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Burden sharing for CdR: balancing fair liability with feasibility

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National Science Review 2023年第12期10卷 47-48页

作者： chris d.Jones Met Office Hadley Centre

The basics are clear:climate is changing,it is caused by human activity and it is affecting everyone and everywhere now[1]. The good news is that we know what to do about it—we can stop global temperatures rising further if we stop emitting greenhouse gases. But because some sectors (such as agriculture or aviation)will have ongoing ‘hard-to-abate’ emissions,

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Interpretation of tangential and radial pressure cells in and on sprayed concrete tunnel linings

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Underground Space 2021年第5期6卷 516-527页

作者： Benoit d.Jones chris R.I.Clayton Inbye Engineering Limited Coventry CV12NPUK department of Engineering University of SouthamptonSouthampton SO171BJUK

It is important to be able to measure stresses in tunnel linings to verify design assumptions and validate numerical *** sprayed concrete-lined tunnels,continuous monitoring of stresses from the time of spraying onwards is desirable,and this can only be achieved using pressure cells installed on and in the sprayed concrete *** there has been some success in using radial pressure cells between the ground and the lining,a method for obtaining reliable absolute values of stress from tangential pressure cells embedded in the sprayed concrete has not been *** paper describes numerical and experimental studies of the behavior of pressure cells for monitoring stresses in a sprayed concrete lining and describes an original methodology to achieve reliable *** particular,data from tangential pressure cells require careful interpretation,as they are sensitive to temperature,and this temperature sensitivity is found in parametric numerical analyses to vary as the stiffness of the concrete and its coefficient of thermal expansion evolve at early *** pressure cells are also sensitive to shrinkage strains in the concrete,and a methodology for removing this effect is *** the approach described in this paper,it is now possible to use pressure cells to measure absolute values of stresses in and on sprayed concrete tunnel linings from early age into the *** example of radial and tangential pressure cells installed in the Heathrow Terminal 4 concourse tunnel is used to illustrate the methodology.

关键词： Lining stresses Sprayed concrete Shotcrete Monitoring Pressure cells

differential variable speed limits to improve performance and safety of car-truck mixed traffic on freeways

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第6期9卷 1003-1016页

作者： Anas Abdulghani chris Lee department of Civil and Environmental Engineering University of WindsorWindsorON N9B 3P4Canada

This study develops a differential variable speed limit(dVSL)which assigns different speed limits for car and truck,and varies speed limits based on traffic *** proposed dVSL algorithm changes speed limits in real time based on truck percentage and occupancy immediately upstream of the ramp and the average speed of the control road sections upstream of the *** algorithm also considers spatial coordination of speeds,which gradually changes the speed limits in successive road sections upstream of the ramp when the severe congestion *** study tested the impacts of dVSL and three other speed limit strategies on delay and safety for a section of the Gardiner Expressway in Toronto,Canada using the VISSIM traffic simulation *** other strategies are 1)uniform speed limit(USL),2)differential speed limit for car and truck(dSL),and 3)USL&dSL(U&d)-i.e.,USL at low truck percentage and dSL at high truck *** was found that dVSL showed the lowest delays for both car and truck among the four *** is mainly because dVSL increased the spacing between vehicles in the right lane upstream of the on-ramp and facilitated vehicles’merging into the mainline *** was also found that dVSL showed the lowest likelihood of rear-end crash between the lead and following vehicles among the four *** study demonstrates that the proposed dVSL algorithm can better control car and truck speeds to reduce delay and improve safety of car-truck mixed traffic flow on freeways.

关键词： Variable speed limit differential speed limit Truck Traffic performance Safety Freeway

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Verification of the 2019 GloSea5 Seasonal Tropical Cyclone Landfall Forecast for East China

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Journal of Meteorological Research 2020年第5期34卷 917-925页

作者： Joanne CAMP Philip E.BETT Nicola GOLdING chris d.HEWITT Timothy d.MITCHELL Adam A.SCAIFE Met Office Hadley Centre Exeter EX 13PBUK University of Southern Queensland Toowoomba QLD 4350Australia College of Engineering Mathematics and Physical SciencesUniversity of ExeterDevon EX44QFUK

A prototype climate service was developed and trialled in early 2019 to provide seasonal forecast of the June–July–August(JJA) tropical cyclone(TC) landfall risk for the East China region ahead of the forthcoming typhoon *** forecasts were produced in both March and April 2019 and a final forecast was released to the China Meteorological Administration(CMA) on 1 May 2019. The trial service was produced by using the Met Office Global Seasonal forecast system(GloSea5), and a forecast of the western Pacific subtropical high(WPSH) index was used to infer the TC landfall risk based on a simple linear regression between historical model WPSH indices and observed TC landfalls in East China. The forecast method shows significant skill for forecasting the JJA TC landfall risk in East China with up to three-month lead time, with the greatest skill for predictions initialized in May. The 2019 forecast provided good guidance of the near-average TC activity observed in East China in JJA 2019. Success of the forecast adds confidence to an improved climate service ahead of the 2020 typhoon season.

