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Liver transplantation for colorectal metastasis: a stepwise approach

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Hepatobiliary Surgery and Nutrition 2020年第3期9卷 336-338页

作者： Axel Andres christian Toso Abdominal Surgery and Transplantation Geneva University Hospital Geneva Switzerland

Six years after publishing their first results on liver transplantation for colorectal liver metastases(SECA-I)(1),Dueland et al.

关键词： colorectal metastasis al.

Improving circulating fluidized bed dehydrogenation technology through optimization of fluidization

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Particuology 2020年第3期18卷 127-134页

作者： Mayank Kashyap Malleswara Rao Tadiboyina christian Okolo Sami Al-Mutairi SABIC Technology and Innovation SABIC14100 Southwest FreewaySuite 600Sugar LandTexas 77478USA SABIC Technology Management SABICUrmonderbaan 22/6167 RdGeleenNetherlands SABIC Technology Management SABICJubail Industrial CityJubail31961Saudi Arabia

The dehydrogenation of light alkanes to corresponding light olefins is an important industrial *** present work involved the assessment of a commercial alkane dehydrogenation circulating fluidized bed (CFB) reactor unit that had been underperforming and exhibiting higher than expected catalyst losses over a long period of *** aspects of this unit related to fluidization,catalysis,and process engineering were investigated to understand and resolve these *** primary focus was on the fluidization aspects of the process,along with a comparison of equipment design and operating conditions to accepted best practices in the *** designs of key equipment in the reactor and regenerator,including feed distributors,fuel gas distributors,cyclones,baffles,strippers,transfer lines,risers,riser terminations,and refractories,were studied in *** attrition rates of different types of catalysts used in the unit were also *** recommendations and improvement opportunities were proposed to significantly increase light olefins production and reduce catalyst losses,and were accepted and *** study provides insights into means of improving fluidization behavior and highlights the viability of employing a systematic approach to determine the underlying root causes of issues in a commercial CFB reactor unit.

关键词： Fluidization Circulating fluidized bed Dehydrogenation Light olefin Catalyst loss

Genomics of pancreatic ductal adenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2014年第4期13卷 381-385页

作者： christian Pilarsky Robert Grützmann Department of Vascular- Thoracic and Visceral Surgery University Hospital Dresden Technische Universitt DresdenFetscherstr. 74 Dresden 01307 Germany

Pancreatic cancer is one of the worst prognostic cancers because of the late diagnosis and the absence of effective treatment. Within all subtypes of this disease, ductal adenocarcinoma has the shortest survival time. In recent years,global genomics profiling allowed the identification of hundreds of genes that are perturbed in pancreatic cancer. The integration of different omics sources in the study of pancreatic cancer has revealed several molecular mechanisms, indicating the complex history of its development. However, validation of these genes as biomarkers for early diagnosis, prognosis or treatment efficacy is still incomplete but should lead to new approaches for the treatment of the disease in the future.

关键词： pancreatic ductal adenocarcinoma genomes DNA RNA next-generation sequencing precision medicine

Hidden in the parts:How the cell-type perspective reveals novel insights into plant-microbe interactions

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Molecular Plant 2023年第9期16卷 1359-1362页

作者： christian Froschel Wolfgang Droge-Laser Pharmaceutical Biology Julius-von-Sachs-InstituteJulius-Maximilians-Universitat WurzburgJulius-von-Sachs Platz 297082 WurzburgGermany Present address:Botany ll Julius-von-Sachs-lnstituteJulius-Maximilians-Universitat WurzburgJulius-von-Sachs Platz 397082 WurzburgGermany

The origin of multicellularity is considered an evolutionary milestone,as cellular differentiation and cooperation have allowed the emergence of specialized and unique *** crucial biological processes involve only a few cells,making it difficult to detect specific transcriptional signatures in classical bulk tissue *** information often remains hidden in the sum of thousands of cells,and thus localized studies are *** plant responses to microbes are well known to occur highly localized(Emonet et al.,2021),approaches to describe their impact at a cellular level have been established only very *** single-cell transcriptomics,Verbon et al.,2023 addressed this topic and disclosed heterogeneous responses of root cells when colonized by the beneficial bacterium Pseudomonas *** on Arabidopsis,we here compare this study with some groundbreaking methodological advances and provides perspectives on upcoming endeavors(Figure 1).

