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神经病理性疼痛不同性质疼痛患者血清BDNF、TLR4表达水平差异及其诊断价值分析

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现代生物医学进展 2024年第10期24卷 1931-1936页

作者：王欢王辉王崇祥赵博卜岗西安交通大学第一附属医院疼痛科陕西西安710000

目的:分析神经病理性疼痛(NP)不同性质疼痛患者血清脑源性神经生长因子(BDNF)、Toll受体4(TLR4)表达水平差异及其诊断价值。方法:选取2021年5月~2022年5月本院收治的80例NP患者和100例健康体检者作为研究对象,将NP患者其纳入NP组,将健... 详细信息

目的:分析神经病理性疼痛(NP)不同性质疼痛患者血清脑源性神经生长因子(BDNF)、Toll受体4(TLR4)表达水平差异及其诊断价值。方法:选取2021年5月~2022年5月本院收治的80例NP患者和100例健康体检者作为研究对象,将NP患者其纳入NP组,将健康体检者纳入对照组,并参照神经病理性疼痛量表(NPS)区分NP组患者的疼痛性质(钝痛20例,不适感28例,深部痛17例,体表痛15例),分别检测两组患者和NP组不同性质疼痛患者的血清BDNF、TLR4表达水平,采用双变量Spearman相关性检验血清BDNF、TLR4与NP不同性质疼痛的相关性,同时建立多因素Logistic模型,分析NP不同性质疼痛的影响因素,并比较其诊断效能。结果:与对照组比较,NP组血清BDNF表达水平较低,TLR4表达水平较高(P0.70。结论:血清BDNF、TLR4与钝痛、不适感、深部痛、体表痛等性质的NP均存在一定关联,在诊断不同NP性质方面具有较高的敏感性和特异性,有利于为临床治疗提供参考依据。

关键词： NP 钝痛不适感深部痛体表痛 BDNF TLR4

Renormalization: single-photon processes of two-level system in free space

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Journal of Systems Engineering and Electronics 2020年第5期31卷 908-915页

作者： wang chong ZHU Yong LI Liangsheng YIN Hongcheng Beijing Institute of Environment Features Beijing 100854China Science and Technology on Electromagnetic Scattering Laboratory Beijing Institute of Environmental FeaturesBeijing 100854China

The investigation on quantum radar requires accurate computation of the state vectors of the single-photon processes of the two-level system in free space. However, the traditional Weisskopf-Wigner(W-W) theory fails to deal with those processes other than spontaneous emission. To solve this problem, we provide a new method based on the renormalization theory. We evaluate the renormalized time-ordered Green functions associated with the single-photon processes, and relate them to the corresponding state vectors. It is found that the ultraviolet divergences generated by the Lamb shift and higher-order interactions can be systematically subtracted in the state vectors. The discussions on spontaneous emission and single-photon absorption are then presented to illustrate the proposed method. For spontaneous emission, we obtain the same results of the W-W theory. For single-photon absorption where W-W theory fails, we find that the two-level electric dipole first gets excited rapidly and then decays exponentially, and that the efficiency of the single-photon absorption declines as the bandwidth of the incident photon becomes narrow. The proposed method can improve the investigation on quantum radar.

关键词： single-photon process two-level system(2LS) renormalization time-ordered Green function(RTGF) quantum radar

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亮氨酸对哺乳期湖羊羔羊小肠发育的影响

动物营养学报 2024年第6期36卷 3833-3844页

作者：魏智远蔡奕涛孙梦珍纪雯雯王翀茅慧玲浙江农林大学动物科技学院、动物医学院杭州311300 浙江省畜禽绿色生态健康养殖应用技术研究重点实验室浙江311300

本试验旨在研究亮氨酸对哺乳期湖羊羔羊小肠组织形态、屏障功能及菌群组成的影响。选取30只体重[(3.60±0.37)kg]相近的5日龄湖羊羔羊,随机分成对照组(Con组,未添加亮氨酸)和亮氨酸组(Leu组,添加0.66 g/d亮氨酸),每组5个重复,每个重复3... 详细信息

