检索结果-南通市图书馆

Neferine inhibits the progression of diabetic nephropathy by modulating the miR-17-5p/nuclear factor E2-related factor 2 axis

引用

Journal of Traditional Chinese Medicine 2024年第1期44卷 44-53页

作者： HUANG Hongmei yang Maojun LI Ting WANG Dandan LI Ying TANG Xiaochi YUAN Lu GU shi XU Yong Department of Endocrinology Chengdu Shuangliu District First People's Hospital(West China Airport of Sichuan University)Chengdu 610200China Department of Endocrinology Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China

OBJECTIVE:To investigate the effect of Neferine(Nef)on diabetic nephropathy(DN)and to explore the mechanism of Nef in DN based on miRNA regulation theory.METHODS:A DN mouse model was constructed and treated with Nef.Serum creatinine(Crea),blood urea(UREA)and urinary albumin were measured in mice by kits,and renal histopathological changes and fibrosis were observed by hematoxylin-eosin staining and Masson staining.Renal tissue superoxide dismutase(SOD),malondialdehyde(MDA)and glutathione peroxidase(GSH-Px)activities were measured by enzyme-linked immunosorbent assay(ELISA).Western blotting was used to detect the expression of nuclear factor E2-related factor 2(Nrf2)/heme oxygenase 1(HO-1)signaling pathway-related proteins in kidney tissues.Quantitative reverse transcription-polymerase chain reaction(q RT-PCR)was used to detect the expression of miR-17-5p in kidney tissues.Subsequently,a DN in vitro model was constructed by high glucose culture of human mesangial cells(HMCs),cells were transfected with miR-17-5p mimic and/or treated with Nef,and we used q RTPCR to detect cellular miR-17 expression,flow cytometry to detect apoptosis,ELISAs to detect cellular SOD,MDA,and GSH-Px activities,Western blots to detect Nrf2/HO-1 signaling pathway-related protein expression,and dual luciferase reporter gene assays to verify the targeting relationship between Nrf2 and miR-17-5p.RESULTS:Administration of Nef significantly reduced the levels of blood glucose,Crea,and UREA and the expression of miR-17-5p,improved renal histopathology and fibrosis,significantly reduced MDA levels,elevated SOD and GSH-Px activities,and activated Nrf2 expression in kidney tissues from mice with DN.Nrf2 is a post-transcriptional target of miR-17-5p.In HMCs transfected with miR-17-5p mimics,the m RNA and protein levels of Nrf2 were significantly suppressed.Furthermore,miR-17-5p overexpression and Nef intervention resulted in a significant increase in high glucose-induced apoptosis and MDA levels in HMCs and a significant decrease in the protein expr

关键词： diabetic nephropathies neferine miR-17-5p NF-E2-related factor 2 oxidative stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Porous garnet as filler of solid polymer electrolytes to enhance the performance of solid-state lithium batteries

引用

Nano Research 2024年第4期17卷 2663-2670页

作者： yang Zhang Lei Zhang Peng Guo Chaoyan Zhang Xiaochuan Ren Zhen Jiang Jianjun Song Chuan shi College of Physics Qingdao UniversityQingdao 266071China Industrial Research Institute of Nonwovens and Technical Textiles College of Textiles and ClothingQingdao UniversityQingdao 266071China Department of Chemistry University of PennsylvaniaPhiladelphiaPA 19104USA

In order to enhance the ionic conductivity of solid polymer electrolytes(SPEs)and their structural rigidity against lithium dendrite during lithium-ion battery(LIB)cycling,we propose porous garnet Li6.4La3Zr2Al0.2O12(LLZO),as the filler to SPEs.The porous LLZO with interlinked grains was synthesized via a resol-assisted cationic coordinative co-assembly approach.The porous structure of LLZO with high specific surface area facilitates the interaction between polymer and filler and provides sufficient entrance for Li^(+)migration into the LLZO phase.Furthermore,the interconnection of LLZO grains forms continuous inorganic pathways for fast Li^(+)migration,which avoid the multiple diffusion for Li^(+)in interface.As a result,the SPEs with porous LLZO(SPE-PL)show a high ionic conductive of 0.73 mS·cm^(-1) at 30℃ and lithium-ion transference number of 0.40.The porous LLZO with uniformly dispersed pores also acts as an ion distributor to regulate ionic flux.The lithium-symmetrical batteries assembled with SPE-PL show a highly stable Li plating/stripping cycling for nearly 3000 h at 0.1 mA·cm^(-2).The corresponding Li/LiFePO_(4) batteries also exhibit excellent cyclic performance with capacity retention of 75%after nearly 500 cycles.This work brings new insights into the design of conductive fillers and the optimization of SPEs.

