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Long-term outcomes of endoscopic submucosal dissection and surgery for undifferentiated intramucosal gastric cancer regardless of size

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World Journal of Gastroenterology 2022年第8期28卷 840-852页

作者： Gil Ho Lee Eunyoung Lee Bumhee Park Jin Roh Sun Gyo Lim Sung Jae Shin Kee Myung Lee choong-kyun noh Department of Gastroenterology Ajou University School of MedicineSuwon 16499South Korea Department of Biomedical Informatics Ajou University School of MedicineSuwon 16499South Korea Department of Pathology Ajou University School of MedicineSuwon 16499South Korea

BACKGROUND The clinical outcomes of endoscopic submucosal dissection(ESD)for undifferentiated(UD)intramucosal early gastric cancer(EGC)compared with those of surgery,regardless of lesion size,are not well ***,there is a concern regarding the treatment plan before and after ESD in cases of UD intramucosal EGC within expanded *** To evaluate clinical outcomes of ESD compared with those of surgery in UD intramucosal EGC patients regardless of tumor *** We enrolled patients with UD intramucosal EGC after ESD with complete resection or surgery from January 2005 to August 2020 who met the within or beyond expanded indications with lesion size>2 cm(the only non-curative factor).Overall,123 and 562 patients underwent ESD and surgery,*** propensity-score matching,clinical and long-term outcomes,i.e.,recurrencefree survival(RFS)and overall survival(OS),were *** multivariable Cox proportional hazard model with treatment modality and ESD indication was used to evaluate the recurrence *** After matching,119 patients each were finally enrolled in the ESD and surgery *** median length of hospital stay was shorter in the ESD group than surgery group(4.0 vs 9.0 days,P<0.001).Four cases of recurrence after ESD were local recurrences,all of which occurred within 1 *** recurrence was seven(5.9%)and two(1.7%)in the ESD and surgery groups,*** difference was observed between the two groups with respect to OS(P=0.948).However,the ESD group had inferior RFS compared with the surgery group(P=0.031).ESD was associated with the risk of recurrence after initial treatment in all enrolled patients(hazard ratio,5.2;95%confidence interval:1.0-25.8,P=0.045).CONCLUSION Although OS was similar between the two groups,surveillance endoscopy was important for the ESD than for the surgery group because RFS was inferior and local recurrence was an issue.

关键词： Early gastric cancer Undifferentiated cancer Expanded indication Endoscopic submucosal dissection Surgery

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Impact of guideline adherence on the prognosis of Barcelona clinic liver cancer stage B hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第47期29卷 6122-6137页

作者： Ji Eun Han Hyo Jung Cho Jae Youn Cheong Sun Gyo Lim Min Jae Yang choong-kyun noh Gil Ho Lee Soon Sun Kim Department of Gastroenterology Ajou University School of MedicineSuwon 16499Gyeonggi-doSouth Korea

BACKGROUND Patients with Barcelona clinic liver cancer(BCLC)stage B hepatocellular carcinoma(HCC)are considerably heterogeneous in terms of tumor burden,liver function,and performance *** improve the poor survival outcomes of these patients,treatment approaches other than transarterial chemoembolization(TACE),which is recommended by HCC guidelines,have been adopted in realworld clinical *** hypothesize that this non-adherence to treatment guidelines,particularly with respect to the use of liver resection,improves survival in patients with stage B *** To assess guideline adherence in South Korean patients with stage B HCC and study its impact on *** A retrospective analysis was conducted using data from 2008 to 2016 obtained from the Korea Central Cancer *** with stage B HCC were categorized into three treatment groups,guideline-adherent,upward,and downward,based on HCC guidelines recommended by the Asian Pacific Association for the Study of the Liver(APASL),the European Association for the Study of the Liver(EASL),and the American Association for the Study of Liver Diseases(AASLD).The primary outcome was HCC-related deaths;tumor recurrence served as the secondary *** among the groups was compared using the Kaplan-Meier method and the log-rank *** of survival outcomes were identified using multivariable Cox regression *** In South Korea, over the study period from 2008 to 2016, a notable trend was observed in adherence to HCCguidelines. Adherence to the EASL guidelines started relatively high, ranging from 77% to 80% between 2008 and2012, but it gradually declined to 58.8% to 71.6% from 2013 to 2016. Adherence to the AASLD guidelines began at71.7% to 75.9% from 2008 to 2010, and then it fluctuated between 49.2% and 73.8% from 2011 to 2016. In contrast,adherence to the APASL guidelines remained consistently high, staying within the range of 90.14% to 94.5%throughout the entire study per

