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Journal of Geriatric Cardiology 2007年第4期4卷 195-199页

作者： Kui Hian Sim Kok Han Chee Inderjit Singh Choon Kiat Ang HoungBang liew Kim Heung Tan Omar Ismail Department of Cardiology Sarawak General Hospital Sarawak Malaysia Department of Cardiology Universiti Malaya Medical Centre Petaling Jaya Malaysia Department of Cardiology Penang General Hospital Penang Malaysia

Background For patients with cardiovascular disease (CVD), co-existence of peripheral artery disease (PAD) predicts increased mortality, and such patients are also more likely to benefit from aggressive therapy. Surveillance of PAD is often neglected at health clinics. Our aim is to highlight the importance and ease of surveillance of PAD in patients with CVD. Objective To determine the prevalence of symptomatic and asymptomatic PAD in a Malaysian patient population with documented CVD. Methods and Results A total of 393 subjects with established CVD were recruited from three centres (85 women and 308 men), as part of a larger international (AGATHA) survey. PAD, determined by presence of claudicant symptoms on interview and/or abnormal ankle-brachial index (ABI) score of less than 0.9, was present in 21.4% of patients-of whom 64% were asymptomatic. Abnormal ABI is associated with higher systolic blood pressure and number of arterial beds affected. Conclusions Concomitant PAD is prevalent among CVD patients in Malaysia. ABI screening is simple and yields a high proportion of patients with extensive atherosclerosis who may require more aggressive atherosclerotic risk management.(J Geriatr Cardiol 2007;4:195-199.)

关键词： arteriosclerosis atherothrombosis Malaysia cardiovascular diseases epidemiologic factors anklebrachial index peripheral arterial disease

Convalescent plasma: A potential therapeutic option for COVID-19 patients

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Asian Pacific Journal of Tropical Medicine 2020年第11期13卷 477-486页

作者： Swee Li Ng Tsuey Ning Soon Wei Hsum Yap Kai Bin liew Ya Chee Lim Long Chiau Ming Yin-Quan Tang Bey Hing Goh Biofunctional Molecule Exploratory Research Group(BMEX) School of PharmacyMonash University MalaysiaBandar SunwayMalaysia School of Biosciences Faculty of Medical and Health SciencesTaylor’s UniversitySubang JayaSelangorMalaysia Faculty of Pharmacy University of CyberjayaCyberjayaSelangorMalaysia PAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences Universiti Brunei DarussalamGadongBrunei Darussalam College of Pharmaceutical Sciences Zhejiang UniversityHangzhouP.R.China

The new coronavirus disease(COVID-19)outbreak has challenged us to take unprecedented steps to bring this pandemic under *** view of the urgency of this situation,convalescent plasma which was used in previous coronavirus outbreaks has emerged as one of the treatment options in this current *** is mainly due to the fact that convalescent plasma has been studied in a few case series with promising *** addition,on-going large clinical trials aimed to further evaluate the effectiveness,safety,and optimal dosage,duration and timing of administration of convalescent plasma are indeed revealing a certain level of promising ***,this article aims to provide an overview of possible mechanisms of actions of convalescent plasma,its benefits and its level of usage safeness by summarizing the existing evidence on the use of convalescent plasma in COVID-19 patients.

关键词： Coronavirus Convalescent plasma COVID-19 SARS-COV-2 Neutralizing antibody Immunomodulation Convalescent plasma transfusion

Surface modification and functionalization by electrical discharge coating:a comprehensive review

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International Journal of Extreme Manufacturing 2020年第1期2卷 68-99页

作者： Pay Jun liew ching Yee Yap Jingsi Wang Tianfeng Zhou Jiwang Yan Fakulti Kejuruteraan Pembuatan Universiti Teknikal Malaysia MelakaHang Tuah Jaya76100Durian TunggalMelakaMalaysia Marine Engineering College Dalian Maritime University1 Linghai RoadGanjingzi DistrictDalian 116026People’s Republic of China Key Laboratory of Fundamental Science for Advanced Machining Beijing Institute of TechnologyNo.5 Zhongguancun South StreetHaidian DistrictBeijing 100081People’s Republic of China Department of Mechanical Engineering Faculty of Science and TechnologyKeio UniversityHiyoshi 3-14-1Kohoku-kuYokohama 223-8522Japan

Hard coatings are extensively required in industry for protecting mechanical/structural parts that withstand extremely high temperature,stress,chemical corrosion,and other hostile *** discharge coating(EDC)is an emerging surface modification technology to produce such hard coatings by using electrical discharges to coat a layer of material on workpiece surface to modify and enhance the surface characteristics or create new surface *** paper presents a comprehensive overview of EDC technologies for various materials,and summarises the types and key parameters of EDC processes as well as the characteristics of resulting *** provides a systematic summary of the fundamentals and key features of the EDC processes,as well as its applications and future trends.

