检索结果-南通市图书馆

Serum prostate-specific antigen as a predictor of prostate volume and lower urinary tract symptoms in acommunity-based cohort： a large-scale Korean screening study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2013年第2期15卷 249-253,I0008页

作者： Dong Soo Park Jong jin Oh Jae Yup Hong young Kwon Hong Don Kyung choi In Hyuck Gong jin HoHwang Sung Won Kwon Department of Urology CHA Bundang Medical Center CHA University Seongnam 463-712 Korea CHA Cancer Research Center Seou1135-081 Korea Department of Urology CHA Gangnam Medical Center CHA University Seou1135-081 Korea Korea Prostate Health Council Seou1137-070 Korea

The aim of this study is to assess the ability of serum prostate-specific antigen （PSA） to predict prostate volume （PV） and lower urinary tract symptoms （LUTS） represented by the international prostate symptom score （IPSS）. From January 2001 to December 2011, data were collected from men who first enrolled in the Korean Prostate Health Council Screening Program. Patients with a serum PSA level of 10 ng ml^-1 or age 〈40 years were excluded. Accordingly, a total of 34 857 men were included in our study, and serum PSA, PV and the IPSS were estimated in all patients. Linear and age-adjusted multivariate logistic analyses were used to assess the potential association between PSA and PV or IPSS. The predictive value of PSA for estimating PV and IPSS was assessed based on the receiver operating characteristics-derived area under the curve （AUC）. The mean PV was 29.9 ml, mean PSA level was 1.49 ng ml^-1 and mean IPSS was 15.4. A significant relationship was shown between PSA and PV, and the IPSS and PSA were also significantly correlated after adjusting by age. The AUCs of PSA for predicting PV ~20 ml, 〉25 ml and 〉35 ml were 0.722, 0.728 and 0.779, respectively. The AUCs of PSA for predicting IPSS 〉 7, 〉 13 and 〉 19 were 0. 548, 0.536 and 0. 537, respectively. Serum PSA was a strong predictor of PV in a community-based cohort in a large-scale screening study. Although PSA was also significantly correlated with IPSS, predictive values of PSA for IPSS above the cutoff levels were not excellent. Further investigations are required to elucidate the exact interactions between PSA and LUTS and between PSA and PV in prospective controlled studies. Such studies may suggest how PSA can be used to clinically predict PV and the IPSS.

关键词： lower urinary tract symptoms (LUTS) prostate prostate-specific antigen (PSA) prostate volume (PV)

Osteochondral lesion of talus with gout tophi deposition:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第17期8卷 3814-3820页

作者： Taeho Kim young-Rak choi Department of Orthopaedic Surgery CHA Bundang Medical CenterCHA UniversitySeongnam 13497Gyeonggi-doSouth Korea Department of Orthopaedic Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Osteochondral lesion of talus is a broad term used to describe an injury or abnormality of the talar articular cartilage and adjacent *** arises from diverse causes,and although trauma is implicated in many cases,it does not account for the etiology of every *** is a chronic arthritic disease caused by excess levels of uric acid in *** deposition of monosodium urate in the clavicle,femur,patella and calcaneus was reported *** is common disease but rare at a young age,especially during teenage *** lesion caused by intra-articular gouty invasion is very *** SUMMARY We encountered a rare case of a 16-year-old male who has osteochondral lesion of the talus(OLT)with *** had fluctuating pain for more than 2 *** could see intra-articular tophi with magnetic resonance image(MRI)and *** performed arthroscopic exploration,debridement and *** were resolved after operation,and bony coverage at the lesion was seen on postoperative *** had checked image and uric acid levels for 18 *** It is rare to see OLT with gouty tophi in young *** it is challenging,the accuracy of diagnosis can be improved through history taking,MRI and arthroscopy.

关键词： Ankle Gout Osteochondral lesion of the talus Tophi Magnetic resonance image Arthroscope Case report

Three-dimensional endoanal ultrasonographic assessment of an anal fistula with and without H_2O_2 enhancement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第38期15卷 4810-4815页

作者： Yung Kim young jin Park Department of Surgery Dongguk University Ilsan HospitalDongguk University School of Medicine

