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real-time high-resolution mid-infrared optical coherence tomography

Light(Science & Applications) 2019年第1期8卷 1076-1088页

作者： Niels M.Israelsen christian r.petersen Ajanta Barh Deepak Jain Mikkel Jensen Gunther Hannesschlager Peter Tidemand-Lichtenberg christian Pedersen Adrian Podoleanu Ole Bang DTU Fotonik Technical University of Denmark2800 KgsLyngbyDenmark NOrBLIS IVS Virumgade 35 DVirum 2830Denmark research Center for Non-Destructive Testing(rECENDT) Altenberger Straße 694040 LinzAustria NLIr ApS Hirsemarken 1Farum 3520Denmark Applied Optics Group School of Physical SciencesUniversity of KentCanterbury CT27NHUK

The potential for improving the penetration depth of optical coherence tomography systems by using light sources with longer wavelengths has been known since the inception of the technique in the early ***,the development of mid-infrared optical coherence tomography has long been challenged by the maturity and fidelity of optical components in this spectral region,resulting in slow acquisition,low sensitivity,and poor axial *** this work,a mid-infrared spectral-domain optical coherence tomography system operating at a central wavelength of 4μm and an axial resolution of 8.6μm is *** system produces two-dimensional cross-sectional images in real time enabled by a high-brightness 0.9-to 4.7-μm mid-infrared supercontinuum source with a pulse repetition rate of 1 MHz for illumination and broadband upconversion of more than 1-μm bandwidth from 3.58–4.63μm to 820–865 nm,where a standard 800-nm spectrometer can be used for fast *** images produced by the mid-infrared system are compared with those delivered by a state-of-the-art ultra-high-resolution near-infrared optical coherence tomography system operating at 1.3μm,and the potential applications and samples suited for this technology are *** doing so,the first practical mid-infrared optical coherence tomography system is demonstrated,with immediate applications in real-time non-destructive testing for the inspection of defects and thickness measurements in samples that exhibit strong scattering at shorter wavelengths.

关键词： resolution repetition illumination

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Thermo-mechanical dynamics of nanoimprinting anti-reflective structures onto small-core mid-Ir chalcogenide fibers [Invited]

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Chinese Optics Letters 2021年第3期19卷 46-52页

作者： christian r.petersen Mikkel B.Lotz Christos Markos Getinet Woyessa David Furniss Angela B.Seddon rafael J.Taboryski O.Bang DTU Fotonik Technical University of DenmarkDK-2800 Kgs.LyngbyDenmark DTU Nanolab Technical University of DenmarkDK-2800 Kgs.LyngbyDenmark NOrBLIS DK-2830 VirumDenmark Mid-Infrared Photonics Group University of NottinghamNottingham NG72RDUK NKT Photonics DK-3460 Bi「ke「0dDenmark

Thermal nanoimprinting is a fast and versatile method for transferring the anti-reflective properties of subwavelength nanostructures onto the surface of highly reflective substrates, such as chalcogenide glass optical fiber end faces. In this paper, the technique is explored experimentally on a range of different types of commercial and custom-drawn optical fibers to evaluate the influence of geometric design, core/cladding material, and thermo-mechanical properties. Up to32.4% increased transmission and 88.3% total transmission are demonstrated in the 2–4.3 μm band using a mid-infrared(Ir) supercontinuum laser.

关键词： nanoimprint lithography anti-reflection hot imprint chalcogenide glass optical fiber mid-infrared supercontinuum

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Instant evaluation of contrast enhanced endoscopic ultrasound helps to differentiate various solid pancreatic lesions in daily routine

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World Journal of Clinical Cases 2019年第1期7卷 19-27页

作者： Klaus Kannengiesser reiner Mahlke Frauke petersen Anja Peters Torsten Kucharzik christian Maaser Department of General Internal Medicine and Gastroenterology University Teaching Hospital Lueneburg Department of Pathology University Teaching Hospital Lueneburg