关键词： electrical discharge coating(EDC) surface modification material characteristics mechanical properties extreme conditions

Kaolin-based geopolymers with various NaOH concentrations

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International Journal of Minerals,Metallurgy and Materials 2013年第3期20卷 313-322页

作者： C.Y. Heah H. Kamarudin A.M. Mustafa Al Bakri M. Bnhussain M. Luqman I. Khairul Nizar C.M. Ruzaidi Y.M. liew Center of Excellence Geopolymer and Green Technology (CEGeoGTech) School of Materials Engineering Universiti Malaysia Perlis (UniMAP) King Abdulaziz City Science and Technology

Kaolin geopolymers were produced by the alkali-activation of kaolin with an activator solution （a mixture of NaOH and sodium silicate solutions）. The NaOH solution was prepared at a concentration of 6-14 mol/L and was mixed with the sodium silicate solution at a Na2SiO3/NaOH mass ratio of 0.24 to prepare an activator solution. The kaolin-to-activator solution mass ratio used was 0.80. This paper aimed to analyze the effect of NaOH concentration on the compressive strength of kaolin geopolymers at 80℃ for 1, 2, and 3 d. Kaolin geopolymers were stable in water, and strength results showed that the kaolin binder had adequate compressive strength with 12 mol/L of NaOH concentration. When the NaOH concentration increased, the SiO2/Na20 decreased. The increased Na20 content enhanced the dissolution of kaolin as shown in X-ray diffraction （XRD） and Fourier transform infrared spectroscopy （FTIR） analyses. However, excess in this content was not beneficial for the strength development of kaolin geopolymers. In addition, there was the formation of more geopolymeric gel in 12 mol/L samples. The XRD pattern of the samples showed a higher amorphous content and a more geopolymer bonding existed as proved by FTIR analysis.

关键词： geopolymers kaolin compressive strength sodium hydroxide

Microwave torrefaction of empty fruit bunch pellet:Simulation and validation of electric field and temperature distribution

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Journal of Bioresources and Bioproducts 2022年第4期7卷 270-277页

作者： Peter Nai Yuh Yek Sieng Huat Kong Ming Chiat Law Changlei Xia Rock Keey liew Teck Sung Sie Jun Wei Lim Su Shiung Lam Centre for Research of Innovation and Sustainable Development University of Technology SarawakJalan UniversitySibuSarawak 96000Malaysia School of Foundation Studies University of Technology SarawakJalan UniversitySibuSarawak 96000Malaysia Department of Mechanical Engineering Faculty of Engineering and ScienceCurtin University Malaysia CampusMiriSarawak 98009Malaysia Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China NV WESTERN PLT GeorgetownPenang 10400Malaysia Department of Fundamental and Applied Sciences HICoE-Centre for Biofuel and Biochemical ResearchInstitute of Self-Sustainable BuildingUniversity Technology PETRONASDarul RidzuanSeri IskandarPerak 32610Malaysia Higher Institution Centre of Excellence(HICoE) Institute of Tropical Aquaculture and Fisheries(AKUATROP)University Malaysia TerengganuKuala NerusTerengganu 21030Malaysia Sustainability Cluster School of EngineeringUniversity of Petroleum&Energy StudiesDehradunUttarakhand 248007India

Microwave simulation is significant in identifying a reactor design allowing the biomass to be heated and processed *** study integrated the radio frequency and transient heat transfer modules to simulate the microwave distribution and investigated the performance of microwave heating in the *** simulation results were compared with the experimental findings us-ing the finite element analysis software of COMSOL MULTIPHYSICS to predict the temperature profile and electric field of microwave in the biomass(empty fruit bunch pellets).The higher temperature distribution was observed at the bottom and centre section of the empty fruit bunch pellet bed in the reactor,showing the uniqueness of microwave *** to the simula-tion results,the temperature profile obtained through the specific cavity geometry and dielectric properties agreed with the experimental temperature *** simulated temperature profile demonstrated a logarithmic increase of 120°C/min at the first 50 s followed by 50°C/min until 350 *** experimental temperature profile showed three different heating rates before reaching 300°C,including 78.3°C/min(50-120°C),30.6°C/min(121-250°C),and 105°C/min(250-300°C).The results of this study might contribute to the improvement of microwave heating in biomass torrefaction.