关键词： Figure insight specialized

A numerical and experimental comparison of heat transfer in a quasi two-dimensional packed bed

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Particuology 2024年第1期84卷 136-144页

作者： Matthias Tyslik Mirko Ebert Martin Schiemann Siegmar Wirtz christian Lessig Department of Energy Plant Technology Ruhr-University BochumGermany Institute for Simulation and Graphics Otto-von-Guericke-Universität MagdeburgGermany

Heat transfer plays a major role in many industrial processes taking place in packed *** accurate and reliable simulation of the heat exchange between particles is therefore crucial for a reliable operation and to optimize the processes in the *** discrete ordinates method(DOM)provides an established numerical technique to model radiative heat transfer in granular media that offers the possibility to consider the directional dependence of the radiation *** this work,DOM is compared with Monte Carlo ray tracing,which provides an alternative method for heat transfer ***-rically simple configurations are used to investigate the influence of the angular discretization on the accuracy of the results and the computation time in both *** obtained insights are then transferred to a more complex configuration of a quasi two-dimensional test rig consisting of metal rods for which also experimental results are *** results show that both DOM and Monte Carlo ray tracing allow for an accurate simulation of heat transfer in packed *** Carlo ray tracing requires thereby computation times that are surprisingly competitive(although still somewhat slower)compared to DOM and allows for an easier computation of highly accurate reference *** our preliminary comparison to the experimental test rig,Monte Carlo ray tracing also provides the advantage that it can more easily model highly specular materials such as stainless *** methods are comparable for diffuse materials such as magnesium oxide.

关键词： Heat transfer Discrete ordinates method Monte Carlo ray tracing

Preparation and hydration of industrial solid waste-cement blends:A review

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International Journal of Minerals,Metallurgy and Materials 2022年第12期29卷 2106-2116页

作者： Qian Zhang Bo Liu Kui Xiao christian Ekberg Shengen Zhang Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Nuclear Chemistry and Industrial Material Recycling Department of Chemistry and Chemical EngineeringChalmers University of TechnologyGothenburg 41296Sweden Xinjiang Research Institute for Nonferrous Metals Urumqi 830009China

Industrial solid waste(ISW)-cement blends have the advantages of low carbon,low energy consumption,and low pollution,but their clinker replacement level in low carbon cement is generally *** address this challenge,this study considers the latest progress and development trends in the ISW-cement blend research,focusing on the activation of ISWs,the formation of ISW-cement blends,and their associated hydration *** the mechanical activation of ISWs,the D50(average size)typically drops below 10μm,and the specific surface area increases above 350 m2/*** activation can increase the glassy-phase content and reactivity of ISWs,where the coal gangue activation temperature is usually set at 400-1000°***,the roles of ISWs in the hydration of ISW-cement blends are divided into physical and chemical *** physical action of ISWs usually acts in the early stage of the hydration of ISW-cement ***,ISWs participate in the hydration reaction of ISW-cement blends to generate products,such as C-(A)-S-H ***,alkali activation affects the hydration kinetics of ISW-cement blends and modifies the proportion of *** impacts and costs of ISW-cement blends have also been discussed to guide stakeholders in selecting sustainable ISWs.

