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Multiscale patterning of a metallic glass using sacrificial imprint lithography

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Microsystems & Nanoengineering 2015年第1期1卷 16-25页

作者： Jonathan P.Singer Candice I.Pelligra Noga Kornblum Youngwoo Choo Manesh Gopinadhan Punnathat Bordeenithikasem Jittisa Ketkaew Seng Fatt liew Hui Cao Jan Schroers chinedum O.Osuji Department of Mechanical and Aerospace Engineering Rutgers UniversityPiscatawayNJ 08854USA Department of Chemical and Environmental Engineering Yale UniversityNew HavenCT 06511USA Department of Chemical and Environmental Engineering Center for Research on Interfacial PhenomenaYale UniversityNew HavenCT 06511USA Department of Mechanical Engineering and Materials Science Yale UniversityNew HavenCT 06511USA Department of Applied Physics Yale UniversityNew HavenCT 06511USA Department of Mechanical Engineering and Materials Science Center for Research on Interfacial PhenomenaYale UniversityNew HavenCT 06511USA

Bulk metallic glasses(BMGs)have been developed as a means to achieve durable multiscale,nanotextured surfaces with desirable properties dictated by topography for a multitude of *** barrier to this achievement is the lack of a bridging technique between macroscale thermoplastic forming and nanoimprint lithography,which arises from the difficulty and cost of generating controlled nanostructures on complex geometries using conventional top-down *** difficulty is compounded by the necessary destruction of any resulting reentrant structures during rigid *** have developed a generalized method to overcome this limitation by sacrificial template imprinting using zinc oxide(ZnO)*** is established that such structures can be grown inexpensively and quickly with tunable morphologies on a wide variety of substrates out of solution,which we exploit to generate the nanoscale portion of the multiscale pattern through this bottom-up *** this way,we achieve metallic structures that simultaneously demonstrate features from the macroscale down to the nanoscale,requiring only the top-down fabrication of macro/microstructured *** detachment of the formed part from the multiscale molds,the ZnO remains embedded in the surface and can be removed by etching in mild conditions to both regenerate the mold and render the surface of the BMGs *** ability to pattern metallic surfaces in a single step on length scales from centimeters down to nanometers is a critical step toward fabricating devices with complex shapes that rely on multiscale topography for their intended functions,such as biomedical and electrochemical applications.

关键词： bulk metallic glasses nanoimprint multiscale structures optical properties

Cost-effectiveness of Crohn's disease post-operative care

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World Journal of Gastroenterology 2016年第14期22卷 3860-3868页

作者： Emily K Wright Michael A Kamm Peter Dr Cruz Amy L Hamilton Kathryn J Ritchie Sally J Bell Steven J Brown William R Connell Paul V Desmond Danny liew Department of Gastroenterology St Vincent's Hospital University of Melbourne Fitzroy VIC 3065 Melbourne Australia Imperial College London SW7 2AZ United Kingdom Melbourne EpiCentre University of Melbourne and Melbourne Health Parkville VIC 3010 Melbourne Australia

AIM: To define the cost-effectiveness of strategies, including endoscopy and immunosuppression, to prevent endoscopic recurrence of Crohn’s disease following intestinal ***: In the “POCER” study patients undergoing intestinal resection were treated with post-operative drug therapy. Two thirds were randomized to active care (6 mo colonoscopy and drug intensification for endoscopic recurrence) and one third to drug therapy without early endoscopy. Colonoscopy at 18 mo and faecal calprotectin (FC) measurement were used to assess disease recurrence. Administrative data, chart review and patient questionnaires were collected prospectively over 18 ***: Sixty patients (active care n = 43, standard care n = 17) were included from one health service. Median total health care cost was $6440 per patient. Active care cost $4824 more than standard care over 18 mo. Medication accounted for 78% of total cost, of which 90% was for adalimumab. Median health care cost was higher for those with endoscopic recurrence compared to those in remission [$26347 (IQR 25045-27485) vs $2729 (IQR 1182-5215), P < 0.001]. FC to select patients for colonoscopy could reduce cost by $1010 per patient over 18 mo. Active care was associated with 18% decreased endoscopic recurrence, costing $861 for each recurrence ***: Post-operative management strategies are associated with high cost, primarily medication related. Calprotectin use reduces costs. The long term cost-benefit of these strategies remains to be evaluated.

