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智慧健康 2024年第11期10卷 20-22页

作者：陈畅杨冲谷孝立王灿阳苏圆圆上海天佑医院上海200331

目的本研究旨在探究中医十二井穴刺络放血对脑梗死的干预效果,以及其对脑组织代谢的影响,通过质子磁共振波谱技术定量分析。方法选择2019—2022年本院收治的120例患者随机分成两组,将实验组(接受十二井穴刺络放血干预)与对照组(未干预)... 详细信息

目的本研究旨在探究中医十二井穴刺络放血对脑梗死的干预效果,以及其对脑组织代谢的影响,通过质子磁共振波谱技术定量分析。方法选择2019—2022年本院收治的120例患者随机分成两组,将实验组(接受十二井穴刺络放血干预)与对照组(未干预)进行比较。使用质子磁共振波谱技术对脑组织进行扫描,分析能量代谢及N-乙酰天门冬氨酸(NAA)、乳酸(Lac)、胆碱(cho)等指标的变化。同时,通过神经炎症指标的检测评估炎症反应的变化。结果实验组减轻了脑缺血缺氧损伤,乳酸/丙酮酸比值升高,反映出能量代谢的积极变化。神经炎症指标明显降低,表明十二井穴刺络放血具有抗炎作用。结论十二井穴刺络放血在脑梗死治疗中的潜在作用机制,通过改善脑组织血流、能量代谢以及抑制炎症反应,为中医治疗脑梗死提供了新的理论依据。

关键词：十二井穴刺络放血脑梗死质子磁共振波谱局部血流灌注能量代谢

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复合材料层合壳受冲击破坏的实验研究

航空学报 2006年第2期27卷 250-252页

作者：赵桂平趙鐘斗權五陽西安交通大学航天航空学院陕西西安710049 韩国仁荷大学机械工程系

为了研究复合材料层合壳在冲击荷载作用下的破坏始因、扩展机理及破坏模式,对一组20层对称正交铺设[04/904/02]s的航空用复合材料UIN125B石墨/环氧树脂圆柱壳段进行了低速落重实验。试件按层合壳的曲率半径R不同分为4组,每组尺寸相同的... 详细信息

为了研究复合材料层合壳在冲击荷载作用下的破坏始因、扩展机理及破坏模式,对一组20层对称正交铺设[04/904/02]s的航空用复合材料UIN125B石墨/环氧树脂圆柱壳段进行了低速落重实验。试件按层合壳的曲率半径R不同分为4组,每组尺寸相同的试件7件,共完成28件试件在冲击荷载作用下的试验研究。观察并分析其破坏的发生和发展过程,通过热揭层对脱层损伤及其模式进行测试和测量,了解破坏的扩展机理及最后模式。讨论曲率半径不同对破坏区域的分布及破坏尺寸大小的影响。最后将实验测得的破坏域与计算模拟的结果作以比较,可以看到实测破坏模式与分析结果吻合较好,实测破坏面积略小于计算分析结果。

关键词：复合材料层合壳冲击载荷破坏模式实验研究

Characterization of transgenic mice expressing EGFP under the control of the monkey 20α-hydroxysteroid dehydrogenase promoter

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Science China(Life Sciences) 2018年第8期61卷 966-974页

作者： Chae-Won Park Seong-Keun Jeong Tsevelmaa Nanjidsuren Munkhzaya Byambaragchaa Myung-Hwa Kang Bo-Woong Sim kwan-Sik Min Animal Biotechnology Graduate School of Future Convergence Technology Department of Animal Life Science Institute of Genetic Engineering Hankyong National University Department of Food Science and Nutrition Hoseo University National Primate Research Center Korea Research Institute of Bioscience and Biotechnology

To directly assess the molecular function of the monkey 20α-hydroxysteroid dehydrogenase （20α-HSD） promoter, we generated transgenic mice （tg） expressing enhanced green fluorescent protein （EGFP） under control of this promoter. We demonstrated that prostaglandin F2α induced 20α-HSD promoter activity in cho cells in a dose-dependent manner. Furthermore, forskolin treatment markedly reduced 20α-HSD promoter activity, and prolactin exhibited weak inhibitory activity. The transgenic mouse obtained one positive founder male. The transgene was propagated in 10 successive generations without any notable defects to the progeny. EGFP and 20α-HSD in the tg mice were colocalized in the luteal cells of the ovary during late pregnancy. Strong EGFP and 20et-HSD protein signals were also detected in the adult testis. Immtmohistochemical analysis revealed high EGFP levels in the seminiferous epithelium, whereas 20α-HSD was expressed in the seminiferous tubules. Our data suggest that the ovaries in monkey and mouse exhibit similar expression patterns of 20α-HSD during pregnancy. However, the expression pattern of EGFP in tg mice testis slightly differed from that of the endogenous 20α-HSD. Further investigation is required to elucidate the functional mechanisms underlying regulation of the monkey 20α-HSD promoter in the tg mice.

