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Association between early viral lower respiratory tract infections and subsequent asthma development

World Journal of Critical Care Medicine 2022年第4期11卷 298-310页

作者： Sebastien Kenmoe Etienne Atenguena Okobalemba Guy Roussel Takuissu Jean Thierry Ebogo-Belobo Martin Gael Oyono Jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Jean Bosco Taya-Fokou chris andre mbongue mikangue Raoul Kenfack-Momo Donatien Serge Mbaga Arnol Bowo-Ngandji Cyprien Kengne-Ndé Seraphine Nkie Esemu Richard Njouom Lucy Ndip Department of Microbiology and Parasitology University of BueaBuea 00237Cameroon Department of Virology Centre Pasteur of CameroonYaounde 00237Cameroon Faculty of Medicine and Biomedical Science The University of Yaounde IYaounde 00237Cameroon Centre of Research in Food Food Security and NutritionInstitute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Medical Research Centre Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Laboratory of Parasitology and Ecology The University of Yaounde IYaounde 00237Cameroon Department of Biochemistry The University of Yaounde IYaounde 00237Cameroon Department of Microbiology The University of Yaounde IYaounde 00237Cameroon Epidemiological Surveillance Evaluation and Research UnitNational Aids Control CommitteeDouala 00237Cameroon

BACKGROUND The association between hospitalization for human respiratory syncytial virus(HRSV)bronchiolitis in early childhood and subsequent asthma is well *** long-term prognosis for non-bronchiolitis lower respiratory tract infections(LRTI)caused by viruses different from HRSV and rhinovirus,on the other hand,has received less *** To investigate the relationship between infant LRTI and later asthma and examine the influence of confounding *** The PubMed and Global Index Medicus bibliographic databases were used to search for articles published up to October 2021 for this systematic *** included cohort studies comparing the incidence of asthma between patients with and without LRTI at≤2 years regardless of the virus *** meta-analysis was performed using the random effects *** of heterogeneity were assessed by stratified *** This review included 15 articles(18 unique studies)that met the inclusion *** at≤2 years were associated with an increased risk of subsequent asthma up to 20 years[odds ratio(OR)=5.0,95%CI:3.3-7.5],with doctor-diagnosed asthma(OR=5.3,95%CI:3.3-8.6),current asthma(OR=5.4,95%CI:2.7-10.6),and current medication for asthma(OR=1.2,95%CI:0.7-3.9).Our overall estimates were not affected by publication bias(P=0.671),but there was significant heterogeneity[I 2=58.8%(30.6-75.5)].Compared to studies with hospitalized controls without LRTI,those with ambulatory controls had a significantly higher strength of association between LRTIs and subsequent *** strength of the association between LRTIs and later asthma varied significantly by country and age at the time of the *** sensitivity analyses including only studies with similar proportions of confounding factors(gender,age at LRTI development,age at interview,gestational age,birth weight,weight,height,smoking exposure,crowding,family history of atopy,and family history of asthma)between cases and controls

关键词： Asthma Lower respiratory tract infections Respiratory viruses Long term sequelae Children

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Systematic review and meta-analysis of seroprevalence of human immunodeficiency virus serological markers among pregnant women in Africa, 1984-2020

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World Journal of Critical Care Medicine 2023年第5期12卷 264-285页

作者： Jean Thierry Ebogo-Belobo Sebastien Kenmoe chris andre mbongue mikangue Serges Tchatchouang Lontuo-Fogang Robertine Guy Roussel Takuissu Juliette Laure Ndzie Ondigui Arnol Bowo-Ngandji Raoul Kenfack-Momo Cyprien Kengne-Ndé Donatien Serge Mbaga Elisabeth Zeuko'o Menkem Ginette Irma Kame-Ngasse Jeannette Nina Magoudjou-Pekam Josiane Kenfack-Zanguim Seraphine Nkie Esemu Paul Alain Tagnouokam-Ngoupo Lucy Ndip Richard Njouom Center for Research in Health and Priority Pathologies Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Department of Microbiology and Parasitology University of BueaBuea 00237Cameroon Department of Microbiology The University of Yaounde IYaounde 00237Cameroon Scientific Direction Centre Pasteur du CamerounYaounde 00237Cameroon Department of Animal Biology University of DschangDschang 00237Cameroon Centre for Food Food Security and Nutrition ResearchInstitute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Department of Biochemistry The University of Yaounde IYaounde 00237Cameroon Epidemiological Surveillance Evaluation and Research UnitNational AIDS Control CommitteeDouala 00237Cameroon Department of Biomedical Sciences University of BueaBuea 00237Cameroon Department of Virology Centre Pasteur du CamerounYaounde 00237Cameroon

