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Prediction of and for new environments: What's your model?

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Molecular Plant 2022年第4期15卷 581-582页

作者： hans-Peter Piepho University of Hohenheim Institute of Crop ScienceBiostatistics UnitFruwirthstrasse 2370599 StuttgartGermany

Genomic prediction(GP)and genome-wide association studies(GWAs)employ genetic variants(markers)to predict phenotypic performance and identify superior *** plants,due to genotype-environment interaction(GEI),performance is usually assessed across multiple environments,giving rise to phenotypic data matrices with genotypes in rows and environments in columns(Figure 1).The standard approaches to GP and GWAs employ genotype(row)means across environments as a response and analysis focuses on the *** et al.,2022 proposed to apply the same idea using environment(column)means across genotypes as the response and scanning environmental variants for their ability to predict environmental performance.

关键词： environments Figure performance

Twin-Wire Networks for Zero Interconnect,High-Density 4-Wire Electrical Characterizations of Materials

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Research 2022年第2期2022卷 225-234页

作者： Nerio Andres Montoya Valeria Criscuolo Andrea Lo Presti Raffaele Vecchione christian Falconi Department of Electronic Engincering University of Rome Tor VergataVia del Politecnico 1Roma 00133Italy school of Physics Universidad Nacional de ColombiaA.A.3840 MedellinColombia Center for Advanced Biomaterial for Health Care Istituto Italiano di TecnologiaLargo Barsantie Matteucci 53Naples 80125Italy

Four-wire measurements have been introduced by Lord Kelvin in 1861 and have since become the standard technique for characterizing small resistances and ***,high-density 4-wire measurements are generally complex,time-consuming,and inefficient because of constraints on interconnects,pads,external wires,and mechanical contacts,thus reducing reproducibility,statistical significance,and throu ***,we introduce,systematically design,analyze,and experimentally validate zero interconnect networks interfaced to external instrumentation by couples of twin wire.3D-printed holders with magnets,interconnects,nonadhesive layers,and spacers can effortlessly establish excellent electrical connections with tunable or minimum contact forces and enable accurate measurements even for delicate devices,such as thin metals on soft *** an example,we measured all the resistances of a twin-wire 29-resistor network made of silver-nanoparticle ink printed on polyimide,paper,or photo paper,including during sintering or temperature calibration,resulting in anunprecedentedly easy and accurate characterization of both resistivity and its temperature *** theoretical framework and experimental strategies reported here represent a breakthrough toward zero interconnect,simple,and efficient high-density 4-wire characterizations,can be generalized to other 4-wire measurements(impedances,sensors)and can open the way to more statistically meaningful and reproducible analyses of materials,high-throughput measurements,and minimally invasive characterizations of biomaterials.

关键词： impedance characterization breakthrough

Recycling of automotive aluminum

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Transactions of Nonferrous Metals society of China 2010年第11期20卷 2057-2063页

作者： Jirang CUI hans J.ROVEN Department of Materials science and Engineering Norwegian University of Science and Technology(NTNU)

With the global warming of concern,the secondary aluminum stream is becoming an even more important component of aluminum production and is attractive because of its economic and environmental *** this work,recycling of automotive aluminum is reviewed to highlight environmental benefits of aluminum recycling,use of aluminum alloys in automotive applications,automotive recycling process,and new technologies in aluminum scrap *** survey shows that newly developed techniques such as laser induced breakdown spectroscopy(LIBs) and solid state recycling provide promising alternatives in aluminum scrap *** with conventional remelting and subsequent refinement,solid state recycling utilizing compression and extrusion at room or moderate temperature can result in significant energy savings and higher metal yield.

关键词： recycling automotive aluminum sorting mechanical separation solid state recycling

Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs,enalaprilat and hexarelin, in rats

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Acta Pharmaceutica sinica B 2021年第6期11卷 1667-1675页

作者： David Dahlgren Tobias Olander Markus sjoblom Mikael Hedeland hans Lennernas Department of Pharmaceutical Biosciences Translational Drug Discovery and DevelopmentUppsala UniversityUppsala 75236Sweden Department of Neuroscience Division of PhysiologyUppsala UniversityUppsala 75236Sweden Department of Medicinal Chemistry Analytical Pharmaceutical ChemistryUppsala UniversityUppsala 75236Sweden Department of Chemistry Environment and Feed HygieneNational Veterinary Institute(SVA)Uppsala 75189Sweden

