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Nitrogen-doped graphene nanosheets as reactive water purification membranes

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Nano Research 2016年第7期9卷 1983-1993页

作者： Yanbiao Liu Ling Yu choon nam ong Jianping Xie NUS Environmental Research Institute National University of Singapore 117411 Singapore Department of Chemical and Biomolecular Engineering National University of Singapore 117585 Singapore

Oxidation of organic pollutants by sulfate radicals produced via activation of persulfate has emerged as a promising advanced oxidation technology to address various challenging environmental issues. The development of an effective, environmentally-friendly, metal-free catalyst is the key to this technology. Additionally, a supported catalyst design is more advantageous than conventional suspended powder catalysts from the point of view of mass transfer and practical engineering applications （e.g. post-use separation）. In this study, a metal-free N-doped reduced graphene oxide （N-rGO） catalyst was prepared via a facile hydrothermal method. N-rGO filters were then synthesized by facile vacuum filtration, such that water can flow through nanochannels within the filters. Various advanced characterization techniques were employed to obtain structural and compositional information of the as-synthesized N-rGO filters. An optimized phenol oxidative flux of 0.036 ＋_ 0.002 mmol.h ~ was obtained by metal-flee catalytic activation of persulfate at an influent persulfate concentration of 1.0 mmol-L 1 and filter weight of 15 rag, while a N-free rGO filter demonstrated negligible phenol oxidation capability under similar conditions. Compared to a conventional batch system, the flow-through design demonstrates obviously enhanced oxidation kinetics （0.036 vs. 0.010 retool-h-I）, mainly due to the liquid flow through the filter leading to convection-enhanced transfer of the target molecule to the filter active sites. Overall, the results exemplified the advantages of organic compound removal by catalytic activation of persulfate using a metal-free catalyst in flow- through mode, and demonstrated the potential of N-rGO filters for practical environmental applications.

关键词： persulfate activation nitrogen-doped graphene phenol oxidation convective flow batch system

Metabolites change of Scenedesmus obliquus exerted by AgNPs

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Journal of Environmental Sciences 2019年第2期31卷 310-318页

作者： Pu Wang Bo Zhang Hui Zhang Yiliang He choon nam ong Jun Yang School of Environmental Science & Engineering Shanghai Jiaotong University School of Municipal and Environmental Engineering Lanzhou Jiaotong University NUS Environmental Research Institute National University of Singapore

With increasing emission of silver nanoparticles(AgNPs) into the environment, it is important to understand the effects of ambient concentration of AgNPs. The biological effects of AgNPs on Scenedesmus obliquus, a ubiquitous freshwater microalgae, was evaluated. AgNPs exerted a minor inhibitory effect at low doses. Non-targeted metabolomic studies were conducted to understand and analyze the effect of AgNPs on algal cells from a molecular perspective. During the 48 hr of exposure to AgNPs, 30 metabolites were identified, of which nine had significant changes compared to the control group. These include D-galactose, sucrose, and *** carbohydrates are involved in the synthesis and repair of cell walls. Glycine, an important constituent amino acid of glutathione, increased with AgNP exposure concentration increasing, likely to counteract an increased intracellular oxidative stress. These results provide a new understanding of the toxicity effects and mechanism of AgNPs. These metabolites could be useful biomarkers for future research, employed in the early detection of environmental risk from AgNPs.

关键词： Silver nanoparticles (AgNPs) Scenedesmus obliquus Metabolomics Molecular mechanism

Protective effects of Asian green vegetables against oxidant induced cytotoxicity

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World Journal of Gastroenterology 2005年第48期11卷 7607-7614页

作者： Peter Rose choon nam ong Matt Whiteman Department of Biochemistry Department of Community

AIM: To evaluate the antioxidant and phase Ⅱ detoxification enzyme inducing ability of green leaf vegetables consumed in ***: The antioxidant properties of six commonly consumed Asian vegetables were determined using the ABTS, DPPH, deoxyribose, PR bleaching and ironascorbate induced lipid peroxidation assay. Induce of phase Ⅱ detoxification enzymes was also determined for each respective vegetable extract. Protection against authentic ONOO- and HOCI mediated cytotoxicity in human colon HCT116 cells was determined using the MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrasodium bromide) viability ***: All of the extracts derived from green leaf vegetables exhibited antioxidant properties, while also having cytoprotective effects against ONOO- and HOCI mediated cytotoxicity. In addition, evaluation of the phase Ⅱ enzyme inducing ability of each extract,as assessed by quinone reductase and glutathioneS-transferase activities, showed significant variation between the vegetables ***: Green leaf vegetables are potential sources of antioxidants and phase Ⅱ detoxification enzyme inducers in the Asian diet. It is likely that consumption of such vegetables is a major source of beneficial phytochemical constituents that may protect against colonic damage.

