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Impact of gender on outcomes after transcatheter aortic valve implantation

Journal of Geriatric Cardiology 2018年第6期15卷 394-400页

作者： Nooraldaem Yousif Slayman Obeid Ronald Binder Andrea Denegri Mohammady Shahin christian Templin Thomas f Luscher Department of Cardiology University Heart Center University Hospital Zurich Switzerland and Royal Brompton & Harefield Hospital imperial College London United Kingdom

Backgound The influence of gender on clinical outcomes following transcatheter aortic valve implantation （TAVI） was considerably discrepant in previous studies. We aimed to investigate the impact of gender in our registry. Methods The study is a retrospective observational analysis of a prospectively designed cohort （546 consecutive patients treated at the University Hospital Zurich who were enrolled in Swiss TAVI Cohort from May 2008 to April 2014）. The Study took place in University Heart Centre at University Hospital Zurich, Switzerland. Results Both genders were equally represented with 51.5 % （n = 281） of the populations being females, who were significantly older and had a more pronounced history of hypertension （P 〈 0.001 ）. Males on the other hand showed a higher incidence of diabetes （P = 0.004）, coronary artery disease （P 〈 0.001）, chronic obstructive pulmonary disease （P 〈 0.001） and renal failure requiring renal replacement therapy （P = 0.018）. Patients were followed up for a median of 391 days with a 100% complete follow-up at one year. The primary outcome （all-cause mortality） occurred in 6.8% （n = 37） and 15% （n = 82） of patients at 30 days and one year, respectively. The 30-day all-cause mortality outcome did not significantly differ between females （7.5%） and males （6.0%）（P = 0.619）, but one year all-cause mortality occurred significantly more in males than in females （18.7% vs. 11.7%, P 〈 0.037）. Conclusion After TAVI implantation for severe aortic stenosis, males have a less favorable long-term （one year） mortality outcome than females.

关键词： Aortic stenosis Aortic valve Gender Transcatheter aortic valve implantation

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Cubosome nanoparticles for enhanced delivery of mitochondria anticancer drug elesclomol and therapeutic monitoring via sub-cellular NAD(P) H multi-photon fluorescence lifetime imaging

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Nano Research 2019年第5期12卷 991-998页

作者： Ana R.faria Oscar f.Silvestre christian Maibohm Ricardo M.R.Adao Bruno f.B.Silva Jana B.Nieder Department of Nanophotonics Ultrafast Bio- and Nanophotonics GroupINL - International Iberian Nanotechnology LaboratoryAv.Mestre Jose Veiga s/n4715-330 BragaPortugal Department of Life Sciences INL-International Iberian Nanotechnology LaboratoryAv.Mestre Jose Veiga s/n4715-330 BragaPortugal

Elesclomol (ELC) is an anticancer drug inducing mitochondria cytotoxicity through reactive oxygen ***,for the first time,we encapsulate the poorly water soluble ELC in monoolein-based cubosomes stabilized with Pluronic *** uptake and nanocarrier accumulation close to the mitochondria with sub-micrometer distance is identified via three-dimensional (3D) confocal microscopy and edge-to-edge compartment *** monitor the therapeutic effect of the ELC nanocarrier,we apply for the first time,label-free time-lapse multi-photon fluorescence lifetime imaging microscopy (MP-fLIM) to track NAD(P)H cofactors with sub-cellular resolution on live cells exposed to an anticancer *** in vitro cytotoxicity is verified when loading the pre-complexed ELC with copper (ELC-Cu).Importantly,for equivalent copper concentration,cubosomes loaded with ELC-Cu show higher cytotoxicity compared to the free *** novel nanocarrier shows promising features for systemic ELC-Cu administration,and furthermore we establish the MP-fLIM technique for the assessment of anticancer drug delivery systems.

