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Don´t give up on mitochondria as a target for the treatment of diabetes and its complications

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World Journal of Diabetes 2024年第10期15卷 2015-2021页

作者： christian Cortés-Rojo Manuel Alejandro Vargas-Vargas Instituto de Investigaciones Químico-Biológicas Universidad Michoacana de San Nicolás de HidalgoMorelia 58030MichoacánMexico

In this editorial,we discuss an article by Wang et al,focusing on the role of mitochondria in peripheral insulin resistance and insulin *** numerous in vitro and pre-clinical studies supporting the involvement of mitochondrial dysfunction and oxidative stress in the pathogenesis of diabetes and its complications,efforts to target mitochondria for glycemic control in diabetes using mitochondria-targeted antioxidants have produced inconsistent *** intricate functionality of mitochondria is summarized to underscore the challenges it poses as a therapeutic *** mitochondria-targeted antioxidants have demonstrated improvement in mitochondrial function and oxidative stress in pre-clinical diabetes models,the results regarding glycemic control have been mixed,and no studies have evaluated their hypoglycemic effects in diabetic ***,pre-clinical trials have shown promising outcomes in ameliorating diabetes-related ***,we review some reasons why mitochondria-targeted antioxidants may not function effectively in the context of mitochondrial *** also highlight several alternative approaches under development that may enhance the targeting of mitochondria for diabetes treatment.

关键词： Diabetes mellitus Insulin resistance Mitochondrion Mitochondrial dysfunction MitoQ MitoTEMPO skQ Elamipretide Mitochondria transplantation Glycemic control

solvent Interactions with Polymeric Heat Transfer surfaces

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材料科学与工程（中英文A版） 2013年第9期3卷 591-600页

作者： christian Dreiser hans-Joeg Bart Chair of separation science and Technology University of Kaiserslautern Kaiserslautern D-67653 Germany

The influence of physiobiomechanical parameters,technical aspects of shooting,and psychophysiological factors on biathlon performance:A review

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Journal of sport and Health science 2018年第4期7卷 394-404页

作者： Marko s.Laaksonen Thomas Finkenzeller hans-Christer Holmberg Gerold sattlecker Department of Health sciences Swedish Winter Sports Research CentreMid Sweden UniversityOstersund 83125Sweden Department of sport science and Kinesiology Paris Lodron University of SalzburgSalzburg 5020Austria school of sport sciences UiT The Arctic University of NorwayTromso 9019Norway Corresponding author.E-mail address：marko.laaksonen@miun.se

The biathlon, an Olympic sporting discipline that combines cross-country skiing with rifle marksmanship, entails considerable physiological demands, as well as fine motor control while shooting after intense exercise and under mental pressure. Although much of our knowledge about cross-country skiing is probably also applicable to the biathlon, carrying the rifle and shooting under stress make this discipline somewhat unique. The present review summarizes and examines the scientific literature related to biathlon performance, with a focus on physiological and biomechanical factors and shooting technique, as well as psychophysiological aspects of shooting performance. We conclude with suggestions for future research designed to extend our knowledge about the biathlon, which is presently quite limited.2018 Published by Elsevier B.V. on behalf of shanghai University of sport. This is an open access article under the CC BY-NC-ND license. （http：//***/licenses/by-nc-nd/4.0/）.

关键词： Cortical activity Gaze behavior Postural balance skiing Triggering

Little Tiny or Thumbelina （III）

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考试与评价（英语高二专刊） 2017年第6期 44-45,38页

作者： hans christian Andersen 曹硕不详吉林长春

Little Tiny or Thumbelina （I）

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考试与评价（英语高二专刊） 2017年第4期 44-46,39页

作者： hans christian Andersen 曹硕不详吉林长春

世界上有一些书是可以从小读到老的，丹麦作家安徒生的童话就具有这种独特魅力。人们如此隆重地纪念一位童话作家，是因为他的童话作品已成为一代又一代读者心目中的经典，而经典的魅力是不会随时间的流逝而改变的。本期向你讲述其中的... 详细信息

世界上有一些书是可以从小读到老的，丹麦作家安徒生的童话就具有这种独特魅力。人们如此隆重地纪念一位童话作家，是因为他的童话作品已成为一代又一代读者心目中的经典，而经典的魅力是不会随时间的流逝而改变的。本期向你讲述其中的一个故事——拇指姑娘。

关键词：中等教育英语阅读理解

Anisotropic deformation for local shape control

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Computational Visual Media 2017年第4期3卷 305-313页

作者： Matteo Colaianni christian siegl Jochen süвmuth Frank Bauer Günther Greiner Computer Graphics Group University Erlangen-Nuremberg Adidas AG

We present a novel approach to mesh deformation that enables simple context sensitive manipulation of 3 D geometry. The method is based on locally anisotropic transformations and is extended to global control directions. This allows intuitive directional modeling within an easy to implement framework. The proposed method complements current sculpting paradigms by providing further possibilities for intuitive surface-based editing without the need for additional host geometries. We show the anisotropic deformation to be seamlessly transferable to free boundary parameterization methods, which allows us to solve the hard problem of flattening compression garments in the domain of apparel design.