关键词： Microwave Torrefaction Simulation Energy Temperature

上皮性卵巢癌组织脆性组氨酸三联基因甲基化和3p14的等位基因丢失

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中华病理学杂志 2005年第5期34卷 257-261页

作者：洪凡真王波李晓明刘宗石山东大学齐鲁医院妇科济南250012 香港中文大学医学院病理解剖及细胞学系

目的　探讨肿瘤抑制基因脆性组氨酸三联(FHIT)基因在上皮性卵巢癌(简称卵巢癌)组织中的甲基化状态以及该基因定位的3p14位点的等位基因丢失及其在卵巢癌的发生发展中的作用。方法　采用甲基化特异性聚合酶链反应(MSP)方法检测61例卵巢... 详细信息

目的　探讨肿瘤抑制基因脆性组氨酸三联(FHIT)基因在上皮性卵巢癌(简称卵巢癌)组织中的甲基化状态以及该基因定位的3p14位点的等位基因丢失及其在卵巢癌的发生发展中的作用。方法　采用甲基化特异性聚合酶链反应(MSP)方法检测61例卵巢癌组织及10例交界性上皮性卵巢肿瘤(简称交界性卵巢肿瘤)组织FHIT基因启动子CpG岛的甲基化频率,并采用微卫星多态性标志D3S1287检测45例卵巢癌组织3p14位点杂合子丢失(LOH)和纯合子丢失(HD)状态。结果　卵巢癌组织中FHIT基因甲基化频率为39 3% (24 /61),其中浆液性囊腺癌为45 2% ( 19 /42 ),黏液性囊腺癌为14 3% (1 /7),子宫内膜样癌为33 3% (4 /12);交界性卵巢肿瘤组织中FHIT基因甲基化为6 /10,其中交界性浆液性囊腺瘤1 /3,交界性黏液性囊腺瘤5 /7。卵巢癌组织甲基化频率与临床分期、细胞分化程度相关性无统计学意义。交界性卵巢肿瘤与卵巢癌之甲基化频率差异无统计学意义。43 5% (10 /23)卵巢癌显示LOH;有信息的浆液性囊腺癌中33 3% (6 /18)检测到HD。FHIT基因甲基化与基因丢失之间无明显相关性。结论　首次证实卵巢癌FHIT基因启动子有较高的甲基化频率,这可能是FHIT基因沉默的重要原因,在卵巢癌的发生与发展过程中起着重要的作用;同时3p14位点等位基因的丢失可使基因?

关键词：上皮性卵巢癌癌组织脆性组氨酸三联基因甲基化 3p14 等位基因丢失肿瘤

Multi-scale Mechanics and Materials Modeling

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Multi-scale Mechanics and Materials Modeling

反复张力下V形切口圆条的表面裂纹的疲劳扩展(英文)

第十一届南方计算力学学术会议（SCCM-11）

作者： K.M.liew Department of Architecture and Civil Engineering City University of Hong Kong

Multi-scale methods have been used to model complex materials systems to understand their mechanical behaviors across multiple length scales. Multi-scale modeling enables us to design smarter, multi-functional, and better sustainable structural systems. This talk will focus on several reseach works which were done in recent years in multi-scale mechanics and materials modeling. To solve a mechanical problem, theoretical, computational or experimental techniques can be used. While there is a trend towards interaction among these different techniques, curently is very limited. Because of the extremely small size in micro-and nano-structures, experimental studies are generally quite difficult. Although experimental studies can capture certain phenomena, it is impossible to understand their delicate properties well through experimental investigations alone. In addition to a large amount of experimental works, theoretical analysis and numerical modeling play important roles in capturing the delicate behavior of complex materials systems. Theoretical and numerical approaches can be generally classified into two categories: microscale method and macroscale method. A microscale method can capture the microscale mechanism of micro-and nano-structures and yield results which are in many cases explicit in nature. However, a microscale method may consume a large amount of computational resources, thus computation can carry out on a very small size domain. This huge computational limitation likely restricts their application. A macroscale continuum simulation can largely reduce the degrees of freedom in a problem, and the theoretical and numerical analyses of large-size structures thus become possible. However, a continuum simulation cannot reflect the microscale physical laws, and is inadequate. The limitations of the microscale method as well as the macroscale method have motivated extensive research into the multi-scale method that couples the microscale method and the contin

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第11期15卷 873-882页

作者： Devi CHANDRA Judha PURBOLAKSONO Yusoff NUKMAN Haw-ling liew Singh RAMESH Mohsen-abdel HASSAN Center of Advanced Manufacturing and Materials Processing Department of Mechanical EngineeringFaculty of EngineeringUniversity of Malaya Department of Mechanical Engineering Faculty of Engineering University of Andalas Center of Manufacturing System Integration Department of Mechanical EngineeringFaculty of Engineering University of Malaya

研究目的:在相同的反复张力下,研究V形切口圆条表面裂纹的疲劳扩展规律。研究方法:1.构建V形切口圆条模型(图1),基于线性二次元将模型表面离散成一个个网格点(图2);2.以AZ-6A-T5镁合金为例,利用J积分计算应力强度因数,利用NASGRO裂纹增... 详细信息