本试验旨在研究亮氨酸对哺乳期湖羊羔羊小肠组织形态、屏障功能及菌群组成的影响。选取30只体重[(3.60±0.37)kg]相近的5日龄湖羊羔羊,随机分成对照组(Con组,未添加亮氨酸)和亮氨酸组(Leu组,添加0.66 g/d亮氨酸),每组5个重复,每个重复3只羔羊。试验期25 d。结果显示:1)与Con组相比,Leu组的空肠绒毛高度有增加的趋势(P=0.073),空肠隐窝深度显著降低(P<0.05),空肠绒毛高度/隐窝深度显著增加(P<0.05);回肠绒毛高度显著增加(P<0.05)。2)与Con组相比,Leu组的空肠上皮超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物(GSH-Px)的基因相对表达量均显著升高(P<0.05)。3)与Con组相比,Leu组的空肠上皮咬合蛋白(Occludin)和闭锁小带蛋白-1(ZO-1)的基因和蛋白相对表达量均显著或极显著升高(P<0.05或P<0.01)。4)与Con组相比,Leu组的空肠布雷德菌属(Bulleidia)的相对丰度有增加的趋势(P=0.076),而空肠颤螺旋菌属(Oscillospira)和链球菌属(Streptococcus)的相对丰度显著降低(P<0.05)。5)相关性分析结果显示,空肠Bulleidia的相对丰度与空肠ZO-1的基因相对表达量呈极显著正相关(P<0.01),空肠Streptococcus的相对丰度与空肠隐窝深度呈极显著正相关(P<0.01)。由此可见,添加亮氨酸可增强湖羊羔羊空肠抗氧化能力,调控肠道上皮紧密连接蛋白的表达,改变空肠菌群结构,从而促进哺乳期羔羊小肠发育。

关键词：亮氨酸哺乳期湖羊羔羊小肠发育空肠菌群

无人机点云与图像跨模态混合融合的乔木林单木尺度树种分类研究

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遥感技术与应用 2024年第1期39卷 87-97页

作者：鄢敏夏永华王冲孔夏丽太浩宇李晨昆明理工大学国土资源工程学院云南昆明650093 昆明理工大学城市学院云南昆明650051 中国电建集团昆明勘测设计研究院有限公司云南昆明650200

为探索机载点云与无人机可见光影像在乔木树种识别与分类领域的应用潜力,提出了一种多模态特征与决策混合融合的无人机单木尺度树种分类识别方法。首先使用Kendall Rank相关系数法与排列重要性分析(Permutation Importance, PI)进行特... 详细信息

为探索机载点云与无人机可见光影像在乔木树种识别与分类领域的应用潜力,提出了一种多模态特征与决策混合融合的无人机单木尺度树种分类识别方法。首先使用Kendall Rank相关系数法与排列重要性分析(Permutation Importance, PI)进行特征选择,采用高效低秩多模态融合算法(Low-rank Multimodal Fusion, LMF)融合点云与影像特征。再引入集成学习,将点云、影像及融合特征分别输入Stacking集成的极限梯度提升机(eXtreme Gradient Boosting, XGBoost)、轻型梯度提升机(Light Gradient Boosting Machine, LightGBM)与随机森林(Random Forest, RF)3个基分类器,最后采用元分类器—朴素贝叶斯进行决策融合。实验数据表明:所提方法独立测试精度达99.4%,较传统的特征串联融合随机森林分类器提升了22.58%,Kappa系数提升了0.285 4。与卷积神经网络(Convolutional Neural Network, CNN)对比实验证明:所提算法在小样本训练的优势明显,且具有更好的泛化能力。

关键词：多模态融合单木尺度树种分类集成学习

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机载LiDAR输电线对地距离智能检测

应用激光 2024年第4期44卷 104-112页

作者：麻卫峰吴小东王冲闻平曹磊朱琪云南师范大学地理学部云南昆明650500 中国电建集团昆明勘测设计研究院有限公司云南昆明650000 云南省高校资源与环境遥感重点实验室云南昆明650500 云南大学国际河流与生态安全研究院云南昆明650500

对地距离是输电线路巡检和电网风险评估的重要指标,受限于复杂线路环境及地形条件,传统人工测量方法存在作业困难、效率低下等不足。以无人机载LiDAR激光点云数据为基础,提出一套高效的输电线路对地距离智能检测技术流程,包括点云分类... 详细信息

对地距离是输电线路巡检和电网风险评估的重要指标,受限于复杂线路环境及地形条件,传统人工测量方法存在作业困难、效率低下等不足。以无人机载LiDAR激光点云数据为基础,提出一套高效的输电线路对地距离智能检测技术流程,包括点云分类、最下层输电线提取、对地距离检测及风险点识别等。主要贡献点包括:(1)通过把输电线三维点云投影至二维残差空间,将输电线点云分割过程转换为投影点聚类问题,淡化了数据缺失、点云噪声因素对单根输电线精细分割的消极影响;(2)设计了基于类簇重心分析的最下层输电线识别与提取策略;(3)实现了基于激光点云的输电线对地距离智能化检测。试验结果表明:该方法可快速从原始点云数据中精确识别最下层输电线,并实现对地距离高效检测及风险点精准识别,具有操作简单、自动化高的特点。研究为机载LiDAR输电线路安全巡检提供理论和实践参考。

关键词：激光雷达输电线路对地距离智能检测

A Distributed Cooperative Dynamic Task Planning Algorithm for Multiple Satellites Based on Multi-agent Hybrid Learning

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Chinese Journal of Aeronautics 2011年第4期24卷 493-505页

