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Arecoline inhibits catecholamine release from perfused rat adrenal gland

Acta Pharmacologica Sinica 2006年第1期27卷 71-79页

作者： Dong-yoon LIM II-sik KIM Department of Pharmacology,College of Medicine,chosun university,Gwangju 501-759,Korea Department of Pharmacology College of Medicine Chosun University Gwangju Korea

Aim:To study the effect of arecoline,an alkaloid isolated from Areca catechu,onthe secretion of catecholamines (CA) evoked by cholinergic agonists and themembrane depolarizer from isolated perfused rat adrenal ***:Adrenalglands were isolated from male Sprague-Dawley *** adrenal glands wereperfused with Krebs bicarbonate solution by means of a peristaltic *** CAcontent of the perfusate was measured directly using the fluorometric ***:Arecoline (0.1-1.0 mmol/L) perfused into an adrenal vein for 60 min pro-duced dose-and time-dependent inhibition in CA secretory responses evoked byacetylcholine (ACh) (5.32 mmol/L),1.1-dimethyl-4-phenyl piperazinium iodide(DMPP) (100μmol/L for 2 min) and 3-(m-choloro-phenyl-carbamoyl-oxy)-2-butynyltrimethyl ammonium chloride (McN-A-343)(100μmol/L for 2 min).However,lowerdoses of arecoline did not affect CA secretion of high K~+(56 mmol/L);higherdoses greatly reduced CA secretion of high K~+.Arecoline also failed to affectbasal catecholamine ***,in adrenal glands loaded with arecoline(0.3 mmol/L),CA secretory response evoked by Bay-K-8644 (10μmol/L),an activa-tor of L-type Ca2+channels,was markedly inhibited,whereas CA secretion bycyclopiazonic acid(10μmol/L),an inhibitor of cytoplasmic Ca2+-ATPase,was *** (30μmol/L),which was perfused into the adrenal gland for 60min,however,initially enhanced ACh-evoked CA secretory *** timeelapsed,these responses became more inhibited,whereas the initially enhancedhigh K~+-evoked CA release *** secretion evoked by DMPP and McN-A-343 was significantly depressed in the presence of ***:Arecoline dose-dependently inhibits CA secretion from isolated perfused rat ad-renal gland evoked by activation of cholinergic *** lower doses arecolinedoes not inhibit CA secretion through membrane depolarization,but at largerdoses it *** inhibitory effect of arecoline may be mediated by blocking thecalcium inf

关键词： arecoline catecholamine secretion adrenal gland nicotine

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Altered pharmacokinetics of zalcitabine by concurrent use of NSAIDs in rats

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Acta Pharmacologica Sinica 2006年第1期27卷 119-122页

作者： Yo-han OH~2 Hyo-kyung HAN College of Pharmacy,chosun university,Gwangju 501-759,Korea College of Pharmacy Chosun University Gwangju Korea

Aim:To investigate the pharmacokinetic interactions between zalcitabine andnonsteroidal anti-inflammatory drugs (NSAIDs) in ***:Zalcitabinewas administered to rats via an iv injection (20 mg/kg) in the presence or absenceof ketoprofen or naproxen (20 mg/kg),and the pharmacokinetic parameters weredetermined by using non-compartmental ***:Compared with thecontrol (zalcitabine alone),pretreatment with ketoprofen or naproxen 30 min priorto intravenous administration of zalcitabine significantly altered the pharmacoki-netic profiles of zalcitabine in *** clearance of zalcitabine was reduced byapproximately 3-4-fold in the presence of ketoprofen or ***,systemic exposure (AUC) to zalcitabine in the rats pretreated with ketoprofen ornaproxen was significantly greater than that for the control group given *** terminal plasma half-life of zalcitabine was also prolonged by 4-5-foldin the presence of ketoprofen or ***:The NSAIDs ketoprofenand naproxen effectively altered the pharmacokinetics of ***,concomitant use of ketoprofen or naproxen in patients being treated with zalcitabinemay necessitate close monitoring for potential drug interactions.

关键词： zalcitabine ketoprofen naproxen pharmacokinetics drug interactions

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