关键词： transgenic mice EGFP monkey 20α-HSD promoter

Transverse Flux Induction Coil for Uniform Bar Heating Excluding Edge

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Transverse Flux Induction Coil for Uniform Bar Heating Exclu...

Superior gallstone dissolubility and safety of tert-amyl ethyl ether over methyl-tertiary butyl ether

第七届冶金与材料电磁过程国际会议（EPM2012）

作者： PARK Jong-Soo BAE Jin-Su cho Un-kwan HA Tae-Jong KIM Goo-Hwa Process Engineering Design Research Group Engineering Research CenterPOSCO

This work particularly focuses on compensating Joule heat in under-heated areas occurred when thin steel bar is(< 20 mm) heated by transverse flux induction heater(TFIH).The under-heated areas take place in range of 50 150 mm from the both edges,so Transverse Flux Induction Coil(TFIC) including a magnetic core is proposed and optimized to supplement this *** solutions on the electromagnetic field are obtained numerically by commercial code MAXWELL 3D software from ANSYS *** then,verified experimentally by pilot-scale tests,in which the TFIH was manufactured with a nominal power of 100 kW at a fundamental frequency of 1 ***,TFIC having geometrically the optimized magnetic core made the heating pattern U-shaped,so could supply a desirable temperature profile for the rolling process.

关键词： Transverse Flux Induction heating(TFIH) induction coil magnetic core uniform heating

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World Journal of Gastroenterology 2019年第39期25卷 5936-5952页

作者： Dong Do You Suk Joon cho Ok-Hee Kim Jin Sook Song Kyu-Seok Hwang Sang Chul Lee Kee-Hwan Kim Ho Joong choi Ha-Eun Hong Haeyeon Seo Tae Ho Hong Jung Hyun Park Tae Yoon Lee Joseph Ahn Jae-Kyung Jung kwan-Young Jung Say-June Kim Department of Surgery St.Vincent's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 16247South Korea College of Pharmacy Chungbuk National UniversityCheongju 28644South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Bio and Drug Discovery Division Korea Research Institute of Chemical TechnologyDaejeon 34114South Korea Department of Surgery Daejeon St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 34943South Korea Department of Surgery Uijeongbu St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 11765South Korea Department of Biomedicine and Health Science College of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Eunpyeong St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 03312South Korea Department of Medicinal Chemistry and Pharmacology University of Science and TechnologyDaejeon 34113South Korea

BACKGROUND The use of methyl-tertiary butyl ether(MTBE)to dissolve gallstones has been limited due to concerns over its toxicity and the widespread recognition of the safety of laparoscopic *** adverse effects of MTBE are largely attributed to its low boiling point,resulting in a tendency to ***,if there is a material with a higher boiling point and similar or higher dissolubility than MTBE,it is expected to be an attractive alternative to *** To determine whether tert-amyl ethyl ether(TAEE),an MTBE analogue with a relatively higher boiling point(102°C),could be used as an alternative to MTBE in terms of gallstone dissolubility and *** The in vitro dissolubility of MTBE and TAEE was determined by measuring the dry weights of human gallstones at predetermined time intervals after placing them in glass containers with either of the two *** in vivo dissolubility was determined by comparing the weights of solvent-treated gallstones and control(dimethyl sulfoxide)-treated gallstones,after the direct infusion of each solvent into the gallbladder in both hamster models with cholesterol and pigmented *** The in vitro results demonstrated a 24 h TAEE-dissolubility of 76.7%,56.5%and 38.75%for cholesterol,mixed,and pigmented gallstones,respectively,which represented a 1.2-,1.4-,and 1.3-fold increase in dissolubility compared to that of *** the in vitro experiment,the 24 h-dissolubility of TAEE was 71.7%and 63.0%for cholesterol and pigmented gallstones,respectively,which represented a 1.4-and 1.9-fold increase in dissolubility compared to that of *** addition,the results of the cell viability assay and western blot analysis indicated that TAEE had a lower toxicity towards gallbladder epithelial cells than *** We demonstrated that TAEE has higher gallstone dissolubility properties and safety than those of *** such,TAEE could present an attractive alternative to MTBE if our findings

关键词： Tert-amyl ethyl ether Gallstones Methyl-tert-butyl ether Contact litholytic agent

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家中的“迷你酒店”