关键词： seasonal forecasting typhoons tropical cyclones(TCs) landfall risk East China western Pacific subtropical high(WPSH)

Laparoscopic liver resection for colorectal liver metastases—shortand long-term outcomes:A systematic review

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World Journal of Gastrointestinal Oncology 2021年第7期13卷 732-757页

作者： Emily Taillieu Celine de Meyere Frederiek Nuytens chris Verslype Mathieu d'Hondt department of digestive and Hepatobiliary/Pancreatic Surgery AZ GroeningeKortrijk 8500Belgium department of Gastroenterology and Hepatology KU LeuvenLeuven 3000Belgium

BACKGROUNd For well-selected patients and procedures,laparoscopic liver resection(LLR)has become the gold standard for the treatment of colorectal liver metastases(CRLM)when performed in specialized ***,little is currently known concerning patient-related and peri-operative factors that could play a role in survival outcomes associated with LLR for *** To provide an extensive summary of reported outcomes and prognostic factors associated with LLR for *** A systematic search was performed in PubMed,EMBASE,Web of Science and the Cochrane Library using the keywords“colorectal liver metastases”,“laparoscopy”,“liver resection”,“prognostic factors”,“outcomes”and“survival”.Only publications written in English and published until december 2019 were ***,abstracts of which no accompanying full text was published,reviews,case reports,letters,protocols,comments,surveys and animal studies were *** search results were saved to Endnote Online and imported in Rayyan for systematic *** of interest were extracted from the included publications and tabulated for qualitative *** Out of 1064 articles retrieved by means of a systematic and grey literature search,77 were included for qualitative ***-two research papers provided data concerning outcomes of LLR for *** papers were eligible for extraction of data concerning prognostic factors affecting survival *** analysis of the collected data showed that LLR for CRLM is safe,feasible and provides oncological *** research groups have reported on the short-term advantages of LLR compared to open *** obtained results accounted for minor LLR,as well as major LLR,simultaneous laparoscopic colorectal and liver resection,LLR of posterosuperior segments,twostage hepatectomy and repeat LLR for *** research groups so far have studied prognostic factors affecting long-term outcomes of LLR for ***

关键词： Laparoscopic liver resection Colorectal liver metastases Outcomes Prognostic factors Systematic review

Midventricular Takotsubo syndrome

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Journal of Geriatric Cardiology 2020年第5期17卷 303-304页

作者： Konstantinos C Theodoropoulos Ioannis Felekos chris Abell Nicholas d Palmer Turab Ali department of Cardiology Liverpool Heart and Chest Hospital NHS Foundation TrustLiverpoolUK

A 78-year-old woman with a background of type 2 diabetes mellitus,hyperlipidaemia and hypertension experienced sudden onset severe chest pain while in the emergency department,after a stressful emotional *** pain last... 详细信息

关键词： Left ventriculography Midventricular Takotsubo syndrome

Converting antimicrobial into targeting peptides reveals key features governing protein import into mitochondria and chloroplasts

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Plant Communications 2023年第4期4卷 99-116页

作者： Oliver d.Caspari Clotilde Garrido chris OLaw Yves Choquet Francis-Andre´Wollman Ingrid Lafontaine UMR7141(CNRS/Sorbonne Universite´) Institut de Biologie Physico-Chimique13 Rue Pierre et Marie Curie75005 ParisFrance Centre for Microscopy and Cellular Imaging Biology Department Loyola Campus of Concordia University7141 Sherbrooke W.Montre´alQC H4B 1R6Canada Present address:department of Microbiology Institut Pasteur28 Rue Docteur Roux75015 ParisFrance Present address:UMR7238(CNRS/Sorbonne Universite´) Institut de Biologie Paris-SeineSorbonne Jussieu 7-9 quai Saint Bernard75005 ParisFrance

