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工业计算机IPC阼为中央控制装置

现代制造 2008年第34期 42-43页

作者： christian Grebe Markus werner Jela Krajinovic

无论是工厂、办公楼或者单户住宅，工业计算机到处都在承担着整套自动化技术的指导。在位于德国Eifel市面积为600m^2的单户住宅里，房屋主人通过厨房里的中央控制单元，可以对房屋内外实现自动化控制。

关键词：中央控制单元工业计算机控制装置 IPC 自动化技术自动化控制办公楼住宅

Readmission after acute decompensation:challenges in heart failure care

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中华心力衰竭和心肌病杂志（中英文） 2018年第2期2卷 114-118页

作者： Michael Bohm christian werner Yvonne Bewarder Jan Wintrich Ingrid Kindermann Universitiitsklinikurri des Saarlandes Klinik fur Innere Medizin IIIUniversitat des Saarlandes KardiologieAngiologie und lnlemistische Intensivmedizin Kirrberger Str.I 66421 Homburg/SaarGermany

Introduction Despite intensive multidrug therapy,patients with heart failure are often readmitted resulting in an annual rehospitalization rate for heart failure in the United States of 1 million patients per year[1].Despite evidence-based treatments,often initiated in the hospital,these individuals face a high post discharge mortality and rehospitalization rate,such as 15% and 30%,respectively,within 60-90 days[2-4].Mechanistically,in the vulnerable phase an excess of neuroendocrine activation is likely to contribute to the high event *** example is the escape phenomenon of the renin-angiotensin-aldosterone system (RAAS) providing the basis for a combined inhibitor therapy in this condition[5-7] in stable ***,in the post-discharge vulnerable phase,combined RAAS inhibition with the renin inhibitor aliskiren failed to show benefits[s-9].The treatment of these patients is limited due to the fact that they quite often have low blood pressure and high heart rate preventing physicians to treat patients with adequate dosis of neuroendocrine antagonists[10].

关键词： Readmission Introduction challenges

Single-mode and tunable VCSELs in the near-to mid-infrared Invited Paper

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Chinese Optics Letters 2008年第10期6卷 743-747页

作者： Markus-christian Amann werner Hofmann Walter Schottky Institut Technische Universitt MnchenD-85748 GarchingGermany

Single-mode, long-wavelength vertical-cavity surface-emitting lasers （VCSELs） in the near- to mid-infrared covering the wavelength range from 1.3 to 2.3 μm are presented. This wide spectral emission range opens applications in gas sensing and optical interconnects. All these lasers are monolithically grown in the InGaAlAs-InP material system utilizing a buried tunnel junction （BTJ） as current aperture. Fabricated with a novel high-speed design with reduced parasitics, bandwidths in excess of 10 GHz at 1.3 and 1.55 μm have been achieved. Therefore, the coarse wavelength division multiplexing （CWDM） wavelength range of 1.3 to 1.6 μm at 10 Gb/s can be accomplished with one technology. Error-free data-transmission at 10 Gb/s over a fiber link of 20 km is demonstrated. One-dimensional arrays have been fabricated with emission wavelengths addressable by current tuning. Micro-electro-mechanical system （MEMS） tunable devices provide an extended tuning range in excess of 50 nm with high spectral purity. All these devices feature continuous-wave （CW） operation with typical single-mode output powers exceeding 1 mW. The operation voltage is around 1 - 1.5 V and power consumption is as low as 10 - 20 mW. Furthermore, we have also developed VCSELs based on GaSb, targeting functionality of tunable diode laser spectroscopy （TDLS） applying a 1.84-μm VCSEL. at the wavelength range from 2.3 to 3.0 μm. The systems is shown by presenting a laser hygrometer

关键词： mode VCSEL Single-mode and tunable VCSELs in the near-to mid-infrared Invited Paper

过度通气4小时对控制式脑皮质撞击损伤大鼠的神经认知行为和病损大小的远期影响

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麻醉与镇痛 2012年第1期8卷 16-22页

作者： Eva Eberspacher, DVM, DACVA Manfred Blobner, MD christian werner, MD Stefanie Ruf, DVM Barbara Eckel, MD Kristin Engelhard, MD Wolfgang Schmahl, DW Adrian W. Gelb, MBChB, FRCP 邓希锦（译） Klinik ftir Anasthesiologie und perioperative Intensivrnedizin VeterinarmedizinischeUniversitat Wien Vienna Austria Klinik ftir Anaesthesiologie Klinikum rechts der Isar TechnischeUniversitat Munchen Munich Klinik ftir Anasthesiologie Klinikum der JohannesGutenberg-Universitat Mainz Insfitut fiirTierpathologie Tierarztliche Fakultat derLudwig-Maximilians-Universitat Miinchen Munich Germany Department of Anesthesia andPerioperative Care University of California San Francisco California