Transcellular permeation enhancers are known to increase the intestinal permeability of enalaprilat,a 349 Da peptide,but not hexarelin(887 Da).The primary aim of this paper was to investigate if paracellular permeability enhancers affected the intestinal permeation of the two *** was investigated using the rat single-pass intestinal perfusion model with concomitant blood *** luminal compositions included two paracellular permeation enhancers,chitosan(5 mg/mL) and ethylenediaminetetraacetate(EDTA,1 and 5 mg/mL),as well as low luminal tonicity(100 mOsm) with or without *** were evaluated by the change in lumen-to-blood permeability of hexarelin and enalaprilat,and the blood-to-lumen clearance of ^(51)chromium-labeled EDTA(CL_(Cr-EDTA)),a clinical marker for mucosal barrier *** two paracellular permeation enhancers increased the mucosal permeability of both peptide drugs to a similar *** data in this study suggests that the potential for paracellular permeability enhancers to increase intestinal absorption of hydrophilic peptides with low molecular mass is greater than for those with transcellular ***,the mucosal blood-to-lumen flux of ^(51)Cr-EDTA was increased by the two paracellular permeation enhancers and by luminal *** contrast,luminal hypotonicity did not affect the lumen-to-blood transport of enalaprilat and *** suggests that hypotonicity affects paracellular solute transport primarily in the mucosal crypt region,as this area is protected from luminal contents by a constant water flow from the crypts.

关键词： Permeation enhancers Absorption-modifying excipients Oral peptide delivery Intestinal permeability Intestinal perfusion Pharmaceutical development

single-mode and tunable VCsELs in the near-to mid-infrared Invited Paper

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Chinese Optics Letters 2008年第10期6卷 743-747页

作者： Markus-christian Amann Werner Hofmann Walter schottky Institut Technische Universitt MnchenD-85748 GarchingGermany

single-mode, long-wavelength vertical-cavity surface-emitting lasers （VCsELs） in the near- to mid-infrared covering the wavelength range from 1.3 to 2.3 μm are presented. This wide spectral emission range opens applications in gas sensing and optical interconnects. All these lasers are monolithically grown in the InGaAlAs-InP material system utilizing a buried tunnel junction （BTJ） as current aperture. Fabricated with a novel high-speed design with reduced parasitics, bandwidths in excess of 10 GHz at 1.3 and 1.55 μm have been achieved. Therefore, the coarse wavelength division multiplexing （CWDM） wavelength range of 1.3 to 1.6 μm at 10 Gb/s can be accomplished with one technology. Error-free data-transmission at 10 Gb/s over a fiber link of 20 km is demonstrated. One-dimensional arrays have been fabricated with emission wavelengths addressable by current tuning. Micro-electro-mechanical system （MEMs） tunable devices provide an extended tuning range in excess of 50 nm with high spectral purity. All these devices feature continuous-wave （CW） operation with typical single-mode output powers exceeding 1 mW. The operation voltage is around 1 - 1.5 V and power consumption is as low as 10 - 20 mW. Furthermore, we have also developed VCsELs based on Gasb, targeting functionality of tunable diode laser spectroscopy （TDLs） applying a 1.84-μm VCsEL. at the wavelength range from 2.3 to 3.0 μm. The systems is shown by presenting a laser hygrometer

关键词： mode VCsEL single-mode and tunable VCsELs in the near-to mid-infrared Invited Paper

Pathophysiological role of guanylate-binding proteins in gastrointestinal diseases

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World Journal of Gastroenterology 2016年第28期22卷 6434-6443页

作者： Nathalie Britzen-Laurent christian Herrmann Elisabeth Naschberger Roland s Croner Michael stürzl Division of Molecular and Experimental surgery Department of Surgery University Medical Center Erlangen Translational Research Center Friedrich-Alexander University of Erlangen-Nuremberg Physical Chemistry I Ruhr-University Bochum Department of surgery University Medical Center Erlangen Friedrich-Alexander University of Erlangen-Nuremberg

Guanylate-binding proteins(GBPs) are interferonstimulated factors involved in the defense against cellular pathogens and inflammation. These proteins, particularly GBP-1, the most prominent member of the family, have been established as reliable markers of interferon-γ-activated cells in various diseases, including colorectal carcinoma(CRC) and inflammatory bowel diseases(IBDs). In CRC, GBP-1 expression is associated with a Th1-dominated angiostatic micromilieu and is correlated with a better outcome. Inhibition of tumor growth by GBP-1 is the result of its strong antiangiogenic activity as well as its direct anti-tumorigenic effect on tumor cells. In IBD, GBP-1 mediates the anti-proliferative effects of interferon-γ on intestinal epithelial cells. In addition, it plays a protective role on the mucosa by preventing cell apoptosis, by inhibiting angiogenesis and by regulating the T-cell receptor signaling. These functions rely to a large extent on the ability of GBP-1 to interact with and remodel the actin cytoskeleton.