关键词： cubosomes mitoch on dria reactive oxyge n species elesclomol NAD(P)H fluoresce nee lifetime anticancer therapy

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Existence of global solutions to isentropic gas dynamics equations with a source term

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Science China Mathematics 2010年第1期53卷 115-124页

作者： KLINGENBERG christian Institut fr angewandte Mathematik Universitt WrzburgAm Hubland97074 WrzburgGermany

In this paper we prove existence of isentropic gas dynamic equations with a source term (1.2). To this end we construct a sequence of regular hyperbolic systems (1.1) to approximate the inhomogeneous system of isentropic gas dynamics (1.2). first,for each fixed approximation parameter δ and very general condition on P (ρ),we establish the existence of entropy solutions for the Cauchy problem (1.1) with bounded initial date (1.4). Second,letting=o(δ),we obtain a complete proof of the H-1loc compactness of weak entropy pairs of system (1.2) in the form η(ρ,u) =ρH(ρ,u) given in Chen-Lefloch (2003). finally,for the conditions of P(ρ) given in Chen-Lefloch (2003),applied to the results in Theorems 1 and 2,we obtain the global existence of entropy solutions for the Cauchy problem (1.2) with bounded initial date (1.4).

关键词： isentropic gas dynamics system global entropy solution compactness in H-loc1 compensated compactness method

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fortuitously discovered liver lesions

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World Journal of Gastroenterology 2013年第21期19卷 3173-3188页

作者： Christoph f Dietrich Malay Sharma Robert N Gibson Schreiber-Dietrich christian Jenssen Department of Internal Medicine Caritas-Krankenhaus Bad Mergentheim97980 Bad MergentheimGermany Department of Gastroenterology Jaswantrai Speciality HospitalOpposite Sports StadiumMeerut UP 250001India Department of Radiology University of MelbourneRoyal Melbourne HospitalVictoria 3050Australia Dagmar Department of Pediatrics Asklepiosklinik St. AugustinAbt. Neonatologie und P diatrische Intensivmedizin52757 AugustinGermany Klinik für Innere Medizin Krankenhaus Mrkisch Oderland15334 StrausbergGermany

The fortuitously discovered liver lesion is a common problem. Consensus might be expected in terms of its work-up, and yet there is none. This stems in part from the fact that there is no preventive campaign involving the early detection of liver tumors other than for patients with known liver cirrhosis and oncological patients. The work-up (detection and differential diagnosis) of liver tumors comprises theoretical considerations, history, physical examination, laboratory tests, standard ultrasound, Doppler ultrasound techniques, contrastenhanced ultrasound (CEUS), computed tomography and magnetic resonance imaging, as well as imageguided biopsy. CEUS techniques have proved to be the most pertinent method; these techniques became part of the clinical routine about 10 years ago in Europe and Asia and are used for a variety of indications in daily clinical practice. CEUS is in many cases the first and also decisive technical intervention for detecting and characterizing liver tumors. This development is reflected in many CEUS guidelines, e.g. , in the European federation of Societies for Ultrasound in Medicine and Biology (EfSUMB) guidelines 2004, 2008 and 2012 as well as the recently published World federation for Ultrasound in Medicine and Biology-EfSUMB guidelines 2012. This article sets out considerations for making a structured work-up of incidental liver tumors feasible.

关键词： Contrast-enhanced ultrasound Hepatocellular carcinoma Hemangioma focal nodular hyperplasia Metastasis Ultrasonography Recommendations Guidelines

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Photonic molecules with a tunable inter-cavity gap

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Light(Science & Applications) 2016年第1期5卷 195-201页

作者： Tobias Siegle Stefan Schierle Sarah Kraemmer Benjamin Richter Sentayehu f Wondimu Peter Schuch christian Koos Heinz Kalt Institute of Applied Physics Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany Zoological Institute Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany Institute of Microstructure Technology Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany Institute of Photonics and Quantum Electronics Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany

Optical micro-resonators have broad *** are used,for example,to enhance light–matter interactions in optical sensors or as model systems for investigating fundamental physical mechanisms in cavity quantum *** two or more micro-cavities is particularly interesting as it enlarges the design freedom and the field of *** this context,achieving tunability of the coupling strength and hence the inter-cavity gap is of utmost importance for adjusting the properties of the coupled micro-resonator *** this paper,we report on a novel coupling approach that allows highly precise tuning of the coupling gap of polymeric micro-resonators that are fabricated side by side on a common *** structure goblet-shaped whispering-gallery-mode resonators on an elastic silicone-based polymer substrate by direct laser *** silicone substrate is mechanically stretched in order to exploit the lateral shrinkage to reduce the coupling *** a laser dye into the micro-resonators transforms the cavities into micro-lasers that can be pumped *** have investigated the lasing emission by micro-photoluminescence spectroscopy,focusing on the spatial localization of the *** results demonstrate the formation of photonic molecules consisting of two or even three resonators,for which the coupling strengths and hence the lasing performance can be precisely *** and tunability are key elements in future photonics,making our approach interesting for various photonic *** instance,as our coupling approach can also be extended to larger cavity arrays,it might serve as a platform for tunable coupled-resonator optical waveguide devices.