关键词： Crohn’ s disease Post-operative Health economics Health care cost Biologics

Resorption of impacted teeth as a marker of squamous cell carcinoma infiltrating the mandible

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Open Journal of Stomatology 2013年第1期3卷 15-18页

作者： Sathesh Balasundram Nicolas Dulguerov Donald Murray Walker Colin liew Department of Oral and Maxillofacial Surgery University College London Hospital London UK Eastman Dental Institute University College London London UK University College London Hospital London UK

The?invasion?of?the?mandible?by?oral?squamous?cell?carcinoma?has?been?firmly?demonstrated?by?anatomical?and?histological?***?squamous?cell?carcinomas?may?induce?resorption?of?the?roots?of?standing?teeth,?there?have?been?no?reports?of?them?also?causing?resorption?of?the?crowns?of?teeth. A?73-year-old?patient?presented?with?an?invading?buccal?squamous?cell?carcinoma. Radiological?investigations?showed?tumour?invasion?of?the?dentate?region?of?the?left?mandible?and?resorption?of?the?crowns?of?right?and?left?mandibular?impacted?third?molars. The?patient?underwent?a?left?segmental?mandibulectomy?and?histopathological?examination?of?the?resected?specimen?revealed?resorption?of?the?enamel?and?dentine?of?an?unerupted?impacted?third?molar?closely?associated?with?the?infiltrating?tumour. Thus?infiltrating?carcinomas?may?rarely?cause?resorption?of?the?crowns?as?well?as?the?roots?of?unerupted?teeth?and?can?be?a?valuable?marker?of?the?extent?of?spread?of?a?tumour?for?the?planning?of?complete?surgical?resection. These?dental?changes?must?be?distinguished?radiologically?from?idiopathic?changes?in?unerupted?teeth?in?the?absence?of?malignancy.

关键词： Squamous Cell Carcinoma Invasion Tooth Resorption

Polarization shaping of Poincare´ beams by polariton oscillations

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Light(Science & Applications) 2015年第1期4卷 122-128页

作者： David Colas Lorenzo Dominici Stefano Donati Anastasiia A Pervishko Timothy CH liew Ivan A Shelykh Dario Ballarini Milena de Giorgi Alberto Bramati Giuseppe Gigli Elena del Valle Fabrice P Laussy Alexey V Kavokin Daniele Sanvitto Departamento de Fı´sica Teorica de la Materia Condensada and Condensed Matter Physics Center(IFIMAC) Universidad Autonoma de MadridE-28049Spain NANOTEC Istituto di Nanotecnologia-CNRVia Arnesano73100 LecceItaly Istituto Italiano di Tecnologia IIT-LecceVia Barsanti73010 LecceItaly Universita del Salento Via Arnesano73100 LecceItaly Division of Physics and Applied Physics Nanyang Technological University637371 SingaporeSingapore Science Institute University of IcelandDunhagi 3IS-107ReykjavikIceland Laboratory of Light-Matter Coupling in Nanostructures ITMO University197101 St.PetersburgRussia Laboratoire Kastler Brossel UPMC-Paris 6ENS et CNRS75005 ParisFrance Russian Quantum Center Novaya 100143025 SkolkovoMoscow RegionRussia CNR-SPIN Tor Vergataviale del Politechnico 1I-00133 RomeItaly

We propose theoretically and demonstrate experimentally the generation of light pulses whose polarization varies temporally to cover selected areas of the Poincare´sphere with both tunable swirling speed and total duration(1 ps and 10 ps,respectively,in our implementation).The effect relies on the Rabi oscillations of two polariton polarized fields excited by two counter-polarized and delayed *** superposition of the oscillating fields result in the precession of the Stokes vector of the emitted light while polariton lifetime imbalance results in its drift from a circle of controllable radius on the Poincare´sphere to a single point at long *** positioning of the initial circle and final point allows to engineer the type of polarization spanning,including a full sweeping of the Poincare´*** universality and simplicity of the scheme should allow for the deployment of time-varying full-Poincare´polarization fields in a variety of platforms,timescales,and regimes.

关键词： full Poincare beams polaritons polarization pulse shaping Rabi oscillations

Elastic Bending Analysis of Folded Plates and Plate Structures Using the Meshfree Galerkin Method

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Elastic Bending Analysis of Folded Plates and Plate Structur...

第一届工程科学与力学中的计算方法国际会议

作者： K.M.liew S.Kitipornchai Department of Building and Construction City University of Hong KongHong KongChina Department of Building and Construction City University of Hong KongHong KongChina

＜正＞A meshfree Galerkin method that is based on the first-order shear deformation theory （FSDT） is introduced to investigate the elastic bending behaviors of stiffened and un-stiffened folded plates under different loadings and boundary conditions. Folded plates are regarded as assemblies of flat plates that lie in different planes. The stiffness matrices of the flat plates are given by the meshfree Galerkin method. Employing the element concept, which is borrowed from the finite element method, and treating every flat plate as a super element, the global stiffness matrix of the entire folded plate is obtained by superposing the stiffness matrices of the flat plates. This is about the same for the analysis of stiffened folded plates. They are considered as assemblies of stiffened flat plates. The stiffness matrices of the stiffened plates are also given by the meshfree method. Unlike the finite element methods, no mesh is required in determining the stiffness matrices for the flat plates and the stiffened plates in this paper, which means time-consuming remeshing is entirely avoided for problems such as stiffener position changes of stiffened folded plates. To demonstrate the accuracy and convergence of the method, several numerical examples are calculated by it and the finite element commercial software ANSYS. Good agreement is observed between the two sets of results.