关键词： Guanylate-binding proteins Colorectal carcinoma Inflammatory bowel diseases Interferon

Complications of dexamethasone implants:risk factors,prevention,and clinical management

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1612-1620页

作者： Nil Celik Ramin Khoramnia Gerd.U Auffarth saadettin sel christian s Mayer Department of Ophthalmology University Hospital of HeidelbergHeidelberg 69120Germany

AIM:To evaluate major complications after intravitreal injection of dexamethasone implants(Ozurdex)and their clinical ***:In a retrospective observational study between 2014 and 2016 at two university hospitals,we reviewed the clinical records of 1241 consecutive macular edema patients treated with the dexamethasone implant,and separated severe adverse events in the injection procedure from those that were post-injection *** evaluated the cause and the outcomes in each ***:In twenty-one procedures(1.69%)we noticed significant complications during and after intravitreal injection of the dexamethasone *** related to the injection procedure were in one case,that a second implant was injected by mistake in the same eye on the same *** another case,the implant lodged in the sclera during retraction of the injector *** scleral tunnel at the injection site led to hypotony in another *** were 10 cases of post-injection displacement of the implant into the anterior chamber and one case with a migrated and trapped device between the intraocular lens and an artificial *** typically occurred in patients with preexisting risk factors:eyes with complicated intraocular lens implantation,iris reconstruction or iris defects or pseudophakic eyes after vitrectomy were prone to develop this *** led to secondary corneal decompensation with *** case developed an endophthalmitis,and we observed four cases of retinal *** eyes presented with long-lasting hypotony due to ciliary ***:Treatment with the dexamethasone implant may cause various expected or unexpected complications that may have serious consequences for the patient and require further *** reduce complications,clinicians should evaluate certain risk factors before scheduling patients for dexamethasone implant treatment and use proper injection techniques.

关键词： intravitreal implants dexamethasone implants Ozurdex intravitreal injection slow release drug

Estimation of Pool Boiling Heat Transfer Coefficients of Ethanol-Water Mixtures

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Chinese Journal of Chemical Engineering 1999年第2期7卷 95-103页

作者：谷俊杰 hans-JrgBart Lehrstuhl fur Thermische Verfahrenstechnik Universitat Kaiserslautern67653 KaiserslauternGermany

Based on the analysis of the principles of heat and mass transfer from the liquid bulk to bubble surface during nucleation, a new estimation method to predict the heat transfer of the nucleate pool boiling in binary mixtures is proposed in this paper by using the heat and mass transfer analogy (Colburn analogy) at the bubble surface transfer layers. With the use of Thome's concept of boiling range, an approximate method is derived to realize the calculation. The predicted results by this method are in good agreement with the experimental data from different sources.

关键词： heat transfer boiling water-ethanol mixture estimation

Efficient multi-level fault simulation of HW/sW systems for structural faults

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science China(Information sciences) 2011年第9期54卷 1784-1796页

作者： BARANOWsKI Rafal DI CARLO stefano HATAMI Nadereh IMHOF Michael E. KOCHTE Michael A. PRINETTO Paolo WUNDERLICH hans-Joachim ZOELLIN christian G. University of stuttgart Institute of Computer Architecture and Computer Engineering Politecnico di Torino Dipartimento di Automatica e Informatica

In recent technology nodes,reliability is increasingly considered a part of the standard design flow to be taken into account at all levels of embedded systems *** traditional fault simulation techniques based on low-level models at gate-and register transfer-level offer high accuracy,they are too inefficient to properly cope with the complexity of modern embedded ***,they do not allow for early exploration of design alternatives when a detailed model of the whole system is not yet available,which is highly required to increase the efficiency and quality of the design ***-level models that combine the simulation efficiency of high abstraction models with the accuracy of low-level models are therefore essential to efficiently evaluate the impact of physical defects on the *** paper proposes a methodology to efficiently implement concurrent multi-level fault simulation across gate-and transaction-level models in an integrated simulation *** leverages state-of-the-art techniques for efficient fault simulation of structural faults together with transaction-level *** combination of different models allows to accurately evaluate the impact of faults on the entire hardware/software system while keeping the computational effort ***,since only selected portions of the system require low-level models,early exploration of different design alternatives is efficiently *** results obtained from three case studies are presented to demonstrate the high accuracy of the proposed method when compared with a standard gate/RT mixed-level approach and the strong improvement of simulation time which is reduced by four orders of magnitude in average.

关键词： fault simulation multi-level transaction-level modeling