关键词： industrial solid waste-cement blend activation technology hydration mechanism carbon emission reduction

On the origin of plasticity-induced microstructure change under sliding contacts

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Friction 2023年第3期11卷 473-488页

作者： Yilun XU Daniel S.BALINT christian GREINER Daniele DINI Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK Department of Materials Imperial College LondonLondon SW72AZUK Karlsruhe Institute of Technology(KIT) Institue for Applied Materials(IAM)Kaisertrasse 12Karlsruhe 76131Germany KITIAM-CMS MicroTribology Center(μTC) Strasse am Forum 5Karlsruhe 76131Germany

Discrete dislocation plasticity(DDP)calculations are carried out to investigate the response of a single crystal contacted by a rigid sinusoidal asperity under sliding loading conditions to look for causes of microstructure change in the dislocation *** mechanistic driver is identified as the development of lattice rotations and stored energy in the subsurface,which can be quantitatively correlated to recent tribological experimental *** of surface slip initiation and substrate permanent deformation obtained from DDP calculations for varying contact size and normal load suggest ways of optimally tailoring the interface and microstructural material properties for various frictional loads.

关键词： discrete dislocation plasticity sliding size effect microstructure change

Melt flow,heat transfer and solidification in a flexible thin slab continuous casting mold with vertical-combined electromagnetic braking

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Journal of Iron and Steel Research International 2024年第2期31卷 401-415页

作者： Lin Xu Ze-feng Han christian Karcher En-gang Wang Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern UniversityShenyang110819LiaoningChina Key Laboratory of Liaoning Province for Clean Combustion Power Generation and Heating Technology Shenyang Institute of EngineeringShenyang110136LiaoningChina Institute of Thermodynamics and Fluid Mechanics Technische Universität IlmenauIlmenau98684Germany

During continuous casting of steel slabs,the application of electromagnetic braking technology(EMBr)provides an effective tool to influence solidification by controlling the pattern of melt flow in the ***,the quality of the final product can be improved considerably.A new electromagnetic braking(EMBr)method,named vertical-combined electromagnetic braking(VC-EMBr),is proposed to be applied to a flexible thin slab casting(FTSC)*** evaluate the beneficial effects of the VC-EMBr,the melt flow,heat transfer,and solidification processes in the FTSC mold are studied by means of numerical *** detail,a Reynolds-averaged Navier–Stokes turbulence model together with an enthalpy-porosity approach was *** numerical findings are compared with respective simulations using the traditional *** results demonstrate that the application of the VC-EMBr contributes significantly to preventing relative slab *** contrast to the Ruler-EMBr,the additional vertical magnetic poles of the VC-EMBr preferentially suppress the direct impact of jet flow on the narrow face of FSTC mold and considerably diminish the level fluctuation near the meniscus *** instance,by applying a magnetic flux density of 0.3 T,the maximum amplitude of meniscus deflection reduces by about 80%.Moreover,the braking effect of the VC-EMBr effectively improves the homogeneity of temperature distribution in the upper recirculation region and increases the solidified shell thickness along the casting *** this basis,the newly proposed VC-EMBr shows a beneficial effect in preventing relative slab defects for FTSC thin slab continuous casting.

关键词： Electromagnetic braking Mold Melt flow Heat transfer Solidification

APolygonal Discontinuous Galerkin Formulation for Contact Mechanics in Fluid-Structure Interaction Problems

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Communications in Computational Physics 2021年第6期30卷 1-33页

作者： Stefano Zonca Paola FAntonietti christian Vergara MOX Dipartimento di MatematicaPolitecnico di MilanoItaly LABS Dipartimento di ChimicaMateriali e Ingegneria Chimica“Giulio Natta”Politecnico di MilanoItaly

In this work,we propose a formulation based on the Polygonal Discontinuous Galerkin(PolyDG)method for contact mechanics that arises in fluid-structure interaction *** particular,we introduce a consistent penalization approach to treat the frictionless contact between immersed structures that undergo large *** key feature of the method is that the contact condition can be naturally embedded in the PolyDG formulation,allowing to easily support polygonal/polyhedral *** proposed approach introduced a fixed background mesh for the fluid problem overlapped by the structure grid that is able to move independently of the fluid *** assess the validity of the proposed approach,we report the results of several numerical experiments obtained in the case of contact between flexible structures immersed in a fluid.

关键词： Polygonal Discontinuous Galerkin method fluid-structure interaction contact mechanics