关键词： solid polymer electrolytes lithium metal battery porous conductive filler solid state battery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Investigation of high-quality-factor aluminum nitride MEMS cantilever resonators

引用

Nanotechnology and Precision Engineering 2024年第1期7卷 32-43页

作者： Shuai shi Qingrui yang Yi Yuan Haolin Li Pengfei Niu Wenlan Guo Chen Sun Wei Pang State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072China

This paper presents the design,fabrication,and characterization of cantilever-type resonators with a novel stacked structure.Aluminum nitride is adopted as the material for both the structural layer and the piezoelectric layer;this simpliﬁes the fabrication process and improves the quality factor of the resonator.Both in-plane and out-of-planeﬂexural modes were investigated.The effect of the structural dimensions and electrode patterns on the resonator’s performance were also studied.Finite-element simulations and experiments examining anchor loss and thermoelastic damping,which are the main loss mechanisms affecting the quality factor of these resonators,were carried out.The optimal structural dimensions and electrode patterns of the cantilever-type resonators are presented.A quality factor of 7922 with a motional impedance of 88.52 kΩand a quality factor of 8851 with a motional impedance of 67.03 kΩwere achieved for the in-plane and out-of-planeﬂexural-mode resonators,respectively.The proposed resonator design will contribute to the development of high-performance devices such as accelerometers,gyroscopes,and pressure sensors.

关键词： MEMS Cantilever-type micro-resonator AlN Finite-element simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experiment on inducing apoptosis of melanoma cells by micro-plasma jet

引用

Nanotechnology and Precision Engineering 2024年第1期7卷 10-17页

作者： Hua Li Qihao shi Yanhua yang Jinghao Qi Yuhan Zhang Fengyun Wang Xiaoxia Du Wenxiang Xiao School of Life and Environmental Sciences GuiLin University of Electronic TechnologyGuilinGuangXi 541004People’s Republic of China The Guangxi Human Physiological Information Noninvasive Detection Engineering Technology Research Center GuilinGuangXi 541004People’s Republic of China Guilin URIT MEDICAL Electronic Sales Co. Ltd.GuilinGuangXi 541004People’s Republic of China

As a promising cancer treatment method,cold atmospheric plasma has received widespread attention in recent years.However,previous research has focused more on how to realize and expand the anti-cancer scope of plasma jet.There are also studies on the killing of small-scale cancer cells,but the effects of plasma jet on normal cells and normal cell clusters have been ignored.Therefore,we proposed a 50μm sized micro-plasma jet device,and used the device to treat melanoma cells(A-375)and human glial cells(HA1800)to evaluate their anti-cancer effects and effects on normal cells.The experimental results show that this kind of micro-plasma jet device can effectively inactivate cancer cells in a short period of time,while having little effect on normal cells.This work provides a certain experimental basis for the application ofﬁne plasma jet to clinically inactivate cancer cells.

关键词： 3D cell clusters Micro-plasma jet Cancer therapy Reactive oxygen species Plasma direct treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of nonalcoholic fatty liver disease on response to antiviral treatment in patients with chronic hepatitis B:A meta-analysis

引用

World Journal of Hepatology 2024年第3期16卷 465-476页

作者： shi-Yi Liu Dian Wang Jing Liu Lu-Ping yang Gong-Ying Chen Department of Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Medicine Hangzhou Normal UniversityHangzhou 310011Zhejiang ProvinceChina Department of Infectious and Hepatology Diseases Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina

BACKGROUND Although hepatitis B virus infection is the leading cause of chronic liver injury globally,nonalcoholic fatty liver disease(NAFLD)is gradually gaining attention as another major chronic liver disease.The number of patients having chronic hepatitis B(CHB)with concomitant hepatic steatosis has increased.AIM To analyze the effect of NAFLD on the response to antiviral treatment in patients with CHB.METHODS Relevant English studies were systematically searched across PubMed,EMBASE,Web of Science,and Cochrane Library until October 2023.Studies in which the treatment outcomes were compared between patients with CHB only and those with CHB and hepatic steatosis were included.RESULTS Of the 2502 retrieved studies,11 articles were finally included.Biochemical response until 48 wk(OR=0.87,95%CI:0.50–1.53,P=0.000)and 96 wk(OR=0.35,95%CI:0.24–0.53,P=0.24)and virological response until 96 wk(OR=0.80,95%CI:0.43–1.49,P=0.097)were lower in patients with hepatic steatosis than in patients with CHB alone.CONCLUSION Hepatic steatosis lowers the biochemical response to antiviral treatment in patients with CHB.

关键词： Nonalcoholic fatty liver disease Hepatitis B virus Antiviral treatment effect Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Manipulator tracking technology based on FSRUKF

引用

Journal of Systems Engineering and Electronics 2024年第2期35卷 473-484页

作者： shi Guoqing ZHANG Boyan ZHANG Jiandong yang Qiming HUANG Xiaofeng QUE Jianyao PU Junwei GENG Xiutang School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China Northwest Institute of Mechanical&Electrical Engineering Xianyang 712000China

Aiming at the shortcoming that the traditional industrial manipulator using off-line programming cannot change along with the change of external environment,the key technologies such as machine vision and manipulator control are studied,and a complete manipulator vision tracking system is designed.Firstly,Denavit-Hartenberg(D-H)parameters method is used to construct the model of the manipulator and analyze the forward and inverse kinematics equations of the manipulator.At the same time,a binocular camera is used to obtain the threedimensional position of the target.Secondly,in order to make the manipulator track the target more accurately,the fuzzy adaptive square root unscented Kalman filter(FSRUKF)is proposed to estimate the target state.Finally,the manipulator tracking system is built by using the position-based visual servo.The simulation experiments show that FSRUKF converges faster and with less error than the square root unscented Kalman filter(SRUKF),which meets the application requirements of the manipulator tracking system,and basically meets the application requirements of the manipulator tracking system in the practical experiments.

关键词： square root unscented Kalman filter(SRUKF) fuzzy inference manipulator visual servo

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Coherent link between a Ti:sapphire comb and a 1.5μm laser via nonlinear interaction in photonic crystal fiber

引用

Photonics Research 2024年第2期12卷 350-355页

作者： YUAN YAO HAOSEN shi GUANG yang BO LI CONGYU WANG HONGFU YU LONGSHENG MA YANYI JIANG State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Optical clock networks have distinct advantages for the dissemination of time/frequency,geodesy,and fundamental research.To realize such a network,the telecom band and optical atomic clocks have to be coherently bridged.Since the telecom band and optical atomic clocks reside in a distinct spectral region,second-harmonic generation is usually introduced to bridge the large frequency gap.In this paper,we introduce a new method to coherently link a 1550 nm continuous wave laser with a Ti:sapphire mode-locked laser-based optical frequency comb.By coupling the 1550 nm continuous wave laser light and the Ti:sapphire comb light together into a photonic crystal fiber,nonlinear interaction takes place,and new comblike frequency components related to the 1550 nm laser frequency are generated in the visible region.Consequently,we can detect beat notes between two combs in the visible region with a signal-to-noise ratio of more than 40 dB in a resolution bandwidth of300 kHz.With this signal,we realize an optical frequency divider for converting the frequency of optical clocks in the visible region to the telecom band at 1.55μm.An out-of-loop measurement shows that the additional noise and uncertainty induced in optical frequency conversion are 5×10^(-18)at 1 s averaging time and 2.2×10^(-19),respectively,which are limited by the uncompensated light path fluctuation but fulfill precision measurement using state-of-the-art optical clocks.