缤纷 2008年第7期 72-79页

作者： Minsuk cho+Kisu Park Jerry Yong-kwan Kim

整个建筑沉浸在淡淡的禅意之中。穿越平和的空气,主人能够与自然、生活的细节毫不矫情地对话。

关键词：建筑家玻璃窗生活理想艺术品空间需求退休住宅酒店幸福享受

The Hong Kong consensus statements on unresectable hepatocellular carcinoma:narrative review and update for 2021

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 366-385页

作者： Tan-To Cheung Simon Chun-Ho Yu Stephen L.Chan Ronnie T.P.Poon Philip Kwok Ann-Shing Lee Anna Tai Derek Tam Chin-Cheung Cheung Tak-Wing Lai Nam-Hung Chia Ada Law Tracy Shum Yim-kwan Lam Vince Lau Victor Lee Charing chong Chung-Ngai Tang Thomas Yau Department of Surgery Queen Mary HospitalThe University of Hong KongHong KongChina Department of Imaging&Interventional Radiology Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina State Key Laboratory of Translational Oncology and Department of Clinical Oncology Sir YK Pao Centre for CancerPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Radiology and Imaging Queen Elizabeth HospitalHong KongChina Department of Clinical Oncology Tuen Mun HospitalHong KongChina Department of Clinical Oncology Queen Elizabeth HospitalHong KongChina Department of Surgery United Christian HospitalHong KongChina Department of Surgery Tuen Mun HospitalHong KongChina Department of Surgery Princess Margaret HospitalHong KongChina Department of Surgery Queen Elizabeth HospitalHong KongChina Department of Clinical Oncology Pamela Youde Nethersole Eastern HospitalHong KongChina Department of Clinical Oncology Princess Margaret HospitalHong KongChina Department of Medicine and Geriatrics United Christian HospitalHong KongChina Department of Radiology Queen Mary HospitalHong KongChina Department of Clinical Oncology Queen Mary HospitalThe University of Hong KongHong KongChina Department of Surgery Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Surgery Pamela Youde Nethersole Eastern HospitalHong KongChina Department of Medicine Queen Mary HospitalThe University of Hong KongHong KongChina

Background and Objective:Hong Kong,like many parts of Asia,faces a high burden of hepatocellular carcinoma(HCC)caused by high endemic rates of hepatitis B virus *** Kong clinicians have developed a high level of expertise in HCC treatment across surgical,transarterial,ablative,radiotherapeutic and systemic *** publication summarizes the latest evidence-based recommendations on how these modalities should be ***:In two meetings held in 2020,a multidisciplinary panel of surgeons,oncologists and interventional radiologists performed a narrative review of evidence on the management of HCC,with an emphasis on treatment of HCC not amenable to surgical *** attention was paid to new evidence published since the previous version of these statements in *** Content and Findings:The expert panel has formulated 60 consensus statements to guide the staging and treatment of unresectable *** the previous version of these statements,considerable additions have been made to the recommendations on use of targeted therapies and immunotherapies because of the large volume of new ***:Our consensus statements offer guidance on how to select HCC patients for surgical or non-surgical treatment and for choosing among non-surgical modalities for patients who are not candidates for *** particular,there is a need for more evidence to aid physicians in the selection of second-line systemic therapies,as currently most data are limited to patients with disease progression on first-line sorafenib.

关键词： Hepatocellular carcinoma(HCC) Hong Kong guidelines consensus

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推动“以家庭为中心”的预立医疗照护计划

中国护理管理 2019年第3期19卷 326-329页

作者：李子芬彭楚君香港中文大学那打素护理学院香港中文大学赛马会老年学研究所香港公开大学护理及健康学院

家庭参与和家庭关系对建立预立医疗照护计划有着重要的影响。因此,要有效推动预立医疗照顾计划,家人参与是绝不能忽略的。本文综述了"以家庭为中心"的预立医疗照护计划相关概念,分析了家庭参与对制定预立医疗照护计划的重要性,总结了如... 详细信息

家庭参与和家庭关系对建立预立医疗照护计划有着重要的影响。因此,要有效推动预立医疗照顾计划,家人参与是绝不能忽略的。本文综述了"以家庭为中心"的预立医疗照护计划相关概念,分析了家庭参与对制定预立医疗照护计划的重要性,总结了如何实践"以家庭为中心"的预立医疗照护计划,为我国推动"以家庭为中心"的预立医疗照护计划提供理论依据和实践指导。

关键词：预立医疗照护计划家庭关系家庭参与

Dose verifying system used in Leksell GammaKnife Radiosurgery:Variable Ellipsoid Modeling Technique（VEMT）

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Dose verifying system used in Leksell GammaKnife Radiosurger...