关键词： anisotropy modeling as-rigid-aspossible(ARAP) deformation parameterization

Associations of cerebrospinal fluid amyloidogenic nanoplaques with cytokines in Alzheimer’s disease

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Translational Neurodegeneration 2021年第2期10卷 230-239页

作者： Mari Aksnes hans christian DAass Ann Tiiman Trine Holt Edwin Lars Terenius Nenad Bogdanovic Vladana Vukojevic Anne-Brita Knapskog Department of Geriatric Medicine Institute of Clinical MedicineFaculty of MedicineUniversity of OsloOsloNorway Department of Medical Biochemistry Oslo University HospitalOsloNorway Department of Clinical Neurosciences(CNs) Center for Molecular Medicine CMM L8:01Karolinska InstitutetStockholmSweden Department of Geriatric Medicine The Memory ClinicOslo University HospitalOsloNorway Institute of Health and society Faculty of MedicineUniversity of OsloOsloNorway Norwegian National Advisory Unit on Ageing and Health Vestfold Hospital TrustTonsbergNorway Department of Neurobiology Care Science and Society(NVS)Division of Clinical GeriatricsKarolinska InstitutetHuddingeSweden

Background:The aggregation of amyloidβ(Aβ)is central in the pathogenesis of Alzheimer’s disease(AD).Recently it has been shown that specifically,larger,Thioflavin T-binding Aβaggregates are associated with increased neuroinflammation and cytokine *** study was aimed to quantify fibrillary amyloid aggregates,so-called nanoplaques,and investigate their relationship with cytokines in the cerebrospinal fluid(CsF).Methods:CsF was collected from 111 patients assessed for cognitive complaints at the Oslo University Hospital Memory *** patients were grouped based on their amyloid *** CsF nanoplaque concentration was quantified with the Thioflavin T-fluorescence correlation spectroscopy(ThT-FCs)*** levels of nine cytokines(eotaxin-1,granulocyte stimulating factor,interleukin[IL]-6,IL-7,IL-8,monocyte chemoattractant protein-1,gammainduced protein 10,macrophage inflammatory protein[MIP]-1α,and MIP-1β)were quantified with a magnetic bead-based multiplex assay and read on a Luminex Is 200 ***:There were 49 amyloid-negative and 62 amyloid-positive patients in the cohort;none of the cytokines differed significantly between the amyloid *** increased nanoplaque levels were associated with levels of MIP-1βbelow the lower limit of quantification,and with decreased levels of MIP-1αand *** associations remained significant when adjusted for age,sex,cognitive function,apolipoproteinε4 status and CsF core biomarker ***:The cytokine levels were not associated with amyloid status in this *** nanoplaque levels were negatively associated with MIP-1β,MIP-1αand IL-8,which is in line with recent findings suggesting that the upregulation of some cytokine markers has a protective role and is negatively associated with AD progression.

关键词： Alzheimer's disease Amyloid Amyloid beta peptides Amyloidogenic proteins Biomarkers Cerebrospinal fluid Cytokines Inflammation Fluorescence correlation spectroscopy Thioflavin T

Putting Faces to Names： snapshots of Two Committee Meetings, 95 Years Apart, Emphasize Continuous International Cooperation in the Atmospheric sciences

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Advances in Atmospheric sciences 2017年第5期34卷 571-575页

作者： hans VOLKERT Deutsches Zentrum für Luft- und Raumfahrt lnstitut für Physik der Atmosphare 82234 Oberpfaffenhofen Germany

*** spectacular advances have been made in the atmospheric sciences on a global level during a period of one hundred years or more,which is arguably most evident through"the quiet revolution of numerical weather predi... 详细信息

关键词： Co work Putting Faces to Names:snapshots of Two Committee Meetings,95 Years Apart,Emphasize Continuous International Cooperation in the Atmospheric sciences

Phosphorus recovery from municipal and fertilizer wastewater:China's potential and perspective

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Journal of Environmental sciences 2017年第2期29卷 151-159页

作者： Kuangxin Zhou Matthias Barjenbruch christian Kabbe Goulven Inial christian Remy Berlin Centre of Competence for Water Berlin 10709Germany Department of Urban Water Management Technical University of BerlinBerlin 13355Germany Research&Innovation Asia Veolia EnvironmentBeijing 10004China

Phosphorus（P） is a limited resource, which can neither be synthesized nor substituted in its essential functions as nutrient. Currently explored and economically feasible global reserves may be depleted within generations. China is the largest phosphate fertilizer producing and consuming country in the world. China’s municipal wastewater contains up to 293,163 Mg year of phosphorus, which equals approximately 5.5% of the chemical fertilizer phosphorus consumed in China. Phosphorus in wastewater can be seen not only as a source of pollution to be reduced, but also as a limited resource to be recovered. Based upon existing phosphorus-recovery technologies and the current wastewater infrastructure in China, three options for phosphorus recovery from sewage sludge, sludge ash and the fertilizer industry were analyzed according to the specific conditions in China.

关键词： Phosphorus recovery Municipal Wastewater Fertilizer Industry sewage sludge China