BACKGROUND Human immunodeficiency virus(HIV)is a major public health concern,particularly in Africa where HIV rates remain *** women are at an increased risk of acquiring HIV,which has a significant impact on both maternal and child *** To review summarizes HIV seroprevalence among pregnant women in *** also identifies regional and clinical characteristics that contribute to study-specific estimates *** The study included pregnant women from any African country or region,irrespective of their symptoms,and any study design conducted in any *** electronic literature searches,articles published until February 2023 were *** quality of the included studies was *** DerSimonian and Laird random-effects model was applied to determine HIV pooled seroprevalence among pregnant women in *** and sensitivity analyses were conducted to identify potential sources of *** was assessed with Cochran's Q test and I2 statistics,and publication bias was assessed with Egger's *** A total of 248 studies conducted between 1984 and 2020 were included in the quantitative synthesis(meta-analysis).Out of the total studies,146(58.9%)had a low risk of bias and 102(41.1%)had a moderate risk of *** HIV-positive pregnant women died in the included *** overall HIV seroprevalence in pregnant women was estimated to be 9.3%[95%confidence interval(CI):8.3-10.3].The subgroup analysis showed statistically significant heterogeneity across subgroups(P<0.001),with the highest seroprevalence observed in Southern Africa(29.4%,95%CI:26.5-32.4)and the lowest seroprevalence observed in Northern Africa(0.7%,95%CI:0.3-1.3).CONCLUSION The review found that HIV seroprevalence among pregnant women in African countries remains significant,particularly in Southern African *** review can inform the development of targeted public health interventions to address high HIV seroprevalence

关键词： Human immunodeficiency virus Pregnant women Africa Prevalence Review Meta-analysis

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Global prevalence of hepatitis B virus serological markers among healthcare workers:A systematic review and meta-analysis

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World Journal of Hepatology 2021年第9期13卷 1190-1202页

作者： Gadji Mahamat Sebastien Kenmoe Etheline W Akazong Jean Thierry Ebogo-Belobo Donatien Serge Mbaga Arnol Bowo-Ngandji Joseph Rodrigue Foe-Essomba Marie Amougou-Atsama Chavely Gwladys Monamele chris andre mbongue mikangue Ginette Irma Kame-Ngasse Jeannette Nina Magoudjou-Pekam Cromwel Zemnou-Tepap Dowbiss Meta-Djomsi Martin Maidadi-Foudi Sabine Aimee Touangnou-Chamda Audrey Gaelle Daha-Tchoffo Abdel Aziz Selly-Ngaloumo Rachel Audrey Nayang-Mundo Jacqueline Felicite Yengue Jean Bosco Taya-Fokou Lorraine K M Fokou Raoul Kenfack-Momo Dimitri Tchami Ngongang Efietngab Atembeh Noura Herve Raoul Tazokong Cynthia Paola Demeni Emoh Cyprien Kengne-Nde Jean Joel Bigna Onana Boyomo Richard Njouom Department of Microbiology The University of Yaounde IYaounde 00237Cameroon Department Centre Pasteur of CameroonYaounde 00237Cameroon Department of Biochemistry University of DschangDschang 00237Cameroon Medical Research Centre Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Department of Mycobacteriology Centre Pasteur of CameroonYaounde 00237Cameroon Centre de Recherche sur les Maladies Emergentes et Re-Emergentes Institut de Recherches Medicales et d'Etudes des Plantes MedicinalesYaounde 00237Cameroon Department of Biochemistry The University of Yaounde IYaounde 00237Cameroon Department of Medical Biochemistry The University of Yaounde IYaounde 00237Cameroon Department of Microbiology Protestant University of Central AfricaYaounde 00237Cameroon Department of Animals Biology and Physiology The University of Yaounde IYaounde 00237Cameroon Evaluation and Research Unit National AIDS Control CommitteeYaounde 00237Cameroon Department of Epidemiology and Public Health Centre Pasteur of CameroonYaounde 00237Cameroon