AIM： To evaluate the effectiveness of three-dimensional endoanal ultrasound （3D-EAUS） in the assessment of anal fistulae with and without H202 enhancement. METHODS： Sixty-one patients （37 males, aged 17-74 years） with anal fistulae, which were not simple low types, were evaluated by physical examination and 3D-EAUS with and without enhancement. Fistula classification was determined with each modality and compared to operative findings as the reference standard. RESULTS： The accuracy of 3D-EAUS was significantly higher than that of physical examination in detecting the primary tract （84.4% vs 68.7%, P = 0.037） and secondary extension （81.8% vs 62.1%, P = 0.01） and localizing the internal opening （84.2% vs 59.7%, P = 0.004）. A contrast study with H202 detected several more fistula components including two primary suprasphincteric fistula tracks and one supralevator secondary extension, which were not detected on non-contrast study. However, there was no significant difference in accuracy between 3D-EAUS and H202- enhanced 3D-EAUS with respect to classification of the primary tract （84.4% vs 89.1%, P = 0.435） or secondary extension （81.8% vs 86.4%, P = 0.435） or localization of the internal opening （84.2% vs 89.5%, P = 0.406）. CONCLUSION： 3D-EAUS was highly reliable in the diagnosis of an anal fistula. H2O2 enhancement was helpful at times and selective use in difficult cases may be economical and reliable.

关键词： Anal fistula Endoanal ultrasound H2O2enhancement

Assessment of risk of complications in cirrhosis using portal thallium scans

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第1期20卷 228-234页

作者： Hye-jin Tae Dae-Won Jun Yun-young choi Min-Jung Kwak Min-Ho Lee Department of Internal Medicine Hanyang University School of MedicineSeoul 133-792South Korea Department of Nuclear Medicine Hanyang University College of MedicineSeoul 133-792South Korea Department of Computer Science and Statistics Pyongtaek UniversityPyongtaek 450-701South Korea

AIM:To investigate the usefulness of a novel thallium scan shunt index for assessing portosystemic shuntrelated cirrhotic ***:We enrolled 209 chronic hepatitis B-related cirrhosis *** rectal thallium instillation,radioactive isotope activity in the heart and liver was *** ratio of radiation uptake between the heart and the liver was calculated(the shunt index).This value indicates the degree of portosystemic circulation *** tests,serum biochemistry tests,abdominal ultrasonography,gastroscopy and examination of clinical features such as the occurrence of varices,bleeding and hepatic encephalopathy were *** analysis was used to identify independent risk factors for *** compared the cumulative incidence rates of complications during the follow-up ***:The thallium scan shunt index was significantly higher in the decompensated liver cirrhosis group than in the compensated liver cirrhosis group(0.91±0.39 vs 0.39±0.32,P<0.001).It was also higher in the varices group,the hepatic encephalopathy group,and the variceal bleeding group than in the control group(P<0.001).Multivariate analysis showed that the index was an independent risk factor for predicting decompensated liver *** the cut-off value was 0.75,the shunt index had a sensitivity of 82.6%,a specificity of 84%,a positive predictive value of 61.5%,and a negative predictive value of 94.4%in diagnosing decompensated *** the shunt index was greater than 0.75,there was a significant increase in the number of decompensated ***:The thallium shunt index is a good predictor of cirrhosis-related complications.

关键词： Liver cirrhosis Portosystemic shunt Decompensation

Black esophagus with concomitant candidiasis developed after diabetic ketoacidosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第42期13卷 5662-5663页

作者： Yong Hwan Kim Si young choi Department of Thoracic and Cardiovascular Surgery Uijeongbu St. Mary's Hospital The Catholic University of Korea College of Medicine Seoul 480-821 Korea Department of Thoracic and Cardiovascular Surgery Uijeongbu St. Mary’s Hospital The Catholic University of Korea College of Medicine Seoul 480-821 Korea

Black esophagus is a very rare disease and its pathogenesis has been *** esophagus developed concomitantly with candidiasis after diabetic ketoacidosis has not been reported *** report a case who developed esophageal stricture after the treatment of black esophagus and thus balloon dilatation was performed several times but failed,hence,surgical treatment was performed.

关键词： Esophagus Candidiasis Diabetic ketoacidosis Surgery

Role of kaempferol to increase bioavailability and pharmacokinetics of nifedipine in rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2019年第9期17卷 690-697页

作者： PARK Ji-Won choi jin-Seok Hazardous Substances Analysis Division Gwangju Regional Office of Food and Drug SafetyGwangju 61012Republic of Korea Department of Medical Management Chodang UniversityJeollanam-do 58530Republic of Korea

Herein,the purpose of this study is to evaluate the effects of kaempferol on bioavailability and pharmacokinetics of nifedipine and its metabolite dehydronifedipine in *** experimental design is based on with or without kaempferol in the oral and intravenous administration of nifedipine in ***,the pharmacokinetic parameters including nifedipine and dehydronifedipine were evaluated in *** in vitro studies of kaempferol were investigated on P-glycoprotein(P-gp)and cytochrome P450(CYP)3A4 *** reduced a 50%inhibitory concentration(IC50)of 8.6μmol·L-1 on CYP3A4 enzyme ***,kaempferol clearly improved the cell internalization of rhodamine-123 in MCF-7/ADR cells overexpressing *** on increased concentrations of kaempferol,the areas under the plasma concentration–time curve(AUC0-∞)and the peak concentration(Cmax)of nifedipine were increased after oral and intravenous ***,the absolute bioavailability(AB)and relative bioavailability(RB)of nifedipine in the presence of kaempferol was significantly higher than those of the control group after oral and intravenous *** of bioavailability of nifedipine by kaempferol may be mainly because of the inhibition of the P-gp-mediated efflux transporter in the small intestine and CYP3A4-mediated metabolism in the small intestine or liver,or both.

