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Neural Regeneration Research 2024年第4期19卷 788-799页

作者： R.Scott Duncan Sean M.Riordan Matthew C.Gernon peter Koulen Department of Ophthalmology School of MedicineUniversity of Missouri Department of Biomedical Sciences School of MedicineUniversity of Missouri

Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a variety of effects in the human *** have been studied in cellular and animal models as well as in human clinical trials for their therapeutic benefits in several human *** of these include central nervous system(CNS)diseases and dysfunctions such as forms of epilepsy,multiple sclerosis,Parkinson’s disease,pain and neuropsychiatric *** addition,the endogenously produced cannabinoid lipids,endocannabinoids,are critical for normal CNS function,and if controlled or modified,may represent an additional therapeutic avenue for CNS *** review discusses in vitro cellular,ex vivo tissue and in vivo animal model studies on cannabinoids and their utility as therapeutics in multiple CNS *** addition,the review provides an overview on the use of cannabinoids in human clinical trials for a variety of CNS *** and endocannabinoids hold promise for use as disease modifiers and therapeutic agents for the prevention or treatment of neurodegenerative diseases and neurological disorders.

关键词： anandamide cannabidiol cannabinoid endocannabinoid epilepsy multiple sclerosis neurodegeneration neuroprotection tetrahydrocannabinol

Relationship between the unique microstructures and behaviors of high-entropy alloys

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1350-1363页

作者： Yaqi Wu peter KLiaw Ruixuan Li Weiran Zhang Guihong Geng Xuehui Yan Guiqun Liu Yong Zhang State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA Xi’an Rare Metal Materials Institute Co.Ltd. Xi’an 710016China School of Materials Science and Engineering North Minzu UniversityYinchuan 750030China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China

High-entropy alloys(HEAs),which were introduced as a pioneering concept in 2004,have captured the keen interest of nu-merous ***,in this context,can be perceived as representing disorder and *** contrast,elemental composi-tions within alloy systems occupy specific structural sites in space,a concept referred to as *** accordance with Shannon entropy,structure is analogous to ***,the arrangement of atoms within a material,termed its structure,plays a pivotal role in dictating its *** addition to expanding the array of options for alloy composites,HEAs afford ample opportunities for diverse structural *** profound influence of distinct structural features on the exceptional behaviors of alloys is underscored by numer-ous *** features include remarkably high fracture strength with excellent ductility,antiballistic capability,exceptional radi-ation resistance,and corrosion *** this paper,we delve into various unique material structures and properties while elucidating the intricate relationship between structure and performance.

关键词： high-entropy alloys unique microstructure special properties alloy design

Sparse identification-assisted exploration of the atomic-scale deformation mechanism in multiphase CoCrFeNi high-entropy alloys

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Science China(Technological Sciences) 2024年第4期67卷 1124-1132页

作者： XIAO Lu GUO XiaoXiang SUN YuTong WANG Gang LONG WeiMin LIAW peter K. REN JingLi School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China Institute of Materials Shanghai UniversityShanghai 200444China SKL of Advanced Brazing Metals&Technology Zhengzhou Research Institute of Mechanical EngineeringZhengzhou 450001China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA

This study investigated the atomic-scale deformation mechanism of multiphase CoCrFeNi high-entropy alloys(HEAs)at liquid helium,liquid nitrogen,and room temperatures.A million-atom multiphase HEA was prepared using molecular dynamics simulation involving melt and quench *** HEA exhibited high-density dislocations and some twins,consistent with experimental *** analysis revealed an inconsistent evolution of the microstructure under tensile *** particular,the elastic and initial plastic stages exhibited an increase in the disordered structure at the expense of the face-centered cubic and hexagonal close-packed structures,followed by a subsequent transformation involving multiple structural ***,through sparse identification,a model depicting microstructural evolution during tension was extracted for the CoCrFeNi HEA at three typical temperatures and three tensile *** model highlighted the importance of the body-centered cubic structure in the evolutionary process.