关键词： Hepatocellular carcinoma Barcelona clinic liver cancer stage B Guideline adherence Liver neoplasms Transarterial chemoembolization Liver resection

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Comparative analysis on homogeneity of Pb and Cd in epoxy molding compounds

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 160-164页

作者： kyun-Gmee LEE Yong-Keun SON Jin-Sook LEE Tai-Min noh Hee-Soo LEE Department of Chemistry Sungkyunkwan University Department of Chemistry Yonsei University School of Materials Science and Engineering Pusan National University

Reference materials for quantitative determination of regulated heavy metals, such as Pb and Cd in electronic components, were designed and investigated in terms of stability and homogeneity. Reference materials with two concentration levels of heavy metals were prepared by spiking Pb and Cd compounds to epoxy molding compounds made by mixing silica powders and epoxy resin. The concentration changes of the reference materials during stability test for 1 a were not observed. In the homogeneity assessment, the as-prepared reference materials were studied by using three different analytical tools, inductively coupled plasma atomic emission spectrometry (ICP-AES), X-ray fluoroescence spectrometry (XRF) and laser ablation ICP mass. The results show different homogeneities by the characteristics of analytical tools and the materials.

关键词： epoxy molding compound Pb Cd reference materials homogeneity

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POLYMERIZATION OF ISOBUTYL VINYL ETHER CATALYSED BY DINUCLEAR HALF-TITANOCENES

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Chinese Journal of Polymer Science 2008年第5期26卷 611-620页

作者： Nguyen Thi Le Thanh Seok kyun noh Won Seok Lyoo Dong-Ho Lee School of Display and Chemical Engineering Yeungnam University214-1 DaedongGyeongsanGyeongbuk 712-749Korea School of Textiles Yeungnam University214-1 DaedongGyeongsanGyeongbuk 712-749Korea Department of Polymer Science Engineering CollegeKyungpook National UniversityDaegu 702-701Korea

Polymerization of isobutyl vinyl ether(IBVE)has been studied with mononuclear half-titanocene,CpTiCl_3[1]and dinuclear half-titanocenes,[(C_5H_4)_2(CH_2)_n][(TiCl_3)_2][2(n=3),3(n=6)],and[(C_5H_4)_2(CH_2)_n[(TiCl_2OR_2](R=2,6- diisopropylphenoxyl)[4(n=3),5(n=6)],in the presence of methyl aluminoxanes(MAO)as cocatalyst in methylene *** influences of the length of polymethylene brigde and the substitution of aryloxy group at the metal center have been investigated at three polymerization temperature(...

关键词： Dinuclear half-titanocene Poly(isobutyl vinyl ether) Vinyl ether polymerization by metallocene Stereoregularity control by metallocene.

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PREPARATION AND PROPERTIES OF MMA/1-PROPYLMETHACRYLATE-POSS COPOLYMER WITH ATOM TRANSFER RADICAL POLYMERIZATION

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Chinese Journal of Polymer Science 2008年第5期26卷 533-537页

作者： He-xin Zhang Ho-young Lee Young-jun Shin Dong-ho Lee Seok kyun noh Department of Polymer Science and Engineering Kyungpook National UniversityDaegu 702-701Korea School of Display and Chemical Engineering Yeungnam UniversityGyeongsan 712-749Korea

The methyl methacrylate(MMA)/1-propylmethacrylate-polyhedral oligomeric silsesquioxane(PM-POSS) copolymers were synthesized via atom transfer radical polymerization with CuBr as *** unreacted PM-POSS monomer could be removed completely by washing the copolymerization product with *** copolymers were characterized with ~1H-NMR,X-ray diffraction,differential scanning calorimetry,thermogravimetric analysis and gel permeation *** increasing PM-POSS feed ratio,the total conversi...

