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Aurora B facilitates cholangiocarcinoma progression by stabilizing c-Myc

Animal Models and Experimental Medicine 2024年第05期 626-640页

作者： Ke Liu Xuxuan Zhou Fei Huang Lihao Liu Zijian Xu chongqing gao Keke Zhang Jian Hong Nan Yao Guohua Cheng College of Pharmacy Jinan University Department of Pathophysiology School of Medicine Jinan University School of Medicine Jinan University

Background: Cholangiocarcinoma(CCA), a malignancy that arises from biliary epithelial cells, has a dismal prognosis, and few targeted therapies are available. Aurora B, a key mitotic regulator, has been reported to be involved in the progression of various tumors, yet its role in CCA is still ***: Human CCA tissues and murine spontaneous CCA models were used to assess Aurora B expression in CCA. A loss-of-function model was constructed in CCA cells to determine the role of Aurora B in CCA progression. Subcutaneous and liver orthotopic xenograft models were used to assess the therapeutic potential of Aurora B inhibitors in ***: In murine spontaneous CCA models, Aurora B was significantly upregulated. Elevated Aurora B expression was also observed in 62.3% of human specimens in our validation cohort(143 CCA specimens), and high Aurora B expression was positively correlated with pathological parameters of tumors and poor survival. Knockdown of Aurora B by siRNA and heteroduplex oligonucleotide(HDO)or an Aurora B kinase inhibitor(AZD1152) significantly suppressed CCA progression via G2/M arrest induction. An interaction between Aurora B and c-Myc was found in CCA cells. Targeting Aurora B significantly reduced this interaction and accelerated the proteasomal degradation of c-Myc, suggesting that Aurora B promoted the malignant properties of CCA by stabilizing c-Myc. Furthermore, sequential application of AZD1152 or Aurora B HDO drastically improved the efficacy of gemcitabine in ***: Aurora B plays an essential role in CCA progression by modulating c-Myc stability and represents a new target for treatment and chemosensitization in CCA.

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Low-Carbon Dispatching for Virtual Power Plant with Aggregated Distributed Energy Storage Considering Spatiotemporal Distribution of Cleanness Value

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 346-358页

作者： Hongchao gao Tai Jin Guanxiong Wang Qixin Chen chongqing Kang Jingkai Zhu State Key Laboratory of Power System Operation and Control Department of Electrical EngineeringTsinghua UniversityBeijing 100084China Sichuan Energy Internet Research Institute Tsinghua University Chengdu 200016China Power Dispatching and Control Center of Shanghai Municipal Electric Power Company Shanghai 200122China IEEE

The scale of distributed energy resources is increasing,but imperfect business models and value transmission mechanisms lead to low utilization ratio and poor *** address this issue,the concept of cleanness value of distributed energy storage(DES)is proposed,and the spatiotemporal distribution mechanism is discussed from the perspectives of electrical energy and *** on this,an evaluation system for the environmental benefits of DES is constructed to balance the interests between the aggregator and the power system ***,an optimal low-carbon dispatching for a virtual power plant(VPP)with aggregated DES is constructed,where-in energy value and cleanness value are both *** achieve the goal,a green attribute labeling method is used to establish a correlation constraint between the nodal carbon potential of the distribution network(DN)and DES behavior,but as a cost,it brings multiple nonlinear ***,a solution method based on the convex envelope(CE)linear re-construction method is proposed for the multivariate nonlinear programming problem,thereby improving solution efficiency and ***,the simulation verification based on the IEEE 33-bus DN is *** simulation results show that the multidimensional value recognition of DES motivates the willingness of resource users to ***,resolving the impact of DES on the nodal carbon potential can effectively alleviate overcompensation of the cleanness value.