关键词： high-entropy alloy data-driven method microstructure evolution multiphase structure molecular dynamics simulation

铜锌交互作用和土壤γ-辐射对大麦和黑麦草生长的影响

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土壤 2000年第2期32卷 95-98页

作者：骆永明严蔚东 peterchristie 中国科学院南京土壤研究所南京210008 TheQueen’sUniversityofBelfast

盆栽试验结果表明 ,在外加铜 1 0 0mgkg-1和锌 1 5 0mgkg-1时 ,铜锌交互作用可提高其毒性 ,使大麦和黑麦草生物量显著减少和土壤铜锌临界限值降低。土壤γ -辐射可促进金属单一或复合污染及对照土壤上大麦和黑麦草生长而增产 ,但在外源... 详细信息

盆栽试验结果表明 ,在外加铜 1 0 0mgkg-1和锌 1 5 0mgkg-1时 ,铜锌交互作用可提高其毒性 ,使大麦和黑麦草生物量显著减少和土壤铜锌临界限值降低。土壤γ -辐射可促进金属单一或复合污染及对照土壤上大麦和黑麦草生长而增产 ,但在外源铜污染 (1 0 0mgkg-1)时 ,植物受害、生物量显著减少。黑麦草对Cu的敏感性高于春大麦。

关键词：铜锌交互作用 γ-辐射大麦土壤标准土壤污染

Comparisons and optimization of two absorption chiller types by considering heat transfer area,exergy and economy as single-objective functions

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Clean Energy 2024年第1期8卷 55-65页

作者： Yida Qiu Jingkun Wang Jing Han Yuzhu Chen Jun Wang peter D.Lund Management School University of LiverpoolLiverpool L693BXUK Power China Huadong Engineering Corporation Limited No.201 Gaojiao RoadHangzhou 311122China Key Laboratory of Solar Energy Science and Technology in Jiangsu Province Southeast UniversityNo 2 Si Pai LouNanjing210096China School of Science Aalto UniversityPO Box 15100FI-00076Aalto(Espoo)Finland

Absorption cooling technology is an environmentally friendly method to generate continuous chilled water making use of multiple thermal sources,such as waste heat and renewable thermal *** this study,two absorption chillers(nominal capacity of 400 kW)with series and parallel connections are *** research the ideal configuration of chillers after thermodynamic analysis,the structures of the chillers are optimized using the particle swarm optimization algorithm by considering the heat transfer area(HTA),exergy efficiency and total annual cost as single-objective *** impact of temperature differences between external and internal flows,heat exchanger efficiencies and the solution allocation ratio is *** optimized HTA,coefficient of perform-ance,exergy efficiency and total annual cost are 149.0 m^(2),1.56,29.44%and$229119 for the series-connected chiller,and 146.7 m^(2),1.59,31.45%and$234562 for the parallel-connected type,*** the lowest HTA condition,compared with the reference simulation results,the energy and exergy performances are improved,while the annual total cost is *** annual total cost is highest when maximizing the exergy efficiency,which is attributed to the increase in the *** operating cost accounts for 27.42%(series type)and 26.54%(parallel type)when the annual cost is the lowest.

关键词： absorption chiller series/parallel-connected temperature difference parameters solution allocation ratio

Advancements in adsorption and photodegradation technologies for Rhodamine B dye wastewater treatment: fundamentals, applications, and future directions

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Green Chemical Engineering 2024年第4期5卷 440-460页

作者： peter Olusakin Oladoye Mohammed Kadhom Idrees Khan Kosar Hikmat Hama Aziz Yakubu Adekunle Alli Department of Chemistry and Biochemistry Florida International University Analytical/Environmental Chemistry Unit Department of Pure and Applied ChemistryLadoke Akintola University of Technology Department of Environmental Science College of Energy and Environmental ScienceAlkarkh University of Science School of Chemistry and Chemical Engineering Northwestern Polytechnical University Department of Chemistry College of ScienceUniversity of Sulaimani Department of Medical Laboratory of Science College of Health SciencesUniversity of Human Development CNRS LCC (Laboratoire de Chimie de Coordination)UPR8241Université de Toulouse