关键词： Methyl methacrylate(MMA) Polyhedral oligomeric silsesquioxane(POSS) Copolymer ATRP

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Carbon and nitrogen dynamics in a Pinus densiflora forest with low and high stand densities

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Journal of Plant Ecology 2013年第5期6卷 368-379页

作者： Nam Jin noh Choonsig Kim Sang Won Bae Woo kyun Lee Tae kyung Yoon Hiroyuki Muraoka Yowhan Son Division of Environmental Science and Ecological Engineering Korea UniversitySeoul 136-713Republic of Korea River Basin Research Center Gifu UniversityGifu 501-1193Japan Department of Forest Resources Gyeongnam National University of Science and TechnologyJinju 660-758Republic of Korea Department of Forest Conservation Korea Forest Research InstituteSeoul 130-712Republic of Korea

Aims Understanding carbon(C)and nitrogen(N)dynamics and their dependence on the stand density of an even-aged,mature forest provides knowledge that is important for forest *** study investigated the differences in ecosystem total C and N storage and flux between a low-density stand(LD)and a high-density stand(HD)and examined the effects of stand density on aboveground net primary productivity(ANPP),total belowground C allocation(TBCA)and net ecosystem production(NEP)in a naturally regenerated,65-to 75-year-old Pinus densiflora *** *** LD(450 trees ha^(−1))and HD(842 trees ha^(−1))were established in an even-aged,mature *** forest in September *** forest had been naturally regenerated following harvesting,and the stand density was naturally maintained without any artificial management such as *** diameter at breast height(DBH≥5.0cm)of all live stems within the stands was measured yearly from 2007 to *** compare C and N storage and fluxes in LD and HD,C and N pools in aboveground and belowground biomass,the forest floor,coarse woody debris(CWD)and soil;soil CO_(2) efflux(R_(S));autotrophic respiration(R_(A));litter production;and soil N availability were ***,ANPP,TBCA and NEP were estimated from plot-based measurement *** Findings Ecosystem C(Mg C ha^(−1))and N(Mg N ha^(−1))storage was,respectively,173.0±7.3(mean±SE)and 4.69±0.30 for LD and 162±11.8 and 4.08±0.18 for *** were no significant differences in C and N storage in the ecosystem components,except for soils,between the two *** contrast,there were significant differences in aboveground ANPP and TBCA between the two stands(P<0.05).Litterfall,biomass increment and R_(S) were major C flux components with values of,respectively,3.89,3.74 and 9.07 Mg C ha^(−1) year^(−1) in LD and 3.15,2.94 and 7.06 Mg C ha^(−1) year^(−1) in ***-based NEP(Mg C ha^(−1) year^(−1))was 4.18 in LD and 5.50 in *** the even-aged,mature P

关键词： aboveground net primary productivity net ecosystem production Japanese red pine stand density total belowground carbon allocation

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Recent trends in metal ion based hydrogel biomaterials for tissue engineering and other biomedical applications

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Journal of Materials Science & Technology 2021年第4期63卷 35-53页

作者： Gopinathan Janarthanan Insup noh Department of Chemical and Biomolecular Engineering Seoul National University of Science and TechnologySeoul01811Republic of Korea Convergence Institute of Biomedical Engineering and Biomaterials Seoul National University of Science and TechnologySeoul01811Republic of Korea