关键词： coupled resonators photonic molecules micro-lasers tunable coupling gap whispering gallery mode resonators

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A multi-mode super-fano mechanism for enhanced third harmonic generation in silicon metasurfaces

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Light(Science & Applications) 2023年第5期12卷 847-854页

作者： David Hahnel christian Golla Maximilian Albert Thomas Zentgraf Viktor Myroshnychenko Jens forstner Cedrik Meier Theoretical Electrical Engineering&CeOPP Paderborn University33098 PaderbornGermany Physics Department&CeOPP Paderborn University33098 PaderbornGermany

We present strong enhancement of third harmonic generation in an amorphous silicon metasurface consisting of elliptical nano *** show that this enhancement originates from a new type of multi-mode fano ***‘Super-fano’resonances are investigated numerically in great detail using full-wave *** theoretically predicted behavior of the metasurface is experimentally verified by linear and nonlinear transmission ***,quantitative nonlinear measurements are performed,in which an absolute conversion efficiency as high as η_(max)≈2.8×10^(-7) a peak power intensity of 1.2 GW cm^(-2) is *** to an unpatterned silicon film of the same thickness amplification factors of up to ~900 are *** results pave the way to exploiting a strong fano-type multi-mode coupling in metasurfaces for high THG in potential applications.

关键词： spectroscopy mechanism harmonic

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An open-source albedo-wand for the measurement of sea ice albedo

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Advances in Polar Science 2019年第2期30卷 106-117页

作者： christian KATLEIN Alfred-Wegener-Institut Helmholtz Zentrum für Polar-und Meeresforschung Takuvik Joint International Laboratory Université Laval and CNRS

Surface albedo is defined as the ratio of incident and reflected solar irradiance and describes the ability of a surface to reflect, rather than absorb incident solar shortwave radiation. It is thus a crucial parameter in the climate system, particularly in the polar oceans. Sea ice albedo is a main driver for light transmission into the polar oceans and thus has a high impact on ocean warming, ice melting and marine primary production. During spring and summer, sea ice albedo can exhibit a significant spatial variability caused by meltwater accumulations on the ice. While complex and expensive solutions for albedo measurements are already available, we want to present a simple open-source design that allows for affordable mapping of spatially varying surface albedo on sea ice and beyond. Our solution is based on off-the-shelf components, such as an Arduino microcontroller integrating affordable light sensors, a GPS unit, data recording on memory card and data display into a simple field strengthened unit. We provide example data from two Arctic field deployments showing the capabilities and limitations of this system.

关键词： sea ice albedo spatial variability mapping GPS open-source

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Prospective cohort study on facial profile changes in infants with Robin sequence and healthy controls

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World Journal of Pediatrics 2024年第6期20卷 581-589页

作者： Cornelia Wiechers Julian Sowula Karen Kreutzer Christoph E.Schwarz Christina Weismann Michael Krimmel christian f.Poets Bernd Koos Department of Neonatology Tuebingen University HospitalCalwerstrasse 772076 TuebingenGermany Center for Cleft Lip Palate and Craniofacial MalformationsTuebingen University HospitalTuebingenGermany Department of Orthodontics Tuebingen University HospitalTuebingenGermany Department of Oral and Maxillofacial Surgery Tuebingen University HospitalTuebingenGermany