研究目的:在相同的反复张力下,研究V形切口圆条表面裂纹的疲劳扩展规律。研究方法:1.构建V形切口圆条模型(图1),基于线性二次元将模型表面离散成一个个网格点(图2);2.以AZ-6A-T5镁合金为例,利用J积分计算应力强度因数,利用NASGRO裂纹增长率模拟裂纹的疲劳扩展;3.通过研究不同的裂纹纵横比和对应的应力强度因数之间的相关性来研究裂纹的扩展。重要结论:1.在裂纹扩展时裂纹纵横比的初始值对断裂形状的发展有重要影响;2.裂纹纵横比对疲劳负荷寿命的作用比缺口半径更加明显;3.当裂纹前缘演变成一条直线形时可观察到不稳定的裂纹扩展;4.裂纹深度一定时,断裂纵横比越小,疲劳负荷寿命越短;5.当裂纹纵横比为0.6–0.7时,出现了不稳定的裂纹扩展。

关键词：疲劳裂纹扩展裂纹纵横比边界元法应力强度因数

Utilization of microwave steam pyrolysis to produce biochar for thermal energy storage

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Waste Disposal and Sustainable Energy 2022年第4期4卷 335-341页

作者： Wahap bin Abu Bakar Peter Nai Yuh Yek Kah Yein Cheong Augustine Chioma Affam Chee Chung Wong Rock Keey liew Yie Hua Tan Su Shiung Lam Centre for Research of Innovation and Sustainable Development University of Technology SarawakNo.1Jalan University96000SibuMalaysia Centre on Technological Readiness and Innovation in Business Technopreneurship(CONTRIBUTE) University of Technology Sarawak96000SibuSarawakMalaysia NV Western PLT No.208BSecond FloorMacalister Road10400GeorgetownPenangMalaysia Department of Chemical and Energy Engineering Faculty of Engineering and ScienceCurtin University MalaysiaCDT 25098009MiriSarawakMalaysia Higher Institution Centre of Excellence(HICoE) Institute of Tropical Aquaculture and Fisheries(AKUATROP)Universiti Malaysia Terengganu21030 Kuala NerusTerengganuMalaysia

Microwave steam pyrolysis(MSP)is an innovative thermochemical approach to converting biomass into high-quality biochar using steam to improve the dielectric heating of microwave *** shows high fixed carbon and carbon contents at a maximum temperature of 550℃in 10 *** MSP achieved a heating rate of 112℃/min from 200℃to 400℃to produce biochar ***,the thermal properties of biochar in microwave heating were investigated in this study to explore its potential as a microwave heat-absorbent *** is able to perform volumetric and controllable heating to the ***,biochar shows good microwave heat absorbency,storing and transferring heat *** temperature profile of three different sizes of biochar was investigated to examine the efficiency of biochar in heat absorption from microwave *** was found that the powder form of biochar showed a higher heat transfer rate of 40℃/min and a low cooling rate of 7.5℃/*** presented results are useful for evaluating the application of biochar as a promising medium for heat storage systems.

关键词： Microwave Steam Pyrolysis Biochar Thermal Storage

装配式组合结构柱高强钢管连接节点界面黏结性能试验

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工业建筑 2023年第4期53卷 120-124,179页

作者：朱张峰 RICHARD liew 杜咏姚兵南京工业大学土木工程学院南京211816 新加坡国立大学土木与环境工程系新加坡119077

为确定装配式组合结构柱高强钢管连接节点常用的φ114×25、φ152×16和φ194×10截面规格Q420连接钢管的黏结长度及构造,开展了在不同黏结长度(600 mm、800 mm)、不同黏结材料(C35混凝土、M50灌浆料)及钢管外壁增设φ6@50螺旋筋条件下... 详细信息

为确定装配式组合结构柱高强钢管连接节点常用的φ114×25、φ152×16和φ194×10截面规格Q420连接钢管的黏结长度及构造,开展了在不同黏结长度(600 mm、800 mm)、不同黏结材料(C35混凝土、M50灌浆料)及钢管外壁增设φ6@50螺旋筋条件下的钢管推出试验。通过对比分析荷载-位移/滑移曲线及黏结强度,探讨钢管连接节点的界面黏结性能。试验及分析结果表明,600 mm黏结长度即可保证节点具备满足相关规范要求的黏结强度,黏结长度增大可延缓滑移,但黏结强度随之降低;高强度灌浆料明显提高峰值点荷载大小,对曲线走势无明显影响;长细比与径厚比影响规律不明显;条件相同的情况下φ114×25截面钢管可获得较高的黏结强度;螺旋筋可有效提高黏结强度,延缓界面滑移,且施工简便,建议采用。

关键词：装配式组合结构柱节点高强钢管黏结强度灌浆料螺旋筋