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The comparative efficacy of ezetimibe added to atorvastatin 10 mg versus uptitration to atorvastatin 40 mg in subgroups of patients aged 65 to 74 years or greater than or equal to 75 years

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Journal of Geriatric Cardiology 2011年第1期8卷 1-11页

作者： Ori Ben-Yehuda Nanette K. Wenger christian constance Franklin Zieve Mary E. Hanson Jian-Xin Lin Arvind K. Shah Charlotte Jones-Burton Andrew M. Tershakovec University of California San Diego 200 West Arbor Drive La Jolla CA 92103 USA Emory University School of Medicine 49 Jess Hill Jr Dr SE Atlanta GA 30303 USA SHopital Maisonneuve-Rosemont Recherche Clinique/Polyclinique 5415 Boulevard de l＇Assomption Suite 295 Montreal Quebec QC H1T2M4 Canada McGuire VA Medical Center 1201 Broad Rock Blvd （151） Richmond VA 23249 USA Merck-Sharp ＆ Dohme One Merck Drive Whitehouse Station NJ 08889 USA

Background Coronary heart disease （CHD） risk increases with age; yet lipid-lowering therapies are significantly under-utilized in patients 〉 65 years. The objective was to evaluate the safety and efficacy of lipid-lowering therapies in older patients treated with atorvastatin 10 nag ＋ ezetimibe 10 mg （EZ/Atorva） vs. increasing the atorvastatin dose to 40 mg, Methods Patients 〉 65 years with atherosclerotic vascular disease （LDL-C ≥1.81 mmol/L） or at high risk for coronary heart disease （LDL-C 〉 2.59 mmol/L） were randomized to EZ/Atorva for 12 wk vs. uptitration to atorvastatin 20 nag for 6 wk followed by atorvastatin 40 nag for 6 wk. The percent change in LDL-C and other lipid parameters and percent patients achieving prespecified LDL-C levels were assessed after 12 wk. Results EZ/Atorva produced greater reductions in most lipid parameters vs. uptitration of atorvastatin in patients 〉 75 years （n = 228）, generally consistent with patients 65-74 years （n = 812）. More patients achieved LDL-C targets with combination therapy vs. monotherapy in both age groups at 6 wk and in patients 〉 75 years at 12 wk. At 12 wk, more patients 〉 75 years achieved LDL-C targets with monotherapy vs. combination therapy. EZ/Atorva produced more favorable improvements in most lipids vs. doubling or quadrupling the atorvastatin dose in patients 〉 75 years, generally consistent with the findings in patients 65-74 years. Conclusions Our results extended previous findings demonstrating that ezetimibe added to a statin provided a generally well-tolerated therapeutic option for improving the lipid profile in patients 65 to 74 years and 〉 75 years of age.

关键词： cholesterol absorption inhibitor LDL-C hypercholesterolemia statin

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Socio-Demographic Factors Associated with Obesity among Adolescents in Secondary School in Onitsha, South East Nigeria

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Open Journal of Endocrine and Metabolic Diseases 2023年第7期13卷 85-106页

作者： Nkiru Veronica Agu Kenneth Nchekwube Okeke Sylvia Tochukwu Echendu Chinyere Ukamaka Onubogu Joy Chinelo Ebenebe Thomas Obiajulu Ulasi Njideka constance Uchefuna christian Chukwuemeka Ifezulike Amalachukwu Okwukweka Odita Joseph Ezeogu Department of Paediatrics Nnamdi Azikiwe University Teaching Hospital Nnewi Nigeria Department of Paediatrics Faculty of Clinical Medicine Nnamdi Azikiwe University Awka Nigeria Department of Paediatrics Faculty of Clinical Sciences Chukwuemeka Odumegwu Ojukwu University Teaching Hospital Awka Nigeria Department of Paediatrics Imo state Teaching Hospital Orlu Nigeria

Background: The prevalence of obesity among adolescent has been on the increase worldwide. This is probably a result of increase in the sedentary life style and the increasing shift to western diet. Obesity in children and adolescents has adverse consequences. These include increase in the rate of Diabetes Mellitus, hypertension, dyslipidemia, cardiovascular diseases, etc with resultant increase in premature deaths. Objectives: To determine the socio-demographic and behavioral factors associated with overweight and obesity in apparently healthy secondary school adolescents. Methods: This was a cross-sectional study of secondary school adolescents aged 10 - 19 years randomly selected from two public schools and three private schools. The weight and heights of study subjects were measured using standard equipment. Body mass index (BMI) was appropriately calculated and the WHO growth reference standard for age and gender, specific percentile for BMI was used to define overweight 85th to 97th and obese (97th percentile and above). Results: Data were initially collected from 1250 participants, but 52 were excluded due to improperly completed questionnaires. Thus, a total of 1198 students were ultimately included in the study, giving a response rate of 95.8%. These included 621 females (51.8%) and 577 males (48.2%) aged 10 - 19 years giving a F:M ratio of 1:0.9. The mean age of the students was 15.07 ± 1.96 years overall, 15.13 ± 2.08 years for males and 15.03 ± 1.83 years for females. There was no statistically significant difference between male and female in the distribution of age groups (p = 0.12). The mean BMI was 21.51 ± 3.57 kg/m2 for females and 20.22 ± 3.16 kg/m2 for males. The BMI was significantly higher in females in all age groups (p < 0.001) except those aged 10 - p = 0.13). The prevalence rates of overweight and obesity were higher in females than males (17.7% vs 10.7%, 5.6% vs 4.5% respectively;p ≤ 12

关键词： Adolescent Obesity Socio-Demographic Behavioral Factors

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