关键词： Distributed energy storage virtual power plant(VPP) spatiotemporal distribution low-carbon dispatching

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自体组织预防盆腔多脏器联合切除术后出现直肠阴道瘘的临床疗效

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中华胃肠外科杂志 2024年第3期27卷 278-282页

作者：王影阎庆辉王刚成汪涛高重庆李凌娟丁亮亮张志王聪张燕齐作超河北医科大学第二医院肛肠外科石家庄050004 郑州大学第一附属医院腹盆部肿瘤外科郑州450052 郑州大学附属肿瘤医院普通外科郑州450008

目的探讨自体组织在预防盆腔肿瘤联合子宫、直肠等多脏器切除(保肛)术后出现直肠阴道瘘的临床疗效。方法本研究采用回顾性队列研究方法。分析河北医科大学第二医院和郑州大学附属肿瘤医院自2017年2月至2022年2月收治的83例盆腔多脏器联... 详细信息

目的探讨自体组织在预防盆腔肿瘤联合子宫、直肠等多脏器切除(保肛)术后出现直肠阴道瘘的临床疗效。方法本研究采用回顾性队列研究方法。分析河北医科大学第二医院和郑州大学附属肿瘤医院自2017年2月至2022年2月收治的83例盆腔多脏器联合切除患者的临床资料,并根据手术方式不同分为两组。其中,51例患者术中采用自体组织(包括:带蒂的大网膜、结肠肠系膜、腹直肌)预防直肠阴道瘘作为自体组织预防组;32例未采用自体组织预防直肠阴道瘘作为对照组。分析两组患者的基本资料,包括肿瘤类型、手术方式、手术时间、术中出血量和术后直肠阴道瘘的发生率。结果两组患者的肿瘤类型、手术方式和术中出血量差异均没有统计学意义(均P>0.05);自体组织预防组手术时间长于对照组,两组比较差异具有统计学意义(t=3.888,P<0.001);自体组织预防组出现直肠阴道瘘3例,对照组出现直肠阴道瘘10例(χ2=9.579,P=0.002)。结论自体组织对直肠吻合口及阴道残端进行保护性预防修复重建能有效降低盆腔肿瘤联合子宫、直肠等盆腔多脏器切除后直肠阴道瘘发生率。

关键词：盆腔多脏器切除直肠阴道瘘大网膜腹直肌肠系膜

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Relation of abnormal gallbladder arterioles to gallbladder emptying in patients with gallstone and diabetes mellitus

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 275-278页

作者： Xiong Ding, Jian-Ping Gong, Chang-You Lu, Chang-An Liu, Yu-Jun Shi and Gen-Wu gao chongqing, China Department of Hepatobiliary Surgery, Second Clinical College, chongqing University of Medical Science, chongqing 400010, China Department of Hepatobiliary Surgery Second Clinical College Chongqing University of Medical Science Chongqing 400010 China. dingpanda@***

BACKGROUND: Diabetes mellitus is thought to be related to gallstone formation in emptying the gallbladder. Diabe- tes mellitus may lead to many changes in microarterioles and micronerves; the aim of this study was to investigate the abnormality of arterioles in the gallbladder and its rela- tion to gallbladder hypomotility in patients with gallstone and diabetes mellitus. METHODS: Thirty patients with simple gallstones and 30 patients with gallstones and diabetes mellitus were analy- zed , and their gallbladder emptying function was measured with B ultrasound before operation. After operation, the arterioles of the gallbladder rinsed with periodic acid-schiff (PAS) reagent in photos were used for analysis of the tu- blar area and stereo system with the Beihang CM-2000B biological and medical photo system. RESULTS: In patients with gallstones and diabetes mellitus, the gallbladder emptying function was significantly im- paired, the area ratio of the arteriole wall to whole arte- rioles in cross section was significantly higher than that in patients with simple gallstones (0.81 ±0.09 vs. 0.58±0.15, P 0.05). CONCLUSION: In patients with diabetes mellitus, the se- dimentation of PAS positive material in the wall of arte- rioles leads to the stenosis of arterioles. It is probably con- tributive to hypomotility of the gallbladder.