关键词： Nifedipine Kaempferol CYP3A4 P-gp Pharmacokinetics Bioavailability

维普期刊数据库

Time-domain channel estimator based on cyclic correlationfor OFDM systems with guard interval

在线全文

学校读者我要写书评

暂无评论

The Journal of China Universities of Posts and Telecommunications 2008年第2期15卷 26-31页

作者： IM Se-bin choi Hyung-jin Communication Research Center Harbin Institute of Technology

Channel impulse response （CIR） can be estimated on the basis of cyclic correlation in time-domain for orthogonal frequency division multiplexing （OFDM） systems, This article proposes a generalized channel estimation method to reduce the estimation error by taking the average of different CIRs. Channel impulse responses are derived according to the different starting points of cyclic correlation. In addition, an effective CIR length estimation algorithm is also presented. The whole proposed methods are more effective to OFDM systems, especialiy to those with longer cyclic prefix. The analysis and the simulation results verify that the mean square error performance is 4-5 dB better than the conventional schemes under the same conditions.

关键词： CIR OFDM channel estimation mean squareerror (MSE)

维普期刊数据库

Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2022年第2期14卷 192-200页

作者： Bongkun choi Ji-Eun Kim Si-On Park Eun-young Kim Soyoon Oh Hyuksu choi Dohee Yoon Hyo-jin Min Hyung-Ryong Kim Eun-Ju Chang Department of Biomedical Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Stem Cell Immunomodulation Research Center Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Pharmacology College of DentistryJeonbuk National UniversityJeonjuKorea Department of Biochemistry and Molecular Biology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Sphingosine-1-phosphate(S1P)is an important lipid mediator that regulates a diverse range of intracellular cell signaling pathways that are relevant to tissue engineering and regenerative ***,the precise function of S1P in dental pulp stem cells(DPSCs)and its osteogenic differentiation remains *** here investigated the function of S1P/S1P receptor(S1PR)-mediated cellular signaling in the osteogenic differentiation of DPSCs and clarified the fundamental signaling *** results showed that S1P-treated DPSCs exhibited a low rate of differentiation toward the osteogenic phenotype in association with a marked reduction in osteogenesis-related gene expression and AKT *** note,both S1PR1/S1PR3 and S1PR2 agonists significantly downregulated the expression of osteogenic genes and suppressed AKT activation,resulting in an attenuated osteogenic capacity of *** importantly,an AKT activator completely abrogated the S1P-mediated downregulation of osteoblastic markers and partially prevented S1P-mediated attenuation effects during ***,the pro-inflammatory TNF-αcytokine promoted the infiltration of macrophages toward DPSCs and induced S1P production in both DPSCs and *** findings indicate that the elevation of S1P under inflammatory conditions suppresses the osteogenic capacity of the DPSCs responsible for regenerative endodontics.

关键词： pulp hinder precise

维普期刊数据库

Seroepidemiology of echovirus 30 in Korean children

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2017年第6期13卷 611-614页

作者： Joo young Lee Yumi Seo Ui Yoon choi Jong-Hyun Kim jin Han Kang Department of Pediatrics College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

Background:Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern,no data have been reported on children's immune status against echovirus type *** current study aimed to investigate the seropositivity among Korean children for antibodies against echovirus ***:Two hundred and fifty residual serum samples were collected at ***'s *** were categorized by age into four groups:group 1 (3 months-2 years),group 2 (3-6 years),group 3 (7-10 years) and group 4 (11-15 years).Neutralizing antibodies against echovirus 30 were ***:Seroprotective neutralizing antibodies against echovirus 30 were detected in 129 (49%) *** rates were 23%,48%,55% and 73% in groups 1-4,*** antibody titers,1:256-1:512 was the highest neutralizing antibody titer range in group 2,while 1:1024-1:2048 in group 3 and *** the seropositive individuals in group 3 and 4,6% and 12% had neutralizing antibody titers of 1:2048,***:The seropositivity rate increased significantly with age..The distribution of neutralizing antibody titers varied by age group,and higher ranges of neutralizing antibody titers were observed in higher age *** findings suggest high susceptibility to echovirus 30 infection in children younger than 2 years *** 30 infection in childhood may have contributed to increased neutralizing antibody titers with age.

关键词： echovirus 30 Korea seroepidemiology