BACKGROUND The hepatitis B virus(HBV)infection is a global public health concern that affects about 2 billion people and causes 1 million people deaths *** is a bloodborne disease and healthcare workers(HCWs)are a high-risk group because of occupational hazard to patients’*** regions of the world show a highly variable proportion of HCWs infected and/or immunized against *** data on serologic markers of HBV infection and immunization in HCWs are very important to improve strategies for HBV *** To determine the worldwide prevalence of HBV serological markers among *** In this systematic review and meta–analyses,we searched PubMed and Excerpta Medica Database(Embase)to identify studies published between 1970 and 2019 on the prevalence of HBV serological markers in HCWs *** also manually searched for references of relevant *** independent investigators selected studies and included those on the prevalence of each of the HBV serological markers including hepatitis B surface antigen(HBsAg),hepatitis e antigen(HBeAg),immunoglobulin M anti-HBc,and *** quality of eligible studies was assessed and random-effect model meta-analysis resulted in the pooled prevalence of HBV serological markers HBV infection in ***(I²)was assessed using theχ²test on Cochran’s Q statistic and H ***’sources were explored through subgroup and metaregression *** study is registered with PROSPERO,number *** We reviewed 14059 references,out of which 227 studies corresponding to 448 prevalence data among HCWs(224936 HCWs recruited from 1964 to 2019 in 71 countries)were included in this *** pooled seroprevalences of current HBsAg,current HBeAg,and acute HBV infection among HCWs were 2.3%[95% confidence interval(CI):1.9-2.7],0.2%(95%CI:0.0-1.7),and 5.3%(95%CI:1.4-11.2),*** pooled seroprevalences of total immunity against HBV and immu

关键词： Healthcare workers Hepatitis B virus Seroprevalence Hepatitis B surface antigen Hepatitis e antigen

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Global prevalence of occult hepatitis C virus: A systematic review and meta-analysis

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World Journal of Methodology 2022年第3期12卷 179-190页

作者： Donatien Serge Mbaga Sebastien Kenmoe Jacky Njiki Bikoï Guy Roussel Takuissu Marie Amougou-Atsama Etienne Atenguena Okobalemba Jean Thierry Ebogo-Belobo Arnol Bowo-Ngandji Martin Gael Oyono Jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Alex Durand Nka Alfloditte Flore Feudjio Cromwel Zemnou-Tepap Elie Adamou Velhima Juliette Laure Ndzie Ondigui Rachel Audrey Nayang-Mundo Sabine Aimee Touangnou-Chamda Yrene Kamtchueng Takeu Jean Bosco Taya-Fokou chris andre mbongue mikangue Raoul Kenfack-Momo Cyprien Kengne-Ndé Carole Stephanie Sake Seraphine Nkie Esemu Richard Njouom Lucy Ndip Sara Honorine Riwom Essama Department of Microbiology The University of Yaounde IYaounde 00237Cameroon Department of Microbiology and Parasitology University of BueaBuea 00237Cameroon Department of Virology Centre Pasteur of CameroonYaounde 00237Cameroon Centre of Research in Food Food Security and NutritionInstitute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Centre de Recherche sur les Maladies Emergentes et Re-Emergentes Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Faculty of Medicine and Biomedical Science The University of Yaounde IYaounde 00237Cameroon Medical Research Centre Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Laboratory of Parasitology and Ecology The University of Yaounde IYaounde 00237Cameroon Department of Biochemistry The University of Yaounde IYaounde 00237Cameroon Virology Laboratory Chantal Biya International Reference Center for Research on HIV/AIDS Prevention and ManagementYaounde 00237Cameroon