关键词：保护作用亚洲绿色蔬菜细胞毒性异硫氰酸酯

Regulation of aging by NELF-A and RNA polymerase Ⅱ elongation

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Neural Regeneration Research 2024年第7期19卷 1415-1416页

作者： Chin-Tong ong Zhen-Kai Ngian Temasek Life Sciences Laboratory and Department of Biological Sciences National University of SingaporeSingaporeSingapore Department of Genetics Harvard Medical SchoolBostonMAUSA Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingaporeSingapore

Epigenetic regulation of aging:Aging is defined as the gradual decline of physiological function and cellular integrity,causing o rganismal vulnerability to age-onset diseases and *** in different animal models have l... 详细信息

关键词： aging twelve integrity

Synergistic integration of self-supported 1T/2H-WS_(2) and nitrogendoped rGO on carbon cloth for pH-universal electrocatalytic hydrogen evolution

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Nano Research 2024年第3期17卷 1267-1280页

作者： Feng Ming Yap Jian Yiing Loh Wee-Jun ong School of Energy and Chemical Engineering Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia Center of Excellence for NaNo Energy&Catalysis Technology(CONNECT) Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Gulei Innovation Institute Xiamen UniversityZhangzhou 363200China Shenzhen Research Institute of Xiamen University Shenzhen 518057China

Hydrogen economy based on electrochemical water splitting exemplified one of the most promising means for overcoming the rapid consumption of fossil fuels and the serious deterioration of global *** development of earth-abundant,efficient,and durable electrocatalysts for hydrogen evolution reaction(HER)plays a vital role in the commercialization of water ***,the self-supported electrode with unique nitrogen-doped reduced graphene oxide(N-rGO)nanoflakes and WS_(2) hierarchical nanoflower that were grown directly on carbon cloth(CC)substrate(WS_(2)/N-rGO/CC)was successfully synthesized using a facile dual-step hydrothermal *** as-synthesized 50%1T/2H-WS_(2)/N-rGO/CC(WGC),which possessed high metallic 1T phase of 57%not only efficiently exposed more active sites and accelerated mass/charge diffusion,but also endowed excellent structural lustiness,robust stability,and durability at a high current *** a result,the 50%WGC exhibited lower overpotentials and Tafel slopes of 21.13 mV(29.55 mV∙dec^(-1))and 80.35 mV(137.02 mV∙dec^(-1))as compared to 20%Pt-C/CC,respectively for catalyzing acidic and alkaline hydrogen evolution ***,the as-synthesized 50%WGC also depicted long-term stability for more than 8 h in the high-current-density regions(100 and 220 mA∙cm^(-2)).In brief,this work reveals a self-supported electrode as an extraordinary alternative to Pt-based catalysts for HER in a wide pH range,while paving a facile strategy to develop advanced electrocatalysts with abundant heterointerfaces for practical applications in energy-saving hydrogen production.

关键词： self-supported electrocatalyst carbon-based substrate phase engineering pH-universal water splitting

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职业工效学与卫生

科学对社会的影响 1993年第1期42卷 11-19页

作者： choon-nam ong 张雁新加坡国立大学社区职业及家庭医学系

工效学包括预防职业病和提高健康水平两个方面。新近的一些研究表明,许多职业病与工具、机器和作业场所的不良设计有关。为了防止不必要的失误和暴露性及累积性损伤,工效学通过制造适应于使用者和劳动者能力的工具或机器,在提高工作效... 详细信息

工效学包括预防职业病和提高健康水平两个方面。新近的一些研究表明,许多职业病与工具、机器和作业场所的不良设计有关。为了防止不必要的失误和暴露性及累积性损伤,工效学通过制造适应于使用者和劳动者能力的工具或机器,在提高工作效率和生产力方面具有关键作用。

关键词：工效学职业工效学卫生

Chrysin sensitizes tumor necrosis factor-α-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB

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Chrysin sensitizes tumor necrosis factor-α-induced apoptosi...