Background Various conservative and surgical approaches exist to treat Robin sequence(RS),but their effects on facial profile and mandibular catch-up growth are unclear.A functional treatment concept,used in our centre for 25 years,includes an individualized palatal plate with a velo-pharyngeal extension and intensive feeding *** We performed a prospective study to objectively describe facial profiles in infants with RS treated with the above *** with isolated RS were admitted to our tertiary perinatal and national referral centre for craniofacial malformations between May 2018 and Nov *** with RS received 3D-photographs during clinically indicated *** controls were recruited from Dec 2018 to Sep 2019 and received 3D-photographs every 3 *** digitally measured jaw index(JI),defined as alveolar overjet(O)x maxillary arch(U)/mandibular arch(L),and the soft tissue reference points A’-point,Nasion’,B’-point angle(ANB’),describing the relative position of maxilla to mandible,were *** mixed models were used to examine time trajectories in JI and ANB’.Results A total of 2073D images,obtained in 19 infants with RS and 32 controls,were *** and ANB’decreased over time in both groups[for JI−0.18(95%CI−0.25 to−0.10);for ANB’:−0.40°per month[(95%CI−0.48 to−0.32)]]but remained lower in controls[for JI−2.5(95%CI−3.2 to−1.8);for ANB’-1.7°(95%CI−2.4 to−1.0)].Also,the ANB’model showed a significant effect of the interaction term diagnosis x *** Based on longitudinal 3D images,we describe changes in objective parameters of facial profile in infants with and without RS during the first year of *** findings indicate catch-up growth in infants treated for RS.

关键词： Infant Mandibular catch-up growth Pre-epiglottic Baton Plate Robin sequence Three-dimensional photography

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Amorphous Polylactide Bead foam–Effect of Talc and Chain Extension on foaming Behavior and Compression Properties

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Journal of Renewable Materials 2021年第11期9卷 1859-1868页

作者： christian Brütting Julia Dreier christian Bonten Volker Altstädt Holger Ruckdäschel Department of Polymer Engineering University BayreuthBayreuth95447Germany Institut für Kunststofftechnik University of StuttgartStuttgart70569Germany

Polylactide(PLA)bead foams show a high potential regarding their applicability in packaging or consumer *** the comparable properties of PLA to Polystyrene(PS)and the good CO_(2) footprint it represents a potential alternative to petroleum-based polymer ***,foaming of PLA is challenging,due to its low melt strength,therefore chemical modifiers are often *** the bead foam technology regarding PLA,the available literature is limited so *** this study,the bead foaming behavior of neat and modified amorphous PLA was *** material was modified by talc and an epoxy-based chain *** compounds have been investigated regarding their sorption behavior in CO_(2) atmosphere and their foaming *** was conducted by using the batch foaming method based on a rapid temperature increase after saturation with CO_(2).In order to achieve welded bead foams,a one-step processing for foaming and welding has been ***,the compression properties of the PLA bead foams have been *** below 50 kg/m^(3) for single bead foams and 80 kg/m^(3) for molded foams were achieved,respectively.

关键词： Polylactide biofoam bead foam CO_(2) low density

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Pho-view of Auxin:Reversible Protein Phosphorylation in Auxin Biosynthesis,Transport and Signaling

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Molecular Plant 2021年第1期14卷 151-165页

作者： Shutang Tan christian Luschnig Jiri friml Institute of Science and Technology Austria(1ST Austria) Am Campus 13400 KlosterneuburgAustria Department of Applied Genetics and Cell Biology University of Natural Resources and Life SciencesVienna(BOKU)Muthgasse 181190 WienAustria

The phytohormone auxin plays a central role in shaping plant growth and *** decades of genetic and biochemical studies,numerous core molecular components and their networks,underlying auxin biosynthesis,transport,and signaling,have been ***,protein phosphorylation,catalyzed by kinases and oppositely hydrolyzed by phosphatases,has been emerging to be a crucial type of post-translational modification,regulating physiological and developmental auxin output at all *** this review,we comprehensively discuss earlier and recent advances in our understanding of genetics,biochemistry,and cell biology of the kinases and phosphatases participating in auxin *** provide insights into the mechanisms by which reversible protein phosphorylation defines developmental auxin responses,discuss current challenges,and provide our perspectives on future directions involving the integration of the control of protein phosphorylation into the molecular auxin network.

关键词： Arabidopsis auxin protein kinase phosphatase phosphorylation

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