关键词： gallstone diabetes mellitus arterioles gallbladder motility

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两针固定法对乙状结肠单腔造口术后造口脱垂的预防效果

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中华胃肠外科杂志 2022年第6期25卷 542-545页

作者：李志猛高安庆李春光余萌高重庆郑州大学附属肿瘤医院普通外科郑州450000 新乡医学院第一临床学院新乡453000 暨南大学基础医学与公共卫生学院广州510000

目的探讨利用"两针固定法"预防合并高危因素直肠癌患者在乙状结肠单腔造口术后造口脱垂等并发症的临床疗效。方法采用回顾性队列研究方法。收集自2015年1月至2020年6月期间,在郑州大学附属肿瘤医院连续收治的行腹会阴联合直肠癌根治(Mil... 详细信息

目的探讨利用"两针固定法"预防合并高危因素直肠癌患者在乙状结肠单腔造口术后造口脱垂等并发症的临床疗效。方法采用回顾性队列研究方法。收集自2015年1月至2020年6月期间,在郑州大学附属肿瘤医院连续收治的行腹会阴联合直肠癌根治(Miles)乙状结肠单腔造口手术的232例患者的临床病理资料,根据造口固定方式的不同分为两针固定组(102例)和传统固定组(130例)。两组患者基线资料差异无统计学意义(均P>0.05)。比较两组的手术时间、术后造口脱垂及其他相关并发症的发生率和转归。结果两组患者均顺利完成手术,均无术中严重并发症的发生。两针固定组手术时间较传统固定组明显缩短[(1.4±0.3)d比(6.3±0.7)d,t=-65.615,P0.05)。结论对于合并高危因素的低位直肠癌患者,两针固定法固定Miles术乙状结肠单腔造口可以有效降低术后造口脱垂等并发症的发生。

关键词：乙状结肠肿瘤乙状结肠造口术造口脱垂两针固定法

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大气污染:危害人类健康的“无形杀手”

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四川环境 2000年第4期19卷 65-68页

作者：王承鳌重庆第一财贸学校重庆400036

环境保护是事关人类生存发展的战略性、全球性、世纪性的大课题 ,而大气污染则是城市环境问题的首要问题 ,作者站在创建“生态环境医学”的制高点上 ,引证了大量翔实的例症 ,剖析了大气污染给人类生存环境和心身健康所带来的种种危害和... 详细信息

环境保护是事关人类生存发展的战略性、全球性、世纪性的大课题 ,而大气污染则是城市环境问题的首要问题 ,作者站在创建“生态环境医学”的制高点上 ,引证了大量翔实的例症 ,剖析了大气污染给人类生存环境和心身健康所带来的种种危害和机理 ,并从多角度提示了标本兼治大气污染的应急措施 ,从而疾呼“地球人”要确立科学的发展 ,坚定地走经济发展、环境保护、生态文明的可持续发展之路 ,这才是“依法治气”

关键词：大气污染温室效应生态环境医学人类健康危害

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利用浅地表层所蓄太阳能改善室内热环境的埋管热过程研究

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太阳能学报 1994年第4期15卷 380-385页

作者：冯雅陈启高重庆建筑大学

讨论了一种利用浅地表层蓄存的太阳能改善室内热环境的方法，建立了埋管冷却或加热空气的热过程数学模型，通过理论分析、数值模拟和实验测试较系统地揭示了热过程规律。结果表明，利用受太阳辐射影响较大的浅地表层蓄能改善室内热环境... 详细信息

讨论了一种利用浅地表层蓄存的太阳能改善室内热环境的方法，建立了埋管冷却或加热空气的热过程数学模型，通过理论分析、数值模拟和实验测试较系统地揭示了热过程规律。结果表明，利用受太阳辐射影响较大的浅地表层蓄能改善室内热环境是可行的。

关键词：太阳辐射地下埋管热过程数值模拟

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Hybrid pedestrian positioning system using wearable inertial sensors and ultrasonic ranging

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Defence Technology（防务技术） 2024年第3期33卷 327-338页

作者： Lin Qi Yu Liu Chuanshun gao Tao Feng Yue Yu School of Communication and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong Kong 999077China