Recently,the metal ion cross-linked hydrogels have gained enormous interest because of its excellent properties like self-healing,fast recovery,biocompatibility and high mechanical properties combined with multi-stimuli *** this review article,we have summarized the recent trends in the development of metal ion cross-linked hydrogels for tissue engineering and biomedical applications.A number of metal ions and their contribution in the synthesis of various cross-linked hydrogels are discussed with respect to their crosslinking mechanisms,compositions,physio-chemical and biological properties.A special emphasis has been given to ferric(Fe^(3+))ion cross-linked hydrogels and their different combinations owing to their numerous researches reported in the recent past with exceptional *** application of these metal ion based hydrogels in biomedical applications including tissue engineering,sensing,wound healing,drug delivery and as tissue adhesive and tissue sealants are reviewed with specific ***,the application of these metal ion cross-linked hydrogels as inks in 3 D printing is explained in a separate ***,the possible toxic effects of the different metal ions and their effects have been *** directions and comprehensive applications of the hydrogels are highlighted.

关键词： properties. biomaterials exceptional

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URECA:Efficient Resource Location Middleware for Ubiquitous Environment

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Journal of Computer Science & Technology 2008年第6期23卷 929-943页

作者： Donggeon noh Heonshik Shin Mobile System and Software Laboratory School of Computer Science and EngineeringSeoul National University

We describe an effective resource location framework for ubiquitous computing environments populated by a diverse set of networks, devices, services and computational entities. Our framework provides context adaptation with the aid of a middleware service to improve the quality of resource location. A resource location protocol suitable to each type of network locates resource effectively by means of dynamic reconfiguration to the current context. Our framework is also refined by support for interoperability between different types of resource location protocols occurring across a hybrid ubiquitous network. These characteristics also reduce the control overhead for resource location, saving resource, decreasing latency and permitting a considerable degree of scalability.

关键词： resource location resource discovery middleware context-aware interoperability ubiquitous

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UV Photolysis of N2O Isotopomers： Isotopic Fractionations and Product Rotational Quantum State Distributions

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Chinese Journal of Chemical Physics 2011年第6期24卷 679-685,I0003页

作者： Mohammad noh Daud 吉隆坡马来亚大学化学系吉隆坡50603

The time-dependent quantum wave packet method is used to study the dynamics of the pho- todissociation processes for the isotopomers 14N14N16O, 14N15N16O, 15N14N16O, 15N15N16O, 14N14N17O, and 14N14N18O. In general, the computed isotopic fractionation factors derived from the absorption cross sections of five heavy isotopomers are in good agreement with the experimental results. Relative to the 14NI4N16O isotopomer, the N2 rotational state distributions for the isotopically nitrogen substituted N2O are found to be entirely shifted to higher rotational states. Similar to its isotopic fractionation factors, the N2 rotational state distributions for the asymmetric isotopomers 14N15N16O and 15N14N16O are found to be observably different.

关键词： Time-dependent wavepacket Isotopic fractionation Product rotational distribution

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Rare earth double activated phosphors for different applications

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Journal of Rare Earths 2010年第S1期28卷 1-11页

作者： Mihail Nazarov Do Young noh Department of Materials Science and Engineering Gwangju Institute of Science and Technology1 Oryong-dongBuk-guGwangju 500-712Republic of Korea

For the purpose of development of highly energy-efficient light sources,one needs to design highly efficient green,red and yellow phosphors,which are able to absorb excitation energy and generate *** this contribution,we present our results on producing some efficient phosphors with improved luminescence *** double activation,energy could be transferred from one luminescent activator to the other one,resulting in more efficient or brighter device ***-activators could be added to a host material to change the color of the emitted *** incorporation of Eu3+ or Tb3+ ions into the CaWO4 crystal lattice modified the luminescence spectrum due to the formation of the emission centers that generated the specific red and green *** efficient new red phosphors based on YNbO4 and doped by Eu3+,Ga3+,Al3+ allowed recommending these materials as good candidates for different applications including LED and X-ray intensifying *** double activated TAG with Ce3+ and Eu3+ and for different mole ratios of Ce/Eu,the color temperature changed from 5500 K(0.331,0.322) up to 4200 K(0.370,0.381) and the light became 'warmer'.Application of TAG:Ce,Eu in the light emitting device showed better chromaticity coordinates of luminescence and color rendering index of LEDs.

关键词： optical materials phosphors luminescence rare earths

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