves to perform further ZZE development as well as state of charge prediction for other novel energy storage technologies.

关键词： Electrolyzer Battery ZZE Energy storage State of charge Machine learning Sequence-to-sequence model

The Disintegration of a Floating Ferrofluid Layer into an Ordered Drop System in a Vertical Magnetic Field

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Fluid Dynamics & Materials Processing 2024年第10期20卷 2205-2218页

作者： christina Khokhryakova Konstantin Kostarev Irina Mizeva Laboratory of Dispersed System Dynamics Institute of Continuous Media Mechanics UrB RASPerm614018Russia Laboratory of Hydrodynamical Stability Institute of Continuous Media Mechanics UrB RASPerm614018Russia Laboratory of Turbulence Institute of Continuous Media Mechanics UrB RASPerm614018Russia

Magnetic fluids,also known as ferrofluids,are versatile functional materials with a wide range of *** applications span from industrial uses such as vacuum seals,actuators,and acoustic devices to medical uses,including serving as contrast agents for magnetic resonance imaging(MRI),delivering medications to specific locations within the body,and magnetic hyperthermia for cancer *** use of a non-wettable immiscible liquid substrate to support a layer of magnetic fluid opens up new possibilities for studying various fluid flows and related instabilities in multi-phase systems with both a free surface and an *** presence of two deformable boundaries within a ferrofluid layer significantly reduces the critical magnetic field strength required to transform the layer into an organized system of drops or polygonal figures evolving according to the intensity,frequency and direction of the considered magnetic *** paper experimentally investigates this problem by assuming a uniform magnetic field perpendicular to the *** specific subject has not been previously explored *** critical magnetic field intensity required to destabilize the ferrofluid layer is determined based on the layer’s thickness and the fluid’s initial magnetic *** is demonstrated that the critical magnetic field strength needed to disrupt the initially continuous ferrofluid layer increases with the layer’s ***,an increase in the ferrofluid’s magnetic susceptibility results in a decrease in the critical magnetic field *** emerging droplet structures are analyzed in terms of the number of drops,their size,and the periodicity of their *** number of droplets formed depends on the initial thickness of the layer,the presence or absence of a stable rupture in the upper layer,and the rate at which the magnetic field strength is increased to the critical value.A characteristic viscous time is proposed

关键词： Ferrofluid liquid substrate normal field instability ordered droplet structure

Microglial complex I activity: a crucial factor for smoldering inflammation in the central nervouss system

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3165-3166页

作者： Jana K.Sonner christina Mayer Manuel A.Friese Institute of Neuroimmunology and Multiple Sclerosis University Medical Center Hamburg-EppendorfHamburgGermany

In their article published in Nature,Peruzotti-Jametta et *** metabolic reprogramming of microglia as a defining characteristic of their persistent and harmful activation during inflammatory neurodegeneration,which is observable in conditions like multiple sclerosis(MS).Subsequently,the authors demonstrate how mitigating mitochondrial dysregulation in microglia alleviates disease progression in an animal model of MS,thereby unveiling a potential novel target for the treatment of MS(Fig.1).

关键词： inflammation al. thereby

Expedition to the blockchain application potential for higher education institutions

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Blockchain(Research and Applications) 2024年第3期5卷 53-66页

作者： Matthias Gottlieb christina Deutsch Felix Hoops Hans Pongratz Helmut Krcmar Bavarian Ministry of Digital Affairs 80333 MunichGermany Technical University of Munich 85478 Garching By MunichGermany TU Dortmund University 44139 DortmundGermany

In the education sector,blockchain is currently at the end of the peak of inflated expectations in Gartner’s Hype ***,it is crucial to understand whether this technology meets the expectations of Higher Education Institutions(HEIs).We go on an expedition to identify blockchain application scenarios and its potential for HEI administration-the universities are digitalized to just 23.3%.Current information systems research addresses classifications of blockchain-based projects(application level)rather than their technical realization(protocol level).Thus,when evaluating blockchain application scenarios in HEI administration,we intensively consider the technical side of blockchain-based *** perform a threestep approach:(1)systematic literature review,(2)qualitative exploratory semi-structured interviews to sup-plement information on market-ready solutions,and(3)an evaluation of the potential of the blockchain-based projects identified,based on HEI administration *** find that the leading blockchain application scenarios are credential verification and *** the protocol level,we obtain equivocal results regarding the technical realization of projects,e.g.,their underlying blockchain types and storage *** the application level,when discussing the potential of different projects,we find that most of them address adaptability,complexity decomposition,and cost reduction requirements between HEIs;interest diversity and stakeholder collaboration between HEIs and business actors;privacy and trust between HEIs and students.