BACKGROUND Occult hepatitis C infection(OCI)is characterized by the presence of hepatitis C virus(HCV)RNA in the liver,peripheral blood mononuclear cells(PBMC)and/or ultracentrifuged serum in the absence of detectable HCV-RNA in *** has been described in several categories of populations including hemodialysis patients,patients with a sustained virological response,immunocompromised individuals,patients with abnormal hepatic function,and apparently healthy *** To highlight the global prevalence of *** We performed a systematic and comprehensive literature search in the following 4 electronic databases PubMed,EMBASE,Global Index Medicus,and Web of Science up to 6th May 2021 to retrieve relevant studies published in the *** studies were unrestricted population categories with known RNA status in serum,PBMC,liver tissue and/or ultracentrifuged *** were extracted independently by each author and the Hoy et al tool was used to assess the quality of the included *** used the random-effect meta-analysis model to estimate the proportions of OCI and their 95%confidence intervals(95%CI).The Cochran's Q-test and the I2 test statistics were used to assess heterogeneity between *** plot and Egger test were used to examine publication bias.R software version 4.1.0 was used for all *** The electronic search resulted in 3950 *** obtained 102 prevalence data from 85 included *** pooled prevalence of seronegative OCI was estimated to be 9.61%(95%CI:6.84-12.73)with substantial heterogeneity[I^(2)=94.7%(95%CI:93.8%-95.4%),P<0.0001].Seropositive OCI prevalence was estimated to be 13.39%(95%CI:7.85-19.99)with substantial heterogeneity[I^(2)=93.0%(90.8%-94.7%)].Higher seronegative OCI prevalence was found in Southern Europe and Northern Africa,and in patients with abnormal liver function,hematological disorders,and kidney *** seropositive OCI prevalence was found in Southern Europe,Northern

关键词： Occult hepatitis C virus infection Prevalence Worldwide Peripheral blood mononuclear cells Hepatitis C virus

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Converting antimicrobial into targeting peptides reveals key features governing protein import into mitochondria and chloroplasts

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Plant Communications 2023年第4期4卷 99-116页

作者： Oliver D.Caspari Clotilde Garrido chris OLaw Yves Choquet Francis-andre´Wollman Ingrid Lafontaine UMR7141(CNRS/Sorbonne Universite´) Institut de Biologie Physico-Chimique13 Rue Pierre et Marie Curie75005 ParisFrance Centre for Microscopy and Cellular Imaging Biology Department Loyola Campus of Concordia University7141 Sherbrooke W.Montre´alQC H4B 1R6Canada Present address:Department of Microbiology Institut Pasteur28 Rue Docteur Roux75015 ParisFrance Present address:UMR7238(CNRS/Sorbonne Universite´) Institut de Biologie Paris-SeineSorbonne Jussieu 7-9 quai Saint Bernard75005 ParisFrance

We asked what peptide features govern targeting to the mitochondria versus the chloroplast,using antimicrobial peptides as a starting *** approach was inspired by the endosymbiotic hypothesis that organelle-targeting peptides derive from antimicrobial amphipathic peptides delivered by the host cell,to which organelle progenitors became *** explore the molecular changes required to convert antimicrobial into targeting peptides,we expressed a set of 13 antimicrobial peptides in Chlamydomonas *** were systematically modified to test distinctive features of mitochondrion-and chloroplast-targeting peptides,and we assessed their targeting potential by following the intracellular localization and maturation of a Venus fluorescent reporter used as a cargo *** targeting can be achieved by some unmodified antimicrobial peptide *** to both organelles is improved by replacing lysines with *** targeting is enabled by the presence of flanking unstructured sequences,additional constraints consistent with chloroplast endosymbiosis having occurred in a cell that already contained *** indeed targeting peptides evolved from antimicrobial peptides,then required modifications imply a temporal evolutionary scenario with an early exchange of cationic residues and a late acquisition of chloroplast-specific motifs.

关键词： antimicrobial peptide Chlamydomonas reinhardtii endosymbiotic organellogenesis presequence targeting peptide transit peptide

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Optical clearing of the mouse skull

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Light(Science & Applications) 2022年第10期11卷 2267-2268页

作者： chris Xu School of Applied and Engineering Physics Cornell UniversityIthacaNY 14853USA

High spatial resolution imaging of the mouse brain through the intact skull is challenging because of the skull-induced aberration and *** research group of Dan Zhu from Huazhong University of Science and Technology has developed a skull-clearing technique that provides a long-term(~weeks),stable,transparent window for high resolution optical imaging over a large field of view.