背景局部创伤性脑损伤大鼠过度通气4小时对其神经认知行为、运动功能、协调能力和病损大小的远期影响。方法对大鼠进行为期14天的神经认知行为学训练，包括孔板实验、木梁行走实验、木梁平衡实验。21只SD大鼠（369±15g），氟烷麻醉后... 详细信息

背景局部创伤性脑损伤大鼠过度通气4小时对其神经认知行为、运动功能、协调能力和病损大小的远期影响。方法对大鼠进行为期14天的神经认知行为学训练，包括孔板实验、木梁行走实验、木梁平衡实验。21只SD大鼠（369±15g），氟烷麻醉后气管插管，机械通气，行控制性皮质撞击损伤（深1．75mm，直径5mm，速度4m／s）。将大鼠随机分入正常通气组（n=10；Paco2=38-42mmHg）和过度通气组（n=11；Paco2=28-32mmHg），机械通气4小时。创伤后持续检测大鼠的行为学和运动能h20天。随后，将大鼠在深麻醉下断头取脑，冰冻脑组织，切片，评估病损大小。结果过度通气组与正常通气组相比外显记忆受损严重。两组大鼠在损伤初期的运动功能和协调能力的测试（木梁行走和木梁平衡实验）中表现均有欠缺，过度通气组更为严重。但是，在实验结束时，两组并无明显差异。创伤后第20天，过度通气组大鼠测得的病损大小（69．7±13．0mm^3）明显大于正常通气组（48．3±15．6mm^3）。结论创伤性脑损伤后过度通气4／1,时（Paco2=28-32mmHg）虽然增加了组织学损伤，但并没有对大鼠远期的神经认知功能造成不良影响。

关键词：神经认知功能过度通气 SD大鼠认知行为撞击损伤脑皮质病损创伤性脑损伤

开颅手术中动脉CO2分压和七氟烷对毛细血管静脉脑血流和氧饱和度的影响

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麻醉与镇痛 2011年第6期7卷 50-55页

作者： Departments of Klaus Ulrich Klein, MD Martin Glaser, MD Robert Reisch, MD, PhD Achim Tresch, MSc christian werner, MD, PhD Kristin EngeLhard, MD, PhD 刘鲲鹏（译）李成辉（校） Departments of AnesthesiologyLudwig-Maximilians-University Munich Germany Departments ofNeurosurgery Johannes Gutenberg-University MainzGermanyLudwig-Maximilians-University Munich Germany Departmentof Chemistry and Biochemistry Gene Center MunichLudwig-Maximilians-University Munich Germany 不详

背景手术中常规监测脑血流和氧饱和度是一项技术上的挑战。基于脑血管对CO，反应性的生理学原理．我们对新近开发的一种神经监测仪（oxygen—to—see，O2CTM）在开颅手术患者同步监测毛细血管静脉局部脑血流量（rvCBF）、血流速度（rvV... 详细信息

背景手术中常规监测脑血流和氧饱和度是一项技术上的挑战。基于脑血管对CO，反应性的生理学原理．我们对新近开发的一种神经监测仪（oxygen—to—see，O2CTM）在开颅手术患者同步监测毛细血管静脉局部脑血流量（rvCBF）、血流速度（rvVelo）、氧饱和度（srvO2）和血红蛋白计数（rvHb）方面的表现进行评估。方法26例实施神经外科手术的患者，随机分g4采用呼气术浓度为1．4％和2．O％七氟烷进行麻醉。在颅骨切开后，在邻近手术部位肉眼所视正常的脑组织表面放置一光纤探头。每例患者同步监测较低动脉二氧化碳分压（PaCO2=35mmHg）和较高二氧化碳分压（PaC0，=45mmHg）时（随机排序）脑深度2mm和8mm处的组织脑血流。联合应用激光多普勒血流监测仪（rVcBF，rvVdo）和分光光度计（srvO，，rvHb）进行测量。采用线性模型检验较低和较高PaCO2、1.4％和2，0％呼气末七氟炕浓度2mm和8mm脑深度时rvCBF、rvVelo、srvO，和rvHb数值变化的线性关系。结果在脑组织深度2mm和8mm处，rvCBF和rvVelo随PaCO2升高而增加，与七氟皖浓度无关（P〈Q001）。高PaCO2使平均srvO2由50％升高至68％（P〈0．001）。与脑深度2mm处相比，脑深度8mm处的rvVelo（P〈0．001）和srvO，（P=0．007）较高。RvHb不受PaCO2变化的影响，但是与七氟垸浓度呈正相关（P=0．005）。结论PaCO：导致rvCBF和rvVelo增加，表明在呼气末七氟皖浓度1．4％和2％麻醉下，CO2增多可引起保护性血管扩张。SrvO2的连续升高表明PaCO2增高可导致脑动脉-静脉氧差缩小。RvHb不变表示测量期间未发生血液丢失。本研究显示，该神经监测仪可监测脑微血管主要静脉在不同PaCO2水平脑血流和氧饱和度的局部变化。