关键词： Blockchain Higher education institution(HEI) Administration Protocol level Application level Application

Microalgae contribution in enhancing the circular economy drive of biochemical conversion systems-A review

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Carbon Resources Conversion 2024年第2期7卷 95-109页

作者： Kelechi E.Anyaoha Felix Krujatz Isla Hodgkinson Roman Maletz christina Dornack Technische Universität Dresden Chair of Waste Management and Circular EconomyPratzschwitzer Str.1501796 PirnaGermany Institute of Natural Materials Technology RadebergGermany Biotopa gGmbH Center for Applied Aquaculture and Bioeconomy RadebergGermany Department of Agricultural Engineering Imo State Polytechnic OmumaNigeria

The global impact of greenhouse gas emissions requires concerted efforts to reduce emissions and energy use,and to increase carbon capture and *** the circular economy in CO_(2)sequestration systems optimises resource use and reduces the emissions burden throughout the supply *** capture from anaerobic digestion,composting and fermentation(particularly ethanol)processes offers great opportunities for climate change *** waste/by-products generated from these processes can limit the need to source nutrients from outside the system and increase the potential for circular *** integration of microalgae cultivation with each of anaerobic digestion,composting and ethanol fermentation processes provides a new model for climate change mitigation of biogenic CO_(2)and circular *** this model is limited by high energy consumption and nutrient demand,seasonal variability,operational efficiency and end-user requirements,further research and policy support will go a long way in realising the associated benefits,including in CO_(2)fixation,nutrient recovery,waste remediation and as an alternative source of animal feed.

关键词： Circular economy Anaerobic digestion Composting Microalgae

Exploring impacts of COVID-19 on spatial and temporal patterns of visitors to Canadian Rocky Mountain National Parks from social media big data

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Journal of Forestry Research 2024年第4期35卷 13-33页

作者： Dehui christina Geng Amy Li Jieyu Zhang Howie W.Harshaw Christopher Gaston Wanli Wu Guangyu Wang National Park Research Centre Faculty of ForestryUniversity of British ColumbiaVancouver V6T 1Z4Canada Faculty of Applied Science University of British ColumbiaVancouver V6T 1Z3Canada Paul G.Allen School of Computer Science&Engineering University of WashingtonSeattleWA 98195USA Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmonton T6G 2J9Canada Department of Wood Science Faculty of ForestryUniversity of British ColumbiaVancouver V6T 1Z4Canada

COVID-19 posed challenges for global tourism *** in visitor temporal and spatial patterns and their associated determinants pre-and peri-pandemic in Canadian Rocky Mountain National Parks are *** was collected through social media programming and analyzed using spatiotemporal analysis and a geographically weighted regression(GWR)*** highlight that COVID-19 significantly changed park visitation *** tended to explore more remote areas *** GWR model also indicated distance to nearby trails was a significant influence on visitor *** results indicate that the pandemic influenced tourism temporal and spatial *** research presents a novel approach using combined social media big data which can be extended to the field of tourism management,and has important implications to manage visitor patterns and to allocate resources efficiently to satisfy multiple objectives of park management.