关键词： fiber interaction nonlinear

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lensless opto-electronic neural network with quantum dot nonlinear activation

引用

Photonics Research 2024年第4期12卷 682-690页

作者： WANXIN shi XI JIANG ZHENG HUANG XUE LI YUyang HAN SIGANG yang HAIZHENG ZHONG HONGWEI CHEN Beijing National Research Center for Information Science and Technology(BNRist) Department of Electronic EngineeringTsinghua UniversityBeijing 100084China China Mobile Research Institute Beijing 100053China MIIT Key Laboratory for Low-dimensional Quantum Structure and Devices School of Materials Sciences&EngineeringBeijing Institute of TechnologyBeijing 100081China

With the swift advancement of neural networks and their expanding applications in many fields, optical neural networks have gradually become a feasible alternative to electrical neural networks due to their parallelism, high speed, low latency, and power consumption. Nonetheless, optical nonlinearity is hard to realize in free-space optics, which restricts the potential of the architecture.

关键词： network neural networks

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel integrated microfluidic chip for on-demand electrostatic droplet charging and sorting

引用

Bio-Design and Manufacturing 2024年第1期7卷 31-42页

作者： Jinhui Yao Chunhua He Jianxin Wang Canfeng yang Ye Jiang Zhiyong Liu Guanglan Liao Tielin shi State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

On-demand droplet sorting is extensively applied for the efficient manipulation and genome-wide analysis of individual cells.However,state-of-the-art microfluidic chips for droplet sorting still suffer from low sorting speeds,sample loss,and labor-intensive preparation procedures.Here,we demonstrate the development of a novel microfluidic chip that integrates droplet generation,on-demand electrostatic droplet charging,and high-throughput sorting.The charging electrode is a copper wire buried above the nozzle of the microchannel,and the deflecting electrode is the phosphate buffered saline in the microchannel,which greatly simplifies the structure and fabrication process of the chip.Moreover,this chip is capable of high-frequency droplet generation and sorting,with a frequency of 11.757 kHz in the drop state.The chip completes the selective charging process via electrostatic induction during droplet generation.On-demand charged microdroplets can arbitrarilymove to specific exit channels in a three-dimensional(3D)-deflected electric field,which can be controlled according to user requirements,and the flux of droplet deflection is thereby significantly enhanced.Furthermore,a lossless modification strategy is presented to improve the accuracy of droplet deflection or harvest rate from 97.49% to 99.38% by monitoring the frequency of droplet generation in real time and feeding it back to the charging signal.This chip has great potential for quantitative processing and analysis of single cells for elucidating cell-to-cell variations.

关键词： Copper wire Droplet generation Droplet sorting Microfluidic chips On-demand charging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Wetting sub-nanochannels via ionic hydration effect for improving charging dynamics

引用

Green Energy & Environment 2024年第3期9卷 473-480页

作者： Yayun shi Xiaoli Zhao Qihang Liu Zhenghui Pan Congcong Liu Shanyi Zhu Zhijun Zuo Xiaowei yang State Key Laboratory of Clean and Efficient Coal Utilization Taiyuan University of TechnologyTaiyuan030024China School of Materials Science and Engineering Tongji UniversityShanghai201804China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai200240China

The ionic transport in sub-nanochannels plays a key role in energy storage,yet suffers from a high energy barrier.Wetting sub-nanochannels is crucial to accelerate ionic transport,but the introduction of water is challenging because of the hydrophobic extreme confinement.We propose wetting the channels by the exothermic hydration process of pre-intercalated ions,the effect of which varies distinctly with different ionic hydration structures and energies.Compared to the failed pre-intercalation of SO_(4)^(2-),HSO_(4)^(-) with weak hydration energy results in a marginal effect on the HOMO(Highest Occupied Molecular Orbital)level of water to avoid water splitting during the electrochemical intercalation.Meanwhile,the ability of water introduction is reserved by the initial incomplete dissociation state of HSO_(4)^(-),so the consequent exothermic reionization and hydration processes of the intercalated HSO_(4)^(-) promote the water introduction into sub-nanochannels,finally forming the stable confined water through hydrogen bonding with functional groups.The wetted channels exhibit a significantly enhanced ionic diffusion coef-ficient by~9.4 times.

关键词： Sub-nanochannels Ionic hydration Ionic transport Supercapacitors Confined water

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：