BACKGrOUND Contrast enhanced harmonic endoscopic ultrasound(CEH-EUS) is a spreading technique; some studies have shown its value in the diagnosis of pancreatic adenocarcinoma using quantitative *** To examine the value of CEH-EUS for differentiating various pancreatic lesions in everyday routine with qualitative and quantitative *** Data of 55 patients with pancreatic lesions who underwent CEH-EUS were analysed retrospectively. Perfusion characteristics were classified by the investigator qualitatively immediately upon investigation, quantitative analysis was performed later on. Samples from fine needle aspiration(EUS-FNA) or surgical specimen served as gold *** CEH-EUS showed 39 hypoenhanced lesions, 3 non-enhanced and 13 hyperenhanced lesions. Concordance of the investigators qualitative classification of peak contrast enhancement with quantitative analysis later on was 100%, while other parameters such as arrival time, time to peak or area under the curve did not show additional value. 34 of 39 hypoenhanced lesions were pancreatic adenocarcinoma; of the hyperenhanced lesions 4 were inflammatory, 3 neuroendocrine carcinomas, 1 lymphoma, 1 insulinoma and 4 metastases(2 of renal cell carcinoma, 2 of lung cancer). Non-enhanced lesions showed up as necroses. Sensitivity for the detection of pancreatic adenocarcinoma was 100%,specificity 87.2% for hypoenhancement alone; in otherwise healthy pancreatic tissue all hypoenhanced lesions were pancreatic adenocarcinoma(sensitivity and specificity 100%, PPV and NPV for adenocarcinoma 100%).CONCLUSION This study again shows the excellent value of CEH-EUS in everyday routine for diagnostics of various focal pancreatic lesions suggesting that qualitatively assessed hypoenhancement is highly predictive for adenocarcinoma. Additional quantitative analysis of perfusion parameters does not add diagnostic yield. In case of the various hyperenhanced pancreatic lesions in our data set, histologic samp

关键词： Endoscopic ultrasound Contrast enhanced endoscopic ultrasound Pancreatic adenocarcinoma Neuroendocrine carcinoma Pancreatic metastases Lymphoma

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An assessment of the taxonomy and chemotaxonomy of Ganoderma

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Fungal Diversity 2015年第2期71卷 1-15页

作者： christian richter Kathrin Wittstein Paul M.Kirk Marc Stadler Department Microbial Drugs Helmholtz Centre for Infection Research GmbHInhoffenstraße 738124 BraunschweigGermany Mycology Section Royal Botanic GardensKewSurrey TW93DSUK State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

The taxonomic and nomenclatural history of the genus Ganoderma and related basidiomycetes is reviewed and compared to recent studies on its molecular phylogeny.A basidiomycete belonging to the genus Ganoderma can often rather easily be recognised in the field from the macromorphological characters of the *** most important species and lineages can also be discriminated well by molecular ***,the application of incongruent species concepts and the frequent misapplication of European names by chemists and other non-taxonomists have created confusion in the scientific *** identity of the species reported in the course of mycochemical studies can often not be verified,since no voucher material was *** this review,an overview on the most important types of specific chemotaxonomic traits(i.e.,secondary metabolites of the basidiomes and mycelia)reported from the genus is *** certain triterpenoids such as ganoderic and lucidenic acids,steroids(***)and triterpenes(***)appear to have some chemotaxonomic value at the generic rank,their relevance for species discrimination remains to be *** propose that all important names in Ganoderma should be,as required,epitypified by fresh collections for which living cultures should be made available and that these should be examined by a combination of morphological,chemotaxonomic and molecular phylogenetic methods to attain a more stable taxonomy.

关键词： Polyporales Basidiomycota Chemosystematics Evolution

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Complex regulation of Prolyl-4-Hydroxylases Impacts root Hair Expansion

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Molecular Plant 2015年第5期8卷 734-746页

作者： Silvia M. Velasauez Martiniano M. ricardi christian Peter Poulsen Ai Oikawa Adiphol Dilokpimol Adnan Halim Silvina Mangano Silvina Paola Denita Juarez Eliana Marzol Juan D. Salgado Salter Javier Gloazzo Dorosz Cecilia Borassi Svenning rune Moller rafael Buono Yukiko Ohsawa Ken Matsuoka Marisa S. Otegui Henrik V. Scheller Naomi Geshi Bent Larsen petersen Norberto D. lusem Jose M. Estevez Instituto de Fisiologfa Biologia Molecular y Neurociencias (IFIBYNE-CONICET) Facultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos Aires C1428EGA Argentina VKr research Centre Department of Plant and Environmental Sciences University of Copenhagen DK-1871 Frededksberg C Denmark Joint BioEnergy Institute Feedstocks Division Lawrence Berkeley National Laboratory 5885 Hollis Street Emeryville CA 94608 USA Copenhagen Center for Glycomios Department of Cellular and Molecular Faculty of Health and Medical Sciences University of CopenhagenDK-2200 Copenhagen N Denmark Department of Botany University of Wisconsin Madison WI 53706 USA rIKEN Plant Science Center Tsurumi-ku Yokohama 230-0045 Japan Laboratory of Plant Nutrition Faculty of Agriculture Kyushu University Hakozaki 6-10-1 Higashi-ku Fukuoka 812-8581 Japan Departamento de Fisiologia Biologia Molecular y Celular Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Buenos Aires C1428EGAArgentina These authors contributed equally to the article. Present address: Fungal Physiology CBS-KNAW Fungal Biodiversity Center Uppsalalaan 8 Utrecht 3584 CT The Netherlands Present address: The Danish Stem Cell Center The Panum Institute Blegdamsvej 3B DK-2200 Copenhagen Denmark