Pedestrian positioning system(PPS)using wearable inertial sensors has wide applications towards various emerging fields such as smart healthcare,emergency rescue,soldier positioning,*** performance of traditional PPS is limited by the cumulative error of inertial sensors,complex motion modes of pedestrians,and the low robustness of the multi-sensor collaboration *** paper presents a hybrid pedestrian positioning system using the combination of wearable inertial sensors and ultrasonic ranging(H-PPS).A robust two nodes integration structure is developed to adaptively combine the motion data acquired from the single waist-mounted and foot-mounted node,and enhanced by a novel ellipsoid constraint *** addition,a deep-learning-based walking speed estimator is proposed by considering all the motion features provided by different nodes,which effectively reduces the cumulative error originating from inertial ***,a comprehensive data and model dual-driven model is presented to effectively combine the motion data provided by different sensor nodes and walking speed estimator,and multi-level constraints are extracted to further improve the performance of the overall *** results indicate that the proposed H-PPS significantly improves the performance of the single PPS and outperforms existing algorithms in accuracy index under complex indoor scenarios.

关键词： Pedestrian positioning system Wearable inertial sensors Ultrasonic ranging Deep-learning Data and model dual-driven

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A novel box-counting method for quantitative fractal analysis of threedimensional pore characteristics in sandstone

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International Journal of Mining Science and Technology 2024年第4期34卷 479-489页

作者： Huiqing Liu Heping Xie Fei Wu Cunbao Li Renbo gao State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400030China School of Resources and Safety Engineering Chongqing UniversityChongqing 400030China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Deep Underground Engineering Sciences and Green Energy College of Civil and Transportation EngineeringShenzhen UniversityShenzhen 518060China

Fractal theory offers a powerful tool for the precise description and quantification of the complex pore structures in reservoir rocks,crucial for understanding the storage and migration characteristics of media within these *** with the challenge of calculating the three-dimensional fractal dimensions of rock porosity,this study proposes an innovative computational process that directly calculates the three-dimensional fractal dimensions from a geometric *** employing a composite denoising approach that integrates Fourier transform(FT)and wavelet transform(WT),coupled with multimodal pore extraction techniques such as threshold segmentation,top-hat transformation,and membrane enhancement,we successfully crafted accurate digital rock *** improved box-counting method was then applied to analyze the voxel data of these digital rocks,accurately calculating the fractal dimensions of the rock pore *** numerical simulations of permeability experiments were conducted to explore the physical correlations between the rock pore fractal dimensions,porosity,and absolute *** results reveal that rocks with higher fractal dimensions exhibit more complex pore connectivity pathways and a wider,more uneven pore distribution,suggesting that the ideal rock samples should possess lower fractal dimensions and higher effective porosity rates to achieve optimal fluid transmission *** methodology and conclusions of this study provide new tools and insights for the quantitative analysis of complex pores in rocks and contribute to the exploration of the fractal transport properties of media within rocks.

关键词： 3D fractal analysis Fractal dimension Rock pore structure Box-counting method Permeability simulation Computational geosciences

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Data-driven Static Equivalence with Physics-informed Koopman Operators

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 432-438页

作者： Wei Lin Changhong Zhao Maosheng gao C.Y.Chung Department of Electrical Engineering The Hong Kong Polytechnic UniversityHong Kong SARChina Department of Information Engineering The Chinese University of Hong KongHong Kong SARChina School of Electrical Engineering Chongqing UniversityChongqing 400044China

With deployment of measurement units,fitting static equivalent models of distribution networks(DNs)by linear regression has been recognized as an effective method in power flow analysis of a transmission *** volatility of measurements caused by variable distributed renewable energy sources makes it more difficult to accurately fit such equivalent *** tackle this challenge,this letter proposes a novel data-driven method to improve equivalency accuracy of DNs with distributed energy *** letter provides a new perspective that an equivalent model can be regarded as a mapping from internal conditions and border voltages to border power *** mapping can be established through 1)Koopman operator theory,and 2)physical features of power flow equations at the root node of a *** of the proposed method is demonstrated on the IEEE 33-bus and IEEE 136-bus test systems connected to a 661-bus utility system.

关键词： Data-driven distribution network Koopman operator theory static equivalent model

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