Organic dye pollutants present in wastewater pose a significant global challenge. Among pollutants, the synthetic dye Rhodamine B(RB) stands out due to its non-biodegradable nature and associated neurotoxic, carcinogenic,and respiratory irritant properties. Extensive research has been conducted on the efficacy of adsorption and photodegradation techniques for the removal of RB from wastewater. While adsorption and advanced oxidation processes(AOPs) have gained considerable attention for their effectiveness in recent years, the underlying behaviors and mechanisms of these technologies remain incompletely understood. Therefore, a comprehensive of recent research progress in this domain is imperative to clarify the basics and present the up-to-date *** review provides an in-depth exploration of the fundamentals, advancements, and future trajectories of RB wastewater treatment technologies, mainly encompassing adsorption and photodegradation. This work starts with a general introduction of outlining the sources, toxicity, and diverse applicable removal strategies. Subsequently, it thoroughly examines crucial techniques within non-photochemical, photochemical, and adsorption technologies, such as UV light assisted AOP, catalyst assisted AOP, ozonation, Fenton system, electrochemical AOP, and adsorption technology. The primary objective is to furnish a broad overview of these techniques,elucidating their effectiveness, limitations, and applicability. Following this, the review encapsulates state-of-theart computational simulations pertaining to RB adsorption and interactions with clays and other ***, it delves into column adsorption of RB dye, and elucidates various influencing factors, including bed height, feed concentration, pollutant(RB) feeding or flow rate, and column regeneration. This panoramic review aims to provide valuable insights into suitable techniques, research gaps, and the applicability of nonphotochemical, photochemical, and

关键词： Rhodamine B Wastewater treatment Photodegradation Column adsorption Dye removal Advanced oxidation processes

Context-aware reinforcement learning for cooling operation of data centers with an Aquifer Thermal Energy Storage

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Energy and AI 2024年第3期17卷 233-246页

作者： Lukas Leindals peter Grønning Dominik Franjo Dominković Rune Grønborg Junker Department of Applied Mathematics and Computer Science Technical University of DenmarkDenmark

Data centers are often equipped with multiple cooling units. Here, an aquifer thermal energy storage (ATES) system has shown to be efficient. However, the usage of hot and cold-water wells in the ATES must be balanced for legal and environmental reasons. Reinforcement Learning has been proven to be a useful tool for optimizing the cooling operation at data centers. Nonetheless, since cooling demand changes continuously, balancing the ATES usage on a yearly basis imposes an additional challenge in the form of a delayed reward. To overcome this, we formulate a return decomposition, Cool-RUDDER, which relies on simple domain knowledge and needs no training. We trained a proximal policy optimization agent to keep server temperatures steady while minimizing operational costs. Comparing the Cool-RUDDER reward signal to other ATES-associated rewards, all models kept the server temperatures steady at around 30 °C. An optimal ATES balance was defined to be 0% and a yearly imbalance of −4.9% with a confidence interval of [−6.2, −3.8]% was achieved for the Cool 2.0 reward. This outperformed a baseline ATES-associated reward of 0 at −16.3% with a confidence interval of [−17.1, −15.4]% and all other ATES-associated rewards. However, the improved ATES balance comes with a higher energy consumption cost of 12.5% when comparing the relative cost of the Cool 2.0 reward to the zero reward, resulting in a trade-off. Moreover, the method comes with limited requirements and is applicable to any long-term problem satisfying a linear state-transition system.

关键词： Data centers ATES Smart energy systems Reinforcement learning Delayed rewards

Enhancing prognostic accuracy in predicting rectal neuroendocrine neoplasms

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World Journal of Gastroenterology 2024年第37期30卷 4087-4089页

作者： Renin peter AA Raj Abdulqadir J Nashwan Department of Medicine Aston Medical SchoolBirmingham B47ETUnited Kingdom Department of Nursing&Midwifery Research Hamad Medical CorporationDoha 3050Qatar

The recently published retrospective study introduces the GATIS score,a new predictive model for rectal neuroendocrine *** analyzing data from a large Chinese multicenter cohort,the study shows that the GATIS score,incor-porating tumor grade,T stage,tumor size,age,and prognostic nutritional index,demonstrates superior predictive power for overall survival and progression-free survival compared to traditional World Health Organization grade and tumor,nodes and metastases staging *** editorial aims to discuss the impor-tance of the GATIS score,its potential impact on clinical practice,and the strengths and limitations of the ***,it explores the significance,methodology,and clinical implications of these findings.