关键词： mesh-free Galerkin method meshless folded plate stiffened plate bending

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中华外科杂志 2005年第23期43卷 1528-1532页

作者：赵中海耿小平朱立新李晓明刘宗石安徽医科大学第一附属医院肝胆外科合肥230022 香港中文大学医学院病理解剖及细胞学系

目的探讨肝细胞癌中RAS相关区域家族蛋白1A(RASSF1A)、肿瘤高甲基化基因1(H IC1)和P73基因启动子异常甲基化状况及其与患者临床和病理因素之间的关系。方法收集肝细胞癌组织标本和对应的远癌组织标本各40例及2例健康人的肝组织标本;通... 详细信息

目的探讨肝细胞癌中RAS相关区域家族蛋白1A(RASSF1A)、肿瘤高甲基化基因1(H IC1)和P73基因启动子异常甲基化状况及其与患者临床和病理因素之间的关系。方法收集肝细胞癌组织标本和对应的远癌组织标本各40例及2例健康人的肝组织标本;通过甲基化特异的聚合酶链反应方法检测这些标本中RASSF1A、H IC1和P73基因启动子区的甲基化状况。结果RASSF1A基因在癌和远癌组织中启动子区的甲基化率分别为90.0%和72.5%,癌组织中的甲基化率高于远癌组织(P<0.05)。H IC1基因在癌和远癌组织中的甲基化率分别为77.5%和70.0%。P73基因在癌组织中甲基化率为5.0%,在远癌组织没有发现甲基化。健康人肝组织中未发现任何上述基因的异常甲基化。远癌组织中H IC1基因甲基化患者的年龄[(48±14)岁]比无甲基化患者[(57±11)岁]小(T=2.049,P=0.047)。3个基因甲基化发生情况与患者性别、是否合并乙型肝炎、肝硬化、甲胎蛋白水平、肿瘤大小、有无包膜和门静脉癌栓以及TNM分期之间未发现有统计学相关性。结论肝细胞癌中RASSF1A和H IC1基因启动子的高甲基化是普遍现象,年轻肝细胞癌患者H IC1甲基化现象更常见。

关键词：肝细胞癌 DNA甲基化基因肿瘤抑制

子宫内膜癌组织中内皮素受体B基因启动子区域CpG岛甲基化状况的研究

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中华病理学杂志 2006年第8期35卷 489-490页

作者：朱介之王波洪凡真李晓明刘宗石山东大学齐鲁医院妇科香港中文大学医学院病理解剖及细胞学系

我们对子宫内膜癌组织中内皮素受体B（endothelin receptor B，EDNRB）基因启动子区域CpG岛的甲基化（简称启动子甲基化）状况进行检测，以分析探讨其在子宫内膜癌的发生发展中的作用。

关键词：基因启动子区域内皮素受体B 子宫内膜癌甲基化状况 CpG岛癌组织 receptor 启动子甲基化发生发展

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成长的思考上海佘山常菁藤国际幼儿园

室内设计与装修 2021年第5期 86-91页

作者： Chloe liew 不详

在上海佘山常菁藤国际幼儿园的设计中,设计师把幼儿园当作是孩子们的第二个家。在这里,他们可以组建起自己的小社会关系,当美好的人、美好的事物在美好的空间中相遇,便生长出一种安放身体、培养情商、互相鼓励成长的社群关系。

关键词：社群关系幼儿园上海佘山培养情商社会关系鼓励成长国际

A preliminary comparison of motor learning across different non-invasive brain stimulation paradigms shows No consistent modulations

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中华物理医学与康复杂志 2019年第5期41卷 352-352页

作者： Lopez-Alonso V liew SL Fernfindez DM 不详

BACKGROUND AND OBJECTIVE Non-invasive brain stimulation ( NIBS) has been widely explored as a way to safely modulate brain activity and alter human performance for nearly three decades. Research using NIBS has grown exponentially within the last decade with promising results across a variety of clinical and healthy populations. However, recent work has shown high inter-individual variability and a lack of reproducibility of previous results. Here, we conducted a small preliminary study to explore the effects of three of the most commonly used excitatory NIBS paradigms over the primary motor cortex (Ml) on motor learning ( Sequential Visuomotor Isometric Pinch Force Tracking Task) and secondarily relate changes in motor learning to changes in cortical excitability ( MEP amplitude and SICI).

关键词： Non-invasive brain stimulation(NIBS) MEP amplitude SICI