关键词： Tourism management Social media big data National parks COVID-19 Geographical weighted regression

Sol-gel derived B_(2)O_(3)-CaO borate bioactive glasses with hemostatic,antibacterial and pro-angiogenic activities

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Regenerative Biomaterials 2024年第1期3卷 108-118页

作者： Kai Zheng Faina Bider Mahshid Monavari Zhiyan Xu christina Janko Christoph Alexiou Ana M.Beltran Aldo R.Boccaccini Jiangsu Province Engineering Research Center of Stomatological Translational Medicine College of StomatologyNanjing Medical UniversityNanjing 210029China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing 210029China Institute of Biomaterials University of Erlangen-Nuremberg91058 ErlangenGermany Department of Oto-Rhino-Laryngology Head and Neck SurgerySection of Experimental Oncology and Nanomedicine(SEON)Else Kroener-Fresenius-Stiftung ProfessorshipUniversitaetsklinikum Erlangen91058 ErlangenGermany Departamento de Ingenier�ıa y Ciencia de los Materiales y del Transporte Escuela Politecnica

Sol-gel borate bioactive glasses(BGs)are promising ion-releasing biomaterials for wound healing ***,we report the synthesis of a series of binary B_(2)O_(3)-CaO borate BGs(CaO ranging from 50 to 90mol%)using a sol-gel-based *** influence of CaO content in B_(2)O_(3)-CaO borate BG on morphology,structure and ion release behavior was investigated in *** dissolution(ion release)and crystallization could be observed in borate BGs when CaO content increased,while the morphology was not significantly altered by increasing CaO *** results evidenced that the ion release behavior of borate BGs could be tailored by tuning the B_(2)O_(3)/CaO molar *** also evaluated the in vitro cytotoxicity,hemostatic,antibacterial and angiogenic activities of borate *** was validated for all borate ***,borate BGs exhibited composition-dependent hemostatic,antibacterial and angiogenic ***,higher contents of Ca in borate BGs facilitated hemostatic activity,while higher contents of B_(2)O_(3) were beneficial for pro-angiogenic *** synthesized sol-gel-derived borate BGs are promising materials for developing advanced wound healing dressings,given their fast ion release behavior and favorable hemostatic,antibacterial and angiogenic activities.

关键词： borate glasses sol-gel processing glass composition wound healing

Feasibility,efficacy,and safety of animal-assisted activities with visiting dogs in inpatient pediatric oncology

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World Journal of Pediatrics 2024年第9期20卷 915-924页

作者： Katja Steff Maximilian Grasemann Kira Ostermann Sarah christina Goretzki Peter-Michael Rath Dirk Reinhardt Michael M.Schündeln Pediatric Hematology and Oncology Department of Pediatrics IIIUniversity of Duisburg-EssenHufelandstr.5545122EssenGermany Department of Psychology Medical School HamburgHamburgGermany Pediatric Infectiology Department of Pediatrics IUniversity of Duisburg-EssenEssenGermany Institute of Medical Microbiology University of Duisburg-EssenEssenGermany

Background Childhood cancer entails a heavy burden for patients and their *** advances in overall survival rates have increasingly brought long-term quality of life into ***-assisted activities(AAAs)have long been hypothesized to alleviate the burden on pediatric patients and their peers in the hospital ***,their use in inpatient pediatric oncology has been a sensitive issue mainly due to the fear of infections,resulting in a lack of *** study presents data on the feasibility,safety,and efficacy of AAAs from a single German *** Between 2018 and 2022,60 patients(median age=10.3 years)diagnosed with malignancy and undergoing treatment were visited by an intervention dog(total visits=100).Patients were screened for infections as per hospital policy,with additional microbiological testing performed based on *** dog was screened for human pathogens and *** data and hospitalizations were analyzed from two months prior to the first visit until two months after the last *** of being in the hospital,both with and without planned animal-assisted interventions and pre-and post-intervention state stress,were measured using a validated visual analogue scale(0-10).Results Patients benefited from AAAs,showing increased acceptance of being in the hospital(median:7.25 vs.4.50,P<0.001)and decreased median state stress ratings one hour after the visit compared to one hour before the visit(1.00 vs.4.25,P<0.001).The intervention did not result in an increased number of infections or unplanned hospitalizations,and no zoonoses were *** microbial screening tests of the dog were *** AAAs with visiting dogs in inpatient pediatric oncology are feasible and *** they hold promise for enhancing patients’well-being,further prospective studies are needed.

关键词： Animal-assisted activities Animal-assisted interventions Animal-assisted therapy Feasibility Infection control Inpatient pediatric oncology Safety Stress response Therapy dog Visiting dog