广西原发性肝细胞癌与p53基因72密码子单核苷酸多态性密切相关

2011广东省预防医学会学术年会

作者： Xin Li Qing Huang choon-nam ong Xing-Fen Yang Han-Ming Shen Center for Disease Control and Prevention of Guangdong Province NUS Graduate School for Integrative Sciences and Engineering National University of Singapore

Chrysin(5.7-dihydroxyflavone) is a natural flavonoid commonly found in many *** anti-cancer property of chrysin has been demonstrated although the molecular mechanisms remain to be further *** the present study,we found that,pretreatment with chrysin greatly sensitized various human cancer cells to tumor necrosis factor-alpha (TNFα)-induced *** the search of the molecular mechanisms responsible for the sensitization effect of chrysin,we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on TNFα-mediared nuclear transcription factor-kappaB (NF-κB) *** with chrysin inhibited TNFα-induced degradation of Inhibitor of kappaB(lκB) protein and subsequent nuclear translocation of *** a result, chrysin suppressed the expression of NF-κB-targeted anti-apoptotic *** role of c-FUP-L was further confirmed by its ectopic expression,which significantly protecred cell death induced by combined treatment with chrysin and TNFα.Data from this study thus reveal a novel function of chrysin and enhance the value of chrysin as an anti-cancer agent.

关键词： Chrysin TNFα NF-κB Apoptosis Cancer

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中华外科杂志 2004年第5期42卷 313-314页

作者：彭涛严律南刘志明 Hanming shen choon nam ong 彭民浩黎乐群李家荃 530021 南宁广西医科大学附属第一医院普外科四川大学华西医院普外科新加坡国立大学社区职业与家庭医学部

临床分子流行病学资料提示,肿瘤抑制基因p53-72密码子的单核苷酸多态性(single nucleotide polymorphism,SNP)与某些与人类乳头瘤病毒(human papillomavirus,HPV)感染有关的肿瘤密切相关[1,2];这一多态性还可能增加丙型肝炎病毒(hepatit... 详细信息

临床分子流行病学资料提示,肿瘤抑制基因p53-72密码子的单核苷酸多态性(single nucleotide polymorphism,SNP)与某些与人类乳头瘤病毒(human papillomavirus,HPV)感染有关的肿瘤密切相关[1,2];这一多态性还可能增加丙型肝炎病毒(hepatitis C virus, HCV)某些亚型感染的易感性[3],并与慢性肝病等一些因素共同增加原发性肝细胞癌(hepatocellular carcinoma, HCC)的发病危险度[4].我们对这一多态性在广西HCC中的分布进行了初步的研究探讨,现报告如下。

关键词：原发性肝细胞癌基因单核苷酸多态性 p53-72密码子

Enhancing MXene-based supercapacitors:Role of synthesis and 3D architectures

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Journal of Energy Chemistry 2024年第4期91卷 1-26页

作者： Wen Siong Poh Wen Jie Yiang Wee-Jun ong Pau Loke Show Chuan Yi Foo School of Energy and Chemical Engineering Xiamen University MalaysiaSelangor Darul EhsanMalaysia&College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005FujianChina Kelip-kelip!Center of Excellence for Light Enabling Technologies Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia Center of Excellence for NaNo Energy&Catalysis Technology(CONNECT) Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia Department of Chemical Engineering Khalifa UniversityShakhbout Bin Sultan St-Zone 1Abu DhabiUnited Arab Emirates Zhejiang Provincial Key Laboratory for Subtropical Water Environment and Marine Biological Resources Protection Wenzhou UniversityWenzhou 325035ZhejiangChina Department of Chemical and Environmental Engineering Faculty of Science and EngineeringUniversity of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia Department of Sustainable Engineering Saveetha School of EngineeringSIMATSChennai 602105India

MXene has been the limelight for studies on electrode active materials,aiming at developing supercapacitors with boosted energy density to meet the emerging influx of wearable and portable electronic *** its various desirable properties including intrinsic flexibility,high specific surface area,excellent metallic conductivity and unique abundance of surface functionalities,its full potential for electrochemical performance is hindered by the notorious restacking phenomenon of MXene *** to its two-dimensional(2D)nature and surface functional groups,inevitable Van der Waals interactions drive the agglomeration of nanosheets,ultimately reducing the exposure of electrochemically active sites to the electrolyte,as well as severely lengthening electrolyte ion transport *** a result,energy and power density deteriorate,limiting the application versatility of MXene-based *** 3D architectures using 2D nanosheets presents as a straightforward yet ingenious approach to mitigate the fatal flaws of ***,the sheer number of distinct methodologies reported,thus far,calls for a systematic review that unravels the rationale behind such 3D MXene structural ***,this review aims to serve this purpose while also scrutinizing the structure–property relationship to correlate such structural modifications to their ensuing electrochemical performance ***,the physicochemical properties of MXene play fundamental roles in determining the effective charge storage capabilities of 3D MXene-based *** largely depends on different MXene synthesis techniques and synthesis condition variations,hence,elucidated in this review as ***,the challenges and perspectives for achieving viable commercialization of MXene-based supercapacitor electrodes are highlighted.

关键词： MXene 3D architectures Synthesis design Supercapacitor Energy storage