We asked what peptide features govern targeting to the mitochondria versus the chloroplast,using antimicrobial peptides as a starting *** approach was inspired by the endosymbiotic hypothesis that organelle-targeting peptides derive from antimicrobial amphipathic peptides delivered by the host cell,to which organelle progenitors became *** explore the molecular changes required to convert antimicrobial into targeting peptides,we expressed a set of 13 antimicrobial peptides in Chlamydomonas *** were systematically modified to test distinctive features of mitochondrion-and chloroplast-targeting peptides,and we assessed their targeting potential by following the intracellular localization and maturation of a Venus fluorescent reporter used as a cargo *** targeting can be achieved by some unmodified antimicrobial peptide *** to both organelles is improved by replacing lysines with *** targeting is enabled by the presence of flanking unstructured sequences,additional constraints consistent with chloroplast endosymbiosis having occurred in a cell that already contained *** indeed targeting peptides evolved from antimicrobial peptides,then required modifications imply a temporal evolutionary scenario with an early exchange of cationic residues and a late acquisition of chloroplast-specific motifs.

关键词： antimicrobial peptide Chlamydomonas reinhardtii endosymbiotic organellogenesis presequence targeting peptide transit peptide

Push and pull factors driving movement in a social mammal: context dependent behavioral plasticity at the landscape scale

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Current Zoology 2019年第5期65卷 517-525页

作者： Andrew W.BYRNE James O'KEEFFE christina d.BUESCHING chris NEWMAN Agri-food and Biosciences Institute Veterinary Science DivisionStormontBelfastUK School of Biological Sciences Queen's University BelfastBelfastUK Centre for Veterinary Epidemiology and Risk Analysis(CVERA) School of Veterinary MedicineUniversity College DublinBelfieldDublinIreland department of Agriculture Food and the MarineAgriculture HouseDublinIreland Wildlife Conservation Research Unit Department of ZoologyUniversity of OxfordThe Recanati-Kaplan CentreTubney HouseAbingdon RoadTubneyAbingdonOxfordshireUK

Understanding how key parameters(e.g.,density,range-size,and configuration)can affect animal movement remains a major goal of population *** is particularly important for wildlife disease hosts,such as the European badger Meles meles,a reservoir of Mycobacterium *** we show how movements of 463 individuals among 223 inferred group territories across 755 km2 in Ireland were affected by sex,age,past-movement history,group composition,and group size index from 2009 to *** exhibited a greater probability of moving into groups with a male-biased composition,but male movements into groups were not associated with group *** badgers were,however,more likely to make visits into territories than *** that had immigrated into a territory previously were more likely to emigrate in the *** exhibiting such"itinerant"movement patterns were more likely to belong to younger age ***-territorial movement propensity was negatively associated with group size,indicating that larger groups were more stable and less attractive(or permeable)to *** the landscape,there was substantial variation in inferred territory-size and movement dynamics,which was related to group *** represents behavioral plasticity previously only reported at the scale of the species’biogeographical *** results highlight how a"one-size-fits-all"explanation of badger movement is likely to fail under varying ecological contexts and scales,with implications for bovine tuberculosis management.

关键词： dispersal socio-biology wildlife biology wildlife disease Meles meles social groups territoriality perturbation bTB

The Process and Benefits of developing Prototype Climate Services——Examples in China

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Journal of Meteorological Research 2020年第5期34卷 893-903页

作者： chris d.HEWITT Nicola GOLdING Peiqun ZHANG Tyrone dUNBAR Philip E.BETT Joanne CAMP Timothy d.MITCHELL Edward POPE Met Office Exeter EX 13PBUK University of Southern Queensland Toowoomba QLD 4350Australia Beijing Climate Center/National Climate Center China Meteorological AdministrationBeijing 100081China

Changes in climate pose major challenges to society, and so decision-makers need actionable climate information to inform their planning and policies to make society more resilient to climatic changes. Climate services are being developed to provide such actionable climate information. The successful development and use of climate services benefits greatly from close engagement between developers, providers, and users of the services. The Climate Science for Service Partnership China(CSSP China) is a China–UK collaboration fostering closer engagement between climate scientists, providers of climate services, and users of climate services. We describe the process within CSSP China of co-developing climate services through trials with users to revise and improve a prototype. Examples are provided covering various scientific capabilities, user needs, and parts of China. The development process is yielding many benefits, such as increasing the engagement between providers and users, making users more aware of how climate information can be of use in their decision-making, giving the climate service providers a better understanding of the users’ requirements for climate information, and shaping future scientific research and development. In addition to the benefits, we also document some challenges that have emerged, along with ways of alleviating them. We have two key recommendations from our experiences: make the time and space for effective engagement between the users and developers of any climate service;bring the needs of the users in to the design and delivery of the climate service as early as possible and throughout the development cycle.

关键词： climate services prototypes user engagement