root hairs are single cells that develop by tip growth, a process shared with pollen tubes, axons, and fungal hyphae. However, structural plant cell walls impose constraints to accomplish tip growth. In addition to polysaccharides, plant cell walls are composed of hydroxyproline-rich glycoproteins （HrGPs）, which include several groups of O-glycoproteins, including extensins （EXTs）. Proline hydroxylation, an early post-translational modification （PTM） of HrGPs catalyzed by prolyl 4-hydroxylases （P4Hs）, defines their subsequent O-glycosylation sites. In this work, our genetic analyses prove that P4H5, and to a lesser extent P4H2 and P4H13, are pivotal for root hair tip growth. Second, we demonstrate that P4H5 has in vitro preferred specificity for EXT substrates rather than for other HrGPs. Third, by P4H promoter and protein swapping approaches, we show that P4H2 and P4H13 have interchangeable functions but cannot replace P4H5. These three P4Hs are shown to be targeted to the secretory pathway, where P4H5 forms dimers with P4H2 and P4H13. Finally, we explore the impact of deficient proline hydroxylation on the cell wall architec- ture. Taken together, our results support a model in which correct peptidyl-proline hydroxylation on EXTs, and possibly in other HrGPs, is required for proper cell wall self-assembly and hence root hair elongation in Arabidopsis thaliana.

关键词： enzymology cell expansion cell walls protein targeting proline hydroxylation root hairs

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心血管疾病死亡风险预测随着亚临床器官损害标记物的增加而提高

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中华高血压杂志 2010年第6期18卷 599-599页

作者：沈逸华谢良地 Thomas Sehestedt Jorgen Jeppesen Tine W.Hansen Kristian Wachtell Hans Ibsen christian Torp-petersen PEr Hildebrandt Michael H.Olsen

该文明确了健康受试者的亚临床血管损伤是否会显著增加系统性冠脉风险评估（systematic coronary risk uation, SCOrE）的危险分层。方法和结果：总共1968名受试者，年龄为41、51、61或71岁，排除心血管疾病，从未接受心血管药物、降糖... 详细信息

该文明确了健康受试者的亚临床血管损伤是否会显著增加系统性冠脉风险评估（systematic coronary risk uation, SCOrE）的危险分层。方法和结果：总共1968名受试者，年龄为41、51、61或71岁，排除心血管疾病，从未接受心血管药物、降糖或降脂治疗的糖尿病患者。测量这些受试者的传统心血管危险因素，

关键词：亚临床器官损害心血管疾病死亡风险预测标记物健康受试者心血管危险因素心血管药物风险评估

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丹麦童话如何成真

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中国改革 2013年第6期 103-104页

作者：裴德盛(Friis Arne petersen) 王婷婷(译) 不详新《中国改革》

对很多中国人而言，北欧小国丹麦是个童话王国。这不仅因为丹麦作家汉斯·克里斯蒂安·安徒生（Hans christian Andersen）创作过家喻户晓的童话故事，也因为丹麦是一个拥有免费医疗和丰厚养老金的福利社会，任何接受高等教育的丹麦学... 详细信息

对很多中国人而言，北欧小国丹麦是个童话王国。这不仅因为丹麦作家汉斯·克里斯蒂安·安徒生（Hans christian Andersen）创作过家喻户晓的童话故事，也因为丹麦是一个拥有免费医疗和丰厚养老金的福利社会，任何接受高等教育的丹麦学生都能自动获得政府发放的奖学金。

关键词：童话故事丹麦克里斯蒂福利社会高等教育中国人安徒生养老金

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