关键词： scattering. transparent Optical

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Laboratory and field evaluation of asphalt pavement surface friction resistance

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Frontiers of Structural and Civil Engineering 2018年第3期12卷 372-381页

作者： Zhong WU chris ABADIE Louisiana Transportation Research Center 4101 Gourrier Avenue Baton Rouge LA 70808 USA Louisiana Department of Transportation and Development 5080 Florida Blvd Baton Rouge LA 70806 USA

Pavement surface friction is a significant factor for driving safety and plays a critical role in reducing wet- pavement crashes. However, the current asphalt mixture design procedure does not directly consider friction as a requirement. The objective of this study was to develop a surface friction prediction model that can be used during a wearing course mixture design. To achieve the objective, an experimental study was conducted on the frictional characteristics of typical wearing course mixtures in Louisiana. Twelve wearing course mixtures including dense-graded and open-graded mixes with different combinations of aggregate sources were evaluated in laboratory using an accelerated polishing and testing procedure considering both micro- and macro texture properties. In addition, the surface frictional properties of asphalt mixtures were measured on twenty-two selected asphalt pavement sections using different in situ devices including Dynamic Friction Tester （DFT）, Circular Texture Meter （CTM）, and Lock-Wheel Skid Trailer （LWST）. The results have led to develop a procedure for predicting pavement end-of-life skid resistance based on the aggregate blend polish stone value, gradation parameters, and traffic, which is suited in checking whether the selected aggregates in a wearing course mix design would meet field friction requirements under a certain design traffic polishing.

关键词： friction skid resistance polishing PSV LWST micro-texture macro-texture

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Effects of impeller speed and aeration rate on flotation performance of sulphide ore

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中国有色金属学会会刊：英文版 2006年第1期16卷 185-190页

作者：杨小生 ALDRICH chris Institute of Mineral Engineering Northeastern University Shenyang 110004 China Department of Process Engineering University of Stellenbosch Private Bag X1 Matieland Stellenbos ch 7602 South Africa

The effects of aeration rate and impeller speed on the concentrate sulfur grade and recovery for batch flotation of a complex sulphide ore were investigated. The relationships between the water recovery and solid entrainment were discussed. It is found that the solid entrainment is linearly related to the water recovery regardless of aeration rate and impeller speed, and the higher sulfur recovery at the aeration rate of 2 and 4 L/min for the impeller speed of 1 500 r/min is considered to be the contribution of true flotation. Finally, the sulfur recovery flux is correlated with the bubble surface area flux based on the froth image at the different aeration rates and impeller speeds.

关键词：水回收固体夹带浮选性能叶轮速度通风速率硫化矿

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An energy harvester for all seasons

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National Science Review 2023年第10期10卷 10-11页

作者： Qingping Wang chris Bowen Department of Physics & Mechanical and Electronic Engineering Hubei University of Education Centre for Integrated Materials Processes and Structures Department of Mechanical EngineeringUniversity of Bath

The harvesting of sunlight,wind,heat and even raindrops to produce electrical energy has attracted significant attention to address the global energy crisis,reduce environmental pollution from fossil fuels,and limit the use of batteries[1-3].One challenge to harvesting renewable energy sources is their inherent variability,

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Relationship between solids flux and froth features in batch flotation of sulphide ore

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中国有色金属学会会刊：英文版 2005年第6期15卷 1373-1379页

作者：杨小生 Aldrich chris Institute of Mineral Engineering Northeastern University Shenyang 110004 China Department of Process Engineering University of Stellenbosch Private Bag X1 Matieland 7602 South Africa

The froth features in the batch flotation of a sulphide ore were investigated by using the digital image parameters of the froth, the small number emphasis(Nsne), the average grey level(Dagl) and the instability number(Nins), under different conditions of impeller speeds and aeration rates. It is found that the value of Nsne is strongly dependent on the average bubble size of the froth and Dagl on the volume fraction of solid in the froth, and the froth features during the batch flotation are influenced by impeller speed and aeration rate. A kinetic model of the concentrate solid flux was developed which relates the flotation process to the image parameters, Nsne and Dagl of the froth and predictions are well consistent with the experimental data.

关键词：硫化矿浮选选矿发泡剂

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