关键词： Rectal neuroendocrine neoplasm Nomogram Random forest Prognosis Overall survival Progression-free survival

Metal-Organic Frameworks Housing Active Molecules as Bioinspired Catalysts

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CCS Chemistry 2024年第6期6卷 1380-1402页

作者： Yin Zhang peter E.VanNatta Junyu Ren Shengqian Ma Department of Chemistry University of North TexasDentonTexas 76201 Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585

Optimization of activity,selectivity,and stability of catalysts for practical application is a long-soughtafter *** progress in the advancement of rational catalyst design routinely takes queues from ***,enzymes are renowned for their high efficiency and selectivity in diverse and significant reactions under mild *** the well-known merits of enzymes,they often remain unsuitable for industrial catalysis due to issues,including limited environment(solvent/temperature/pH)compatibility,considerable structural uncertainty,and highly specific reaction *** the context of bioinspired catalysis design,the development of synthetic heterogeneous catalyst analogs,which may not only mimic enzymes to reproduce or even surpass their performance but also bypass their intrinsic limitations,is thus,desirable and has been extensively studied in the context of porous *** metal-organic framework(MOF)is a superior candidate for porous materials towards this goal,thanks to facile and modular preparation,explicit crystalline composition/structure,tunable pore size/environment,and excellent *** introduction of active molecular species such as bioactive molecules(e.g.,proteins,enzymes,peptides,amino acids,porphyrins)and chemically active molecules(e.g.,frustrated Lewis pairs)into metal-organic frameworks(MOFs)via pore encapsulation,chemical postmodification,or bottom-up construction has been shown to facilitate the cooperative enhancement of catalysis through the enforcement of proximity,enhancement of control/activity,and even inducement of unexpected *** this minireview,we sought to summarize the last 5 years of fruitful progress,exploiting MOFs housing active molecules for substantial catalysis applications,including asymmetric reactions,CO_(2)conversion(reduction,cycloaddition),biocatalytic H_(2)O_(2)/dye degradation,and so on,and discuss challenges and opportunities in the prospective exploration of these system

关键词： metal-organic framework bioinspired catalyst active molecular species

Determination of riding comfort on cycleways using a smartphone application

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第4期11卷 747-760页

作者： Anna Niska Leif Sjögren peter Andrén Christian Weber Tineke de Jong Aslak Fyhri Department of Infrastructure Maintenance Swedish National Road and Transport Research Institute(VTI)Linköping SE-58195Sweden Department of Safety and Behavior Institute of Transport EconomicsGaustadalleen 210349 OsloNorway

Well maintained cycleways will encourage more people to cycle,as the condition of cycleways is important for the safety,accessibility and riding comfort of *** that,only a few models used to describe the quality of service for cyclists take the surface condition into *** measuring methods are needed to enable reliable and effective assessment of surface conditions,and measurable performance criteria related to the needs of cyclists should be *** purpose of this study has been to test the reliability and validity of using accelerometers in smartphones to assess the riding comfort on cycleways.A smartphone application converting three-dimensional accelerometer measurements into a single indicator for cycleways has been used to assess road surfaces in two field studies,in Sweden and Norway,*** studies assessed test sections of varying *** relate the measurements to subjective riding comfort assessments by cyclists,recruited cyclists collected quantitative data using the app,whilst also rating their perceived riding comfort by completing a *** were also related to standard road surface condition indicators,generated from a road surface tester equipped with 19 laser sensors:international roughness index(IRI),mega-and *** results show that it is possible to describe the unevenness of a cycleway using the technology present in smartphones.A software application can be used to collect and analyse data from the acceleration sensors in the phone,which can then be used to describe the riding comfort of *** is mainly the unevenness in the 50-1000 mm sizerange that create the greatest discomfort for cyclists,and intermittent vibrations are perceived as more uncomfortable than more evenly distributed ***,IRI is not a relevant measurement for describing the riding comfort of cyclists.

关键词： Cyclist Comfort Assessment Road surface measurement Smartphone application