作者： wang chong LI Jun JING Ning wang Jun CHEN Hao College of Electronic Science and Engineering National University of Defense Technology Changsha 410073 China

Traditionally, heuristic re-planning algorithms are used to tackle the problem of dynamic task planning for multiple satellites. However, the traditional heuristic strategies depend on the concrete tasks, which often affect the result’s optimality. Noticing that the historical information of cooperative task planning will impact the latter planning results, we propose a hybrid learning algorithm for dynamic multi-satellite task planning, which is based on the multi-agent reinforcement learning of policy iteration and the transfer learning. The reinforcement learning strategy of each satellite is described with neural networks. The policy neural network individuals with the best topological structure and weights are found by applying co-evolutionary search iteratively. To avoid the failure of the historical learning caused by the randomly occurring observation requests, a novel approach is proposed to balance the quality and efficiency of the task planning, which converts the historical learning strategy to the current initial learning strategy by applying the transfer learning algorithm. The simulations and analysis show the feasibility and adaptability of the proposed approach especially for the situation with randomly occurring observation requests.

关键词： multiple satellites dynamic task planning problem multi-agent systems reinforcement learning neuroevolution of augmenting topologies transfer learning

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基于物联网技术的植物人生物电流传感研究

移动信息 2024年第8期46卷 295-297页

作者：肖柳吴泽兰王冲湖南应用技术学院信息工程学院湖南常德415100

文中探讨了物联网技术与植物人生物电流的结合应用。通过结合物联网技术与生物电流,可以将生理信号转变为物理信号,再通过传感器对植物人进行实时监测,以评估其康复情况和表达的情感。首先,介绍了研究背景,然后描述了研究现状和应用实例... 详细信息

文中探讨了物联网技术与植物人生物电流的结合应用。通过结合物联网技术与生物电流,可以将生理信号转变为物理信号,再通过传感器对植物人进行实时监测,以评估其康复情况和表达的情感。首先,介绍了研究背景,然后描述了研究现状和应用实例,通过具体案例展示了该技术的应用效果,并通过需求分析,阐述了两者结合的优势。

关键词：物联网植物人生物电流传感器康复评估交流

Distributed cooperative task planning algorithm for multiple satellites in delayed communication environment

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Journal of Systems Engineering and Electronics 2016年第3期27卷 619-633页

作者： chong wang Jinhui Tang Xiaohang Cheng Yingchen Liu Changchun wang National Key Laboratory of Airspace Technology Beijing 100085China

Multiple earth observing satellites need to communicate with each other to observe plenty of targets on the Earth together. The factors, such as external interference, result in satellite information interaction delays, which is unable to ensure the integrity and timeliness of the information on decision making for satellites. And the optimization of the planning result is affected. Therefore, the effect of communication delay is considered during the multi-satel ite coordinating process. For this problem, firstly, a distributed cooperative optimization problem for multiple satellites in the delayed communication environment is formulized. Secondly, based on both the analysis of the temporal sequence of tasks in a single satellite and the dynamically decoupled characteristics of the multi-satellite system, the environment information of multi-satellite distributed cooperative optimization is constructed on the basis of the directed acyclic graph（DAG）. Then, both a cooperative optimization decision making framework and a model are built according to the decentralized partial observable Markov decision process（DEC-POMDP）. After that, a satellite coordinating strategy aimed at different conditions of communication delay is mainly analyzed, and a unified processing strategy on communication delay is designed. An approximate cooperative optimization algorithm based on simulated annealing is proposed. Finally, the effectiveness and robustness of the method presented in this paper are verified via the simulation.

关键词： Earth observing satellite(EOS) distributed coo-perative task planning delayed communication decentralized partial observable Markov decision process(DEC-POMDP) simulated annealing

Numerical analysis of uncertain temperature field by stochastic finite difference method

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Science China(Physics,Mechanics & Astronomy) 2014年第4期57卷 698-707页

作者： wang chong QIU ZhiPing WU Di School of Aeronautic Science and Engineering Beihang University China Academy of Launch Vehicle Technology

Based on the combination of stochastic mathematics and conventional finite difference method,a new numerical computing technique named stochastic finite difference for solving heat conduction problems with random physical parameters,initial and boundary conditions is *** with the analysis of steady-state heat conduction problems,difference discrete equations with random parameters are established,and then the computing formulas for the mean value and variance of temperature field are derived by the second-order stochastic parameter perturbation ***,the proposed random model and method are extended to the field of transient heat conduction and the new analysis theory of stability applicable to stochastic difference schemes is *** layer-by-layer recursive equations for the first two probabilistic moments of the transient temperature field at different time points are quickly obtained and easily solved by ***,by comparing the results with traditional Monte Carlo simulation,two numerical examples are given to demonstrate the feasibility and effectiveness of the presented method for solving both steady-state and transient heat conduction problems.

关键词： heat conduction uncertainty stochastic finite difference parameter perturbation stability