关键词：局部脑血流量 CO2分压氧饱和度毛细血管开颅手术七氟烷静脉动脉二氧化碳分压

Scanning gate imaging of quantum point contacts and the origin of the 0.7 anomaly

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Nano Research 2015年第3期8卷 948-956页

作者： Andrea lagallo Nicola Paradiso Stefano Roddaro christian Reichl werner Wegscheider Giorgio Biasiol Lucia Sorba Fabio Beltram Stefan Heun National Enterprise for Nanoscience and Nanotechnology (NEST) Istituto Nanoscienze-CNR and Scuola Normale Superiore Piazza San Silvestro 12 56127 Pisa Italy Istituto Offcina dei Materiali CNR Laboratorio TASC 34149 Trieste Italy Solid State Physics Laboratory ETH Zurich Schafmattstrasse 16 8093 Zurich Switzerland

The origin of the anomalous transport feature appearing at a conductance G 0.7× （2e2/h） in quasi-lD ballistic devices-the so-called 0.7 anomaly-represents a long standing puzzle. Several mechanisms have been proposed to explain it, but a general consensus has not been achieved. Proposed explanations have been based on quantum interference, the Kondo effect, Wigner crystallization, and other phenomena. A key open issue is whether the point defects that can occur in these low-dimensional devices are the physical cause behind this conductance anomaly. Here we adopt a scanning gate microscopy technique to map individual impurity positions in several quasi-lD constrictions and correlate these with conductance characteristics. Our data demonstrate that the 0.7 anomaly can be observed irrespective of the presence of localized defects, and we conclude that the 0.7 anomaly is a fundamental property of low-dimensional systems.

关键词： two-dimensional electrongas (2-DEG) scanning gate microscopy 0.7 anomaly

N-Propionylmannosamine:using biochemical glycoengineering to promote peripheral nerve regeneration

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Neural Regeneration Research 2015年第12期10卷 1947-1948页

作者： Georgios Koulaxouzidis werner Reutter christian Witzel Department of Plastic and Hand Surgery University of Freiburg Medical Center Institut für Laboratoriumsmedizin Klinische Chemie und Pathobiochemie Charité-Universit?tsmedizin (Freie Universit?t Berlin) Plastic and Reconstructive Surgery Charité-Universit?tsmedizin Berlin

The peripheral nervous system,in contrast to the central nervous system,is capable of spontaneous ***,nerve reconstruction in the peripheral nervous system remains a major challenge,as the functional outcomes followin... 详细信息

关键词： N-Propionylmannosamine Figure Man ST UDP acid

光学纯(4S,5R)-4-甲基-5-羟基-3-羰基己酸特丁酯的化学酶促合成

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有机化学 2002年第12期22卷 1009-1012页

作者：吉爱国 Michael Mueller Michael Wolberg werner Hummel christian Wandreyb 山东大学药学院济南250012 德国于利希研究中心生物技术研究所于利希52425 德国于利希研究中心杜塞尔多夫大学酶技术研究所于利希52426

采用化学方法合成了 4 甲基 3,5 二羰基己酸特丁酯 .以Lactobacillusbrevis醇脱氢酶为生物催化剂 ,选择性地将 4 甲基 3,5 二羰基己酸特丁酯还原为 (4S ,5R) 4 甲基 5 羟基 3 羰基己酸特丁酯 (99.2 %ee,syn∶anti=97∶3) .

关键词：光学纯 (4S,5R)-4-甲基-5-羟基-3-羰基己酸特丁酯化学酶促合成 Lactobacillus brevis醇脱氢酶药物中间体

Lorentz Force Velocimetry for Poorly Conducting Fluids-Development and Validation of a Novel Flow Rate Measurement Device

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Journal of Iron and Steel Research International 2012年第S2期19卷 613-616页

作者： WEGFRASS Andre RESAGK christian DIETHOLD christian FRHLICH Thomas werner Michael HALBEDEL Bernd THESS Andre Institute of Thermodynamics and Fluid Mechanics Department of Mechanical EngineeringIlmenau University of Technology Institute of Process Measurement and Sensor Technology Department of Mechanical EngineeringIlmenau University of Technology Institute of Inorganic-nonmetallic Materials Department of Mechanical EngineeringIlmenau University of Technology

The paper demonstrated the feasibility of Lorentz Force Velocimetry for flow rate measurements of weakly conducting electrolytes using experimental results on salt water flow exposed to a permanent magnet *** innovative flow measurement technique allows the non-contact determination of flow rates and relies on the interaction between a magnetic field and a moving conducting *** an electrically conducting fluid moves through the magnetic field a Lorentz force is generated and acts on the measurement *** present report provides an overview about the experimental setups and the first measurement results.

关键词： Lorentz force velocimetry flow measurement electrolytes non-contact measurement